Find Resorts & Hotels with Spas in Cairo, IL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 6 - Nov 7
Tomorrow
Nov 7 - Nov 8
This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15
No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

A hotel lobby with a reception desk, seating area, and a large window.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
The price is ￥10,902
￥12,099 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cairo I-57
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (684 reviews)
The price is ￥9,287
￥10,400 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
The price is ￥10,450
￥11,701 total
includes taxes & fees
Nov 7 - Nov 8
Eagle Inn Charleston
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

4. La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (24 reviews)
The price is ￥7,268
￥8,629 total
includes taxes & fees
Nov 7 - Nov 8
La Center Motel
A building with a fountain and flower beds in front.

5. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
The price is ￥10,529
￥11,788 total
includes taxes & fees
Nov 8 - Nov 9
The Riverstone Hotel Charleston-Sikeston
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

6. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (39 reviews)
The price is ￥22,169
￥32,892 total
includes taxes & fees
Nov 15 - Nov 16
Peaceful secluded cabin located near Horseshoe Lake
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

7. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
The price is ￥17,814
￥19,551 total
includes taxes & fees
Nov 7 - Nov 8
Cozy cabins on beautiful Horseshoe Lake
A compact RV interior with a bed, kitchenette, and seating area.

8. Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.

Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
La Center
The price is ￥7,126
￥12,375 total
includes taxes & fees
Nov 7 - Nov 8
Cozy 1-bedroom recreational vehicle in peaceful La Center. Sleeps 5.
A bathroom with a wooden shower enclosure, a toilet, a sink with a mirror, and three wall-mounted lights.

9. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
The price is ￥17,814
￥19,551 total
includes taxes & fees
Nov 7 - Nov 8
The Rested Duck Mallard Room
A room with a pool table, a sofa, and a dining table with chairs.

10. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
10.0 out of 10, Exceptional, (6 reviews)
The price is ￥28,503
￥40,110 total
includes taxes & fees
Nov 8 - Nov 9
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Cairo

Pool
Breakfast included

Top Cairo Hotel Reviews

A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo

10/10 Excellent

Amenities, microwave, refrigerator,iron and iron board,Shower soap options
United States
Maurice
Reviewed February 10, 2026
Quality Inn Cairo I-57

Frequently Asked Questions

Looking for a spa hotel in Cairo?

Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Cairo—your day trip starts here. Enjoy the opera and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.

What's there to see and do in Cairo?

When you're in Cairo, enjoy exploring the sights and attractions here including Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have a little extra time during your trip, you might want to check out Ballard Wildlife Management Area and Columbus-Belmont State Park.

What is a Cairo spa hotel?

Spa hotels in Cairo provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia