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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,000 reviews)

Clean big room, great staff

Reviewed on Nov 30, 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,004 reviews)

Check-in took only a few minutes and staff was courteous and efficient. All was explained clearly and efficiently. Room was clean and well maintained. I did not take part in the 5:30 pm event or attend breakfact, so I cannot comment on these amenities. Everything else was wonderful.

Reviewed on Nov 25, 2025

Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.2/10 Very Good! (1,004 reviews)

Nice location. Great staff.

Reviewed on Nov 30, 2025

See all 617 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.