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Our top choices for Louisiana hotels

Balcony
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
Louisiana
9.0 out of 10, Wonderful, (355)
Enjoy Southern hospitality at this welcoming Louisiana establishment. The 24-hour front desk ensures round-the-clock service, while complimentary WiFi keeps you connected. Guests consistently praise the helpful staff and convenient amenities.
"Excellent stay !!! Quite "
United States
Bradley
The price is ￥12,439
￥14,123 total
includes taxes & fees
Dec 25 - Dec 26
River's Edge Motel
Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
Louisiana
9.4 out of 10, Exceptional, (19)
Italian cuisine awaits at Gambino's Eatery in this cozy Louisiana inn. After exploring the nearby Mississippi River, unwind in a plush bathrobe. Free WiFi and parking enhance your stay.
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
The price is ￥16,249
￥18,448 total
includes taxes & fees
Dec 15 - Dec 16
The Eagles Nest Inn
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
Hannibal
8.0 out of 10, Very Good, (1008)
Set near Hospital Park, this welcoming hotel offers a fitness center and terrace for active travelers. Wake up to free breakfast before exploring Mark Twain's hometown. The attentive staff receives high praise from guests who appreciate the convenient location.
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is ￥12,376
￥14,338 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Quality Inn & Suites Hannibal West
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
Hannibal
8.6 out of 10, Excellent, (1002)
Peaceful riverside retreat just a 5-minute walk from Mississippi River and historic downtown Hannibal. Free breakfast energizes before exploring Mark Twain attractions nearby. Indoor and seasonal outdoor pools, hot tub, and fitness center enhance your relaxing stay.
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ￥15,703
￥18,035 total
includes taxes & fees
Dec 14 - Dec 15
Best Western On The River
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1002)
This business-friendly hotel offers an indoor pool and fitness center near Hospital Park. Wake up to complimentary breakfast before exploring local attractions. Guests consistently praise the comfortable beds and helpful staff, plus enjoy free WiFi and parking.
"Great area"
United States
kelvin
The price is ￥15,728
￥18,221 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sleep Inn & Suites Hannibal West
Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (659)
Steps from Hannibal attractions, this welcoming hotel offers an indoor pool and 24-hour fitness center. Guests consistently praise the complimentary breakfast, helpful staff, and convenient location near Sodalis Nature Preserve. Free WiFi and parking complete your stay.
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is ￥12,556
￥14,886 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites - Hannibal
Desk, laptop workspace, iron/ironing board, free WiFi
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
Hannibal
6.4 out of 10, (735)
Located near Mississippi River and West Ely Park, this hotel offers free breakfast, WiFi, and parking. Enjoy a morning swim in the indoor pool or workout at the health club. Guests praise the helpful staff and clean rooms at this business-friendly retreat.
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
The price is ￥10,107
￥11,687 total
includes taxes & fees
Dec 14 - Dec 15
Baymont by Wyndham Hannibal
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
Hannibal
7.4 out of 10, Good, (1002)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ￥9,017
￥10,356 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
Hannibal
7.4 out of 10, Good, (215)
This Hannibal hotel offers convenient access to West Ely Park and Sodalis Nature Preserve. Wake up to complimentary continental breakfast, connect with free WiFi, and enjoy hassle-free parking during your Mississippi River adventure.
"Left before breakfast great cup of coffee"
United States
David
The price is ￥9,796
￥11,251 total
includes taxes & fees
Dec 26 - Dec 27
Days Inn by Wyndham Hannibal
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
Hannibal
7.2 out of 10, Good, (1000)
Set in peaceful surroundings, this Hannibal motel offers a seasonal outdoor pool and easy access to hiking trails. Guests praise the helpful staff and clean accommodations. Complimentary breakfast, WiFi, and parking enhance the value while nearby parks provide outdoor recreation options.
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is ￥8,676
￥9,963 total
includes taxes & fees
Dec 22 - Dec 23
Super 8 by Wyndham Hannibal
Breakfast meal
William Watson Hotel

William Watson Hotel

William Watson Hotel
3.0 star property
Pittsfield
9.2 out of 10, Wonderful, (346)
William Watson Hotel welcomes guests with a fitness center and convenient snack bar. Enjoy nearby John Greene Shastid House and Pike County Historic Museum, plus 24-hour front desk service. Quincy Regional Airport is just an hour's drive away.
"Great location, restaurant downstairs, friendly staff, microwaves and refrigerator in room, historic significance "
United States
Druann
The price is ￥12,557
￥13,811 total
includes taxes & fees
Jan 13 - Jan 14, 2026
William Watson Hotel
Free daily on-the-go breakfast
Rodeway Inn Pittsfield

Rodeway Inn Pittsfield

Rodeway Inn Pittsfield
2.0 star property
Pittsfield
6.8 out of 10, (125)
Conveniently situated in Pittsfield near King Park and John Greene Shastid House, this hotel offers free WiFi, parking, and daily on-the-go breakfast. Guests enjoy comfortable rooms with easy access to local attractions.
"Air conditioning | Pet-friendly | Clean room | Staf"
United States
Anonymous traveler
The price is ￥9,585
￥10,542 total
includes taxes & fees
Dec 25 - Dec 26
Rodeway Inn Pittsfield
Deluxe Room | Down comforters, blackout drapes, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
Hannibal
8.8 out of 10, Excellent, (23)
Stylish apartments with modern amenities await at this 4-star hideaway. Just 5 minutes from the Mississippi River, explore the nearby Molly Brown Museum and Mark Twain Memorial Lighthouse. Smart TVs and luxurious hydromassage showerheads enhance your experience.
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ￥26,256
￥30,153 total
includes taxes & fees
Dec 14 - Dec 15
Lighthouse Inn & Suites
Lobby sitting area
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
Hannibal
7.2 out of 10, Good, (152)
This comfortable Howard Johnson hotel offers convenient amenities including an indoor pool, free WiFi, and complimentary parking. Located near West Ely Park and Sodalis Nature Preserve, guests consistently praise the friendly staff and clean accommodations for a pleasant Missouri getaway.
"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"
United States
Shawn
The price is ￥8,863
￥10,250 total
includes taxes & fees
Dec 14 - Dec 15
Howard Johnson BY Wyndham Hannibal
Front of property
Garden House Bed and Breakfast

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
Hannibal
8.6 out of 10, Excellent, (37)
This charming Hannibal B&B offers complimentary parking and internet access, with hiking trails nearby. Explore Big River Train Town or visit Jim's Journey, then return to relax in provided bathrobes after a day of adventure.
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is ￥16,687
￥19,164 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Garden House Bed and Breakfast
Lobby sitting area
Green Acres Hotel

Green Acres Hotel

Green Acres Hotel
2.5 star property
Pittsfield
8.6 out of 10, Excellent, (141)
Green Acres Hotel offers a relaxing stay near King Park and John Greene Shastid House. Enjoy the complimentary continental breakfast served daily, plus free WiFi and parking. This comfortable hotel provides the perfect base for exploring Pittsfield attractions.
"Great stay"
United States
Jeramy
The price is ￥16,653
￥18,314 total
includes taxes & fees
Dec 14 - Dec 15
Green Acres Hotel
Comfort Room | Premium bedding, desk, iron/ironing board, free cribs/infant beds
Monroe Street Suites

Monroe Street Suites

Monroe Street Suites
2.5 star property
Pittsfield
9.6 out of 10, Exceptional, (57)
Cozy accommodations in Pittsfield with convenient access to John Greene Shastid House and Pike County Historic Museum. This hotel offers complimentary WiFi, free parking, and daily housekeeping for a comfortable, hassle-free stay.
"We had a great stay and would recommend others to stay here!"
United States
Brady
The price is ￥13,411
￥14,750 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Monroe Street Suites
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
Hannibal
9.4 out of 10, Exceptional, (165)
Quaint guesthouse offering free WiFi, parking, and Netflix just 5 minutes from the Mississippi River. Explore Mark Twain Boyhood Home and Museum or catch a show at nearby Planters Barn Theater after a day of riverside wandering.
"Great place to stay!"
United States
Sandy
The price is ￥22,926
￥31,687 total
includes taxes & fees
Dec 20 - Dec 21
Riverside Inn Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Louisiana

Like rivers? Get away to relaxing Louisiana!

See all hotels in Louisiana
Open swing span of Louisiana railroad bridge across the upper Mississippi near the town of Louisiana in Missouri

Top Louisiana Hotel Reviews

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

10/10 Excellent
"Hot tub could be turned up "
Kathy 1-night trip
Posted 3 days ago
Quality Inn & Suites Hannibal West

More cheap stays in Louisiana

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

123 Huckleberry Heights Dr Hannibal MO
The price is ￥9,017 per night from Jan 12 to Jan 13
￥9,017
￥10,356 total
Jan 12 - Jan 13, 2026
includes taxes & fees
7.4/10 Good! (1,000 reviews)

Frequently asked questions

Where is the best place to stay in Louisiana?
The Eagles Nest Inn is a favorite property for Expedia customers. This inn is a short 3-minute walk from Mississippi River, and it offers a restaurant and free parking. Another top choice for your stay based on reviews is River's Edge Motel. See all available top hotels, or vacation rentals in Louisiana.
What are some of the best vacation rentals in Louisiana?
The Yellow Rose Historic Home: Visitors like this Louisiana vacation home rental. It offers a selection of games, a barbecue grill, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Louisiana.
If I need to cancel my hotel reservation in Louisiana, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Louisiana.
Where can I learn more about changing or cancelling my trip to Louisiana?
To access more information about picking new dates or cancelling your trip to Louisiana, go to https://www.expedia.com/service/.
What's the best hotel for a couple visiting Louisiana?
Come see what our Historical town has to offer! is a favorite B&B for couples, and features in-room kitchenettes and private patios. See all romantic hotels in Louisiana.
What's the best pet-friendly hotel in Louisiana?
River's Edge Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Louisiana.
What are some hotels with pools in Louisiana?
Quality Inn & Suites Hannibal West: Features a snack bar/deli, an indoor pool, and buffet. Sleep Inn & Suites Hannibal West and Best Western On The River are two additional hotels with an onsite pool. View all hotels with pools in Louisiana.
What's the best accommodation near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What is staying in Louisiana like?
Visitors to Louisiana are sure to enjoy the riverfront. This city also attracts tourists with its welcoming and relaxing setting. In Louisiana, there are 5 hotels and other accommodations to choose from. Find out more about Louisiana.
What should I do while I'm visiting Louisiana?
A favorite place to visit is Mississippi River. You'll also find Clarksville Riverfront Park and Clarksville State Game Refuge in the area. Check out what more to see and do in Expedia's Louisiana guide.
What's the seasonal weather like in Louisiana?
The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 35°F. Average annual precipitation for Louisiana is 49 inches.

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