Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

￥23,093 total

includes taxes & fees

Jul 14 - Jul 15

Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

￥22,082 total

includes taxes & fees

Jul 5 - Jul 6

Hampton Inn & Suites Effingham

Effingham

Andrew

￥21,896 total

includes taxes & fees

Jul 4 - Jul 5

Comfort Suites Mount Vernon

Mount Vernon

Todd

￥20,435 total

includes taxes & fees

Jun 21 - Jun 22

Desk, laptop workspace, blackout drapes, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Rickey

￥14,360 total

includes taxes & fees

Jun 30 - Jul 1

Best Western Plus MidAmerica Hotel

Mascoutah

Scot

￥21,616 total

includes taxes & fees

Jun 18 - Jun 19

Cobblestone Inn & Suites - Altamont

Altamont

Dominic

￥15,416 total

includes taxes & fees

Jun 17 - Jun 18

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jennifer

￥16,967 total

includes taxes & fees

Jul 7 - Jul 8

Holiday Inn Effingham by IHG

Effingham

Glenn

￥17,413 total

includes taxes & fees

Jul 5 - Jul 6

In-room safe, desk, iron/ironing board, cribs/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Dawn

￥13,106 total

includes taxes & fees

Jun 21 - Jun 22

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

Mark

￥20,996 total

includes taxes & fees

Jun 28 - Jun 29

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

￥19,676 total

includes taxes & fees

Jun 21 - Jun 22

Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Suzanne

￥15,678 total

includes taxes & fees

Jul 12 - Jul 13

Comfort Inn & Suites Marion I-57

Marion

Chase

￥23,371 total

includes taxes & fees

Jul 16 - Jul 17

Drury Inn & Suites Marion

Marion

Brandy

￥22,888 total

includes taxes & fees

Jun 30 - Jul 1

Best Western Plus Parkside Inn & Suites

Olney

James

￥22,522 total

includes taxes & fees

Jul 1 - Jul 2

Ramada by Wyndham Vandalia

Vandalia

Tammy

￥15,541 total

includes taxes & fees

Jun 21 - Jun 22

Super 8 by Wyndham Troy IL/St. Louis Area

Troy

Donta

￥12,099 total

includes taxes & fees

Jun 24 - Jun 25

Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board

Days Inn & Suites by Wyndham Casey

Casey

Beth

￥12,643 total

includes taxes & fees

Jun 21 - Jun 22

Iron/ironing board, free WiFi, bed sheets

Quality Inn & Suites Metropolis I-24

Metropolis

Howard

￥12,142 total

includes taxes & fees

Jun 21 - Jun 22

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Vacation Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Vacation Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Red Lion Inn & Suites Pontoon Beach

10/10 Excellent

"Clean comfortable room. Really comfy bed. Helpful, friendly staff. Breakfast was fresh and tasty. Juices, milk, cereal, yogurt. Scrambled Eggs, sausage and tater tots. Parking was plentiful and secure."