Find hotels in Medical Center District, San Antonio from ¥7,612

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Discover 4,681 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3084)
"good location, breakfast ok and service is ok with the price"
United States
Ha
The price is ¥12,950
¥15,310 total
includes taxes & fees
Dec 7 - Dec 8
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

San Antonio Marriott Northwest Medical Center

3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1032)
"The room is clean and the hotel staff are all nice including the staff from the restourant"
United States
Frank Charles
The price is ¥13,845
¥16,453 total
includes taxes & fees
Dec 7 - Dec 8
San Antonio Marriott Northwest Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1018)
"Breakfast is always great and hotel is always clean and relaxing "
United States
Michelle
The price is ¥11,900
¥13,893 total
includes taxes & fees
Dec 22 - Dec 23
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1304)
"Great place to stay and visit "
United States
Harry
The price is ¥13,999
¥16,547 total
includes taxes & fees
Dec 7 - Dec 8
Drury Inn & Suites San Antonio Northwest Medical Center

Park Inn by Radisson

2.0 star property
Medical Center District
7.2 out of 10, Good, (1013)
"No frills, no hassles, clean, affordable and very convenient to Methodist Hospital."
United States
Tony
The price is ¥9,785
¥11,424 total
includes taxes & fees
Dec 18 - Dec 19
Park Inn by Radisson

Courtyard by Marriott Medical Center San Antonio

3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1000)
"Room was clean, staff was very friendly!!"
United States
Ray
The price is ¥13,090
¥15,474 total
includes taxes & fees
Dec 18 - Dec 19
Courtyard by Marriott Medical Center San Antonio

SpringHill Suites by Marriott San Antonio Medical Center/NW

3.0 star property
Medical Center District
8.6 out of 10, Excellent, (1015)
"good staff. good stay"
United States
Divya
The price is ¥13,355
¥15,787 total
includes taxes & fees
Dec 7 - Dec 8
SpringHill Suites by Marriott San Antonio Medical Center/NW

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

3.0 star property
Medical Center District
6.8 out of 10, (1000)
"Easy check in"
United States
Violet
The price is ¥9,124
¥10,652 total
includes taxes & fees
Dec 24 - Dec 25
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Studio 6 San Antonio, Tx - Northwest Medical Center

2.0 star property
Medical Center District
7.2 out of 10, Good, (212)
"Its was comfy, didnt have any troubles and had sooo many shopping stops around and dinning places"
United States
Heaven
The price is ¥8,243
¥9,625 total
includes taxes & fees
Dec 4 - Dec 5
Studio 6 San Antonio, Tx - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

2.0 star property
Medical Center District
6.0 out of 10, (1002)
"Really enjoyed our stay"
United States
ernest
The price is ¥6,659
¥7,871 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Motel 6 San Antonio, TX - Northwest Medical Center

Atria Inn & Suites

2.0 star property
Medical Center District
7.6 out of 10, Good, (272)
"😊"
United States
John Paul
Atria Inn & Suites

Studio 6 San Antonio, TX - Medical Center

2.0 star property
Medical Center District
6.6 out of 10, (781)
"Clean room staff is really good real friendly I love being there"
United States
Matthew
The price is ¥7,224
¥8,849 total
includes taxes & fees
Dec 4 - Dec 5
Studio 6 San Antonio, TX - Medical Center

OYO Inn & Suites Medical Center San Antonio

2.0 star property
Medical Center District
7.2 out of 10, Good, (222)
"Always great stay"
United States
Juan
The price is ¥8,400
¥10,819 total
includes taxes & fees
Dec 18 - Dec 19
OYO Inn & Suites Medical Center San Antonio

Flex Studios

2.5 star property
Medical Center District
6.0 out of 10, (496)
"heb is nearby. "
United States
Sayeed
The price is ¥6,440
¥7,612 total
includes taxes & fees
Dec 7 - Dec 8
Flex Studios

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1259)
"Awesome place to stay at "
United States
Diego
The price is ¥12,022
¥20,637 total
includes taxes & fees
Dec 14 - Dec 15
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Menger Hotel

3.5 star property
Downtown San Antonio, 12.6 km from Medical Center District
9.0 out of 10, Wonderful, (3582)
"Historic and classy, and you can beat the location."
United States
Warren
The price is ¥14,700
¥17,376 total
includes taxes & fees
Dec 7 - Dec 8
Menger Hotel

Courtyard by Marriott San Antonio SeaWorld - Westover Hills

3.0 star property
Far West Side, 12.1 km from Medical Center District
8.6 out of 10, Excellent, (1078)
"good hotel"
United States
Deborah
The price is ¥14,413
¥17,128 total
includes taxes & fees
Dec 21 - Dec 22
Courtyard by Marriott San Antonio SeaWorld - Westover Hills

Riverwalk Plaza

4.0 star property
12.3 km from Medical Center District
8.2 out of 10, Very Good, (6176)
"Clean room, helpful stay. Great coffee shop."
United States
Brandy
The price is ¥16,660
¥19,695 total
includes taxes & fees
Dec 28 - Dec 29
Riverwalk Plaza

Hotel Valencia Riverwalk

4.5 star property
Downtown San Antonio, 12.1 km from Medical Center District
9.4 out of 10, Exceptional, (2202)
"Beautful hotel would definitely recommend "
United States
Christina Ashley
The price is ¥16,295
¥23,705 total
includes taxes & fees
Dec 18 - Dec 19
Hotel Valencia Riverwalk

La Quinta Inn & Suites By Wyndham San Antonio At The Rim

3.0 star property
11.9 km from Medical Center District
9.2 out of 10, Wonderful, (793)
"Great place to stay!! "
United States
Stacy
The price is ¥13,090
¥15,282 total
includes taxes & fees
Dec 4 - Dec 5
La Quinta Inn & Suites By Wyndham San Antonio At The Rim
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Uptown

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Top Medical Center District Hotel Reviews

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Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
Where can I learn more about changing or cancelling my trip to Medical Center District?
For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute, and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.