Find hotels in Serra Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serra Mesa hotels

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1,287 reviews)
"Clean room, staff was great during check in and checking out. "
United States
Amber
The price is ¥9,663
¥11,108 total
includes taxes & fees
Mar 30 - Mar 31
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
9.4 km from Serra Mesa
8.4 out of 10, Very Good, (375 reviews)
"Great location… stuff was really friendly "
United States
Aurora
The price is ¥12,078
¥13,739 total
includes taxes & fees
Mar 3 - Mar 4
Ash&9th

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,263 reviews)
"Great location, clean rooms, friendly staff"
United States
Beth
Urban Boutique Hotel

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very Good, (1,541 reviews)
"Room was nice, clean, staff was friendly, "
United States
philip
The price is ¥14,401
¥16,265 total
includes taxes & fees
Mar 9 - Mar 10
SureStay Hotel by Best Western San Diego Pacific Beach

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very Good, (1,952 reviews)
"Great stay"
United States
Lizeth
The price is ¥13,778
¥15,838 total
includes taxes & fees
Mar 5 - Mar 6
GreenTree Inn San Diego Mission Bay

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1,025 reviews)
"Clean quiet friendly helpful staff convenient location will stay there again"
United States
David
The price is ¥18,570
¥21,124 total
includes taxes & fees
Mar 8 - Mar 9
Gaslamp Plaza Suites

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,419 reviews)
"Nice beds and breakfast, really convenient "
Canada
Margarita
The price is ¥14,027
¥16,123 total
includes taxes & fees
Mar 2 - Mar 3
Comfort Inn Sea World Area

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very Good, (1,483 reviews)
"Great staff, clean rooms "
United States
Hala
The price is ¥15,711
¥18,063 total
includes taxes & fees
Mar 1 - Mar 2
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1,325 reviews)
"Spotless! Very kind and attentive staff at checkin! Very impressed and will be back! "
United States
Michelle
The price is ¥17,111
¥19,326 total
includes taxes & fees
Mar 9 - Mar 10
Comfort Inn San Diego Airport At The Harbor

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 11.7 km from Serra Mesa
8.0 out of 10, Very Good, (1,186 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
11.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,748 reviews)
"Well stay again love the location"
United States
Lynette
The price is ¥16,990
¥19,496 total
includes taxes & fees
Mar 2 - Mar 3
Best Western Yacht Harbor Hotel

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,164 reviews)
"Good location friendly staff"
United States
Anya
The price is ¥15,449
¥17,758 total
includes taxes & fees
Mar 3 - Mar 4
Wyndham Garden San Diego Near SeaWorld

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
12.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,005 reviews)
"Super clean rooms and a great location "
United States
Mark
Sea Harbor Hotel

The Shoal La Jolla Beach

The Shoal La Jolla Beach
2.5 star property
13.2 km from Serra Mesa
8.8 out of 10, Excellent, (1,003 reviews)
"Super solid place to stay, clean, great staff, walk to the beach."
United Kingdom
Nick
The price is ¥26,626
¥30,073 total
includes taxes & fees
Mar 2 - Mar 3
The Shoal La Jolla Beach

PB Surf Beachside Inn

PB Surf Beachside Inn
2.5 star property
North Pacific Beach, 11.1 km from Serra Mesa
8.2 out of 10, Very Good, (1,001 reviews)
"Great location good room very clean"
United States
Aleena
The price is ¥20,060
¥22,656 total
includes taxes & fees
Mar 4 - Mar 5
PB Surf Beachside Inn

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
10.5 km from Serra Mesa
9.2 out of 10, Wonderful, (2,779 reviews)
"Great location, suite was nice! We had a wonderful stay…"
United States
Alan
The Horton Grand, Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,275 reviews)
"Clean room, friendly staff, great location Very affordable rate Good breakfast variety "
United States
Mary
The price is ¥24,566
¥28,483 total
includes taxes & fees
Mar 2 - Mar 3
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Pacific Shores Inn on Pacific Beach

Pacific Shores Inn on Pacific Beach
2.5 star property
North Pacific Beach, 11.1 km from Serra Mesa
8.0 out of 10, Very Good, (1,006 reviews)
"Fantastic location "
Canada
Regan
The price is ¥18,096
¥20,439 total
includes taxes & fees
Mar 3 - Mar 4
Pacific Shores Inn on Pacific Beach

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,652 reviews)
"Very easy vacation, convenient breakfast as well as location."
United States
Kathy
The price is ¥32,577
¥43,427 total
includes taxes & fees
Mar 1 - Mar 2
Embassy Suites by Hilton San Diego Bay Downtown

Beach Haven - Near Pacific Beach Park

Beach Haven - Near Pacific Beach Park
2.0 star property
North Pacific Beach, 11 km from Serra Mesa
8.8 out of 10, Excellent, (1,003 reviews)
"Very nice staff and room."
United States
Nancy
The price is ¥19,499
¥22,023 total
includes taxes & fees
Mar 4 - Mar 5
Beach Haven - Near Pacific Beach Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
Learn more about Serra Mesa

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighborhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels will I be able to find in the Serra Mesa area?
Expedia has 37 hotels and other accommodations in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, you'll find most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the top deals on offer in Serra Mesa.
Where can I learn more about changing or cancelling my trip to Serra Mesa?
For more information about picking new dates or cancelling your trip to Serra Mesa, click here.
What can I see and do in this San Diego neighborhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

Explore a world of travel with Expedia