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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

5.6/10 (836 reviews)

Room was not clean

Reviewed on Mar 12, 2026

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

8/10 Very Good! (1,001 reviews)

Staff was nice, place looked clean, (Arrived late at Night.) Shower towels and wash cloths were very small and thin like paper towels and shower curtains allowed a lot of water into bathroom floor.

Reviewed on Mar 13, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

7.2/10 Good! (1,003 reviews)

Close access to I-55.

Reviewed on Mar 11, 2026

See all 624 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.