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Our top choices for Sanctuary hotels

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,369 reviews)
"Great location, clean rooms, wonderful basic breakfast and coffee, I will be back again."
United States
Eduardo
The price is ¥15,648
¥17,448 total
includes taxes & fees
May 4 - May 5
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,002 reviews)
"Everything was great and wonderful next time i go to cape coral we will stay there "
United States
Alejandro
The price is ¥13,253
¥14,776 total
includes taxes & fees
Apr 7 - Apr 8
Allure Suites

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,080 reviews)
"Rooms were perfect, bigger than most and very comfortable. Staff was incredibly friendly and the breakfast had a waffle maker! "
United States
Emily
The price is ¥16,670
¥18,587 total
includes taxes & fees
May 3 - May 4
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is ¥16,199
¥18,063 total
includes taxes & fees
May 4 - May 5
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (851 reviews)
"Nice free breakfast"
United States
Janet
The price is ¥15,664
¥17,465 total
includes taxes & fees
Apr 19 - Apr 20
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,060 reviews)
"Wonderful staff, pool and on site restaurant "
United States
Lori
The price is ¥18,199
¥20,291 total
includes taxes & fees
May 5 - May 6
Doubletree by Hilton Fort Myers at Bell Tower Shops

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"Great room and the breakfast was delicious "
United States
Jackeline
The price is ¥19,058
¥21,250 total
includes taxes & fees
May 3 - May 4
Homewood Suites by Hilton - Fort Myers

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,246 reviews)
"We had a fantastic time! "
United States
Amy
The price is ¥14,327
¥15,975 total
includes taxes & fees
Apr 9 - Apr 10
Dolphin Key Resort

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,005 reviews)
"It was perfect for my one night stay definitely will be coming back "
United States
Marice
The price is ¥11,329
¥14,469 total
includes taxes & fees
Apr 21 - Apr 22
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,003 reviews)
"The location was great for access to beaches"
United States
Shelly
The price is ¥13,093
¥14,599 total
includes taxes & fees
May 3 - May 4
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,011 reviews)
"Amazing property! Ernesto was an absolute gem helping has throughout our stay"
Canada
Carlton
The price is ¥15,967
¥17,803 total
includes taxes & fees
Apr 23 - Apr 24
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Lovely sunset views, fire pit table by the docks, hammocks"
United States
Debbie
The price is ¥22,129
¥24,674 total
includes taxes & fees
May 5 - May 6
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Great quick stay"
United States
Jason R
The price is ¥17,755
¥19,798 total
includes taxes & fees
Apr 28 - Apr 29
Hilton Garden Inn Ft Myers

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,003 reviews)
"This hotel was super clean and the staff was so friendly, I would absolutely stay here again!!"
United States
Abigail
The price is ¥16,890
¥18,833 total
includes taxes & fees
Apr 13 - Apr 14
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.0 out of 10, Very Good, (21 reviews)
"We arrived after dark. And the neighborhood seemed sketchy."
United States
Laurie
The price is ¥12,325
¥18,905 total
includes taxes & fees
May 7 - May 8
TriLuxe Inn & Studios

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,002 reviews)
"Everything was nice in room. & clean. Nice place to stay"
United States
Laura
The price is ¥19,001
¥21,187 total
includes taxes & fees
May 3 - May 4
Residence Inn by Marriott Fort Myers Sanibel

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (275 reviews)
"Great location just a couple miles from the beach, close to stores and restaurants"
United States
Kayla
The price is ¥13,183
¥19,862 total
includes taxes & fees
May 6 - May 7
Lazy Cuckoo Inn

Lovers Key Resort

Lovers Key Resort
3.0 star property
30.3 km from Sanctuary
8.8 out of 10, Excellent, (1,045 reviews)
"Beautiful view and the room was great!"
United States
Seana A
The price is ¥20,007
¥48,481 total
includes taxes & fees
May 1 - May 2
Lovers Key Resort

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (247 reviews)
"Great place with comfy beds. "
United States
Rebecca
The price is ¥13,572
¥25,815 total
includes taxes & fees
May 4 - May 5
Matlacha on Shoreview

InTown Suites Extended Stay Fort Myers

InTown Suites Extended Stay Fort Myers
2.0 star property
29.9 km from Sanctuary
4.8 out of 10, (1,000 reviews)
"Room was old and outdated"
United States
William
The price is ¥12,614
¥14,065 total
includes taxes & fees
May 4 - May 5
InTown Suites Extended Stay Fort Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Sea School and Dunes Golf and Tennis Club.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 10 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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