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Our top choices for Southern Illinois hotels

A hotel with a covered entrance, stone pillars, and a modern design.

1. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

￥19,737 total

includes taxes & fees

Nov 29 - Nov 30

A bar area with a long counter, multiple chairs, and hanging light fixtures.

2. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Richard

￥19,736 total

includes taxes & fees

Nov 5 - Nov 6

A hotel lobby with a reception desk, seating area, and a large screen TV.

3. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

￥20,893 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

4. Hampton Inn & Suites Effingham

Effingham

Scott

￥22,160 total

includes taxes & fees

Nov 8 - Nov 9

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

5. Best Western Delta Inn

Effingham

Melissa Rae

￥14,406 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

￥17,861 total

includes taxes & fees

Nov 21 - Nov 22

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

7. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Steve

￥19,208 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

8. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

￥14,172 total

includes taxes & fees

Nov 5 - Nov 6

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

9. Hampton Inn O'Fallon

O'Fallon

Edmond

￥20,826 total

includes taxes & fees

Nov 8 - Nov 9

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

10. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Kenneth

￥22,691 total

includes taxes & fees

Nov 7 - Nov 8

A Holiday Inn Express hotel with a brick facade, large windows, and a central entrance with columns.

11. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

Jennifer

￥20,808 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

12. Drury Inn & Suites Marion

Marion

Heather

￥12,293 total

includes taxes & fees

Nov 29 - Nov 30

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

13. Comfort Inn & Suites Marion I-57

Marion

Suzan

￥21,222 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

14. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

￥13,087 total

includes taxes & fees

Nov 9 - Nov 10

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

15. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

￥12,636 total

includes taxes & fees

Nov 29 - Nov 30

A banquet hall with tables set for a formal event, draped with white fabric and string lights, and a chandelier above.

16. Holiday Inn Effingham by IHG

Effingham

Penny

￥18,537 total

includes taxes & fees

Nov 15 - Nov 16

A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.

17. Country Inn & Suites by Radisson, Marion, IL

Marion

Lisa

￥19,053 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

18. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

￥25,120 total

includes taxes & fees

Nov 15 - Nov 16

A small, clean room with a microwave, a vending machine, and a table with chairs.

19. Rodeway Inn Mount Vernon, IL

Mount Vernon

Karalee

￥11,767 total

includes taxes & fees

Nov 1 - Nov 2

A self-service breakfast area with a coffee machine, refrigerated display case, and various food items.

20. Best Western Marion Hotel

Marion

Cornell

￥14,983 total

includes taxes & fees

Nov 8 - Nov 9

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

Best Western Marion Hotel

8/10 Good

"It was nice with a perfect price. The hotel is currently under going a remodel but will be very, very when complete. Staff were very kind, personal, and helpful. Thank you!"

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"Lots to like at this motel. Rooms were very nice. Beds were extremely comfortable. Not only served a variety of breakfast items but also offered free eats during the evening hours. WiFi was easy to use. Didn't use the pool but it looked very inviting. In door and outdoor. You can't go wrong staying here."