Find hotels in Downtown Rochester, Rochester

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Our top choices for Downtown Rochester hotels

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (893)
"Room was clean and comfortable Staff courteous Comfortable beds Great restaurant"
United States
Matney
The price is ¥12,478
¥14,366 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (547)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ¥26,730
¥30,773 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hilton Rochester Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (1008)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
United States
Elizabeth
The price is ¥20,198
¥23,254 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Hyatt House Rochester/Mayo Clinic Area

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (855)
"Yes the workers are amazing "
United States
Luciana
The price is ¥16,693
¥19,216 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hilton Garden Inn Rochester Downtown, MN

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1847)
"The front desk was super helpful! Rooms are like a studio size. Loved the area!"
United States
Nicole
The price is ¥19,652
¥22,625 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Kahler Grand Hotel

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester
9.6 out of 10, Exceptional, (483)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
United States
Ann
The price is ¥19,808
¥22,803 total
includes taxes & fees
Jan 3 - Jan 4, 2026
TownePlace Suites by Marriott Rochester Mayo Clinic Area

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1000)
"Convenient, clean location and friendly staff"
United States
Kaushika
The price is ¥17,547
¥20,200 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Brentwood Inn & Suites

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester
8.0 out of 10, Very Good, (1528)
"Clean room, good room service and good breakfast."
United States
Donald
The price is ¥20,119
¥23,163 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Kahler Inn and Suites - Mayo Clinic Area

Marriott Rochester Mayo Clinic

Marriott Rochester Mayo Clinic
3.5 star property
Downtown Rochester
8.4 out of 10, Very Good, (527)
"it was a fantastic "
United States
Paul
The price is ¥26,359
¥30,346 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Marriott Rochester Mayo Clinic

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (168)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ¥24,568
¥28,284 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Broadway Plaza, Trademark Collection by Wyndham

Residence Inn by Marriott Rochester Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (200)
"Breakfast great and staff very helpful. "
Canada
John
The price is ¥21,680
¥24,960 total
includes taxes & fees
Jan 30 - Jan 31, 2026
Residence Inn by Marriott Rochester Mayo Clinic Area

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel
4.0 star property
Downtown Rochester
9.4 out of 10, Exceptional, (96)
"Excellent accommodations, amazing staff"
United States
Shannon
The price is ¥62,523
¥71,980 total
includes taxes & fees
Dec 31 - Jan 1, 2026
The Towers At Kahler Grand Hotel

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
2.9 km from Downtown Rochester
9.0 out of 10, Wonderful, (1005)
"We had a wonderful stay!"
United States
Sarah
The price is ¥12,555
¥14,454 total
includes taxes & fees
Jan 24 - Jan 25, 2026
Hampton Inn Rochester-South

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
6.7 km from Downtown Rochester
8.8 out of 10, Excellent, (1006)
"Clean room, clean hotel, friendly staff Would stay here again."
United States
Chee
The price is ¥11,386
¥13,108 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Rochester South - Mayo Area by IHG

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
7.1 km from Downtown Rochester
7.2 out of 10, Good, (1026)
"Staff was courteous and breakfast was well stocked."
United States
Doug
The price is ¥11,230
¥12,929 total
includes taxes & fees
Jan 2 - Jan 3, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
2.6 km from Downtown Rochester
8.2 out of 10, Very Good, (1154)
"Check in was fast, room, and pool area were great, its connected to the crooked pint, making dining convenient. "
United States
Brian
The price is ¥11,383
¥13,105 total
includes taxes & fees
Jan 3 - Jan 4, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 1.1 km from Downtown Rochester
9.4 out of 10, Exceptional, (971)
"The staff was very friendly and the room spotless. "
United States
Judith
The price is ¥17,781
¥20,782 total
includes taxes & fees
Jan 2 - Jan 3, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 1.5 km from Downtown Rochester
9.2 out of 10, Wonderful, (773)
"Clean room and housekeeping service was excellent"
United States
Dawn
The price is ¥13,101
¥15,083 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Quality Inn near Medical Center

Quality Inn near Medical Center
2.5 star property
7.5 km from Downtown Rochester
7.8 out of 10, Good, (814)
"Food was good. Staff was great then you go to know them. "
United States
Kayle
The price is ¥9,148
¥10,531 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Quality Inn near Medical Center

Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
5.1 km from Downtown Rochester
9.0 out of 10, Wonderful, (585)
"Nice place to stay "
United States
Melissa
The price is ¥12,634
¥14,545 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sleep Inn & Suites West-Near Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Rochester

Find the best Downtown Rochester areas and neighborhoods for the activities you enjoy most.

Kutzky Park

While there might not be top attractions in Kutzky Park, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Mayo Civic Center.

Historic Southwest

While visiting Historic Southwest, you might make a stop by sights like Soldiers Field Veterans Memorial and Plummer House.

Slatterly Park

Slatterly Park might not have many top sights, but Rochester Art Center and Soldiers Field Veterans Memorial are two attractions nearby that you can check out.

Folwell

While there might not be top attractions in Folwell, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Apache Mall.

East Side Pioneers

If you're spending some time in East Side Pioneers, Rochester Art Center and Rochester Civic Theater are top sights worth seeing.

Top Downtown Rochester Hotel Reviews

Frequently asked questions

What's it like in Downtown Rochester?
You'll be sure to have fun visiting Rochester's Downtown Rochester neighborhood. Are you looking for Downtown Rochester travel tips? Be sure to check out Mayo Civic Center and Rochester Civic Theater while you're in the neighborhood.
What's a favorite place to stay in Downtown Rochester?
Based on Expedia customer reviews, TownePlace Suites by Marriott Rochester Mayo Clinic Area is the highest ranked property in Downtown Rochester. This hotel is a short 5-minute walk from Mayo Clinic, and it offers free breakfast and a 24-hour fitness center. Other favorite options in the area include Hilton Rochester Mayo Clinic Area and The Towers At Kahler Grand Hotel.
How many hotels will I be able to find in the Downtown Rochester area?
Expedia has 20 hotels and other accommodations in Downtown Rochester to choose from, making this an ideal home base for exploring the greater Rochester area.
If I need to cancel my hotel reservation in Downtown Rochester, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to view the top deals on offer in Downtown Rochester.
Where can I learn more about changing or cancelling my trip to Downtown Rochester?
For additional details about rescheduling or cancelling your trip to Downtown Rochester, click here.
What is there to do in this Rochester neighborhood?
Mayo Civic Center, Rochester Civic Theater, and Rochester Art Center are just a few attractions to check out in Downtown Rochester. Shops University Square and Rochester Public Library are also a couple of places to visit in the neighborhood. A few places to visit in the area around Downtown Rochester include Plummer Building, Soldiers Field Veterans Memorial, and Soldiers Field Golf Course. Kutzky Park Tennis Center and Plummer House are also worth a visit when you're out sightseeing in Rochester.

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