Panama City Vacation Rentals

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Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for Panama City vacation rentals

Superior Double Room | Terrace/patio
La Isabela Suites

La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (171)
"Wonderful charming property in the heart of the historic district. "
United States
Angela
La Isabela Suites
Studio, 1 King Bed, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated
Las Clementinas

Las Clementinas

Las Clementinas
3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (171)
"The front desk receptionist was extremely helpful! The room was clean and comfortable! We would definitely stay again!"
United States
april
The price is ￥23,870
￥26,257 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Las Clementinas
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (175)
"Was a great buy. Beautiful views and spacious rooms. Great amenities. "
United States
Lesley
The price is ￥12,964
￥21,494 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Arcadia Condo Suites
Microwave, coffee/tea maker, cookware/dishes/utensils
La Palma Aparta Suite

La Palma Aparta Suite

La Palma Aparta Suite
3.0 star property
Amador
The price is ￥7,421
￥12,860 total
includes taxes & fees
Dec 29 - Dec 30
La Palma Aparta Suite
Apartment (CC4B) | Balcony
Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House
4.0 star property
Casco Viejo
8.2 out of 10, Very Good, (20)
"Great place!"
United States
Jad
The price is ￥23,955
￥30,265 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Casa Contemporanea by Wynwood House
Standard Apartment | Living area | Flat-screen TV
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (485)
"Room was clean, neat great staff"
United States
Alfredo
Torres de Alba Hotel & Suites
Apartment | Exterior
Centriqo by Wynwood house

Centriqo by Wynwood house

Centriqo by Wynwood house
3.0 star property
Veracruz
The price is ￥20,010
￥27,178 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Centriqo by Wynwood house
Apartment (14D) | Private kitchen
Mini Design By Wynwood House

Mini Design By Wynwood House

Mini Design By Wynwood House
2.0 star property
Bella Vista
The price is ￥19,023
￥25,230 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Mini Design By Wynwood House
Property grounds
Panama View House – A Hilltop Retreat with Stunning Canal Views

Panama View House – A Hilltop Retreat with Stunning Canal Views

Panama View House – A Hilltop Retreat with Stunning Canal Views
Panama City
The price is ￥5,637
￥15,031 total
includes taxes & fees
Dec 29 - Dec 30
Panama View House – A Hilltop Retreat with Stunning Canal Views
Outdoor pool
Studio Apartment with Ocean View

Studio Apartment with Ocean View

Studio Apartment with Ocean View
3.0 star property
Calidonia
8.0 out of 10, Very Good, (2)
"It was similar to a hotel room, but a little smaller.. the bed is big enough for just one person and check in was the most difficult thing he had to wait outside in the rain and download apps"
United States
Gwendolyn
The price is ￥10,177
￥11,195 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Studio Apartment with Ocean View
Outdoor pool, free cabanas, sun loungers
Yoo Panama & Arts Tower

Yoo Panama & Arts Tower

Yoo Panama & Arts Tower
3.0 star property
Bella Vista
9.6 out of 10, Exceptional, (56)
"Ron was amazing and so was the property!"
United States
John
Yoo Panama & Arts Tower
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is ￥25,765
￥52,281 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Wanders Panama by Boutique Apartments
Smart TV
Lodging cerro viento, 2 bedroom apartment with air conditioning.

Lodging cerro viento, 2 bedroom apartment with air conditioning.

Lodging cerro viento, 2 bedroom apartment with air conditioning.
Cerro Viento
10.0 out of 10, Exceptional, (1)
"Tiene todo lo necesario en perfectas condiciones."
Mexico
GLADYS
The price is ￥7,750
￥13,773 total
includes taxes & fees
Dec 29 - Dec 30
Lodging cerro viento, 2 bedroom apartment with air conditioning.
Apartment, 1 Bedroom, Balcony | Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is ￥11,980
￥15,021 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Swette Love 10 Minutes From the Airport Tocumen
Apartment, 2 Bedrooms (2C) | Iron/ironing board, free WiFi, bed sheets
Donovan By Wynwood House

Donovan By Wynwood House

Donovan By Wynwood House
3.0 star property
Casco Viejo
8.4 out of 10, Very Good, (45)
"I always love to stay at Wynwood properties in Panama "
United States
Alberto B
The price is ￥13,622
￥19,681 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Donovan By Wynwood House
Outdoor pool
Beutiful Modern Apartment, High Speed Internet, Best Location

Beutiful Modern Apartment, High Speed Internet, Best Location

Beutiful Modern Apartment, High Speed Internet, Best Location
Bella Vista
9.8 out of 10, Exceptional, (11)
"Great host & great location. Will recommend 10/10"
United States
Hope B.
The price is ￥14,647
￥21,693 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Beutiful Modern Apartment, High Speed Internet, Best Location
Outdoor pool
Yoo by Wynwood House

Yoo by Wynwood House

Yoo by Wynwood House
4.0 star property
Calidonia
9.2 out of 10, Wonderful, (5)
"I will be back!"
United States
Jeffrey
The price is ￥20,996
￥28,607 total
includes taxes & fees
Dec 29 - Dec 30
Yoo by Wynwood House
Interior
LILIA HOUSE 10 MINUTES AIRPORT

LILIA HOUSE 10 MINUTES AIRPORT

LILIA HOUSE 10 MINUTES AIRPORT
Panamá
The price is ￥7,829
￥12,213 total
includes taxes & fees
Jan 1 - Jan 2, 2026
LILIA HOUSE 10 MINUTES AIRPORT
Outdoor spa tub
Gorgeous Apartment, private terrace and Free tour P1

Gorgeous Apartment, private terrace and Free tour P1

Gorgeous Apartment, private terrace and Free tour P1
Casco Viejo
9.0 out of 10, Wonderful, (4)
"The room was absolutely clean and wonderful, but the spa was under construction until the last day"
United States
Jeremiah T.
The price is ￥11,843
￥21,638 total
includes taxes & fees
Dec 29 - Dec 30
Gorgeous Apartment, private terrace and Free tour P1
Outdoor pool
Boutique Apartments Panama

Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (222)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama City Hotel Reviews

Decapolis Hotel Panama City

Decapolis Hotel Panama City

10/10 Excellent
"All"
Juan José 2-night trip
Posted 2 days ago
Decapolis Hotel Panama City

Find out more about Panama City

Search for holiday rentals in Panama City on Expedia! You can easily find your home rentals, villas, holiday apartments in Panama City using one of the methods below:

  • View our selection of featured holiday rentals in Panama City
  • Use the map to find apartments and other holiday homes in the Panama City neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Panama City while they last

Look no further and take a look at our great range of rental properties in Panama City!

Frequently asked questions

Can I find vacation rentals in Panama City?

Yes, we give you a choice of vacation rentals in Panama City near Panama Canal Railway, or you can choose a more remote option if you're looking for a relaxing stay. Tourists like the array of shops and top-notch restaurants in Panama City. While you're in the area, grab a bite or have a drink at the lively bars and cafes.

What's the top vacation rental in Panama City?

Oasis with pool near panama canal: This Panama City vacation home rental offers an outdoor pool, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind. Some other top choices in Panama City are Tropical House with Historic Charm, WiFi, Private Bathrooms and Workspaces and Panama View House – A Hilltop Retreat with Stunning Canal Views.

How many vacation rentals are there in Panama City?

With 56 Expedia vacation rentals, you're sure to find just the right place for your Panama City stay.

What can I see and do in Panama City?

Cultural attractions include National Theater and Interoceanic Canal Museum, whereas Cinta Costera and Miraflores Locks are a couple of picturesque spots to enjoy the outdoors. Albrook Shopping Mall and Via Espana are other places to visit while you're in town.

What are vacation rentals like in Panama City?

Vacation rentals are privately owned accommodations you can stay in for several days or longer in Panama City. Vacation rentals offer amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about cleanliness, vacation rentals can provide a sense of safety away from public hotel elevators and busy lobbies while still allowing you to travel. You'll also find more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for families.