Photo by Southernmost Illinois Tourism Bureau

Find Resorts & Hotels with Spas in Southern Illinois, IL

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Resorts & Hotels with Spas

Our top choices for Southern Illinois hotels with a spa

Sauna, hot tub, body treatments, hot stone massages
Walker's Bluff Casino Resort

Walker's Bluff Casino Resort

4.5 star property
Carterville
9.4 out of 10, Exceptional, (386)
"Great place!!"
United States
Jeff
Walker's Bluff Casino Resort
Property entrance
1895 Washington Hotel

1895 Washington Hotel

3.0 star property
Paducah
9.2 out of 10, Wonderful, (391)
"Well maintained, victorian home. Great hospitality from James the onsite manager. Close to alot of places to visit and dine."
United States
Pat
1895 Washington Hotel
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,800
￥16,696 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 star property
St. Charles
8.4 out of 10, Very Good, (1004)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is ￥23,633
￥30,196 total
includes taxes & fees
Dec 15 - Dec 16
Ameristar Casino Resort and Spa
Lobby
Arthur's Country Inn

Arthur's Country Inn

2.5 star property
Arthur
8.4 out of 10, Very Good, (132)
"We loved this Inn it was a unique experience in comparison to modern hotels but definitely a nice change. "
United States
Latasha
The price is ￥18,383
￥20,402 total
includes taxes & fees
Dec 10 - Dec 11
Arthur's Country Inn
Couples treatment rooms, hot tub, body treatments, aromatherapy
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is ￥64,462
￥75,375 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Four Seasons Hotel St Louis
Massages
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1489)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
The price is ￥19,673
￥23,780 total
includes taxes & fees
Jan 4 - Jan 5, 2026
21C Museum Hotel St Louis
Body treatments, aromatherapy, hot stone massages, deep-tissue massages
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is ￥77,510
￥90,483 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

10/10 Excellent
"Location right off the interstate, good stop for an overnight while traveling "
DANIELLE 1-night trip
Posted 3 days ago
Holiday Inn Express Metropolis by IHG

Explore a world of travel with Expedia