Find Luxury Hotels in Mira Mesa, CA

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Mira Mesa Luxury Hotels

Tonight
Jul 29 - Jul 30
Tomorrow
Jul 30 - Jul 31
This weekend
Aug 1 - Aug 3
Next weekend
Aug 8 - Aug 10

Top Mira Mesa Luxury Hotels

Top Mira Mesa Hotel Reviews

Handlery Hotel

Handlery Hotel

10/10 Excellent
"Very clean, staff very caring and polite. Very convenient to old town and downtown San Diego."
Francisco 2-night trip
Posted 12 hours ago
Handlery Hotel

Frequently asked questions

Are you looking for a luxury hotel for your Mira Mesa vacation?
Use Expedia to arrange your flight to San Diego, CA (MYF-Montgomery Field) airport or San Diego, CA (SEE-Gillespie Field) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to get what you need to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Mira Mesa offers. Mira Mesa has some interesting things to see and do including Regal Edwards Mira Mesa, so you might want to take in the local sights during your visit.
What's the best time to vacation in Mira Mesa?
The hottest months are usually August and September with an average temperature of 71°F,
  • Coldest months: February, January, December, and March
  • Driest months: June, July, September, and August
  • Rainiest months: December, February, January, and March
What's there to see and do in Mira Mesa?
Enjoy Mira Mesa with a stop at Mission Bay, San Diego Zoo, and Mission Beach. If you have a little extra time during your trip, you might want to check out Marine Corps Recruit Depot and Port of San Diego.