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- Residence Inn Marriott Florence
- Quality Inn & Suites Florence Civic Center
- Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
- Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
- Super 8 by Wyndham Florence
- Hotel Florence, Tapestry Collection by Hilton
- Spark by Hilton Florence North I-95, SC
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