Southeast Missouri Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥45,448 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury Southeast Missouri Hotels
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.
5.6/10 (831 reviews)
Awesome
Reviewed on Nov 11, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.
7.8/10 Good! (1,003 reviews)
Was on a roadtrip to Texas was a great stay nice hot water nice bed
Reviewed on Nov 28, 2025
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.
7.2/10 Good! (1,001 reviews)
Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms.
Reviewed on Dec 7, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
