Find hotels in Downtown San Mateo, San Francisco from ¥11,659
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Discover 4,587 Downtown San Mateo hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Downtown San Mateo hotels

The Marina Inn on San Francisco Bay
The Marina Inn on San Francisco Bay

Shashi Hotel Mountain View Palo Alto
Shashi Hotel Mountain View Palo Alto

The Ameswell Hotel
The Ameswell Hotel

Hampton Inn & Suites Mountain View
Hampton Inn & Suites Mountain View

Creekside Inn
Creekside Inn

The Zen Hotel Palo Alto
The Zen Hotel Palo Alto
Where to stay in Downtown San Mateo

Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Top Downtown San Mateo Hotel Reviews

Bay Landing San Francisco Airport Hotel
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