Vacation Homes in Panama

Compare and save
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Our top choices for Panama vacation homes

Vacation Home in Bocas del Toro

Surfari Bocas
2.5 star property
9.0 out of 10, Wonderful, (55 reviews)
"Super friendly and helpful checkin. Clean room, would stay again next time!"
United States
Troy
The price is ¥6,275
¥6,902 total
includes taxes & fees
Jan 29 - Jan 30
Surfari Bocas

Vacation Home in Panamá

Oasis with pool near panama canal
9.4 out of 10, Exceptional, (26 reviews)
"The place was really comfortable and very close to the city and other tourist attractions and even close to the airport. My family really enjoyed the the pool area and the convenience of the spacious house! Would recommend and I would rent this place on my next vacation."
United States
Wendy F.
The price is ¥30,106
¥43,574 total
includes taxes & fees
Jan 20 - Jan 21
Oasis with pool near panama canal

Vacation Home in Penonomé

Enjoy family size cozy home
10.0 out of 10, Exceptional, (2 reviews)
"Erya's home is in a quiet and lovely neighborhood. We appreciated her clear communication and the property was just what we needed to visit with extended family in and around Penonome!"
United States
Katrina S.
The price is ¥11,884
¥15,053 total
includes taxes & fees
Jan 20 - Jan 21
Enjoy family size cozy home
The price is ¥5,704
¥15,211 total
includes taxes & fees
Jan 18 - Jan 19
Panama View House – A Hilltop Retreat with Stunning Canal Views
10.0 out of 10, Exceptional, (4 reviews)
"This was a great place to stay with a group of people. Convenient location. Was a little surprised it was not in Allbrook."
United States
Robin S.
The price is ¥74,155
¥94,912 total
includes taxes & fees
Jan 18 - Jan 19
Tropical House with Historic Charm, WiFi, Private Bathrooms and Workspaces

Vacation Home in Bocas del Toro

Private Luxury Over the Water Bungalow
10.0 out of 10, Exceptional, (8 reviews)
"Lovely home well managed. Just perfect stay over the water."
United States
Emily B.
Private Luxury Over the Water Bungalow

Vacation Home in Bocas del Toro

Casita del Mar, Bocas del Toro, Panama
10.0 out of 10, Exceptional, (60 reviews)
"A perfect combination of private accommodations with access to a personal captain to travel to some of the amazing places the area has to offer. Plenty of wildlife including: Dolphins, starfish, sloths, monkeys, geckos, many types of fish and birds. Access to the kayaks and paddleboards was great too. Amazing how calm the water was a certain times of the day. "
United States
Kevin L.
Casita del Mar, Bocas del Toro, Panama
10.0 out of 10, Exceptional, (40 reviews)
"Great place to stay. Host is very responsive. Short walk to beach. Great views from rooftop pool area. Overall excellent. "
United States
David G.
Beach House with Ocean View - Rooftop Jacuzzi & Pool - Concierge Service

Vacation Home in San Francisco

House in Punta Paitilla B19
10.0 out of 10, Exceptional, (6 reviews)
"It is a beautiful house. "
United States
Earl S.
House in Punta Paitilla B19
9.6 out of 10, Exceptional, (4 reviews)
"Place was awesome. A little out of the way but overall had an excellent experience"
United States
Todd S.
Jungle House, 100m From the Beach, With Private Pool
9.4 out of 10, Exceptional, (11 reviews)
"We had another wonderful stay at Casa Rosie. It’s the perfect place to unwind."
United States
Dimo
The price is ¥39,367
¥49,408 total
includes taxes & fees
Jan 16 - Jan 17
Casa Rosie - relax and unwind in paradise
2.0 star property
Large calm house surrounded by nature

Vacation Home in Red Frog Beach

Private Villa at Red Frog Beach Resort
10.0 out of 10, Exceptional, (7 reviews)
"What a wonderful property and the host is such a great communicator, making preparation and staying there easy. I'd recommend getting food/drink/water supplies on the main island before coming over as the local store is good but is sometimes out of a few things "
United States
Ephraim F.
Private Villa at Red Frog Beach Resort
2.0 star property
Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm

Vacation Home in Gamboa

BirdHouse@Gamboa, Panama Canal
9.6 out of 10, Exceptional, (23 reviews)
"Beautifully artistic home. Loved everything about it!"
United States
Kelly H.
BirdHouse@Gamboa, Panama Canal
10.0 out of 10, Exceptional, (5 reviews)
"Very comfy a quiet, we enjoyed a lot!"
United States
Marisol
Romantic Getaway: Luxury 1-Bedroom in Gated Community of Punta Chame Resort

Vacation Home in Ave María

Tropical Beachfront Home in Cambutal
10.0 out of 10, Exceptional, (1 review)
"Nice house right on the beach. Home is in great condition and well equipped. Host was very responsive and provided all info in a timely fashion. Restaurants, store and great little coffee/cafe within walking distance. Only negative was quite a bit of road noise even though traffic was light. Had no issues with electric or water. Having grown up in Panama many years ago I was surprised that there were very few mosquitoes during my visit. "
United States
Reginald D.
Tropical Beachfront Home in Cambutal

Vacation Home in Nueva Gorgona

Mahi Mahi Apartment - Gorgona
2.0 star property
10.0 out of 10, Exceptional, (1 review)
"Very nice apartment. I didn’t have children with me but it is set up to accommodate them if needed. It had beach chairs, cooler, sand toys. Good communication. The community is older and you must have a car. Not much to do in the immediate area. The beach glitters like diamonds!"
United States
Teri
Mahi Mahi Apartment - Gorgona

Vacation Home in Nueva Gorgona

Casa de Campo Mia
2.5 star property
8.6 out of 10, Excellent, (18 reviews)
"Excellent stay, Owners on property. Very accommodating. "
United States
Jim
Casa de Campo Mia

Vacation Home in Las Lajas, Chiriquí

Mariposa Blanca Playa Lajas Large Modern Beach House
10.0 out of 10, Exceptional, (4 reviews)
"We were welcomed to the home with yummy cookies and a bottle of wine! The beach house was beautiful, each room was decorated in a beach theme. The beach itself is only down a path, and you can see it and hear it from the home. I would highly recommend staying at this property, we had a great time!"
United States
Francine W.
Mariposa Blanca Playa Lajas Large Modern Beach House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Panama Hotel Reviews

Find out more about Panama

Panama Vacation Homes information

Number of reviews
261
Accommodation
481 Vacation Homes
Lowest Price
¥6,902
Highest Price
¥95,070

Explore a world of travel with Expedia