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Our top choices for San Francisco hotels

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1127)
"The room was clean and the location was great."
United States
Wendy
The price is ¥15,344
¥16,878 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2141)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ¥16,855
¥18,540 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Plaza Paitilla Inn Hotel

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Staff was very helpful. Great location."
United States
John
The price is ¥14,506
¥15,957 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Courtyard by Marriott Panama Multiplaza Mall

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1000)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is ¥24,572
¥27,029 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Las Americas Golden Tower Panama

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1464)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is ¥21,955
¥24,151 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Decapolis Hotel Panama City

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very Good, (1312)
"Clean convenient beautiful hotel. "
United States
Daniel
The price is ¥36,465
¥40,111 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Megapolis Hotel Panamá

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (996)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ¥20,996
¥23,096 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sheraton Grand Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco
8.8 out of 10, Excellent, (896)
"Great staff..warm and welcoming...enjoyed our stay!"
United States
Alystra Marissa Arjoon
The price is ¥18,549
¥20,404 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Aloft Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1002)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ¥51,370
¥56,507 total
includes taxes & fees
Jan 3 - Jan 4, 2026
JW Marriott Panama

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (543)
"It's location is close to everything. "
United States
Sharon
The price is ¥25,153
¥27,668 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Residence Inn by Marriott Panama City

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
3.0 star property
San Francisco
The price is ¥29,207
¥32,228 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Dovle Residences by HMS-Preferred Member

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is ¥18,882
¥24,684 total
includes taxes & fees
Jan 15 - Jan 16, 2026
San Francisco by Wynwood House

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
8.0 out of 10, Very Good, (28)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa

Casa Orquídea

Casa Orquídea
2.0 star property
San Francisco
8.0 out of 10, Very Good, (5)
"For me was very convenient "
United States
Natalia
The price is ¥10,774
¥11,851 total
includes taxes & fees
Dec 29 - Dec 30
Casa Orquídea

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is ¥25,694
¥52,136 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Wanders Panama by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is ¥5,991
¥29,547 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Living 73 Panamá by Boutique Apartments

Stylish 2BR Apt Near the Park Omar

Stylish 2BR Apt Near the Park Omar
2.0 star property
San Francisco
The price is ¥31,772
¥40,308 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Stylish 2BR Apt Near the Park Omar

Wanders & Yoo

Wanders & Yoo
4.0 star property
San Francisco
8.0 out of 10, Very Good, (11)
"Cool and modern condos, great location and views."
United States
Jorge
The price is ¥44,165
¥48,718 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Wanders & Yoo

w Bright 1BR w Private Balcony in San Francisco

w Bright 1BR w Private Balcony in San Francisco
2.0 star property
San Francisco
The price is ¥17,200
¥23,558 total
includes taxes & fees
Jan 18 - Jan 19, 2026
w Bright 1BR w Private Balcony in San Francisco

Spacious 2BR w Terrace Lounge

Spacious 2BR w Terrace Lounge
2.0 star property
San Francisco
The price is ¥31,859
¥44,896 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Spacious 2BR w Terrace Lounge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and National Theater are top sights worth seeing.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top San Francisco Hotel Reviews

Frequently asked questions

What is San Francisco like?
San Francisco is a welcoming neighborhood that travelers like for its restaurants. Be sure to check out Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.
Where is the best hotel for a stay in San Francisco?
Based on Expedia customer reviews, Ramada Plaza by Wyndham Panama Punta Pacifica is the highest ranked property in San Francisco. This hotel is a short 4-minute walk from Multiplaza Pacific Mall, and it offers free breakfast and a restaurant. Other top choices in the neighborhood include Plaza Paitilla Inn Hotel and Residence Inn by Marriott Panama City.
How many hotels will I find in San Francisco?
If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 263 San Francisco hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! Most room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in San Francisco.
Where can I learn more about changing or cancelling my trip to San Francisco?
For additional details about updating your trip to San Francisco or cancelling it, head over to our customer service page.
What is there to do in this Panama City neighborhood?
While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa, or Pacific Center, might be the perfect place to find that souvenir you've been looking for. Calle 50 and Panama Canal Murals are some other stops to visit in the neighborhood. A few places to visit in the area around San Francisco include Colonial Religious Art Museum, Bingo 90, and Soho City Center. When you're sightseeing in Panama City, National Shrine of the Heart of Mary and Panama Viejo Museum are also worth a stop.

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