A waterfront with Spanish moss-covered trees, a wooden dock, and a distant shoreline.

Find hotels in Melrose, FL from ¥9,332

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Sep 14 - Sep 15
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Sep 15 - Sep 16
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Sep 18 - Sep 20
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Sep 25 - Sep 27

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Our top choices for Melrose hotels

1. Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG
Starke
United States
Judy
¥16,897
¥18,756 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Starke by IHG

2. Comfort Suites Gainesville near University

Comfort Suites Gainesville near University
Gainesville
United States
Gladys
¥12,304
¥13,842 total
includes taxes & fees
Sep 21 - Sep 22
Comfort Suites Gainesville near University

3. Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
Waldo
United States
Ana Laura
¥12,925
¥14,541 total
includes taxes & fees
Sep 22 - Sep 23
Best Western Waldo Inn and Suites

4. Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown
Downtown Gainesville
United States
maria
¥15,054
¥16,935 total
includes taxes & fees
Sep 21 - Sep 22
Hyatt Place Gainesville Downtown

5. Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville
Gainesville
United States
Shirley
¥15,886
¥17,872 total
includes taxes & fees
Sep 21 - Sep 22
Drury Inn & Suites Gainesville

6. Soho Inn Waldo

Soho Inn Waldo
Waldo
United States
Brandie
¥8,295
¥9,332 total
includes taxes & fees
Sep 15 - Sep 16
Soho Inn Waldo

7. Hampton Inn Gainesville

Hampton Inn Gainesville
Gainesville
United States
Phillip
¥13,991
¥15,740 total
includes taxes & fees
Sep 17 - Sep 18
Hampton Inn Gainesville

8. Red Carpet Inn

Red Carpet Inn
Starke
United States
Mark
¥10,599
¥11,765 total
includes taxes & fees
Sep 15 - Sep 16
Red Carpet Inn

9. Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area
Gainesville
United States
Williams
¥7,341
¥8,259 total
includes taxes & fees
Sep 20 - Sep 21
Super 8 by Wyndham Gainesville I-75 Hospital University Area

10. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
Gainesville
United States
Henry
¥13,579
¥15,277 total
includes taxes & fees
Sep 21 - Sep 22
Country Inn & Suites by Radisson, Gainesville, FL

11. Holiday Inn Express Palatka Northwest by IHG

Holiday Inn Express Palatka Northwest by IHG
Palatka
United States
Felix
¥19,969
¥22,165 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Palatka Northwest by IHG

12. Americas Best Value Inn Starke

Americas Best Value Inn Starke
Starke
United States
Jeanette
¥11,521
¥12,788 total
includes taxes & fees
Sep 15 - Sep 16
Americas Best Value Inn Starke

13. Best Western Starke

Best Western Starke
Starke
United States
Christopher
¥13,364
¥14,834 total
includes taxes & fees
Sep 20 - Sep 21
Best Western Starke

14. HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western
Gainesville
United States
Armando Serradet
¥11,128
¥12,519 total
includes taxes & fees
Sep 20 - Sep 21
HOM Hotel Gainesville, SureStay Collection by Best Western

15. Hampton Inn Palatka

Hampton Inn Palatka
Palatka
United States
elton
¥17,508
¥19,434 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Palatka

16. Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville Hospital/University Area
Gainesville
United States
Andrew
¥9,485
¥10,671 total
includes taxes & fees
Sep 16 - Sep 17
Days Inn by Wyndham Gainesville Hospital/University Area

17. Motel 6 Starke, FL

Motel 6 Starke, FL
Starke
United States
Sunn
¥9,688
¥10,753 total
includes taxes & fees
Sep 28 - Sep 29
Motel 6 Starke, FL

18. Quality Inn & Suites Palatka Riverfront

Quality Inn & Suites Palatka Riverfront
Palatka
United States
Ana
¥12,587
¥13,972 total
includes taxes & fees
Oct 11 - Oct 12
Quality Inn & Suites Palatka Riverfront

19. SpringHill Suites by Marriott Gainesville

SpringHill Suites by Marriott Gainesville
Gainesville
United States
Robert
¥13,579
¥15,277 total
includes taxes & fees
Sep 20 - Sep 21
SpringHill Suites by Marriott Gainesville

20. Depot Village

Depot Village
Gainesville
United States
Trisha
¥10,352
¥22,016 total
includes taxes & fees
Sep 16 - Sep 17
Depot Village
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Learn more about Melrose

Nestled along Lake Santa Fe, this charming town offers peaceful kayaking and fishing at Melrose Bay Park. Art lovers can browse local galleries and studios, then enjoy fresh farm-to-table dining at the weekend farmers' market.

See all hotels in Melrose
A waterfront with Spanish moss-covered trees, a wooden dock, and a distant shoreline.
Photo by Matt Mateo

Top Melrose Hotel Reviews

Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent
"Quick and easy to the interstate and close to good dinning options."
Robert 1-night trip
Posted 1 hour ago
Country Inn & Suites by Radisson, Gainesville, FL
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

8/10 Good
"It’s the red roof ya know. This was still a nice stay mainly because of the staff being so friendly, we all enjoyed the pool my daughter especially and they allow 1 pet to stay for free so we were able to bring along our dog! We did have to request a new room our first night there - the one they originally gave us was extremely broke down and honestly shouldn’t be allowed to be rented out until the several Required repairs are complete, BUT they didn’t give us any hassle. Just went back down to the front desk requested something else and they gave a cleaner/better room on the same floor which made moving easy peasy. I’ve stayed here before in the past and it’s always an ok experience as far as quality goes, but you can’t beat the rate + location + great staff & the pool was clean and cool which makes up for quality in my opinion."
Pamela 2-night trip
Posted 1 hour ago
Red Roof Inn PLUS+ Gainesville
Hampton Inn Gainesville

Hampton Inn Gainesville

10/10 Excellent
"Staff was friendly. Breakfast was great. Coffee was hot. Rooms were clean."
Jennie 1-night trip
Posted 2 hours ago
Hampton Inn Gainesville
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

8/10 Good
"First time staying here. Clean and had wonderful hot water in the rooms! Nice staff. Convenient to restaurants and UF."
Deborah 1-night trip
Posted 4 hours ago
HOM Hotel Gainesville, SureStay Collection by Best Western
Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area

10/10 Excellent
"Great stay the staff amazing nice 👍 👌 👏"
Debrafrazier 1-night trip
Posted 4 hours ago
Super 8 by Wyndham Gainesville I-75 Hospital University Area
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

10/10 Excellent
"Great staff. Game day decorations were fun."
Daniel 1-night trip
Posted 5 hours ago
Comfort Inn Gainesville - University Area
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

10/10 Excellent
"I love staying at The Drury whenever I can. The dinner/breakfast is such a value to me. Every single one is a great experience."
Gwen 1-night trip
Posted 20 hours ago
Drury Inn & Suites Gainesville
Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

10/10 Excellent
"The price was great, and room was modern, clean, and really comfortable, and the staff was outstanding. I stayed in three hotels during this trip, and this one was the best without doubt. I’m really picky about small details like how good are the shampoo and conditioner, and how easy are they to use, and are the corners or grout in the shower clean, are there convenient device charging options by the bed, and the Hyatt was flawless. If I had to find an issue, it would be that the tv wasn’t really a smart tv. It would have been a hassle to stream from my own accounts, and live tv wasn’t great. But that’s really stretching to find something to complain about when I can watch what I want on my laptop. Room service would have also been lovely, but the second floor bar and restaurant were great and easy to take to-go. Absolutely would stay again or recommend to friends and family."
Leslie 1-night trip
Posted 1 day ago
Hyatt Place Gainesville Downtown
Gainesville Lodge

Gainesville Lodge

10/10 Excellent
"Very friendly staff. Good value for the price."
Scott 2-night trip
Posted 1 day ago
Gainesville Lodge

More cheap stays in Melrose

Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville Hospital/University Area

2649 Sw 13th St Gainesville FL
¥9,485
¥10,671 total
Sep 16 - Sep 17
includes taxes & fees
Days Inn by Wyndham Gainesville Hospital/University Area
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL
¥11,128
¥12,519 total
Sep 20 - Sep 21
includes taxes & fees
8.6/10 Excellent! (2,130 reviews)
HOM Hotel Gainesville, SureStay Collection by Best Western
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL
¥11,307
¥13,584 total
Sep 21 - Sep 22
includes taxes & fees
8.2/10 Very Good! (1,092 reviews)
Comfort Inn Gainesville - University Area
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL
¥12,304
¥13,842 total
Sep 21 - Sep 22
includes taxes & fees
Comfort Suites Gainesville near University
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL
¥11,621
¥13,938 total
Oct 5 - Oct 6
includes taxes & fees
Sleep Inn & Suites University/Shands
Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG

15111 S.Highway 301 Starke FL
¥16,897
¥18,756 total
Sep 20 - Sep 21
includes taxes & fees
Holiday Inn Express Starke by IHG

Frequently asked questions

Where is the best place to stay in Melrose?
Drury Inn & Suites Gainesville, located 21 mi (33.9 km) from the heart of Melrose, is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Sleep Inn & Suites University/Shands and DoubleTree by Hilton Gainesville. See all available top hotels, or vacation rentals in Melrose.
What's the top vacation rental in Melrose?
3 Bedroom House on Private Scenic Lake Mable: This highly rated vacation home rental in Melrose is located on a lake and has a garden, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Melrose.
If I need to cancel my hotel reservation in Melrose, will I receive a refund?
Yes! The majority of room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Melrose.
Where can I learn more about changing or cancelling my trip to Melrose?
For more details about changing or cancelling your trip to Melrose, head over to our customer service page.
What are some accommodations with pools in Melrose?
Drury Inn & Suites Gainesville: Hotel located near University of Florida. Features buffet, a pool, and free self parking. Sleep Inn & Suites University/Shands and DoubleTree by Hilton Gainesville are two additional hotels that feature an onsite pool. View all hotels with pools in Melrose.
What's the best accommodation near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
What's it like to stay in Melrose?
Visitors are sure to enjoy all that Melrose has to offer. In Melrose, there are 40 hotels and other accommodations to choose from. Find out more about Melrose.
What are the top places to visit in Melrose?
A favorite place to visit is Santa Fe Lake. You'll also find Gainesville Raceway and Ironwood Golf Course in the area. Check out what more to see and do in Expedia's Melrose guide.
What's the seasonal weather like in Melrose?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 60°F. Average annual precipitation for Melrose is 51 inches.

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