Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.6/10 Exceptional! (1,002 reviews)

"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Johnson's Shut-ins State Park

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.4/10 Very Good! (1,006 reviews)

"The first room I was assigned had air conditioning that was not blowing cold. The second room had no working air conditioning at all. The third room was fine. The hallway was extremely warm. The woman working the overnight at the desk was extremely apologetic and nice."

Reviewed on Jun 25, 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

4 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

9.4/10 Exceptional! (1,000 reviews)

"I was driving north to WI from South AL for work and needed a somewhat halfway stop, as a solo traveler I recommend this hotel. Easy to get to and felt safe at the hotel and the surrounding areas. I even walked over to Outback Steakhouse for dinner with no issues. Friendly and helpful front desk ..."

Reviewed on Jun 24, 2026

See all 672 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.