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Check availability on Southeast Missouri 3 Star Hotels

Tonight
Sep 26 - Sep 27
Tomorrow
Sep 27 - Sep 28
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Southeast Missouri 3-star hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
￥15,726
￥17,741 total
includes taxes & fees
Oct 4 - Oct 5
Drury Plaza Hotel Cape Girardeau Conference Center
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott
￥14,783
￥16,998 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Sikeston, MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

3. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
￥13,235
￥14,324 total
includes taxes & fees
Sep 27 - Sep 28
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.
A conference room with round tables and chairs, equipped with floral centerpieces.
A Holiday Inn hotel with a main entrance, a Holiday Inn Express, and a Carvel restaurant.
A hotel room with two beds, a bedside lamp, a bench, a mirror, and a door leading to another room.

4. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
Nathan
￥13,054
￥14,749 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Poplar Bluff by IHG
A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.
Two grey armchairs with green cushions, a small side table with a white lamp, and wall-mounted sconces.
An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.
A hotel room with a brick wall, two beds, a desk with a TV, and a patterned carpet.

5. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville
Hayti
United States
Philip
￥16,041
￥18,283 total
includes taxes & fees
Oct 18 - Oct 19
Drury Inn & Suites Hayti Caruthersville
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

6. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
￥15,909
￥17,947 total
includes taxes & fees
Oct 4 - Oct 5
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a reception desk, seating area, and large windows.
A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.
A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.
A hotel room with a bed, a desk, a chair, a sofa, and a TV.

7. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
￥14,783
￥16,701 total
includes taxes & fees
Oct 18 - Oct 19
Drury Inn & Suites Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A hotel room with two beds, a brick wall, and a wooden headboard.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

8. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
￥13,525
￥14,299 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Jackson MO
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A lobby with seating areas, a reception desk, and a bar.

9. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
United States
Kristin
￥19,676
￥22,296 total
includes taxes & fees
Oct 8 - Oct 9
Courtyard by Marriott Cape Girardeau Downtown
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.
A modern bathroom with a glass shower enclosure, a vanity with a mirror, and a towel rack.
A modern hotel room with a kitchen area, a dining space, and a living area with a view.
A modern hotel room with a large bed, a desk, a TV, and a balcony with a view.

10. Century Casino & Hotel Caruthersville

Century Casino & Hotel Caruthersville
Caruthersville
United States
Philip
￥19,110
￥21,733 total
includes taxes & fees
Sep 27 - Sep 28
Century Casino & Hotel Caruthersville
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.
An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.
A corner market with a refrigerated display case and a pantry area.
A reception area with a wooden counter, a coffee machine, and a display of pastries.

11. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Vicki
￥15,909
￥17,972 total
includes taxes & fees
Oct 5 - Oct 6
Fairfield Inn & Suites by Marriott Poplar Bluff
A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.
A swimming pool with lounge chairs and a view of the night sky.
A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.
A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

12. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Festus
United States
Lisa-Marie
￥13,235
￥15,135 total
includes taxes & fees
Sep 30 - Oct 1
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

13. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
United States
Teresa
￥14,468
￥16,321 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Cape Girardeau
A conference room with round tables and chairs, a patterned carpet, and a chandelier.
A hotel room with a large bed, a desk, a chair, a TV mounted on the wall, and a window with curtains.
A modern living room with a sectional sofa, a glass coffee table, and a fireplace.
A restaurant with multiple tables and chairs, a counter with a coffee machine, and framed pictures on the walls.

14. Baymont by Wyndham Festus

Baymont by Wyndham Festus
Festus
United States
Linda
￥10,475
￥11,977 total
includes taxes & fees
Oct 25 - Oct 26
Baymont by Wyndham Festus
A red wooden mill with a small bridge over a flowing river, surrounded by lush greenery.
A playground with a slide, climbing structures, and a small shelter.
A row of yellow buildings with white railings and a covered front porch.
A grassy field with trees in the background.

15. Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
Mountain View
United States
Joanne
￥15,571
￥16,880 total
includes taxes & fees
Sep 27 - Sep 28
Honeysuckle Inn - Mountain View
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

16. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
￥15,885
￥17,986 total
includes taxes & fees
Oct 11 - Oct 12
Fairfield Inn & Suites by Marriott Sikeston
A bedroom with a bed, a desk, and a chair. There is a window with curtains, a radiator, and a wall-mounted shelf with a towel.
A motel with a parking lot, a covered picnic area, and a row of rooms with individual entrances.
A group of people sitting at picnic tables outdoors, surrounded by trees and a fenced area.
A playground with slides and swings, a mailbox, and a caution sign.

17. Current River Inn

Current River Inn
Van Buren
United States
Misty
￥17,128
￥18,537 total
includes taxes & fees
Sep 27 - Sep 28
Current River Inn
An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

18. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Stacy
￥15,875
￥17,975 total
includes taxes & fees
Oct 4 - Oct 5
TownePlace Suites by Marriott Sikeston
A living room with a blue wall, a fireplace, a sofa, and a chair.
A brick building with a sign reading "Mercantile & Hotel".
A bar area with stools and a counter where a bartender is serving drinks.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

19. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
￥16,536
￥18,000 total
includes taxes & fees
Oct 18 - Oct 19
EC Reed's Mercantile and Hotel
A bedroom with a bed, bedside table, and wall-mounted light fixtures.
A cozy living room with a sofa, armchairs, a coffee table, and a lamp. There are wall art pieces and a mirror.
A dining area with a wooden table, chairs, and a vase with flowers. There is a refrigerator and a microwave in the kitchen area.
A cabin with a porch and steps leading to a deck, situated near a body of water.

20. Johnson's Shut-ins State Park

Johnson's Shut-ins State Park
Middle Brook
United States
Aleksandr
Johnson's Shut-ins State Park
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 3-star hotels. See all 4-star hotels in Southeast Missouri.
The Riverview

The Riverview

777 Main St Cape Girardeau MO
￥16,512
￥18,628 total
Oct 4 - Oct 5
includes taxes & fees
9.4/10 Exceptional! (667 reviews)
The Riverview
Urban Lofts

Urban Lofts

104 North Jackson Street Perryville MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Food and drinks were very good."
Philip 1-night trip
Posted 19 hours ago
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 3 days ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 3 days ago
Drury Inn & Suites Poplar Bluff

Frequently asked questions

What are the best 3-star hotels in Southeast Missouri?
If you're staying in Cape Girardeau for your Southeast Missouri vacation, you'll find some cozy 3-star hotels. Many Expedia travelers book Courtyard by Marriott Cape Girardeau Downtown. Around 0.64 kilometers west of the downtown area, it features a terrace and a cafe. Another highly rated escape is Drury Plaza Hotel Cape Girardeau Conference Center. Book a room here and enjoy access to a swimming pool and high-speed internet services, and be approximately 8 kilometers west of the center.
How much does it cost to stay in a 3-star hotel in Southeast Missouri?
Use Expedia's sort and search filters to land an affordable 3-star hotel for your Southeast Missouri break. Just set your maximum rate with our pricing tool. You can also pick your amenities, preferred neighborhood and lots more.
  • Search for the lowest price per night right now from ￥18,628
What is the difference between a 4-star and 3-star hotel in Southeast Missouri?
Relaxation is effortless in 3-star hotels in Southeast Missouri. In addition to pleasant surroundings, these more affordable stays come with a wealth of amenities like WiFi, coffee maker and on-site gym. A 4-star hotel offers a more sophisticated experience with upscale features such as an on-site spa center, outdoor or indoor pool and more spacious rooms. Regardless of your desired hotel category or budget, we have the ideal match for you.

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