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Our top choices for Downtown Rochester hotels
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHGDowntown Rochester
8.8 out of 10, Excellent, (893)
"Room was clean and comfortable
Staff courteous
Comfortable beds
Great restaurant"
Matney
The price is ￥12,478
￥14,366 total
includes taxes & fees
Jan 3 - Jan 4, 2026
9.6 out of 10, Exceptional, (547)
"Very courteous staff, loved the valet guy!"
Jean
The price is ￥26,730
￥30,773 total
includes taxes & fees
Jan 10 - Jan 11, 2026
9.2 out of 10, Wonderful, (1008)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
Elizabeth
The price is ￥20,198
￥23,254 total
includes taxes & fees
Dec 31 - Jan 1, 2026
8.8 out of 10, Excellent, (855)
"Yes the workers are amazing "
Luciana
The price is ￥16,693
￥19,216 total
includes taxes & fees
Jan 8 - Jan 9, 2026
8.4 out of 10, Very Good, (1847)
"The front desk was super helpful! Rooms are like a studio size. Loved the area!"
Nicole
The price is ￥19,652
￥22,625 total
includes taxes & fees
Jan 1 - Jan 2, 2026
TownePlace Suites by Marriott Rochester Mayo Clinic Area
TownePlace Suites by Marriott Rochester Mayo Clinic AreaDowntown Rochester
9.6 out of 10, Exceptional, (483)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
Ann
The price is ￥19,808
￥22,803 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Downtown Rochester
Find the best Downtown Rochester areas and neighborhoods for the activities you enjoy most.
Kutzky Park
While there might not be top attractions in Kutzky Park, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Mayo Civic Center.
Photo by Chad Johnson
Open Photo by Chad Johnson
Historic Southwest
While visiting Historic Southwest, you might make a stop by sights like Soldiers Field Veterans Memorial and Plummer House.
Slatterly Park
Slatterly Park might not have many top sights, but Rochester Art Center and Soldiers Field Veterans Memorial are two attractions nearby that you can check out.
Folwell
While there might not be top attractions in Folwell, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Apache Mall.
East Side Pioneers
If you're spending some time in East Side Pioneers, Rochester Art Center and Rochester Civic Theater are top sights worth seeing.
Top Downtown Rochester Hotel Reviews
AmericInn by Wyndham Rochester Near Mayo Clinic
10/10 Excellent
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