Find hotels near Mississippi River, from ￥10,397

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Our top choices for Mississippi River hotels

Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
United States
Bryan
The price is ￥16,315
￥18,523 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Eagles Nest Inn
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1001)
"Very personable staff, easy check in"
United States
Cherie
The price is ￥15,155
￥17,557 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn & Suites Hannibal West
Property grounds
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (357)
"Excellent stay !!! Quite "
United States
Bradley
The price is ￥12,490
￥14,181 total
includes taxes & fees
Dec 25 - Dec 26
River's Edge Motel
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is ￥23,795
￥32,735 total
includes taxes & fees
Dec 27 - Dec 28
Riverside Inn Hannibal
Down comforters, blackout drapes, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (24)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ￥26,362
￥30,274 total
includes taxes & fees
Dec 25 - Dec 26
Lighthouse Inn & Suites
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1001)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ￥15,715
￥18,047 total
includes taxes & fees
Dec 25 - Dec 26
Best Western On The River
Desk, blackout drapes, iron/ironing board, free WiFi
Town & Country Inn and Suites

Town & Country Inn and Suites

Town & Country Inn and Suites
2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (896)
"Staff extremely helpful and kind"
United States
Sandra
Town & Country Inn and Suites
TV
Garden House Bed and Breakfast

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (38)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is ￥16,720
￥19,204 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Garden House Bed and Breakfast
Indoor spa tub
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1000)
"Always love staying here"
United States
Ashlynn
Stoney Creek Inn Quincy
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (605)
"Overall very nice property. "
United States
Jeffrey
The price is ￥17,329
￥19,752 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Quincy East by IHG
Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (449)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is ￥15,261
￥17,394 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Quality Inn & Suites Quincy - Downtown
Free daily continental breakfast
Heritage Hotel Quincy

Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (272)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is ￥13,278
￥15,135 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Heritage Hotel Quincy
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very Good, (1004)
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is ￥10,833
￥12,551 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Inn & Suites Hannibal West
Lobby
Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
2.5 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (335)
"We were very pleased with our stay. The room was clean and the staff was VERY friendly. We were also VERY impressed the breakfast. We would definitely stay there again."
United States
Julie
The price is ￥17,119
￥19,512 total
includes taxes & fees
Dec 28 - Dec 29
Fairfield Inn & Suites Quincy
Jetted tub
Oak Hill Inn & Suites

Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (873)
"Room was clean, comfy bed, and very accommodating "
United States
Wendy
The price is ￥16,438
￥18,736 total
includes taxes & fees
Dec 25 - Dec 26
Oak Hill Inn & Suites
In-room safe, desk, blackout drapes, iron/ironing board
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (661)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is ￥11,865
￥14,095 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Comfort Inn & Suites - Hannibal
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (847)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ￥17,173
￥20,608 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby lounge
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1000)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ￥9,053
￥10,397 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (216)
"Left before breakfast great cup of coffee"
United States
David
The price is ￥10,382
￥11,924 total
includes taxes & fees
Dec 25 - Dec 26
Days Inn by Wyndham Hannibal
In-room safe, desk, laptop workspace, blackout drapes
TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
86.6 km from Mississippi River
9.4 out of 10, Exceptional, (48)
"Great property, would recommend!!"
United States
Karen
The price is ￥23,574
￥27,789 total
includes taxes & fees
Jan 23 - Jan 24, 2026
TownePlace Suites by Marriott Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi River Hotel Reviews

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

10/10 Excellent
"Well maintaining room, no issues, staff was very helpful with our luggage moving to checkout, parking was nearby & easy to get in"
Saige 1-night trip
Posted 11 hours ago
Motel 6 Hazelwood, MO

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savor the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Mississippi River?
Pear Tree Inn St. Louis Airport is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. You'll find it 69.9 mi (112.5 km) from Mississippi River. Other good options around the area include Hilton St. Louis Airport and Hyatt Regency St. Louis at The Arch.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.
Where can I learn more about changing or cancelling my trip in the area near Mississippi River?
For additional details about updating your stay near Mississippi River or cancelling it, head over to our customer service page.