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Find Gay friendly Hotels in Sikeston, MO

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Check availability on Sikeston Gay friendly Hotels

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Sikeston LGBT-friendly hotels

Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,193
￥16,012 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,944
￥13,685 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Inn & Suites Jackson MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
United States
Michael
The price is ￥14,036
￥15,833 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Great place. Friendly staff clean"
United States
Jeff
The price is ￥14,036
￥16,137 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Inn & Suites Sikeston, MO
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
The price is ￥10,916
￥12,315 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Pear Tree Inn Cape Girardeau West
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (445)
"Stay was excellent "
United States
Kourtney
The price is ￥14,543
￥16,466 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Very clean, very friendly! We will be staying again. "
United States
Beth
The price is ￥11,696
￥13,446 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Pear Tree Inn Sikeston
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ￥10,916
￥12,315 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (456)
"Very clean and super friendly staff!"
United States
Katherine
The price is ￥15,976
￥18,090 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hampton Inn Sikeston
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
"Awesome stay!"
United States
Breckin
The price is ￥14,036
￥15,833 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Frequently asked questions

Searching for a gay-friendly accommodation in Sikeston?
Whether you are traveling with your partner or flying solo, you'll find LGBTQ-friendly hotels in Sikeston on our website. Staying in this welcoming area will give you access to its shops and restaurants.
What is the top LGBTQ-friendly place to stay in Sikeston?
Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Hampton Inn Sikeston are two other good choices for your vacation.
How many gay-friendly hotels will I find in Sikeston?
You'll find 4 gay-friendly lodging options in Sikeston.
What should I do while I'm visiting Sikeston?
During your trip, get out and discover everything Sikeston offers. You and your traveling companions may want to visit Sikeston Depot Museum and Central Park.
What is an LGBTQ-friendly hotel in Sikeston?
LGBTQ-friendly hotels are places where lesbian, gay, bisexual, and transgender travelers are proudly welcomed. We have worked with the International Gay and Lesbian Travel Association (IGLTA) to compile a selection of gay-friendly hotels worldwide. In Sikeston, hotels affiliated with IGLTA will provide lesbian, gay, bisexual, and transgender adventurers with the information needed to design the trip of a lifetime.
What can I expect from an LGBTQ-friendly accommodation in Sikeston?
Stay at a gay-friendly hotel in Sikeston and you won't have to hide or your sexuality or your gender identity when you check-in. Some of Expedia's LGBTQ-friendly hotels go the extra mile and offer community-specific packages, exclusive tours, and opportunities for social interaction.