Find Business Hotels in Central San Diego, CA
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Central San Diego Business Hotels
Our top choices for Central San Diego business-friendly hotels
DoubleTree by Hilton Hotel San Diego - Mission Valley
DoubleTree by Hilton Hotel San Diego - Mission ValleyMission Valley
8.4 out of 10, Very Good, (1440)
"The room was super quiet and clean. The staff was kind at check in and check out. We would definitely stay here again. "
Janelle
The price is ￥17,522
￥20,140 total
includes taxes & fees
Jan 3 - Jan 4, 2026
8.8 out of 10, Excellent, (1332)
"Checking in was easy and friendly staff."
Elvira
The price is ￥14,456
￥16,616 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Courtyard by Marriott San Diego Mission Valley/Hotel Circle
Courtyard by Marriott San Diego Mission Valley/Hotel CircleMission Valley
8.4 out of 10, Very Good, (1447)
"Staff was very friendly, everything was very clean. "
Cristine
The price is ￥14,848
￥17,066 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.2 out of 10, Wonderful, (2946)
"Great boutique hotel!!"
Maksim
Best Western Plus Hacienda Hotel Old Town
Best Western Plus Hacienda Hotel Old TownOld Town San Diego
8.4 out of 10, Very Good, (1875)
"Great location, friendly staff, clean room. "
Marleny
The price is ￥18,110
￥20,817 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Garden Inn San Diego Mission Valley Stadium
Hilton Garden Inn San Diego Mission Valley StadiumKearny Mesa
8.0 out of 10, Very Good, (1005)
"Great staff and room was nice and clean. My family and I will definitely be back. "
Bo
The price is ￥16,507
￥18,974 total
includes taxes & fees
Jan 11 - Jan 12, 2026
8.2 out of 10, Very Good, (2260)
"Room and staff were excellent"
Bryant
7.2 out of 10, Good, (1079)
"Another great stay 😇👍"
Dan
The price is ￥11,932
￥13,454 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Central San Diego Hotel Reviews
DoubleTree by Hilton San Diego - Hotel Circle
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Mira Mesa Hotels
- Family Hotels in La Jolla Village
- Scripps Ranch Hotels
- Family Hotels in Linda Vista
- Boutique Hotels in La Jolla Village
- Pet-Friendly Hotels in Central San Diego
- Adventure Hotels in La Jolla Village
- Hotels near La Jolla Shores Park
- Shopping Hotels in Mission Valley
- All-Inclusive Hotel Hotels in Mission Valley
- Hotels near Marine Corps Air Station Miramar
- Mission Valley Hotels
- Kearny Mesa Hotels
- Hotels near Montgomery Field
- Luxury Hotels in Pacific Beach
- Clairemont Hotels
- Cheap Hotels in Sorrento Valley
- Pet-Friendly Hotels in Miramar
- Hotels near Cal Coast Credit Union Open Air Theater
- Village of La Jolla Hotels
- University City Hotels
- Guest Houses in La Jolla
- Residences in La Jolla
- Golf Hotels in Torrey Pines
- Residences in Central San Diego
- Rv Parks in Central San Diego
- Rv Parks in La Jolla
- Hotels near Fashion Valley Mall
- Clairemont Mesa Hotels
- Sorrento Valley Hotels
- Hotels near Black's Beach
- Hotels near Mission San Diego Station
- Aparthotels in Central San Diego
- Condo Resorts in Central San Diego
- Hotels near Fashion Valley Transit Center Station
- Pacific Beach Hotels
- Hotels near Qualcomm Stadium Station
- Luxury Hotels in Miramar
- Resorts & Hotels with Spas in Miramar
- Apartments in Fenton Parkway Station
- Ski Hotels in Mission Valley
- Capsule Hotels in La Jolla
- Cheap Hotels in Central San Diego
- Cheap Hotels in Pacific Beach
- Cheap Hotels in Kearny Mesa
- Country Houses in La Jolla
- Resorts in San Diego Coaster Sorrento Valley Station
- Rv Parks in Mission San Diego Station
- Beach Hotels in Mission Valley
- Luxury Hotels in Kearny Mesa
- Boutique Hotels in Torrey Pines
- Cheap Hotels in University City
- B&B in La Jolla
- Luxury Hotels in Mira Mesa
- Hotels near Birch Aquarium
- Hostels in La Jolla
- La Jolla Village Hotels
- Villas in La Jolla
- Linda Vista Hotels
- La Jolla Shores Hotels
- Ski Hotels in Mira Mesa
- Clairemont Mesa East Hotels
- Hotels near University of California
- Hotels near La Jolla Beach
- Hotels near SDSU Transit Center Station
- Luxury Hotels in Serra Mesa
- Beach Hotels in Pacific Beach
- North Pacific Beach Hotels
- Business Hotels in Kearny Mesa
- Riads in La Jolla
- Farmstay in Fiesta Island
- Hotels near Mission Valley Mall
- All-Inclusive Hotel Hotels in Bay Park
- Hotels near Westfield UTC
- Hotels near Mission Bay Park
- Hotels near La Jolla Playhouse
- Cheap Hotels in Mira Mesa
- Resorts in Fiesta Island
- Hotels near Mission Bay
- Hotels near VA Medical Center
- All-Inclusive Hotel Hotels in Pacific Beach
- Resorts in La Jolla
- Hotels near San Diego State University
- Torrey Pines Hotels
- Miramar Hotels
- Hotels near San Diego Zoo
- Hotels near Convoy District
- Hotels near La Jolla Cove
- Hotels near Old Town San Diego State Park
- Hotels near Hotel Circle
- Winery Hotels in Central San Diego
- Hotels near Pacific Beach
- Pousadas in La Jolla
- Hotels near Scripps Memorial Hospital La Jolla