Our top choices for Southern Illinois hotels

Hampton Inn & Suites Effingham

Effingham

Erin

￥17,300 total

includes taxes & fees

Mar 29 - Mar 30

Drury Plaza Hotel Mt. Vernon

Mount Vernon

Mitch

￥19,994 total

includes taxes & fees

Apr 3 - Apr 4

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Renee

￥14,890 total

includes taxes & fees

Mar 19 - Mar 20

The Principal Hotel

Columbia

David

￥19,399 total

includes taxes & fees

Mar 30 - Mar 31

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Stephen

￥13,560 total

includes taxes & fees

Mar 22 - Mar 23

Holiday Inn Express & Suites Effingham by IHG

Effingham

Michael

￥22,001 total

includes taxes & fees

Mar 22 - Mar 23

La Quinta Inn & Suites by Wyndham Effingham

Effingham

James

￥17,334 total

includes taxes & fees

Mar 22 - Mar 23

Drury Inn & Suites Marion

Marion

Eileen

￥19,162 total

includes taxes & fees

Apr 6 - Apr 7

Best Western Delta Inn

Effingham

Gayle

￥15,024 total

includes taxes & fees

Mar 22 - Mar 23

Charleston House Bed & Breakfast Inn

Charleston

peter

￥14,142 total

includes taxes & fees

Mar 19 - Mar 20

Hampton Inn Carbondale

Carbondale

Joe

￥18,674 total

includes taxes & fees

Mar 29 - Mar 30

Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Carterville

Amy

￥24,103 total

includes taxes & fees

Mar 17 - Mar 18

Best Western Plus Centralia Hotel & Suites

Centralia

Dana

￥20,605 total

includes taxes & fees

Mar 18 - Mar 19

Comfort Suites Mount Vernon

Mount Vernon

Dale

￥21,415 total

includes taxes & fees

Mar 22 - Mar 23

Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

Zachary

￥23,691 total

includes taxes & fees

Mar 17 - Mar 18

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Scott

￥20,528 total

includes taxes & fees

Apr 5 - Apr 6

Holiday Inn Effingham by IHG

Effingham

Steve

￥17,171 total

includes taxes & fees

Mar 22 - Mar 23

Cobblestone Inn & Suites - Altamont

Altamont

Susan

￥14,684 total

includes taxes & fees

Mar 18 - Mar 19

Best Western U. S. Inn

Nashville

Nancy

￥15,316 total

includes taxes & fees

Mar 17 - Mar 18

Fairfield Inn & Suites Marriott Effingham

Effingham

Richard

￥17,018 total

includes taxes & fees

Mar 29 - Mar 30

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Vacation Rentals in Southern Illinois

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Vacation Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Pet-friendly Home w/ Fenced Yard: 'cozy in Casey'

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

4.8/5 (32 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Harrah's Metropolis

4.0/5 (164 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards program to maximize your experience while enjoying Southern classics at the on-site restaurants.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

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Southern Illinois showing forest scenes, a sunset and landscape views

Top Southern Illinois Hotel Reviews

Best Western Delta Inn

10/10 Excellent

"Clean room....friendly staff....great price. "

Holiday Inn Express & Suites Mount Vernon by IHG

10/10 Excellent

"This appeared to be a new hotel. Very clean and modern. The room was well equipped, clean and comfortable. The free breakfast was very good, buffet style with a good selection. The lobby and breakfast area was very nice. I would highly recommend staying here."