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Compare 1,061 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1442)
"Great place like a vacation every time I stay "
The price is ¥13,821
¥15,633 total
includes taxes & fees
Sep 7 - Sep 8
Drury Plaza Hotel Mt. Vernon

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
8.8 out of 10, Excellent, (853)
"The staff was friendly and very helpful."
The price is ¥9,924
¥11,013 total
includes taxes & fees
Sep 7 - Sep 8
SureStay Hotel by Best Western Whittington Rend Lake

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 star property
9.4 out of 10, Exceptional, (475)
"Rooms were clean and comfy, great breakfast "
The price is ¥14,264
¥15,830 total
includes taxes & fees
Sep 2 - Sep 3
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

The Principal Hotel

3.5 star property
9.8 out of 10, Exceptional, (125)
"Perfect stay! "
The price is ¥14,931
¥16,571 total
includes taxes & fees
Sep 14 - Sep 15
The Principal Hotel

Drury Inn & Suites Marion

3.0 star property
9.4 out of 10, Exceptional, (1011)
"We had an excellent stay."
The price is ¥13,674
¥16,406 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Marion

Days Inn & Suites by Wyndham Casey

2.0 star property
7.4 out of 10, Good, (779)
"Clean, nice staff, ok stay"
The price is ¥10,588
¥11,751 total
includes taxes & fees
Sep 1 - Sep 2
Days Inn & Suites by Wyndham Casey

Comfort Suites Mount Vernon

2.5 star property
8.8 out of 10, Excellent, (1011)
"Nice hotel. Would stay here again."
The price is ¥16,028
¥18,082 total
includes taxes & fees
Sep 1 - Sep 2
Comfort Suites Mount Vernon

Cobblestone Inn & Suites - Altamont

2.5 star property
9.6 out of 10, Exceptional, (752)
"Always a great place with comfortable rooms."
Cobblestone Inn & Suites - Altamont

Quality Inn Effingham North

2.5 star property
8.4 out of 10, Very Good, (933)
"The staff is super nice!"
The price is ¥12,864
¥14,276 total
includes taxes & fees
Sep 14 - Sep 15
Quality Inn Effingham North

The Shelby Inn

2.5 star property
8.8 out of 10, Excellent, (117)
"Always a good stay. "
The Shelby Inn

Best Western Plus Parkside Inn & Suites

2.5 star property
9.8 out of 10, Exceptional, (296)
"Very clean, quiet and friendly stay"
The price is ¥16,750
¥18,589 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Plus Parkside Inn & Suites

Best Western Marion Hotel

2.5 star property
8.2 out of 10, Very Good, (1008)
"Nice motel for a decent price."
The price is ¥10,499
¥12,596 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Marion Hotel

Baymont by Wyndham Marion

2.5 star property
8.4 out of 10, Very Good, (1037)
"We stayed overnight for work and were very impressed with the hotel."
The price is ¥12,043
¥14,450 total
includes taxes & fees
Sep 14 - Sep 15
Baymont by Wyndham Marion

Country Inn & Suites by Radisson, Effingham, IL

2.5 star property
8.8 out of 10, Excellent, (1010)
"We had a very nice stay."
The price is ¥15,881
¥17,625 total
includes taxes & fees
Sep 2 - Sep 3
Country Inn & Suites by Radisson, Effingham, IL

Harrah's Metropolis Hotel & Casino

3.5 star property
8.4 out of 10, Very Good, (1003)
"Excellent hotel for the overnight stay "
The price is ¥16,029
¥20,142 total
includes taxes & fees
Sep 1 - Sep 2
Harrah's Metropolis Hotel & Casino

Best Western Delta Inn

2.5 star property
9.2 out of 10, Wonderful, (1013)
"Courteous staff, feel safe, clean rooms Thank you"
The price is ¥13,123
¥14,696 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Delta Inn

La Quinta Inn & Suites by Wyndham Effingham

3.0 star property
9.2 out of 10, Wonderful, (1012)
"Very clean hotel with friendly staff!"
The price is ¥14,251
¥15,958 total
includes taxes & fees
Sep 7 - Sep 8
La Quinta Inn & Suites by Wyndham Effingham

Best Western Plus Centralia Hotel & Suites

2.5 star property
9.6 out of 10, Exceptional, (568)
"Clean and kind staff!"
The price is ¥20,440
¥22,888 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Plus Centralia Hotel & Suites

Baymont by Wyndham Chester IL

2.5 star property
8.6 out of 10, Excellent, (332)
"Quiet area with comfortable rooms and very helpful staff!"
The price is ¥10,852
¥12,043 total
includes taxes & fees
Sep 4 - Sep 5
Baymont by Wyndham Chester IL

Eighteen-Ninety Sleepover

2.5 star property
9.6 out of 10, Exceptional, (297)
"Beautiful restored small hotel,adorable small town ,very walkable to coffee shop,restaurants and ice cream ."
The price is ¥16,438
¥18,408 total
includes taxes & fees
Sep 1 - Sep 2
Eighteen-Ninety Sleepover
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southern Illinois, IL

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Stay near popular Southern Illinois attractions

Southern Illinois University
Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Scott Air Force Base

Scott Air Force Base

After visiting Scott Air Force Base, make a plan to see the other sights and activities in Scott Air Force Base. Attend a sporting event in this family-friendly area.

DuQuoin State Fairgrounds

DuQuoin State Fairgrounds

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Southern Illinois showing forest scenes, a sunset and landscape views
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Top Southern Illinois Hotel Reviews

More cheap stays in Southern Illinois

More cheap stays in Southern Illinois

Hotels in Southern Illinois with star-rating

Hotels in Southern Illinois with star-rating

Explore a world of travel with Expedia

Explore a world of travel with Expedia