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Cape Girardeau Vacation Rentals

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Check prices for these dates

Tonight
Jun 21 - Jun 22
Tomorrow
Jun 22 - Jun 23
Next weekend
Jun 27 - Jun 29
In two weeks
Jul 4 - Jul 6

Vacation Rentals in Cape Girardeau

The Twisted Sassafras Treehouse
Terrace/patio

The Twisted Sassafras Treehouse

10.0 out of 10, Exceptional, (14)
"This place is Magical.."
The price is ￥31,295
￥45,831 total
includes taxes & fees
Jun 30 - Jul 1
The Twisted Sassafras Treehouse
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (133)
"We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!"
The price is ￥21,824
￥35,638 total
includes taxes & fees
Jul 9 - Jul 10
Serenity South -- Gardens, River-Views, and Refreshing Space
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Fridge, microwave, oven, stovetop

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (18)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
Exterior

Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.

8.4 out of 10, Very Good, (13)
"We stayed here with my cousins family while our daughters were playing at Sportplex. Nice and clean property. Host was easy to communicate with. Would stay here again when in this area. "
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Fridge, microwave, oven, stovetop

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

9.8 out of 10, Exceptional, (34)
"Nice place to stay! Clean, able to walk to everything!"
The price is ￥11,916
￥20,127 total
includes taxes & fees
Jun 22 - Jun 23
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Fridge, microwave, oven, stovetop

Loft Apartment Across From Semo University Houch Field House. Walk To Events

10.0 out of 10, Exceptional, (87)
"This rental was perfect for our family’s stay in Cape. Location, amenities, cleanliness, and communication were all five star. Will definitely book again!"
The price is ￥21,824
￥26,771 total
includes taxes & fees
Jun 28 - Jun 29
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Charming Secluded Getaway Cabin within minutes of amenities
Exterior

Charming Secluded Getaway Cabin within minutes of amenities

10.0 out of 10, Exceptional, (13)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
Charming Secluded Getaway Cabin within minutes of amenities
River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi
Interior

River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (4)
"The home was beautiful inside and very clean. The bed was comfortable, and the area was quiet. My father and I really enjoyed our stay. I would stay there again over anywhere else I have stayed in cape. "
River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
Dining

Next Door to Mercy Hospital - Pet Friendly - Fast Wifi

9.4 out of 10, Exceptional, (3)
"Great place for our family to have a quick get together in short notice."
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
River Town Retreat near SEMO
Dining

River Town Retreat near SEMO

9.0 out of 10, Wonderful, (2)
"Very nice place only downsize albeit cute is the claw foot tub with make shift shower, The unit worked very well for what we were looking for near SEMO campus"
River Town Retreat near SEMO
Little Blue Cottage on Spanish
Living area

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (41)
"Has everything you need. Comfy and in a great location. "
The price is ￥11,785
￥14,695 total
includes taxes & fees
Jun 22 - Jun 23
Little Blue Cottage on Spanish
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.6 out of 10, Excellent, (30)
"Everything was great!"
The price is ￥26,057
￥39,340 total
includes taxes & fees
Jun 29 - Jun 30
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Quaint, Beautiful Home next to SEMO and Hospital
Exterior

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (36)
"Great stay, great location! "
Quaint, Beautiful Home next to SEMO and Hospital
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Fridge, microwave, oven, stovetop

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (6)
"Lovely home with historic architectural features in tact. Fully stocked, great location, quite neighborhood. We thoroughly enjoyed our stay."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Exterior

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

9.4 out of 10, Exceptional, (3)
"Great property would recommend 100%. We did not have to leave the house it had everything we needed for nine adult women to have a great streetlight"
The price is ￥45,829
￥71,597 total
includes taxes & fees
Jun 29 - Jun 30
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Charming 3-bedroom house near downtown
Interior

Charming 3-bedroom house near downtown

2.0 star property
10.0 out of 10, Exceptional, (2)
"My husband and I along with one other couple stayed here while in Cape for a wedding. The location was nice and was a short distance for driving or Ubering around town. The price was great!! Highly recommend."
Charming 3-bedroom house near downtown
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Property grounds

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (216)
"Loved the view of the mighty Mississippi!"
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Urban 2-bedroom Escape in Downtown Cape Girardeau
Fridge, microwave, oven, stovetop

Urban 2-bedroom Escape in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (2)
"Great home! Fantastic location! Wonderfully appointed kitchen! Clean and comfortable furniture! Staci was a great host! Thank you. "
Urban 2-bedroom Escape in Downtown Cape Girardeau
Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi
Private kitchen

Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi

Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi
Steps to Southeast Hospital - Fast Wifi - King Bed
Fridge, microwave, oven, stovetop

Steps to Southeast Hospital - Fast Wifi - King Bed

10.0 out of 10, Exceptional, (6)
"This was the perfect place for us to have a small group weekend getaway! All the beds were comfy! High quality sheets! Very clean! "
Steps to Southeast Hospital - Fast Wifi - King Bed
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

Quaint, Beautiful Home next to SEMO and Hospital: This Cape Girardeau vacation home rental offers a fireplace, a selection of games, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. Some other homes for rent in Cape Girardeau include "Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau and Serenity South -- Gardens, River-Views, and Refreshing Space.

How many vacation rentals will I find in Cape Girardeau?

Choose from 22 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Isle Casino Cape Girardeau and Show Me Center are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.