A bridge spanning a body of water with a city skyline in the background during sunset.

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Our top choices for Mississippi River hotels

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
30.3 km from Mississippi River
United States
Patricia
¥18,260
¥21,246 total
includes taxes & fees
Oct 11 - Oct 12
Sleep Inn & Suites Hannibal West

2. River's Edge Motel

River's Edge Motel
13.6 km from Mississippi River
United States
Kim
¥13,054
¥14,822 total
includes taxes & fees
Sep 28 - Sep 29
River's Edge Motel

3. The Eagles Nest Inn

The Eagles Nest Inn
14.2 km from Mississippi River
United States
Gary
¥17,508
¥19,878 total
includes taxes & fees
Oct 28 - Oct 29
The Eagles Nest Inn

4. Best Western On The River

Best Western On The River
25.3 km from Mississippi River
United States
Raymond
¥17,299
¥19,954 total
includes taxes & fees
Oct 4 - Oct 5
Best Western On The River

5. Riverside Inn Hannibal

Riverside Inn Hannibal
25.1 km from Mississippi River
United States
Jack
¥23,852
¥32,956 total
includes taxes & fees
Sep 28 - Sep 29
Riverside Inn Hannibal

6. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
30 km from Mississippi River
United States
Kenneth
¥12,527
¥14,576 total
includes taxes & fees
Oct 11 - Oct 12
Quality Inn & Suites Hannibal West

7. Oak Hill Inn & Suites

Oak Hill Inn & Suites
71.8 km from Mississippi River
United States
Denny
¥15,923
¥18,149 total
includes taxes & fees
Sep 28 - Sep 29
Oak Hill Inn & Suites

8. Heritage Hotel Quincy

Heritage Hotel Quincy
47.8 km from Mississippi River
United States
Dustine
¥11,024
¥12,565 total
includes taxes & fees
Oct 28 - Oct 29
Heritage Hotel Quincy

9. Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
104 km from Mississippi River
United States
Robert
¥21,389
¥24,796 total
includes taxes & fees
Oct 12 - Oct 13
Drury Plaza Hotel St. Louis St. Charles

10. Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
86.2 km from Mississippi River
United States
Renae
¥21,862
¥26,027 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express & Suites Wentzville St Louis West by IHG

11. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
95.3 km from Mississippi River
United States
Tiffany
¥17,299
¥19,886 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites St. Louis St. Peters

12. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
26.2 km from Mississippi River
United States
Charles
¥12,062
¥14,384 total
includes taxes & fees
Oct 4 - Oct 5
Comfort Inn & Suites - Hannibal

13. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
47.8 km from Mississippi River
United States
Cathy
¥19,424
¥22,139 total
includes taxes & fees
Oct 4 - Oct 5
Quality Inn & Suites Quincy - Downtown

14. Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
46.5 km from Mississippi River
United States
Kent
¥18,969
¥21,620 total
includes taxes & fees
Oct 4 - Oct 5
Stoney Creek Inn Quincy

15. Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
103.7 km from Mississippi River
United States
Roseanna
¥22,054
¥25,346 total
includes taxes & fees
Oct 12 - Oct 13
Country Inn & Suites by Radisson, St. Charles Historic District

16. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
46.1 km from Mississippi River
United States
Charles
¥19,975
¥22,767 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Quincy East by IHG

17. Garden House Bed and Breakfast

Garden House Bed and Breakfast
25.2 km from Mississippi River
United States
Edward
¥12,678
¥14,624 total
includes taxes & fees
Sep 30 - Oct 1
Garden House Bed and Breakfast

18. Hampton Inn & Suites St. Louis/Alton

Hampton Inn & Suites St. Louis/Alton
110.3 km from Mississippi River
United States
Kathy
¥20,506
¥23,373 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn & Suites St. Louis/Alton

19. Lighthouse Inn & Suites

Lighthouse Inn & Suites
25.8 km from Mississippi River
United States
Kari
¥26,558
¥30,633 total
includes taxes & fees
Sep 28 - Sep 29
Lighthouse Inn & Suites

20. Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
93.3 km from Mississippi River
United States
Serah
¥18,559
¥22,307 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express & Suites St Peters by IHG
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Compare popular hotels close to Mississippi River

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.
Sleep Inn & Suites Hannibal West
9.6
Exceptional
1,000 reviews
View
A gazebo with a table and benches, surrounded by trees and a body of water.
River's Edge Motel
9.0
Wonderful
389 reviews
View
A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.
The Eagles Nest Inn
9.4
Exceptional
26 reviews
View
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River
8.6
Excellent
1,007 reviews
View
A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.
Riverside Inn Hannibal
9.6
Exceptional
199 reviews
View

Top Mississippi River Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Excellent stay"
Murphy 1-night trip
Posted 1 hour ago
Pear Tree Inn St. Louis Airport
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

8/10 Good
"I wish that the Pear Inn Hotel provided shuttle service to their guests."
Joyce 2-night trip
Posted 1 hour ago
Pear Tree Inn St. Louis Near Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"We loved our stay. Everything was clean and the bed was the most comfortable hotel bed I’ve slept on. We had a blast. The breakfast was delicious."
Joshua 2-night trip
Posted 1 hour ago
Clayton Plaza Hotel & Extended Stay
21C Museum Hotel St Louis

21C Museum Hotel St Louis

10/10 Excellent
"Room was clean, staff were helpful, Art was really neat. Also one of the nicest hotel gyms I’ve ever experienced. Very large pool and hot plus other spa accommodations. Overall really enjoyed our stay here and would definitely go back."
Caleb 2-night trip
Posted 2 hours ago
21C Museum Hotel St Louis
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Well located near the Arch National Park; was able to leave our car at the hotel garage and walk to the Arch. Make sure you check-in before 5:00 or so, so that you can take advantage of their happy hour which features THREE FREE DRINKS and pretty good appetizers. Monday was pulled pork sliders and chili/nachos. Staff was very helpful and attentive. Great place to stay if you’re visiting the Arch."
Mark 1-night trip
Posted 3 hours ago
Drury Plaza Hotel St. Louis at the Arch
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

8/10 Good
"Helpful staff , clean room great stay overall"
Lakeshia 1-night trip
Posted 3 hours ago
Drury Inn & Suites St. Louis Airport
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

10/10 Excellent
"Great place to stay"
David 3-night trip
Posted 4 hours ago
Hyatt Regency St. Louis at The Arch
Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"Wonderful stay. Comfy bed. One of cleanest rooms I’ve ever stayed in. It is convenient to Busch Stadium, but just a heads up that if you stay there, any of the events may be cause for a bit of noise - but with the television on, it just sounded like any metropolitan area. Would not hesitate to stay again."
Lianne 1-night trip
Posted 5 hours ago
Live by Loews - St.Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Great room and fun casino"
Desmond 1-night trip
Posted 7 hours ago
Ameristar Casino Resort and Spa

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savor the top-notch restaurants.
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Sawyer's Creek Fun Park

7.8/10 (16 reviews)
Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savor the top-notch restaurants.
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Lovers Leap

8.8/10 (171 reviews)
Find out about the history of Hannibal with a stop at Lovers Leap. While in this walkable area, you can savor the top-notch restaurants.
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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.
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Bluff City Theater

7.6/10 (5 reviews)
Enjoy a show at Bluff City Theater, a theater with a story to tell in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.
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Planters Barn Theater

8.8/10 (22 reviews)
Enjoy a show at Planters Barn Theater, a storied theater in Hannibal. While in this walkable area, you can savor the top-notch restaurants.
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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)
Find out about the history of Hannibal when you take a trip to Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savor the top-notch restaurants.
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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)
You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your travels to Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.
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Find out more about Mississippi River

Top reasons to visit Mississippi River

  • Vibrant Activities: Enjoy baseball games, live music, and sports events along the river.
  • Scenic Day Trips: Experience breathtaking landscapes and explore charming towns like Minneapolis and the Mississippi Delta.
  • Historic Exploration: Visit historic houses, museums, and engage in river studies for an educational adventure.
  • Steamboat Cruises: Take a ride on iconic steamboats for a unique view of this majestic waterway.
  • Diverse Accommodations: Choose from cozy bed & breakfasts to modern hotels for a perfect stay.

Find great hotels near Mississippi River

Discover a range of charming accommodations along the majestic Mississippi River, from cozy bed & breakfasts to modern hotels. Whether you're seeking a family-friendly retreat, a pet-friendly getaway, or a romantic escape, you're sure to find the perfect place to relax. Explore options like the Hampton Inn and unique wilderness cabins, all designed to enhance your experience in this beautiful region.

  • Best Western On The River: Located in the heart of the city, Best Western On The River offers a budget-friendly stay with a family-oriented atmosphere. With a guest rating of 8.6 out of 10, this hotel is ideal for both business and leisure travelers. Enjoy amenities designed for families, including a PoolGate for children's safety. The convenient city center location provides easy access to local attractions, making it a practical choice for those looking to explore the area while enjoying comfortable accommodations.
  • Super 8 by Wyndham Bowling Green: Super 8 by Wyndham Bowling Green is a cozy and budget-friendly motel located 24km from the Mississippi River, boasting a guest rating of 8.4 out of 10. Guests can start their day with complimentary breakfast options, including a daily breakfast and to-go breakfasts. The motel also features entertainment amenities such as DVD players and televisions with premium channels, ensuring a relaxing stay for travelers. This welcoming environment caters well to those looking for both comfort and convenience.
  • River's Edge Motel: Offering a unique pet-friendly experience, River's Edge Motel is just 13km from the Mississippi River and has garnered a guest rating of 9.0 out of 10. This budget-friendly motel welcomes pets with certain restrictions, making it a great choice for travelers who wish to bring their furry companions along. The property ensures a comfortable stay with its friendly atmosphere and is an excellent option for those seeking a relaxing getaway close to nature.

Where to stay near Mississippi River

Embark on an unforgettable journey along the majestic Mississippi River, where friendly locals and family-friendly activities await. Explore vibrant cities like Minneapolis, rich in culture and history, or relax in the serene beauty of the Mississippi Delta. Don't miss the chance to discover the scenic Iowa River and the picturesque Minnesota River, both offering excellent opportunities for excursions and relaxation amidst nature's splendor.

  • Louisiana: A charming city located 14km from the Mississippi River, Louisiana offers a delightful blend of outdoor activities and scenic beauty. This city attracts visitors year-round, with peak seasons in April, July, and September. Here, you can indulge in romantic strolls along the river or explore the tranquil lakes and nearby national parks. Louisiana is also home to various recreational areas, theaters, and entertainment facilities, making it a perfect destination for those seeking an enriching travel experience.
  • New Canton: Situated 11km from the Mississippi River, New Canton is a family-friendly city known for its seasonal visitor influx. Peak travel times occur between January to February, April, August, and November. Families flock to New Canton for its outdoor adventures, scenic landscapes, and educational opportunities. With golf courses and a natural history museum within reach, it’s an ideal spot for those looking to combine fun and learning during their vacation. The picturesque river and lake further enhance the city's appeal.
  • Rockport: Located 13km from the Mississippi River, Rockport is a vibrant city that offers a mix of family-oriented and city-themed experiences. This destination sees its highest visitor numbers in May, July, and September. Rockport features numerous educational venues, theaters, and golf facilities, catering to diverse interests. Local attractions include an urban park, a history museum, and a modern college university, providing plenty of opportunities for exploration and engagement. The city’s welcoming atmosphere makes it a fantastic place for making lasting memories.

Things to do in Mississippi River

Shopping

In the Mississippi River region, visit the River Market in Little Rock for local crafts and unique souvenirs. If you're up for a drive, check out the Mall of America in Bloomington, located over 16km away, featuring a wide array of shops and entertainment options.

Recreation

The Riverbend Wellness Center offers rejuvenating yoga classes and meditation sessions overlooking the Mississippi River. Nearby, the Natchez Trace Parkway invites visitors to explore scenic trails, ideal for hiking and cycling amidst nature's beauty, promoting relaxation and mindfulness.

Adventure

Explore the Mississippi River on a guided kayak tour, where you can paddle through scenic waterways and witness local wildlife. For a thrilling experience, try zip-lining above the river or take a riverboat cruise to enjoy panoramic views of the landscape and historic sites along the shore.

Nightlife

The nightlife along the Mississippi River features lively spots like the iconic Beale Street in Memphis, known for its blues clubs, and the vibrant bars in New Orleans' French Quarter, where jazz fills the air. Enjoy craft cocktails at rooftop lounges or savor local cuisine at late-night eateries.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mississippi River

The Mississippi River offers a variety of attractions for every type of traveler, including historic houses, caves, and museums. Visitors can immerse themselves in culture and adventure while exploring the Mississippi embayment, river corridor, and the stunning landscapes along the river. Don't miss the chance to experience the fascinating Mississippi River Project and take a ride on the iconic steamboats that cruise this amazing waterway.

  • Mark Twain Boyhood Home and Museum: Explore the charming home where the famous author grew up. The museum showcases artifacts and exhibits that reflect the culture and history of Twain's formative years, offering a glimpse into the life that inspired beloved tales.
  • Mark Twain Cave: Venture into the depths of this fascinating cave, which offers an adventurous experience amid stunning natural formations. Guided tours provide insights into the cave's history and its connection to Twain's stories, making it a thrilling outdoor activity.
  • Mark Twain Memorial Lighthouse: Visit this historic lighthouse that stands as a tribute to the literary legend. Enjoy scenic views of the river and learn about Twain's impact on American literature, all while soaking in the cultural significance of the site.

The nearest major airports for your trip to Mississippi River

Flying into the Mississippi River region is convenient with several major airports nearby. St. Louis Lambert International Airport (STL) is 113km away, offering luxurious hotels like The Ritz-Carlton and Ameristar Casino Resort, both 11km from the airport. Columbia Regional Airport (COU), located 122km from the river, features nearby options like The Broadway Columbia, also 18km away. For those considering Peoria International Airport (PIA), situated 175km from the river, the Embassy Suites is 8km away and provides transportation services to the airport. Each location offers a variety of accommodations to suit your travel needs.

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Mississippi River?
Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveler data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.
Where can I learn more about changing or cancelling my trip in the area near Mississippi River?
For additional details about updating your stay near Mississippi River or cancelling it, head over to our customer service page.