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Find hotels in Downtown San Mateo, San Francisco

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Our top choices for Downtown San Mateo hotels

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
28.1 km from Downtown San Mateo
9.0 out of 10, Wonderful, (7252)
"Great place to stay!"
United States
Isaiah
The price is ¥15,606
¥24,819 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hotel Riu Plaza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
28.2 km from Downtown San Mateo
9.0 out of 10, Wonderful, (3836)
"Excellent stay and great location! "
United States
CHRISTINE
The price is ¥18,314
¥28,742 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Caza Fisherman's Wharf

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
3.3 km from Downtown San Mateo
8.6 out of 10, Excellent, (2785)
"Breakfast was very good, many options to choose. "
United States
Hourn
The price is ¥16,421
¥18,670 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hilton San Francisco Airport Bayfront

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
28.1 km from Downtown San Mateo
9.2 out of 10, Wonderful, (2241)
"Awesome place to stay"
United States
Mark Anthony
The price is ¥18,632
¥26,626 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Handlery Union Square Hotel

Handlery Union Square Hotel
3.5 star property
25.9 km from Downtown San Mateo
8.8 out of 10, Excellent, (2798)
"Clean hotel, great location, kind staff! "
United States
Felix
The price is ¥23,855
¥28,077 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Handlery Union Square Hotel

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.4 km from Downtown San Mateo
8.8 out of 10, Excellent, (2018)
"Comfortable room, welcome glass of wine, easy shuttle to and from airport, friendly staff."
United States
Carole
The price is ¥16,114
¥23,105 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Westin San Francisco Airport

DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport
4.0 star property
3.8 km from Downtown San Mateo
8.6 out of 10, Excellent, (1390)
"Great location and staff"
United States
Ernest Dean
The price is ¥17,935
¥20,391 total
includes taxes & fees
Jan 17 - Jan 18, 2026
DoubleTree by Hilton San Francisco Airport

Shashi Hotel Mountain View Palo Alto

Shashi Hotel Mountain View Palo Alto
5.0 star property
27.2 km from Downtown San Mateo
9.4 out of 10, Exceptional, (1213)
"Perfect place to stay and enjoy "
United States
Ali
The price is ¥23,329
¥25,707 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Shashi Hotel Mountain View Palo Alto

Aloft San Francisco Airport

Aloft San Francisco Airport
3.0 star property
6.5 km from Downtown San Mateo
9.0 out of 10, Wonderful, (2249)
"Spotless — not fancy but clean open and comfortable !!! Great airport hotel!!!!"
United States
Michael
The price is ¥17,636
¥20,271 total
includes taxes & fees
Dec 30 - Dec 31
Aloft San Francisco Airport

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
26.1 km from Downtown San Mateo
9.4 out of 10, Exceptional, (3117)
"Clean room, helpful staff and great location to explore de city."
United States
Alan
The price is ¥11,858
¥14,011 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Chancellor Hotel on Union Square

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
28.2 km from Downtown San Mateo
8.6 out of 10, Excellent, (2341)
"Great location"
United States
Deborah
The price is ¥20,409
¥29,548 total
includes taxes & fees
Jan 27 - Jan 28, 2026
Hotel Zephyr San Francisco

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
26.5 km from Downtown San Mateo
9.0 out of 10, Wonderful, (5055)
"Nice stay. Hotel was clean, quiet and accessible. "
United States
Brandon
The price is ¥17,536
¥20,640 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Holiday Inn Golden Gateway by IHG

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
26.5 km from Downtown San Mateo
8.8 out of 10, Excellent, (2834)
"Clean room, friendly staff and good location"
United States
Jose Eduardo
The price is ¥15,845
¥18,649 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Club Quarters Hotel in San Francisco

King George Hotel

King George Hotel
3.0 star property
25.9 km from Downtown San Mateo
8.6 out of 10, Excellent, (2101)
"Great place!"
United States
Troy
The price is ¥12,466
¥17,023 total
includes taxes & fees
Jan 4 - Jan 5, 2026
King George Hotel

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
26.6 km from Downtown San Mateo
8.8 out of 10, Excellent, (2201)
"Great hotel "
United States
Tanya
The price is ¥16,562
¥19,492 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hilton San Francisco Financial District

SFO El Rancho Inn SureStay Collection by Best Western

SFO El Rancho Inn SureStay Collection by Best Western
3.0 star property
8.1 km from Downtown San Mateo
8.4 out of 10, Very Good, (2976)
"The food was great in the morning very pleasant atmosphere the room was clean I will use them again when I go to San Francisco"
United States
matt
The price is ¥13,042
¥15,090 total
includes taxes & fees
Jan 2 - Jan 3, 2026
SFO El Rancho Inn SureStay Collection by Best Western

The Palo Alto Inn

The Palo Alto Inn
3.0 star property
24.9 km from Downtown San Mateo
8.8 out of 10, Excellent, (983)
"room was nice and clean front desk person was super nice. "
United States
susan
The price is ¥9,511
¥10,985 total
includes taxes & fees
Jan 2 - Jan 3, 2026
The Palo Alto Inn

Hotel Aura SFO

Hotel Aura SFO
3.0 star property
9.6 km from Downtown San Mateo
9.0 out of 10, Wonderful, (2558)
"Clean, quiet, close to the airport."
United States
RICHARD
The price is ¥13,950
¥16,790 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Aura SFO

Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
10.2 km from Downtown San Mateo
8.6 out of 10, Excellent, (2620)
"Great price, clean rooms, and convenient shuttles "
United States
Zhenlin
The price is ¥13,022
¥15,823 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Hotel Aluxor SFO

Half Moon Bay Lodge

Half Moon Bay Lodge
3.0 star property
17.3 km from Downtown San Mateo
9.0 out of 10, Wonderful, (1091)
"Always great staff here, nice rooms, nice jacuzzi "
United States
Pamela
The price is ¥18,389
¥21,634 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Half Moon Bay Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown San Mateo

Find the best Downtown San Mateo areas and neighborhoods for the activities you enjoy most.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Top Downtown San Mateo Hotel Reviews

Frequently asked questions

What's it like in Downtown San Mateo?
Travelers will be sure to enjoy their time in San Mateo's Downtown San Mateo neighborhood. Are you looking for Downtown San Mateo travel tips? Be sure to check out Cinemark Century San Mateo 12 and The San Mateo Japanese Garden while you're in the neighborhood.
How many hotels should I expect to find in the Downtown San Mateo area?
Book one of Expedia's 5 hotels and other accommodations in Downtown San Mateo and start exploring everything San Mateo has to offer.
If I need to cancel my hotel reservation in Downtown San Mateo, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Downtown San Mateo.
Where can I learn more about changing or cancelling my trip to Downtown San Mateo?
To find more details about updating your trip to Downtown San Mateo or cancelling it, head over to our customer service page.
What is there to do in this San Mateo neighborhood?
A few attractions you might want to check out while you're in Downtown San Mateo are Cinemark Century San Mateo 12 and The San Mateo Japanese Garden. While you're out sightseeing, Poplar Creek Golf Course and Burlingame Museum of PEZ Memorabilia are a couple of additional sights to visit in San Mateo.

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