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Find hotels in Southwest Illinois, IL from ¥7,818

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Compare 706 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Southwest Illinois hotels

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1427)
"Our stay was amazing! "
The price is ¥14,238
¥16,099 total
includes taxes & fees
Sep 7 - Sep 8
Drury Plaza Hotel Mt. Vernon

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
8.8 out of 10, Excellent, (850)
"Always a nice place to stay while fishing a tournament on Rend Lake."
The price is ¥9,947
¥11,040 total
includes taxes & fees
Aug 28 - Aug 29
SureStay Hotel by Best Western Whittington Rend Lake

Drury Inn & Suites Marion

3.0 star property
9.4 out of 10, Exceptional, (1001)
"We had an excellent stay."
The price is ¥9,640
¥11,567 total
includes taxes & fees
Sep 7 - Sep 8
Drury Inn & Suites Marion

Quality Inn & Suites Vandalia near I-70 and Hwy 51

2.5 star property
8.4 out of 10, Very Good, (1003)
"Will stay again."
The price is ¥9,708
¥10,579 total
includes taxes & fees
Sep 14 - Sep 15
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Comfort Suites Mount Vernon

2.5 star property
8.8 out of 10, Excellent, (1005)
"Nice hotel. Would stay here again."
The price is ¥16,168
¥18,240 total
includes taxes & fees
Aug 24 - Aug 25
Comfort Suites Mount Vernon

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 star property
9.4 out of 10, Exceptional, (467)
"Rooms were clean and comfy, great breakfast "
The price is ¥15,426
¥17,120 total
includes taxes & fees
Aug 24 - Aug 25
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Vandalia by IHG

2.5 star property
8.8 out of 10, Excellent, (728)
"Great breakfast "
The price is ¥17,948
¥19,560 total
includes taxes & fees
Aug 31 - Sep 1
Holiday Inn Express & Suites Vandalia by IHG

Best Western Marion Hotel

2.5 star property
8.2 out of 10, Very Good, (1007)
"Nice motel for a decent price."
The price is ¥10,524
¥12,626 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Marion Hotel

Baymont by Wyndham Marion

2.5 star property
8.2 out of 10, Very Good, (1030)
"Nice staff clean room and great swimming area"
The price is ¥12,336
¥14,802 total
includes taxes & fees
Aug 24 - Aug 25
Baymont by Wyndham Marion

Drury Inn & Suites St. Louis Collinsville

3.0 star property
9.6 out of 10, Exceptional, (1000)
"Great place to stay "
The price is ¥16,359
¥18,810 total
includes taxes & fees
Sep 8 - Sep 9
Drury Inn & Suites St. Louis Collinsville

The Principal Hotel

3.5 star property
9.8 out of 10, Exceptional, (122)
"Perfect stay! "
The price is ¥15,395
¥17,085 total
includes taxes & fees
Sep 22 - Sep 23
The Principal Hotel

Comfort Inn & Suites Marion I-57

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Great place to stay. Clean, quiet"
The price is ¥16,687
¥20,021 total
includes taxes & fees
Sep 7 - Sep 8
Comfort Inn & Suites Marion I-57

Holiday Inn Express & Suites Salem by IHG

2.5 star property
9.4 out of 10, Exceptional, (716)
"Great hospitality, clean rooms and a nice breakfast!"
The price is ¥16,761
¥18,772 total
includes taxes & fees
Sep 21 - Sep 22
Holiday Inn Express & Suites Salem by IHG

Comfort Inn Edwardsville - St. Louis

2.5 star property
8.4 out of 10, Very Good, (759)
"The view from the hotel is beautiful. The hotel linens and bed were some of the best I have experienced in my recent travels. "
The price is ¥15,886
¥18,265 total
includes taxes & fees
Aug 25 - Aug 26
Comfort Inn Edwardsville - St. Louis

Ramada by Wyndham Vandalia

2.0 star property
7.8 out of 10, Good, (782)
"It was a good stay with food options close. It’s a bit dated but good. "
The price is ¥10,649
¥11,606 total
includes taxes & fees
Aug 31 - Sep 1
Ramada by Wyndham Vandalia

Comfort Inn & Suites Greenville I-70

2.5 star property
8.4 out of 10, Very Good, (397)
"excellent stay"
The price is ¥14,026
¥15,567 total
includes taxes & fees
Sep 7 - Sep 8
Comfort Inn & Suites Greenville I-70

Drury Inn & Suites St. Louis Fairview Heights

3.0 star property
9.2 out of 10, Wonderful, (1002)
"Great stay! "
The price is ¥13,779
¥15,567 total
includes taxes & fees
Sep 14 - Sep 15
Drury Inn & Suites St. Louis Fairview Heights

Quality Inn & Suites near St. Louis and I-255

2.5 star property
7.6 out of 10, Good, (1000)
"Place was nice and clean and in a good area."
The price is ¥10,591
¥11,968 total
includes taxes & fees
Aug 31 - Sep 1
Quality Inn & Suites near St. Louis and I-255

Comfort Inn Collinsville near St. Louis

2.5 star property
8.6 out of 10, Excellent, (818)
"Excellent employees, convenient and affordable as well as an exceptional breakfast "
The price is ¥14,424
¥16,584 total
includes taxes & fees
Aug 25 - Aug 26
Comfort Inn Collinsville near St. Louis

Best Western Plus MidAmerica Hotel

2.5 star property
9.0 out of 10, Wonderful, (1002)
"It was a very comfortable stay."
The price is ¥15,850
¥17,591 total
includes taxes & fees
Aug 28 - Aug 29
Best Western Plus MidAmerica Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southwest Illinois, IL

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Family-friendly hotels in Southwest Illinois you'll enjoy

Hotels with free breakfast in Southwest Illinois may fit your trip

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Stay near popular Southwest Illinois attractions

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

Southern Illinois which includes a lake or waterhole and forests
Photo by Southernmost Illinois Tourism Bureau
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Top Southwest Illinois Hotel Reviews