Top 10 Hotels in Byron, MN from ￥9,070 - Competitive Prices

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Our top choices for Byron hotels

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A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

1. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Deborah

￥12,185

￥14,027 total

includes taxes & fees

Aug 29 - Aug 30

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

2. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Margita

￥15,729

￥18,108 total

includes taxes & fees

Aug 31 - Sep 1

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A hotel room with two beds, a desk, a chair, and a mirror.

A bar with wooden stools and a neon sign.

An indoor swimming pool with a slide, seating area, and a large frog statue.

3. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Ariana

￥11,618

￥13,375 total

includes taxes & fees

Aug 30 - Aug 31

A compact kitchen with white cabinets, a microwave, a refrigerator, a sink, and a chair.

A multi-story hotel with a brick facade, a covered lobby entrance, and a parking lot with several cars.

A hotel reception area with a black reception desk, a 'WELCOME' sign, a bench, and two armchairs.

4. Extended Stay America Suites Rochester North

Rochester

Rick

￥10,171

￥11,709 total

includes taxes & fees

Aug 28 - Aug 29

An indoor swimming pool with clear water, wooden flooring, and a ceiling with wooden beams and lights.

A gym with treadmills, an elliptical, and a water station.

A café with multiple tables and chairs, a kitchen area with appliances, and a clock on the wall.

A hotel room with two beds, a desk, a chair, a television, and a window with curtains.

5. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park

Olivia

￥12,036

￥13,857 total

includes taxes & fees

Aug 28 - Aug 29

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A hotel room with a large window, a clock, a framed picture of pottery, a desk with a computer, and a seating area with patterned chairs.

A reception area with a reception desk, two armchairs, a clock, and a framed artwork on the wall.

A compact hotel room with a kitchenette, a dining area, a sofa, and a bed.

6. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

Siddhartha

￥11,098

￥12,776 total

includes taxes & fees

Sep 2 - Sep 3

A modern dining area with high tables, chairs, and pendant lighting.

A multi-story hotel with a modern design, featuring a prominent entrance with a covered area and a parking lot in front.

A hotel room with two beds, a desk with a computer, a chair, and a window with a view.

A reception desk with a large digital screen displaying a cityscape and the word "happy."

7. Hampton Inn & Suites Rochester-North

Rochester

Albert

￥15,535

￥17,884 total

includes taxes & fees

Sep 3 - Sep 4

An outdoor patio area with stone walls, outdoor seating, and landscaped gardens.

8. Staybridge Suites Rochester - Commerce Dr NW by IHG

Rochester

Brittney

￥20,218

￥23,277 total

includes taxes & fees

Sep 4 - Sep 5

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

A modern dining area with wooden tables and chairs, a kitchen with granite countertops, and a view of the outdoors through large windows.

A spacious living room with a stone fireplace, blue sofas, and a flat-screen TV.

9. Comfort Inn & Suites West - Medical Center

Rochester

Gary

￥13,481

￥15,520 total

includes taxes & fees

Sep 27 - Sep 28

A hotel reception desk with a wooden counter, a computer, and a vase with flowers.

A hotel room with a large bed, a view through a sliding glass door to an outdoor area, a nightstand with a lamp, and a wooden headboard.

An indoor swimming pool with wooden beams and white chairs around it.

A hotel room with a large bed, a separate bathroom with a bathtub, and a skylight ceiling.

10. Baymont by Wyndham Kasson Rochester Area

Kasson

Bryce

￥9,474

￥10,173 total

includes taxes & fees

Sep 6 - Sep 7

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

11. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Jon

￥17,767

￥20,453 total

includes taxes & fees

Sep 3 - Sep 4

A spacious lobby with a reception desk, sofas, and a coffee table.

A hotel room with a large bed, a sofa, a TV, and a desk.

An indoor swimming pool with clear blue water, surrounded by tiled flooring and equipped with a pool ladder.

A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

12. Sleep Inn & Suites West-Near Medical Center

Rochester

Kaitlin

￥13,227

￥15,228 total

includes taxes & fees

Sep 20 - Sep 21

A hotel lobby with a reception desk, seating area, and a bar.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

A gym with treadmills, an elliptical, and a stationary bike.

A multi-story hotel with a grey and orange facade, a covered entrance, and a parking lot with marked spaces.

13. Super 8 by Wyndham Rochester Mayo Clinic Area

Rochester

Amber

￥8,255

￥9,503 total

includes taxes & fees

Sep 6 - Sep 7

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A coffee station with two espresso machines and a variety of coffee pods and cups.

14. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

￥16,079

￥18,512 total

includes taxes & fees

Sep 25 - Sep 26

An indoor swimming pool with a wooden ceiling and large windows.

A restaurant with a staircase, dining tables, chairs, a coffee machine, and a refrigerator.

A spacious lobby with a high ceiling, a central seating area with patterned sofas and ottomans, a reception desk, and a staircase leading to an upper level.

15. Quality Inn near Medical Center

Rochester

Rodney

￥10,014

￥11,528 total

includes taxes & fees

Sep 16 - Sep 17

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

16. Econo Lodge Mayo Clinic Area

Rochester

Markus

￥10,926

￥12,579 total

includes taxes & fees

Sep 20 - Sep 21

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

17. Hampton Inn Rochester-South

Rochester

Lynne

￥16,840

￥19,388 total

includes taxes & fees

Sep 10 - Sep 11

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

18. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

Vickie

￥19,451

￥22,392 total

includes taxes & fees

Sep 4 - Sep 5

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

19. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Jason

￥12,043

￥13,864 total

includes taxes & fees

Aug 30 - Aug 31

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

20. Spark by Hilton Rochester South

Rochester

Helena

￥12,271

￥14,126 total

includes taxes & fees

Sep 4 - Sep 5

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Stay near popular Byron attractions

Somerby Park

Somerby Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

See properties

Oxbow Park

8.8/10 (5 reviews)

Explore the great outdoors at Oxbow Park, a lovely green space in Byron. Check out the top-notch restaurants or charming coffeehouses in this walkable area.

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Salem Glen Winery

You can enjoy a tasting or tour at Salem Glen Winery during your travels to Byron. Amble around the area's parks or experience its art scene.

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East Brookfield Park

After visiting East Brookfield Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Salem Town Hall

After visiting Salem Town Hall, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Cheery Meadows Center

You can search for that perfect souvenir at Cheery Meadows Center during your trip to Byron. Amble around the area's parks or experience its art scene.

See properties

Somerby Golf Club

Enjoy a round of golf in Byron at Somerby Golf Club. Amble around the area's parks or experience its art scene.

See properties

Valley View Park

Valley View Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

See properties

Top Byron Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"nothing great"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"There is free breakfast each morning and free dinner Monday-Wednesday. Nothing fancy. Not safe for those with Celiac though. The gym is excellent. The courtyard is comfortable. The staff lights fire pits outside in the evening."

Brentwood Inn & Suites

10/10 Excellent

"A comfortable stay close by Mayo Clinic"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Loved it it was clean and comfortable and convenient"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"We loved our stay! Staff was excellent, we will be back"

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent

"I loved staying here. It was clean and the staff was helpful and friendly. Free breakfast, parking and shuttle were great! I will definitely stay here again."

Comfort Inn & Suites Rochester South Mayo Clinic

10/10 Excellent

"Everything"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"

More cheap stays in Byron

Super 8 by Wyndham Rochester Mayo Clinic Area

106 SE 21st Street Rochester MN

￥8,255

￥9,503 total

Sep 6 - Sep 7

includes taxes & fees

Quality Inn near Medical Center

5708 Bandel Road NW Rochester MN

￥10,014

￥11,528 total

Sep 16 - Sep 17

includes taxes & fees

7.8/10 Good! (949 reviews)

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

￥12,036

￥13,857 total

Aug 28 - Aug 29

includes taxes & fees

8/10 Very Good! (1,017 reviews)

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

￥15,729

￥18,108 total

Aug 31 - Sep 1

includes taxes & fees

Hampton Inn Rochester-South

1755 S Broadway Rochester MN

￥16,840

￥19,388 total

Sep 10 - Sep 11

includes taxes & fees

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

￥19,900

￥22,910 total

Aug 28 - Aug 29

includes taxes & fees

8.8/10 Excellent! (1,001 reviews)

Frequently asked questions

Where is the best place to stay in Byron?

Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Inn and Suites - Mayo Clinic Area and Med City Inn & Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in Byron.

What's the top vacation rental in Byron?

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester: Visitors like this Byron vacation home rental. It offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Byron.

If I need to cancel my hotel reservation in Byron, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.

Where can I learn more about changing or cancelling my trip to Byron?

To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.

Where is the best place to stay near Oxbow Park?

Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.

How is it to stay in Byron?

Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 3 hotels and other accommodations to choose from. Find out more about Byron.

What should I see while I'm in Byron?

Favorite places to visit include Links of Byron Mini Golf, Cheery Meadows Center, and High Point Shopping Center. A couple of additional sights to add to your agenda are Byron Town Square and Somerby Golf Club. Check out what more to see and do in Expedia's Byron guide.

What's the weather like in Byron?

The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia

Book Hotels in Byron on Expedia.com

Find hotels in Byron, MN from ￥9,070

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Byron

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Byron hotels

1. Comfort Inn & Suites Rochester South Mayo Clinic

2. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

3. AmericInn by Wyndham Rochester Near Mayo Clinic

4. Extended Stay America Suites Rochester North

5. Med City Inn & Suites - Mayo Clinic Area

6. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

7. Hampton Inn & Suites Rochester-North

8. Staybridge Suites Rochester - Commerce Dr NW by IHG

9. Comfort Inn & Suites West - Medical Center

10. Baymont by Wyndham Kasson Rochester Area

11. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

12. Sleep Inn & Suites West-Near Medical Center

13. Super 8 by Wyndham Rochester Mayo Clinic Area

14. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

15. Quality Inn near Medical Center

16. Econo Lodge Mayo Clinic Area

17. Hampton Inn Rochester-South

18. Home2 Suites by Hilton Rochester Mayo Clinic Area

19. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

20. Spark by Hilton Rochester South

Stay near popular Byron attractions

Somerby Park

Oxbow Park

Salem Glen Winery

East Brookfield Park

Salem Town Hall

Cheery Meadows Center

Somerby Golf Club

Valley View Park

Top Byron Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Brentwood Inn & Suites

Med City Inn & Suites - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Comfort Inn & Suites Rochester South Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

More cheap stays in Byron

Super 8 by Wyndham Rochester Mayo Clinic Area

Quality Inn near Medical Center

Med City Inn & Suites - Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Hampton Inn Rochester-South

Brentwood Inn & Suites

Frequently asked questions

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