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Our top choices for Sanctuary hotels

Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (951 reviews)
"It was clean and the staff was great!"
United States
Delia
The price is ¥40,018
¥45,959 total
includes taxes & fees
Feb 12 - Feb 13
Kona Kai Motel

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (232 reviews)
"Beautiful resort, great communication, super clean "
United States
Ronald
The price is ¥15,296
¥27,393 total
includes taxes & fees
Mar 5 - Mar 6
Matlacha on Shoreview

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,000 reviews)
"Amazing room and view. Great place to stay/vacation. Would come back over and over again. "
United States
Frank
The price is ¥46,767
¥58,325 total
includes taxes & fees
Mar 6 - Mar 7
The Westin Cape Coral Resort At Marina Village

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is ¥29,709
¥33,125 total
includes taxes & fees
Mar 1 - Mar 2
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,226 reviews)
"Nice room, great tiki bar and pool area, and friendly staff."
United States
Jason
The price is ¥25,494
¥28,426 total
includes taxes & fees
Mar 6 - Mar 7
Dolphin Key Resort

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,002 reviews)
"Great stay staff was great . Lake veiw was beautifully i definitely rerent rm 207. Has beautiful restaurant next door work price and ambience. "
United States
Rachel
The price is ¥14,023
¥16,872 total
includes taxes & fees
Feb 15 - Feb 16
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,218 reviews)
"Affordable room, super comfortable bed, clean, good breakfast. Great stay!"
United States
Rick
The price is ¥26,267
¥29,288 total
includes taxes & fees
Feb 22 - Feb 23
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.4 out of 10, Very Good, (18 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is ¥17,521
¥24,533 total
includes taxes & fees
Mar 11 - Mar 12
TriLuxe Inn & Studios

Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (151 reviews)
"Nice new rooms and great outdoor seating on the waterway, we saw lots of manatees "
United States
Ellen
The price is ¥34,905
¥44,088 total
includes taxes & fees
Feb 16 - Feb 17
Off the Charts Inn & Out Island Resort

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.2 out of 10, Very Good, (50 reviews)
"Clean, easy access, quiet, best bed and sheets ever!!!"
United States
Brooke
The price is ¥17,923
¥24,980 total
includes taxes & fees
Mar 3 - Mar 4
White Orchid Apartments

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.0 out of 10, Very Good, (11 reviews)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is ¥16,069
¥22,914 total
includes taxes & fees
Feb 12 - Feb 13
Summerwind Studios

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"Lovely location, pools and restaurants."
United States
Linda
The price is ¥48,652
¥59,655 total
includes taxes & fees
Feb 16 - Feb 17
Tween Waters Island Resort & Spa

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (274 reviews)
"The property was super cute and clean! It also had just about anything you could need!"
United States
Wyatt
The price is ¥21,477
¥35,536 total
includes taxes & fees
Feb 12 - Feb 13
Matlacha Tiny Village

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,598 reviews)
"Staff is amazing, amenities are great and is so beautiful! "
United States
Erica
The price is ¥59,504
¥70,209 total
includes taxes & fees
Feb 12 - Feb 13
Sanibel Island Beach Resort

Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.6 out of 10, Excellent, (300 reviews)
"Clean rooms, great staff, beautiful view "
United States
Julia
The price is ¥112,638
¥125,593 total
includes taxes & fees
Feb 22 - Feb 23
Casa Ybel Resort

Angler's Inn

Angler's Inn
2.5 star property
18.8 km from Sanctuary
9.4 out of 10, Exceptional, (323 reviews)
"Cute Inn in Matlacha. Clean rooms, comfy beds, and a great screened in porch for each room. Town still recovering from Ian, but still a great time. "
United States
Crystal
The price is ¥27,039
¥30,149 total
includes taxes & fees
Feb 12 - Feb 13
Angler's Inn

Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (399 reviews)
"Our room was clean and comfortable and the staff was friendly and helpful. We loved our visit to Sanibel and staying at the Tarpon Tale Inn and look forward to going there again some day."
United States
Ed
The price is ¥53,924
¥60,126 total
includes taxes & fees
Feb 19 - Feb 20
Tarpon Tale Inn

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,598 reviews)
"Room was clean and was cleaned in the middle of our stay and staff was great."
United States
Glen
The price is ¥87,916
¥106,468 total
includes taxes & fees
Feb 22 - Feb 23
Sundial Beach Resort & Spa

South Seas Resort

South Seas Resort
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very Good, (1,003 reviews)
"Great family moments created in this place "
United States
Denis
The price is ¥81,905
¥114,644 total
includes taxes & fees
Feb 25 - Feb 26
South Seas Resort

Driftwood Inn

Driftwood Inn
2.0 star property
Mid Island, 13.1 km from Sanctuary
10.0 out of 10, Exceptional, (8 reviews)
"Great place to stay on sanibel"
United States
Terri
The price is ¥59,340
¥103,637 total
includes taxes & fees
Feb 25 - Feb 26
Driftwood Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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