Cairo Ohio River Bridge traversing over the Ohio River at sunset

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Our top choices for Cairo hotels

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (289 reviews)
"The web site said smoking rooms, this is untrue. I was fine with that, but my room smelled like a smoking room. There where cobwebs on the lamps and the tables where dirty. The shower was dirty and had a whole in the ceiling. The outside was very dirty. I would never stay at this hotel aging. I would tell everyone to stay far away from it as they can."
United States
Cyndy
The price is ¥11,051
¥12,264 total
includes taxes & fees
Jul 24 - Jul 25
Quality Inn Cairo I-57

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (642 reviews)
"Clean rooms,"
United States
Karl
The price is ¥9,625
¥10,681 total
includes taxes & fees
Jul 12 - Jul 13
Super 8 by Wyndham Charleston/Sikeston East MO

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (418 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is ¥12,133
¥13,465 total
includes taxes & fees
Jun 28 - Jun 29
The Riverstone Hotel Charleston-Sikeston

La Center Motel

La Center Motel
2.0 star property
La Center
7.4 out of 10, Good, (20 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is ¥8,735
¥10,217 total
includes taxes & fees
Jun 26 - Jun 27
La Center Motel

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is ¥11,551
¥12,819 total
includes taxes & fees
Jul 4 - Jul 5
Eagle Inn Charleston

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ¥19,548
¥46,845 total
includes taxes & fees
Jul 12 - Jul 13
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

More cheap stays in Cairo

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Cairo offers a variety of scenic activities, including national parks and nature preserves perfect for outdoor enthusiasts.
  • Riverboat Tours: Experience the area's natural beauty and history with a unique riverboat tour.
  • Charming Streets: Explore the family-friendly atmosphere and charming streets of Cairo, ideal for leisurely strolls.
  • Rich Historical Experiences: Discover historic forts and sites that showcase Cairo's cultural heritage.
  • Diverse Accommodations: Enjoy a range of lodging options, from cozy inns to modern hotels, accommodating various needs.

Find great hotels in and around Cairo

Explore a variety of hotel accommodations in Cairo, Illinois, where you'll find welcoming options perfect for families, pet owners, and LGBTQIA travelers. From charming motels to comfortable hotels, Cairo offers a range of lodging types to suit your needs. Whether you're looking for a cozy inn or a modern hotel, you can discover the ideal place to unwind during your visit to this unique destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Super 8 by Wyndham Charleston/Sikeston East MO offers a comfortable and budget-friendly motel experience just 16km from Cairo. This property is particularly appealing to families and pet owners, featuring amenities designed for children, including complimentary cribs upon request. The pet-friendly policy allows for certain pets onsite, making it a great choice for those who want to travel with their furry companions. Families can enjoy a relaxed stay with the added convenience of amenities that cater to younger guests.
  • The Riverstone Hotel Charleston-Sikeston: Located 19km from Cairo, The Riverstone Hotel Charleston-Sikeston is ideal for business travelers and pet owners alike. This budget-friendly hotel features a welcoming atmosphere that caters to the needs of those traveling for work while also accommodating pets. With a policy that permits dogs and provides necessary deposits, guests can rest easy knowing their pets are welcome. The hotel's blend of comfort and functionality makes it a solid option for those looking to balance business and leisure during their stay.
  • Quality Inn Cairo I-57: Situated in Cairo, the Quality Inn Cairo I-57 provides a family-friendly and budget-conscious lodging option. This hotel caters to travelers with children, offering amenities such as complimentary cribs and a first aid kit for peace of mind. Additionally, the pet-friendly policy ensures that guests can bring their dogs along, with specific fees and deposits in place. This makes it an excellent choice for families and pet owners looking for convenience and comfort during their vacation.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventures and rich historical experiences. Explore the charming streets of Cairo, where family-friendly vibes abound, or enjoy the scenic beauty at local campgrounds. Nearby cities add to the adventure with vibrant atmospheres perfect for both relaxation and exploration. Whether you're seeking a relaxing holiday or an exciting getaway, Cairo and its surrounding areas promise unforgettable experiences for every traveler.

  • Wickliffe: Located a mere 10km from Cairo, Wickliffe is a charming city that offers a perfect blend of outdoor activities and scenic beauty. Visitors flock here primarily during the spring and late summer months, seeking a romantic getaway amidst nature. With its array of recreational areas and golf courses, Wickliffe is ideal for those who enjoy active pursuits. Don't miss the nearby lake and national state park, which provide excellent opportunities for hiking and picnicking in a picturesque setting.
  • Mound City: Also situated 10km from Cairo, Mound City is an adventure seeker’s paradise. Known for its outdoor and romantic experiences, the city sees a spike in visitors during March, July, and October. The recreational areas and parks are perfect for family outings or a peaceful day in nature. Explore the lush forests and serene lakes in the vicinity, where you can engage in activities like fishing, hiking, and simply enjoying the beautiful landscapes.
  • Wyatt: Just 11km from Cairo, Wyatt caters to families and city enthusiasts alike. The city experiences a busy travel season from June to August, making it a great summer destination. Wyatt features ample outdoor spaces, including golf courses and dog parks, ensuring fun for everyone. Visitors can unwind at local urban parks or attend events at the conference venue, creating a vibrant community atmosphere that invites exploration and relaxation.

Things to do in Cairo

Shopping

In Cairo, visit local shops for unique souvenirs and gifts. If you're up for a drive, head to the nearby Town Center at the Crossings, about 24km away, offering a range of retail options, dining, and entertainment for a more extensive shopping experience.

Recreation

In Cairo, Illinois, the River Wellness Center offers a serene atmosphere with a range of holistic treatments and fitness classes. Nearby, the Shawnee National Forest invites outdoor enthusiasts to explore scenic trails, with opportunities for hiking and meditation amidst nature's beauty.

Adventure

In Cairo, explore the scenic trails of the Mississippi River, ideal for hiking and birdwatching. Visit the confluence of the Ohio and Mississippi Rivers for breathtaking views, and enjoy fishing or kayaking in the nearby waters for a thrilling outdoor experience.

Nightlife

Cairo, Illinois, offers a laid-back nightlife with options like the Riverfront Bar & Grill, where you can enjoy live music and casual dining by the river. The nearby local pubs provide a relaxed atmosphere for drinks and socializing, creating a friendly vibe to unwind after a day of exploring.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is perfect for travelers seeking outdoor adventure and scenic beauty. Popular attractions include national and state parks, nature preserves, and historic forts, offering a rich cultural and natural experience. Whether you're looking to explore the great outdoors or immerse yourself in history, Cairo has something for everyone to enjoy during your vacation.

  • Ballard Wildlife Management Area: Located 8km from Cairo, this reserve offers a serene escape into nature, ideal for birdwatching and exploring diverse habitats. Its historical significance adds a layer of intrigue, making it a peaceful spot for those interested in ecology and history.
  • Columbus-Belmont State Park: Situated 27km away, this state park features stunning scenery and outdoor activities such as hiking and picnicking. The park's rich history from the Civil War era enhances its adventurous atmosphere, perfect for nature lovers and history buffs alike.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort provides a glimpse into the area's cultural heritage. Visitors can enjoy walking trails and scenic views of the confluence of the Mississippi and Ohio Rivers, making it a great place for reflection and exploration.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois is convenient with several nearby airports. Cape Girardeau Municipal Airport (CGI) is situated 42km away, with hotels like Drury Plaza Hotel and Courtyard by Marriott only a short drive from the airport. Paducah Regional Airport (PAH) is located 37km from Cairo, offering nearby accommodations such as The Respite Bed and Breakfast and Harrah's Metropolis Hotel. For those flying into Veterans Airport of Southern Illinois (MWA), 84km away, options include Drury Inn & Suites Marion and Holiday Inn Express & Suites Carbondale. Each airport provides easy access to comfortable lodging for a pleasant stay in Cairo.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Charming Home just minutes from Interstate and Mall: This vacation home rental near Cairo is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a fridge, a stovetop, and a microwave. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 28 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.