Find Resorts & Hotels with Spas in Cairo, IL

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Check availability on Cairo Resorts & Hotels with Spas

Tonight
Dec 2 - Dec 3
Tomorrow
Dec 3 - Dec 4
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Top Cairo Resorts & Hotels with Spas

No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (272)
"Break fast was excellent "
United States
Uma
The price is ￥11,186
￥12,414 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Quality Inn Cairo I-57
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (611)
"Staff was great! Room was nice. "
United States
Lana
The price is ￥9,124
￥10,125 total
includes taxes & fees
Dec 15 - Dec 16
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is ￥10,220
￥11,343 total
includes taxes & fees
Dec 15 - Dec 16
Quality Inn Charleston - Sikeston
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

3.0 star property
Cunningham
The price is ￥18,823
￥45,108 total
includes taxes & fees
Dec 15 - Dec 16
Quiet Country Stay: Modern Home Near Paducah
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

2.0 star property
Charleston
6.8 out of 10, (103)
"Middle of nowhere hotel was ok"
United States
David
The price is ￥9,410
￥10,443 total
includes taxes & fees
Dec 12 - Dec 13
Eagle Inn Charleston
Exterior
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

Dongola
10.0 out of 10, Exceptional, (100)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
The price is ￥21,001
￥43,688 total
includes taxes & fees
Dec 4 - Dec 5
Charming cottage overlooking Lake Acre
Exterior detail
Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall

Kevil
10.0 out of 10, Exceptional, (20)
"We enjoyed staying here very much. Clean and close to where we wanted to be!"
United States
Becky C.
Charming Home just minutes from Interstate and Mall
Fridge, microwave, oven, stovetop
Charming 3-bedroom house near ball park in quiet neighborhood

Charming 3-bedroom house near ball park in quiet neighborhood

Bardwell
10.0 out of 10, Exceptional, (11)
"Quaint stay to see Grand and kids. "
United States
Sheila C.
The price is ￥14,056
￥25,081 total
includes taxes & fees
Dec 8 - Dec 9
Charming 3-bedroom house near ball park in quiet neighborhood
Dining
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
The price is ￥17,570
￥21,932 total
includes taxes & fees
Dec 3 - Dec 4
Cozy cabins on beautiful Horseshoe Lake
Interior
The Rested Duck Mallard Room

The Rested Duck Mallard Room

Olive Branch
9.2 out of 10, Wonderful, (25)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is ￥19,445
￥23,906 total
includes taxes & fees
Jan 2 - Jan 3, 2026
The Rested Duck Mallard Room
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Cairo Hotel Reviews

Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Furniture missing knobs. No chair!!??? No coffee!!?? No breakfast. Nice location. Nice staff!! "
Gregory 1-night trip
Posted 7 months ago
Eagle Inn Charleston

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Frequently asked questions

Looking for a spa hotel in Cairo?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Cairo—your day trip starts here. Enjoy the opera and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Cairo?
When you're in Cairo, enjoy exploring the sights and attractions here including Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have a little extra time during your trip, you might want to check out Ballard Wildlife Management Area and Columbus-Belmont State Park.
What is a Cairo spa hotel?
Spa hotels in Cairo provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.