What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Find hotels in Sanctuary, Sanibel

Where to?

Dates

February 2026

13

March 2026

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Our top choices for Sanctuary hotels

Allure Suites

27.2 km from Sanctuary

Kristin

￥19,590 total

includes taxes & fees

Feb 28 - Mar 1

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Rachel

￥16,595 total

includes taxes & fees

Feb 15 - Feb 16

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

George

￥22,029 total

includes taxes & fees

Mar 1 - Mar 2

Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Linda

￥59,911 total

includes taxes & fees

Mar 6 - Mar 7

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

23.1 km from Sanctuary

￥52,154 total

includes taxes & fees

Feb 15 - Feb 16

Matlacha on Shoreview

20.2 km from Sanctuary

Ronald

￥26,072 total

includes taxes & fees

Mar 5 - Mar 6

Floating Coconut Cottage Houseboat | Terrace/patio

Latitude 26 Waterfront Resort & Marina

22 km from Sanctuary

Cassie

￥55,275 total

includes taxes & fees

Mar 7 - Mar 8

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Stacey

￥32,569 total

includes taxes & fees

Feb 26 - Feb 27

TriLuxe Inn & Studios

22.7 km from Sanctuary

Bobbi

￥22,879 total

includes taxes & fees

Feb 22 - Feb 23

3 restaurants, breakfast, lunch, dinner served; Italian cuisine

Lani Kai Beachfront Resort

21.8 km from Sanctuary

Denise

￥62,468 total

includes taxes & fees

Feb 15 - Feb 16

White Orchid Apartments

20 km from Sanctuary

Brooke

￥25,040 total

includes taxes & fees

Feb 16 - Feb 17

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

denise

￥31,438 total

includes taxes & fees

Mar 15 - Mar 16

Sanibel Inn

East End, 13.8 km from Sanctuary

Rachelle

￥108,146 total

includes taxes & fees

Feb 26 - Feb 27

Grand Studio Suite, Kitchenette | Desk, laptop workspace, free WiFi, bed sheets

Lazy Cuckoo Inn

22.1 km from Sanctuary

Judith

￥24,932 total

includes taxes & fees

Feb 16 - Feb 17

Private beach nearby, motor boating, fishing

MALU LANI Inn & Marina

24.7 km from Sanctuary

￥49,376 total

includes taxes & fees

Feb 20 - Feb 21

Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Brian

￥35,294 total

includes taxes & fees

Mar 8 - Mar 9

Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Matthias

￥66,013 total

includes taxes & fees

Feb 22 - Feb 23

Pink Shell Beach Resort and Marina

20.4 km from Sanctuary

Robyn

￥105,422 total

includes taxes & fees

Feb 17 - Feb 18

Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Jackeline

￥38,144 total

includes taxes & fees

Feb 22 - Feb 23

DiamondHead Beach Resort

22.3 km from Sanctuary

Elizabeth

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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Periwinkle Way which includes cycling as well as an individual femail

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

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Top Sanctuary Hotel Reviews

Margaritaville Beach Resort Fort Myers

10/10 Excellent

"Very nice hotel had a very good time. List of things that we found were positive about the hotel. Friendly and courteous of staff. Entire facility was kept clean. Pool area was large enough so did not feel cramped Had a good choice of restaurants on the site Had multiple areas you could sit an relax. "