Find hotels in San Francisco, Panama City from ¥7,179
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Discover 1,542 San Francisco hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for San Francisco hotels

Las Americas Golden Tower Panama
Las Americas Golden Tower Panama

Residence Inn by Marriott Panama City
Residence Inn by Marriott Panama City

San Francisco by Wynwood House
San Francisco by Wynwood House

Courtyard by Marriott Panama Multiplaza Mall
Courtyard by Marriott Panama Multiplaza Mall

Decapolis Hotel Panama City
Decapolis Hotel Panama City

Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
Where to stay in San Francisco
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.
Punta Paitilla
Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Calidonia
You might enjoy the shopping while in Calidonia. Cinta Costera is a notable sight, and you can get around town at Estación Lotería or Santo Tomas Station to see more of the city.
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Hotels in top Panama City neighborhoods
- Hotels in Casco Viejo
- Hotels in Bella Vista
- Hotels in El Cangrejo
- Hotels in San Francisco
- Hotels in Calidonia
- Hotels in Punta Paitilla
- Hotels in San Felipe
- Hotels in Costa del Este
- Hotels in Marbella
- Hotels in Punta Pacifica
- Hotels in Obarrio
- Hotels in Campo Alegre
- Hotels in Amador
- Hotels in Santa Ana
- Hotels in Balboa
- Hotels in El Chorrillo
- Hotels in Bethania
- Hotels in Juan Diaz
- Hotels in Parque Lefevre
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