Find hotels in Wykoff, MN from ¥9,120

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Compare 320 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Country Lodge inn

2.0 star property
Harmony
9.0 out of 10, Wonderful, (39)
"Old motel but clean, with friendly owners."
United States
Fred
The price is ¥20,704
¥23,767 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Country Lodge inn

Country Trails Inn & Suites

2.0 star property
Preston
9.4 out of 10, Exceptional, (102)
"Great desk host, nice property, comfortable rooms, nice breakfast & dining room within walking from Casey’s gas & market. "
United States
Nancy
The price is ¥17,684
¥19,520 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Country Trails Inn & Suites

Kahler Grand Hotel

3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1806)
"Did know about a breakfast included in our room fee. "
United States
James
The price is ¥20,830
¥23,980 total
includes taxes & fees
Dec 11 - Dec 12
Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

3.0 star property
Rochester
8.2 out of 10, Very Good, (1125)
"Great location and value"
United States
Michelle
The price is ¥11,336
¥13,052 total
includes taxes & fees
Dec 12 - Dec 13
AmericInn by Wyndham Rochester Near Mayo Clinic

Econo Lodge Mayo Clinic Area

2.0 star property
Rochester
9.0 out of 10, Wonderful, (891)
"Good breakfast..shuttle service is excellent..super nice staff.."
United States
DALE K
The price is ¥9,770
¥11,248 total
includes taxes & fees
Dec 22 - Dec 23
Econo Lodge Mayo Clinic Area

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3.0 star property
Rochester
7.2 out of 10, Good, (1017)
"Breakfast was good. The staff was great. "
United States
Kjirsta
The price is ¥11,184
¥12,874 total
includes taxes & fees
Dec 10 - Dec 11
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (952)
"Hotel was spotless, excellent staff and the breakfast was excellent. Late night eats at the restaurant and the food served was fantastic."
United States
Carmino
The price is ¥16,931
¥19,803 total
includes taxes & fees
Dec 26 - Dec 27
EVEN Hotel Rochester - Mayo Clinic Area by IHG

Aspen Suites

3.0 star property
Rochester
9.0 out of 10, Wonderful, (686)
"I always stay at this hotel , love it clean comfortable rooms, they gave us vouchers for 4 free meals for Thanksgiving dinner"
United States
Cindy
The price is ¥22,521
¥27,224 total
includes taxes & fees
Dec 11 - Dec 12
Aspen Suites

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (882)
"Great room and stay!"
United States
Trevor
The price is ¥10,718
¥12,340 total
includes taxes & fees
Dec 27 - Dec 28
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Residence Inn by Marriott Rochester Mayo Clinic Area South

3.0 star property
Rochester
9.6 out of 10, Exceptional, (242)
"Really nice property with a great staff and phenomenal outdoor seating area with fire pit and grill"
United States
Dwight
The price is ¥17,894
¥20,601 total
includes taxes & fees
Dec 14 - Dec 15
Residence Inn by Marriott Rochester Mayo Clinic Area South

Country Inn & Suites Rochester South Mayo Clinic

3.0 star property
Rochester
8.4 out of 10, Very Good, (1004)
"Clean room, fun staff."
United States
Thomas
The price is ¥15,051
¥17,328 total
includes taxes & fees
Dec 27 - Dec 28
Country Inn & Suites Rochester South Mayo Clinic

Spark by Hilton Rochester South

3.0 star property
Rochester
9.4 out of 10, Exceptional, (301)
"The rooms are very nice and the staff is very friendly "
United States
Roberta
The price is ¥10,686
¥12,303 total
includes taxes & fees
Dec 14 - Dec 15
Spark by Hilton Rochester South

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3.0 star property
Kutzky Park
8.6 out of 10, Excellent, (931)
"This is a convenient place to stay when visiting Mayo."
United States
Faith
The price is ¥14,601
¥16,810 total
includes taxes & fees
Dec 19 - Dec 20
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Hilton Rochester Mayo Clinic Area

3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (541)
"Had a great stay. Room was very clean and staff was very courteous. "
United States
Bonita
The price is ¥26,620
¥30,646 total
includes taxes & fees
Dec 19 - Dec 20
Hilton Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area

2.0 star property
Rochester
7.8 out of 10, Good, (1005)
"Great Stay"
United States
Aweng
The price is ¥7,922
¥9,120 total
includes taxes & fees
Dec 14 - Dec 15
Super 8 by Wyndham Rochester Mayo Clinic Area

Stone Mill Hotel & Suites

3.0 star property
Lanesboro
9.2 out of 10, Wonderful, (661)
"Great service, location"
United States
Eric
The price is ¥16,310
¥17,514 total
includes taxes & fees
Dec 8 - Dec 9
Stone Mill Hotel & Suites

Marriott Rochester Mayo Clinic

3.5 star property
Downtown Rochester
8.2 out of 10, Very Good, (521)
"All staff were very nice and friendly and willing to help with whatever we needed. "
United States
Becky
The price is ¥26,251
¥30,223 total
includes taxes & fees
Dec 12 - Dec 13
Marriott Rochester Mayo Clinic

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 star property
Rochester
8.2 out of 10, Very Good, (783)
"Great place to stay. Freindly staff"
United States
joel
The price is ¥14,607
¥16,816 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3.0 star property
Historic Southwest
8.6 out of 10, Excellent, (1002)
"The room was clean, the staff was very friendly and helpful."
United States
kenneth
The price is ¥19,137
¥22,031 total
includes taxes & fees
Dec 11 - Dec 12
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

MainStay Suites Rochester South Mayo Clinic

2.5 star property
Rochester
7.0 out of 10, Good, (89)
"Staff is friendly "
United States
Merry
The price is ¥8,528
¥9,818 total
includes taxes & fees
Dec 10 - Dec 11
MainStay Suites Rochester South Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Where is the best place to stay in Wykoff?
Located 24 mi (38.6 km) from the heart of Wykoff, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Kahler Inn and Suites - Mayo Clinic Area and Spark by Hilton Rochester South. See all available top hotels, or vacation rentals in Wykoff.
What's the top vacation rental that Wykoff has to offer?
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO: Visitors like this Wykoff vacation home rental. It is equipped with a garden, air-conditioning, and laundry facilities to help you feel comfortable during your stay. See all vacation rentals in Wykoff.
If I need to cancel my hotel reservation in Wykoff, will I receive a refund?
Yes, most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Wykoff.
Where can I learn more about changing or cancelling my trip to Wykoff?
For more details about changing or cancelling your trip to Wykoff, click here.
What's the best hotel to stay with easy access to Ed's Museum?
Quiet, comfortable bed & breakfast in a gorgeous rural setting! is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private decks. You'll find it 5.5 mi (8.9 km) from Ed's Museum. Other good options around the area include Americas Best Value Inn & Suites Spring Valley and Oakenwald Terrace.
What is the best accommodation for staying close to Rochester International Airport (RST)?
AmericInn by Wyndham Rochester Airport is a popular hotel, featuring free breakfast and an indoor pool. It's located a short 0.6 mi (1 km) from Rochester Intl. Airport. Other choices near the airport include La Quinta Inn & Suites by Wyndham Rochester and Comfort Suites.
How is it staying in Wykoff?
Visitors can enjoy all that Wykoff has to offer including its museums. There are 317 hotels and other accommodations in the surrounding area. Find out more about Wykoff.
What are the top places to visit in Wykoff?
A favorite place to visit is Ed's Museum. You'll also find Forestville Mystery Cave State Park and Four Daughters Vineyard & Winery in the area. Check out what more to see and do in Expedia's Wykoff guide.
What's the weather like in Wykoff?
The hottest months are usually July and August with an average temp of 68°F, while the coldest months are January and February with an average of 22°F. The snowiest months in Wykoff are January, March, February, and April, with each month seeing an average of 8 inches of snowfall.