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Dec 19 - Dec 20
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Our top choices for Mississippi River hotels

Balcony
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (356)
"Excellent stay !!! Quite "
United States
Bradley
The price is ￥12,448
￥14,133 total
includes taxes & fees
Dec 22 - Dec 23
River's Edge Motel
Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
United States
Bryan
The price is ￥16,260
￥18,461 total
includes taxes & fees
Dec 21 - Dec 22
The Eagles Nest Inn
Desk, laptop workspace, iron/ironing board, free WiFi
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (737)
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
The price is ￥10,114
￥11,694 total
includes taxes & fees
Dec 21 - Dec 22
Baymont by Wyndham Hannibal
Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1002)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ￥15,714
￥18,048 total
includes taxes & fees
Dec 23 - Dec 24
Best Western On The River
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is ￥23,598
￥32,466 total
includes taxes & fees
Dec 20 - Dec 21
Riverside Inn Hannibal
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1001)
"Great area"
United States
kelvin
The price is ￥14,284
￥16,547 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn & Suites Hannibal West
Deluxe Room | Down comforters, blackout drapes, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (24)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ￥26,275
￥30,174 total
includes taxes & fees
Dec 20 - Dec 21
Lighthouse Inn & Suites
Indoor pool, sun loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is ￥11,826
￥14,049 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Inn & Suites - Hannibal
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1000)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ￥9,018
￥10,357 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Motel 6 Hannibal, MO
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1000)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is ￥9,103
￥10,454 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Super 8 by Wyndham Hannibal
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (216)
"Left before breakfast great cup of coffee"
United States
David
The price is ￥10,341
￥11,876 total
includes taxes & fees
Dec 23 - Dec 24
Days Inn by Wyndham Hannibal
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very Good, (1000)
"Very friendly staff. "
United States
Lawrence
The price is ￥11,763
￥13,627 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Quality Inn & Suites Hannibal West
Lobby sitting area
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (152)
"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"
United States
Shawn
The price is ￥8,869
￥10,257 total
includes taxes & fees
Dec 20 - Dec 21
Howard Johnson BY Wyndham Hannibal
Lobby
Economy Inn Wentzville

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (507)
"The Building has a nice exterior"
United States
Christopher
The price is ￥9,336
￥10,591 total
includes taxes & fees
Dec 20 - Dec 21
Economy Inn Wentzville
Lobby
Relax Inn Saint Charles

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
98 km from Mississippi River
6.6 out of 10, (1002)
"Great place to stay "
United States
Askar
The price is ￥9,504
￥10,923 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Relax Inn Saint Charles
Exterior
LAKEVIEWINN

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.6 out of 10, (30)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is ￥10,503
￥11,864 total
includes taxes & fees
Jan 8 - Jan 9, 2026
LAKEVIEWINN
Lobby
Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (489)
"Great location for geode hunting. Irish Pub behind the hotel is the best."
United States
Marty
The price is ￥8,682
￥9,725 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Baymont by Wyndham Keokuk
Lobby
Sleep Inn Saint Charles North

Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
97.1 km from Mississippi River
5.8 out of 10, (519)
"They closed down breakfast earlier than 9. "
United States
Alicea
The price is ￥10,760
￥12,365 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn Saint Charles North
Property amenity
Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City
2.5 star property
107.1 km from Mississippi River
6.6 out of 10, (881)
"Nothing bad to say about this Hotel. Great, clean rooms and awesome staff."
United States
Charles
The price is ￥12,462
￥14,953 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Extended Stay America Select Suites St Louis Earth City
Standard Room, 2 Queen Beds | Desk, iron/ironing board, free WiFi, bed sheets
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (997)
"Very run down and trash around the property, but the room was clean and comfortable for our one night stop. Convenience of the location"
United States
Natalie
The price is ￥9,920
￥11,702 total
includes taxes & fees
Dec 26 - Dec 27
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi River Hotel Reviews

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savor the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Mississippi River?
Hilton St. Louis Airport is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and a 24-hour fitness center. You'll find it 70.4 mi (113.3 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Magnolia Hotel St. Louis, a Tribute Portfolio Hotel.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.
Where can I learn more about changing or cancelling my trip in the area near Mississippi River?
For additional details about updating your stay near Mississippi River or cancelling it, head over to our customer service page.