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Our top choices for Cairo hotels

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
¥11,152
¥12,377 total
includes taxes & fees
Oct 2 - Oct 3
Quality Inn Cairo I-57

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
¥9,417
¥10,451 total
includes taxes & fees
Sep 27 - Sep 28
Super 8 by Wyndham Charleston/Sikeston East MO

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Jay
¥10,469
¥11,618 total
includes taxes & fees
Oct 2 - Oct 3
The Riverstone Hotel Charleston-Sikeston

4. La Center Motel

La Center Motel
La Center
United States
Carrie
¥7,652
¥9,034 total
includes taxes & fees
Sep 25 - Sep 26
La Center Motel

5. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
¥12,122
¥13,452 total
includes taxes & fees
Sep 25 - Sep 26
Eagle Inn Charleston

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
¥23,460
¥45,736 total
includes taxes & fees
Sep 29 - Sep 30
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Súper affordable pricing, and the property was clean and comfortable! Complimentary breakfast was a plus!"
Brianna 1-night trip
Posted 3 days ago
Super 8 by Wyndham Charleston/Sikeston East MO
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"If I could give this place more than five stars, I would this place is amazing if you want peace quiet, and in the country and able to see horses, this is the place for you. The red house had all the amenities that you can ever think of you just need to bring a little food everything else was provided, even eggs and English muffins. Jane and Charles, the owners were amazing. I definitely will be staying there again. Highly recommend this place my dog and I were very, very comfortable."
Tomi W. 7-night trip
Posted 5 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 8 days ago
Cozy cabins on beautiful Horseshoe Lake
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

8/10 Good
"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."
Mark E 13-night trip
Posted 11 days ago
The Riverstone Hotel Charleston-Sikeston
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"This is the 2nd time staying here and location is perfect for exploring Cache River. Brent and Wendy are amazing hosts and excellent at communicating. Already booked in November to come back for a week of relaxing with friends and doing some hunting. I highly recommend staying here if you want something clean, good communication and great location."
David P. 3-night trip
Posted 2 weeks ago
Wandering the wineries or hitting the hills? We got you! Come stay!
Quality Inn Cairo I-57

Quality Inn Cairo I-57

8/10 Good
"Good service,nice stuff and no complaints"
Santiago 1-night trip
Posted 2 weeks ago
Quality Inn Cairo I-57
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

10/10 Excellent
"My bridal party and I stayed here for the days leading up to the wedding, we thought the place was so cute and cozy! You can tell the host takes pride in what they do and wants to make sure their guests are taken care of. The girls appreciated the gas station that’s not even a minute away for their morning snacks and refreshments."
Stephanie H. 3-night trip
Posted 2 weeks ago
Quiet Country Stay: Modern Home Near Paducah
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

10/10 Excellent
"This place is magnificent if you want somewhere to get away and enjoy the peace and quiet of the country. One of the very few places I have found that isn't just surrounded by other rentals. This is one of those from back in the day before resorts started tricking you with 30 identical cabins all in a circle. Suzzie was the perfect host. Amazing views,peace and serenity just 15 or so miles from everything you may need during a stay. This is one of the few places I've reserved that I will try to stay again,if in the area. One thing there that I've never seen in person,a 2 hole outhouse. You could hold your sweeties hand while pooping,back in the day!"
kelly f. 2-night trip
Posted 1 month ago
Charming cottage overlooking Lake Acre
Upscale & Quiet Paducah Retreat on 15 Acres!

Upscale & Quiet Paducah Retreat on 15 Acres!

10/10 Excellent
"Pretty place. Clean. Nicely set back in the woods."
Luanne S. 2-night trip
Posted 2 months ago
Upscale & Quiet Paducah Retreat on 15 Acres!

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
¥7,652
¥9,034 total
Sep 25 - Sep 26
includes taxes & fees
7.6/10 Good! (22 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
¥9,417
¥10,451 total
Sep 27 - Sep 28
includes taxes & fees
6.8/10 (669 reviews)
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
¥10,469
¥11,618 total
Oct 2 - Oct 3
includes taxes & fees
6.8/10 (434 reviews)
The Riverstone Hotel Charleston-Sikeston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
¥11,152
¥12,377 total
Oct 2 - Oct 3
includes taxes & fees
6.4/10 (295 reviews)
Quality Inn Cairo I-57
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
¥12,122
¥13,452 total
Sep 25 - Sep 26
includes taxes & fees
6.6/10 (107 reviews)
Eagle Inn Charleston

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Cairo offers a variety of scenic activities, including national parks and nature preserves perfect for outdoor enthusiasts.
  • Riverboat Tours: Experience the area's natural beauty and history with a unique riverboat tour.
  • Charming Streets: Explore the family-friendly atmosphere and charming streets of Cairo, ideal for leisurely strolls.
  • Rich Historical Experiences: Discover historic forts and sites that showcase Cairo's cultural heritage.
  • Diverse Accommodations: Enjoy a range of lodging options, from cozy inns to modern hotels, accommodating various needs.

Find great hotels in and around Cairo

Explore a variety of hotel accommodations in Cairo, Illinois, where you'll find welcoming options perfect for families, pet owners, and LGBTQIA travelers. From charming motels to comfortable hotels, Cairo offers a range of lodging types to suit your needs. Whether you're looking for a cozy inn or a modern hotel, you can discover the ideal place to unwind during your visit to this unique destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Super 8 by Wyndham Charleston/Sikeston East MO offers a comfortable and budget-friendly motel experience just 16km from Cairo. This property is particularly appealing to families and pet owners, featuring amenities designed for children, including complimentary cribs upon request. The pet-friendly policy allows for certain pets onsite, making it a great choice for those who want to travel with their furry companions. Families can enjoy a relaxed stay with the added convenience of amenities that cater to younger guests.
  • The Riverstone Hotel Charleston-Sikeston: Located 19km from Cairo, The Riverstone Hotel Charleston-Sikeston is ideal for business travelers and pet owners alike. This budget-friendly hotel features a welcoming atmosphere that caters to the needs of those traveling for work while also accommodating pets. With a policy that permits dogs and provides necessary deposits, guests can rest easy knowing their pets are welcome. The hotel's blend of comfort and functionality makes it a solid option for those looking to balance business and leisure during their stay.
  • Quality Inn Cairo I-57: Situated in Cairo, the Quality Inn Cairo I-57 provides a family-friendly and budget-conscious lodging option. This hotel caters to travelers with children, offering amenities such as complimentary cribs and a first aid kit for peace of mind. Additionally, the pet-friendly policy ensures that guests can bring their dogs along, with specific fees and deposits in place. This makes it an excellent choice for families and pet owners looking for convenience and comfort during their vacation.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventures and rich historical experiences. Explore the charming streets of Cairo, where family-friendly vibes abound, or enjoy the scenic beauty at local campgrounds. Nearby cities add to the adventure with vibrant atmospheres perfect for both relaxation and exploration. Whether you're seeking a relaxing holiday or an exciting getaway, Cairo and its surrounding areas promise unforgettable experiences for every traveler.

  • Wickliffe: Located a mere 10km from Cairo, Wickliffe is a charming city that offers a perfect blend of outdoor activities and scenic beauty. Visitors flock here primarily during the spring and late summer months, seeking a romantic getaway amidst nature. With its array of recreational areas and golf courses, Wickliffe is ideal for those who enjoy active pursuits. Don't miss the nearby lake and national state park, which provide excellent opportunities for hiking and picnicking in a picturesque setting.
  • Mound City: Also situated 10km from Cairo, Mound City is an adventure seeker’s paradise. Known for its outdoor and romantic experiences, the city sees a spike in visitors during March, July, and October. The recreational areas and parks are perfect for family outings or a peaceful day in nature. Explore the lush forests and serene lakes in the vicinity, where you can engage in activities like fishing, hiking, and simply enjoying the beautiful landscapes.
  • Wyatt: Just 11km from Cairo, Wyatt caters to families and city enthusiasts alike. The city experiences a busy travel season from June to August, making it a great summer destination. Wyatt features ample outdoor spaces, including golf courses and dog parks, ensuring fun for everyone. Visitors can unwind at local urban parks or attend events at the conference venue, creating a vibrant community atmosphere that invites exploration and relaxation.

Things to do in Cairo

Shopping

In Cairo, visit local shops for unique souvenirs and gifts. If you're up for a drive, head to the nearby Town Center at the Crossings, about 24km away, offering a range of retail options, dining, and entertainment for a more extensive shopping experience.

Recreation

In Cairo, Illinois, the River Wellness Center offers a serene atmosphere with a range of holistic treatments and fitness classes. Nearby, the Shawnee National Forest invites outdoor enthusiasts to explore scenic trails, with opportunities for hiking and meditation amidst nature's beauty.

Adventure

In Cairo, explore the scenic trails of the Mississippi River, ideal for hiking and birdwatching. Visit the confluence of the Ohio and Mississippi Rivers for breathtaking views, and enjoy fishing or kayaking in the nearby waters for a thrilling outdoor experience.

Nightlife

Cairo, Illinois, offers a laid-back nightlife with options like the Riverfront Bar & Grill, where you can enjoy live music and casual dining by the river. The nearby local pubs provide a relaxed atmosphere for drinks and socializing, creating a friendly vibe to unwind after a day of exploring.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is perfect for travelers seeking outdoor adventure and scenic beauty. Popular attractions include national and state parks, nature preserves, and historic forts, offering a rich cultural and natural experience. Whether you're looking to explore the great outdoors or immerse yourself in history, Cairo has something for everyone to enjoy during your vacation.

  • Ballard Wildlife Management Area: Located 8km from Cairo, this reserve offers a serene escape into nature, ideal for birdwatching and exploring diverse habitats. Its historical significance adds a layer of intrigue, making it a peaceful spot for those interested in ecology and history.
  • Columbus-Belmont State Park: Situated 27km away, this state park features stunning scenery and outdoor activities such as hiking and picnicking. The park's rich history from the Civil War era enhances its adventurous atmosphere, perfect for nature lovers and history buffs alike.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort provides a glimpse into the area's cultural heritage. Visitors can enjoy walking trails and scenic views of the confluence of the Mississippi and Ohio Rivers, making it a great place for reflection and exploration.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois is convenient with several nearby airports. Cape Girardeau Municipal Airport (CGI) is situated 42km away, with hotels like Drury Plaza Hotel and Courtyard by Marriott only a short drive from the airport. Paducah Regional Airport (PAH) is located 37km from Cairo, offering nearby accommodations such as The Respite Bed and Breakfast and Harrah's Metropolis Hotel. For those flying into Veterans Airport of Southern Illinois (MWA), 84km away, options include Drury Inn & Suites Marion and Holiday Inn Express & Suites Carbondale. Each airport provides easy access to comfortable lodging for a pleasant stay in Cairo.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This vacation home rental near Cairo is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 29 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

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