Southeast Missouri Luxury Vacations 2026

Photo by JG Morris

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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

8/10 Very Good! (1,002 reviews)

"The room reeked of cleaning solution so it smelled like a pool. Room itself was very humid (idk how) to the point that the bed and pillow were moist enough that you could feel it after laying in bed for a few hours. The room didn’t have towels but I didn’t notice till the morning (went straight to ..."

Reviewed on Aug 31, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

7.2/10 Good! (1,003 reviews)

"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."

Reviewed on Sep 1, 2026

See all 686 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.