What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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Dates

February 2026

8

March 2026

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Our top choices for Sanctuary hotels

3 restaurants, breakfast, lunch, dinner served; Italian cuisine

Lani Kai Beachfront Resort

21.8 km from Sanctuary

Denise

￥53,837 total

includes taxes & fees

Feb 10 - Feb 11

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

denise

￥29,100 total

includes taxes & fees

Feb 22 - Feb 23

Dolphin Key Resort

23.8 km from Sanctuary

Jason

￥28,924 total

includes taxes & fees

Mar 6 - Mar 7

Allure Suites

27.2 km from Sanctuary

Kristin

￥20,159 total

includes taxes & fees

Feb 13 - Feb 14

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

21.5 km from Sanctuary

Andrea

￥41,810 total

includes taxes & fees

Mar 7 - Mar 8

Matlacha Tiny Village

18.8 km from Sanctuary

Wyatt

￥33,723 total

includes taxes & fees

Feb 9 - Feb 10

Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

Brandon

￥32,199 total

includes taxes & fees

Feb 15 - Feb 16

Signature Cottage | Blackout drapes, iron/ironing board, free WiFi, bed sheets

The Anchor Inn

Mid Island, 12.8 km from Sanctuary

￥47,515 total

includes taxes & fees

Feb 10 - Feb 11

Matlacha on Shoreview

20.2 km from Sanctuary

Ronald

￥27,526 total

includes taxes & fees

Mar 5 - Mar 6

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

23.1 km from Sanctuary

￥54,024 total

includes taxes & fees

Feb 15 - Feb 16

Grand Studio Suite, Kitchenette | Desk, laptop workspace, free WiFi, bed sheets

Lazy Cuckoo Inn

22.1 km from Sanctuary

Judith

￥22,736 total

includes taxes & fees

Mar 3 - Mar 4

In-room safe, desk, laptop workspace, blackout drapes

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Lorrin

￥28,224 total

includes taxes & fees

Feb 22 - Feb 23

TriLuxe Inn & Studios

22.7 km from Sanctuary

Bobbi

￥23,701 total

includes taxes & fees

Feb 9 - Feb 10

Outdoor pool, cabanas (surcharge), sun loungers

Margaritaville Beach Resort Fort Myers

21.6 km from Sanctuary

Stephanie

￥55,642 total

includes taxes & fees

Feb 9 - Feb 10

Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Renee Marie

￥36,322 total

includes taxes & fees

Feb 15 - Feb 16

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Stacey

￥30,713 total

includes taxes & fees

Mar 1 - Mar 2

Floating Coconut Cottage Houseboat | Terrace/patio

Latitude 26 Waterfront Resort & Marina

22 km from Sanctuary

Cassie

￥51,714 total

includes taxes & fees

Mar 7 - Mar 8

On the beach, sun loungers, beach towels

Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Freda

￥69,705 total

includes taxes & fees

Feb 9 - Feb 10

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Karen

￥28,222 total

includes taxes & fees

Feb 15 - Feb 16

Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Cindy

￥41,897 total

includes taxes & fees

Mar 1 - Mar 2

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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Periwinkle Way which includes cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

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Top Sanctuary Hotel Reviews

Lani Kai Beachfront Resort

10/10 Excellent

"Excellent place to stay! "

Sanibel Island Beach Resort

10/10 Excellent

"A really good looking resort. A great place to stay - directly on the beach with a great coffee shop and burger restaurant that we used whilst we were there! Easy to find, all the staff were fabulous and nice to have a daily housekeeping service as the sand gets everywhere! Check-in was easy and managed to get a room a little early which helped us get more time on the beach and in the hammocks."

The Lighthouse Resort Inn & Suites

10/10 Excellent

"Yes it has like mini apartment bed room king size bed. Staff was very professional, answer all questions. Showed us were our room was. Tiki bar very nice bartender. John was a very good bartender, food was good. They us a map were to go around town in fort Myers, We went to Perry’s bar, awesome Pizza the we had a upside down pizza, cheese is on the bottom and sauce on top again awesome. Richie G"

Find hotels in Sanctuary, Sanibel

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Dolphin Key Resort

Allure Suites

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Matlacha Tiny Village

Doubletree by Hilton Fort Myers at Bell Tower Shops

The Anchor Inn

Matlacha on Shoreview

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

Lazy Cuckoo Inn

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

TriLuxe Inn & Studios

Margaritaville Beach Resort Fort Myers

Hilton Garden Inn Ft Myers

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Latitude 26 Waterfront Resort & Marina

Sanibel Island Beach Resort

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Residence Inn by Marriott Fort Myers Sanibel

Where to stay in Sanctuary

West End

Mid Island

East End

Beachview Country Club Estates

Shell Harbor

Top Sanctuary Hotel Reviews

Lani Kai Beachfront Resort

Frequently asked questions

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