Find hotels in South Main, Houston from ￥10,567
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in South Main
Apart hotel
Family friendly
Check prices for these dates
Discover 6,604 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
7.2 out of 10, Good, (1182)
"Everyone was very pleasant, I will be returning."
Amy
The price is ￥15,245
￥17,836 total
includes taxes & fees
Nov 4 - Nov 5
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
8.6 out of 10, Excellent, (1006)
"Nice room. No pot smell. It was great. Bed was comfortable and it had a REAL comforter not some cheap blanket! Would stay here again. 😊"
cindy
The price is ￥13,028
￥15,243 total
includes taxes & fees
Nov 17 - Nov 18
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
6.6 out of 10, (1003)
"Everything was great"
Yeimi
The price is ￥9,032
￥10,567 total
includes taxes & fees
Dec 2 - Dec 3
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
6.6 out of 10, (957)
"We got to our room and it wide open …… we tried to call the front guest phones didn’t work …. We went down and only had one person working ….. "
Eduardo
The price is ￥12,165
￥14,232 total
includes taxes & fees
Nov 3 - Nov 4
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
7.4 out of 10, Good, (807)
"Room was clean and roomy. The toilet height was too low. Staff was friendly and professional."
Willie
The price is ￥11,395
￥13,332 total
includes taxes & fees
Nov 16 - Nov 17
The Lancaster Hotel
The Lancaster Hotel
9.8 out of 10, Exceptional, (1008)
"Friendly staff, comfortable bed, great breakfast."
Polly Gay
The price is ￥30,953
￥36,214 total
includes taxes & fees
Nov 23 - Nov 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
Northside
While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
10/10 Excellent
Explore a world of travel with Expedia
Frequently asked questions
Hotels in top Houston neighborhoods
- Hotels in Downtown Houston
- Hotels in The Galleria
- Hotels in Texas Medical Center
- Hotels in Montrose
- Hotels in Northside
- Hotels in Houston Heights
- Hotels in Houston Central Business District
- Hotels in Midtown
- Hotels in Southeast Houston
- Hotels in Washington Ave./ Memorial Park
- Hotels in South Central Houston
- Hotels in Westchase
- Hotels in Museum District
- Hotels in Greater Heights
- Hotels in River Oaks
- Hotels in North Houston
- Hotels in Memorial
- Hotels in Astrodome
- Hotels in Greater Uptown
- Hotels in Memorial City
Hotels near popular Houston Attractions
- Hotels near NRG Stadium
- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
- Hotels near Daikin Park
- Hotels near Toyota Center
- Hotels near Rice University
- Hotels near University of Houston
- Hotels near Westheimer Road
- Hotels near Memorial City Mall
- Hotels near CityCentre
Hotels Close to Nearby Airports
Explore more hotels
- The Whitehall Houston
- Cambria Hotel Houston Downtown Convention Center
- Hilton Americas-Houston
- Holiday Inn Houston Downtown by IHG
- Heritage Place Houston Brookhollow
- SpringHill Suites by Marriott Houston Intercontinental Arprt
- Embassy Suites by Hilton Houston Near the Galleria
- Omni Houston Hotel
- Le Meridien Houston Downtown
- Hyatt Place Houston Medical Center
- C. Baldwin, Curio Collection by Hilton
More ways to book
Expedia's Latest Trends
Hotels
- Dormy Inn Kanazawa Natural Hot Spring
- Potato Head Suites & Studios
- Yumoto Niseko Prince Hotel Hirafutei
- Hotels near Hakuba Iwatake Ski Resort
- Pet-friendly Hotels in Osaka
- Ski Hotels in Hakuba
- Flexstay Inn Shinagawa
- Hotel Sierra Resort Hakuba
- Kyukaruizawa Kikyo, Curio Collection by Hilton
- Weekly Green In Namba
- Hotels near Kyodo Station
- Hotels near Caribbean Beach Heated Pool
Flights
Packages