Southern Illinois Vacations

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Photo by Southernmost Illinois Tourism Bureau

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Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
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Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

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Find the Best Southern Illinois Vacation Packages

Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is ￥13,903 per night from Oct 26 to Oct 27
￥13,903
￥15,725 total
Oct 26 - Oct 27
includes taxes & fees
9.6/10 Exceptional! (1,468 reviews)
"Clean room… friendly staff… pool looks amazing and so does the hot tub… food is close by …"

Reviewed on Sep 25, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is ￥7,544 per night from Oct 12 to Oct 13
￥7,544
￥8,674 total
Oct 12 - Oct 13
includes taxes & fees
7.2/10 Good! (1,001 reviews)
"Amazing"

Reviewed on Sep 17, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
The price is ￥13,829 per night from Oct 5 to Oct 6
￥13,829
￥15,623 total
Oct 5 - Oct 6
includes taxes & fees
9/10 Wonderful! (1,020 reviews)
Housekeeping problem
"They need to teach the housekeeping staff to not park their carts in the middle of the hallway. This makes it really hard to navigate the hallway with luggage."

Reviewed on Sep 18, 2025

Drury Inn & Suites St. Louis Fairview Heights
See all 1,083 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southern Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Southern Illinois University
Superman Statue which includes a statue or sculpture as well as a small group of people

Superman Statue

Superman fans will love getting a photograph taken in front of this giant statue of the Man of Steel himself, dressed in his iconic red-and-blue guise.

Superman Statue
Ferne Clyffe Waterfall Detail Goreville IL #detail

Ferne Clyffe State Park

You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.

Ferne Clyffe State Park

Frequently asked questions

Can I cancel my flight booking to Southern Illinois due to COVID-19?
If you haven't booked yet, check the terms and conditions of your preferred carrier. If you've already locked in your flight to Southern Illinois, click through to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and advise the next steps.
What's the best way to find cheap flights to Southern Illinois that have flexible change policies?
At Expedia, we've been channeling our inner gymnast to bring you the most flexible fares around. Just click on "No change fee" under the filter heading "Flexible change policies" to find your perfect flight to Southern Illinois.
What are some of the general tips for travelers to Southern Illinois during the COVID-19 outbreak?
With new COVID-19 rules and measures to adhere to, travel looks a bit different at present. Here are some useful things to know before you hop on that plane to Southern Illinois:
  • Research the rules and restrictions in both your origin and destination. You may not be able to travel depending on local circumstances, so make sure you check before you lock in your flight.
  • Wear a face mask during airport screening. A TSA employee will ask you to temporarily lower your mask for ID purposes.
  • To minimize the risk of cross-contamination, place your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • One liquid hand sanitizer container is now allowed in your carry-on baggage. It must be no larger than 12 oz (350 ml), and you'll need to take it out of your bag for X-ray scanning.
  • To reduce handling during the screening process, place items such as your phone, keys and wallet into your carry-on rather than the bins.
  • Transport your food items in a clear plastic bag and also put them in a screening bin. Keeping your food separate from your carry-on makes it less likely that a TSA agent will need to open your bag for inspection.

Which airlines fly to Southern Illinois?
Cape Air is a well-known carrier servicing Southern Illinois. Search for a ticket to Williamson County Regional Airport (MWA) and you'll have 160 Cape Air flights a month to pick from.
How can I find cheap tickets to Southern Illinois?
A useful strategy for scoring cheap tickets is to be flexible with your travel dates. Begin with searching for your flight to Southern Illinois, then click on the "flexible dates" box to compare prices for nearby days. Want another tip? Book in advance. To give you an idea of costs, was the lowest price for a flight to Southern Illinois in the last seven days.
How much is a flight to Southern Illinois?
In the last seven days, round-trip tickets to Southern Illinois sold for as low as and reached a maximum of . For one-way trips taking off from (), the lowest amount paid during this same period was .
What are the most popular airports to fly into in Southern Illinois?
The main gateway to Southern Illinois, about 160 flights cruise into Williamson County Regional Airport (MWA) each month. Keep an eye out for a rewarding deal, lock in your seat and get set to discover this sensational region.
When is the cheapest time to fly to Southern Illinois?
If you'd rather spend your vacation savings enjoying Southern Illinois rather than on your trip there, jet off earlier in the week. The most economical day to travel is usually Tuesday, with Monday close behind. With many folks keeping their travel to weekends, Saturday tends to have the most expensive airfares.
How much is a plane ticket to Southern Illinois?
In the last seven days, plane tickets varied between and . Check out our sensational deals to Southern Illinois, make a booking and then get ready for your getaway!
Which airlines with flights to Southern Illinois employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented additional actions and measures to help their passengers get back in the air. Here are some great examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.