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Our top choices for Mississippi River hotels

Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
United States
Bryan
The price is ￥14,974
￥17,002 total
includes taxes & fees
Jan 31 - Feb 1
The Eagles Nest Inn
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1009)
"Clean rooms quiet and really nice place "
United States
Vic
The price is ￥15,840
￥18,350 total
includes taxes & fees
Feb 1 - Feb 2
Sleep Inn & Suites Hannibal West
Balcony
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (358)
"Excellent stay !!! Quite "
United States
Bradley
The price is ￥12,528
￥14,224 total
includes taxes & fees
Jan 31 - Feb 1
River's Edge Motel
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is ￥25,216
￥34,357 total
includes taxes & fees
Jan 8 - Jan 9
Riverside Inn Hannibal
Deluxe Room | Down comforters, blackout drapes, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (24)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ￥26,443
￥30,367 total
includes taxes & fees
Jan 9 - Jan 10
Lighthouse Inn & Suites
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1005)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ￥16,780
￥19,271 total
includes taxes & fees
Jan 7 - Jan 8
Best Western On The River
Classic Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Town & Country Inn and Suites

Town & Country Inn and Suites

Town & Country Inn and Suites
2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (899)
"great room and hotel"
United States
Amy
Town & Country Inn and Suites
Front of property
Garden House Bed and Breakfast

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (38)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is ￥16,771
￥19,261 total
includes taxes & fees
Jan 10 - Jan 11
Garden House Bed and Breakfast
Indoor spa tub
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1004)
"Always love staying here"
United States
Ashlynn
Stoney Creek Inn Quincy
Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (450)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is ￥16,208
￥18,474 total
includes taxes & fees
Jan 28 - Jan 29
Quality Inn & Suites Quincy - Downtown
Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board
Heritage Hotel Quincy

Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (279)
"Check in person was very nice, showed us to our room, explained everything. Room had all the comforts of home—very nice!"
United States
Patrick
The price is ￥13,319
￥15,181 total
includes taxes & fees
Jan 20 - Jan 21
Heritage Hotel Quincy
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (614)
"Overall very nice property. "
United States
Jeffrey
The price is ￥18,664
￥21,273 total
includes taxes & fees
Jan 10 - Jan 11
Holiday Inn Quincy East by IHG
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very Good, (1013)
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is ￥11,945
￥13,838 total
includes taxes & fees
Jan 18 - Jan 19
Quality Inn & Suites Hannibal West
Lobby
Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
2.5 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (336)
"We were very pleased with our stay. The room was clean and the staff was VERY friendly. We were also VERY impressed the breakfast. We would definitely stay there again."
United States
Julie
The price is ￥17,197
￥19,601 total
includes taxes & fees
Jan 18 - Jan 19
Fairfield Inn & Suites Quincy
Bar (on property)
Oak Hill Inn & Suites

Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (882)
"Room was clean, comfy bed, and very accommodating "
United States
Wendy
The price is ￥14,587
￥16,625 total
includes taxes & fees
Feb 1 - Feb 2
Oak Hill Inn & Suites
Business Room, 2 Queen Beds | Desk, laptop workspace, blackout drapes, iron/ironing board
The Atrium Hotel on Third

The Atrium Hotel on Third

The Atrium Hotel on Third
3.5 star property
47.9 km from Mississippi River
8.4 out of 10, Very Good, (759)
"Construction was very loud, lobby and pool were closed, breakfast and vending machines were limited, but staff was friendly and helpful and rooms were nice and clean"
United States
Makaio
The price is ￥20,436
￥23,293 total
includes taxes & fees
Feb 1 - Feb 2
The Atrium Hotel on Third
Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (666)
"Clean and comfortable room. Stayed 1 night. Great breakfast options. Friendly and courteous staff. Stayed w dog. Would stay again. Great price."
United States
erika
The price is ￥11,920
￥14,161 total
includes taxes & fees
Jan 11 - Jan 12
Comfort Inn & Suites - Hannibal
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (856)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ￥17,226
￥20,670 total
includes taxes & fees
Jan 24 - Jan 25
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1001)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ￥9,081
￥10,429 total
includes taxes & fees
Jan 19 - Jan 20
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (221)
"Great"
United States
Joshua
The price is ￥11,048
￥12,689 total
includes taxes & fees
Feb 1 - Feb 2
Days Inn by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mississippi River Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"The staff was exceptional and the room was very neat and clean. Thank you!"
Steve 1-night trip
Posted 7 hours ago
Pear Tree Inn St. Louis Airport

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this walkable area, you can savor the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Mississippi River?
Hyatt Regency St. Louis at The Arch is one of the top choices for your stay based on our traveler data, and this hotel offers 3 restaurants and 2 bars. You'll find it 82.1 mi (132.1 km) from Mississippi River. Other good options around the area include Hampton Inn St. Louis-Downtown (At the Gateway Arch) and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.
Where can I learn more about changing or cancelling my trip in the area near Mississippi River?
For additional details about updating your stay near Mississippi River or cancelling it, head over to our customer service page.