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Find Adventure Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Adventure Hotels

Our top choices for Cape Girardeau adventure hotels

Dining
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is ￥23,324
￥38,088 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is ￥18,192
￥31,311 total
includes taxes & fees
Dec 22 - Dec 23
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Exterior
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (39)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is ￥16,948
￥32,625 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Front of property - evening/night
Makanda Inn

Makanda Inn

Makanda Inn
3.5 star property
Makanda
10.0 out of 10, Exceptional, (33)
"I had a great stay - wonderful hosts and yummy breakfast."
United States
Julie
The price is ￥51,637
￥58,866 total
includes taxes & fees
Dec 13 - Dec 14
Makanda Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian 1-night trip
Posted 9 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

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