Find hotels in Clarksdale, MO from ¥10,228

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Compare 115 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Clarksdale hotels

Econo Lodge Cameron

2.0 star property
6.2 out of 10, (151)
"Quiet."
The price is ¥11,655
¥12,819 total
includes taxes & fees
Sep 4 - Sep 5
Econo Lodge Cameron

SureStay Hotel by Best Western Cameron

2.5 star property
8.4 out of 10, Very Good, (1000)
"Good location off interstate. Room was clean & found bed comfortable. Breakfast was good with scrambled eggs & sausage along with cereal, muffins, & juice. Rooms were quiet & stay was restful."
The price is ¥11,509
¥12,657 total
includes taxes & fees
Sep 12 - Sep 13
SureStay Hotel by Best Western Cameron

Stoney Creek Hotel St. Joseph

3.5 star property
9.0 out of 10, Wonderful, (1521)
"Cute hotel, really liked the Location."
Stoney Creek Hotel St. Joseph

Hampton Inn St. Joseph

2.5 star property
8.2 out of 10, Very Good, (613)
"Great place to stay "
The price is ¥13,756
¥15,916 total
includes taxes & fees
Sep 14 - Sep 15
Hampton Inn St. Joseph

Fairfield Inn & Suites by Marriott St. Joseph

2.5 star property
9.6 out of 10, Exceptional, (447)
"Great stay!"
The price is ¥16,924
¥19,750 total
includes taxes & fees
Sep 14 - Sep 15
Fairfield Inn & Suites by Marriott St. Joseph

Quality Inn Cameron

2.5 star property
8.4 out of 10, Very Good, (594)
"Breakfast excellent, McDonald’s next door, staff friendly, easy check in/out prices. Nice hot tube/pool indoors. Shears like an older property but they are in the process of updating. "
The price is ¥16,853
¥18,701 total
includes taxes & fees
Oct 3 - Oct 4
Quality Inn Cameron

My Place Hotel St Joseph MO

2.0 star property
9.2 out of 10, Wonderful, (118)
"Bed was new and comfortable, location was easily accessible. "
The price is ¥12,313
¥14,247 total
includes taxes & fees
Sep 11 - Sep 12
My Place Hotel St Joseph MO

Super 8 by Wyndham Cameron

2.0 star property
8.4 out of 10, Very Good, (623)
"Very friendly check in. "
The price is ¥12,745
¥14,016 total
includes taxes & fees
Sep 28 - Sep 29
Super 8 by Wyndham Cameron

Red Roof Inn Cameron

2.0 star property
8.8 out of 10, Excellent, (1015)
"Staff friendly, very clean, beds great"
The price is ¥13,044
¥14,344 total
includes taxes & fees
Sep 9 - Sep 10
Red Roof Inn Cameron

AmeriStay Inn

2.5 star property
5.4 out of 10, (681)
"Roaches where every where. I didn't stay there slept in my car in the parking lot. "
AmeriStay Inn

Drury Inn & Suites St Joseph

3.0 star property
9.2 out of 10, Wonderful, (1016)
"Beautiful view, excellent rooms and very affordable "
The price is ¥13,360
¥15,458 total
includes taxes & fees
Sep 14 - Sep 15
Drury Inn & Suites St Joseph

Home2 Suites By Hilton St. Joseph

3.0 star property
9.2 out of 10, Wonderful, (36)
"Great, clean hotel! Will definitely stay again next time in area. "
The price is ¥19,398
¥22,444 total
includes taxes & fees
Sep 6 - Sep 7
Home2 Suites By Hilton St. Joseph

Days Inn by Wyndham Cameron

2.0 star property
7.6 out of 10, Good, (777)
"The artwork above the beds was nice"
The price is ¥10,979
¥12,074 total
includes taxes & fees
Sep 21 - Sep 22
Days Inn by Wyndham Cameron

Motel 6 Saint Joseph, MO

2.0 star property
4.6 out of 10, (1003)
"Gina love here need more staff like her "
The price is ¥10,228
¥11,834 total
includes taxes & fees
Sep 11 - Sep 12
Motel 6 Saint Joseph, MO

Vineyard Mansion & Carriage House Bed & Breakfast

3.0 star property
9.0 out of 10, Wonderful, (191)
"Enjoyed our stay"
The price is ¥16,926
¥24,456 total
includes taxes & fees
Sep 11 - Sep 12
Vineyard Mansion & Carriage House Bed & Breakfast

Holiday Inn Express Hotel & Suites St. Joseph by IHG

2.5 star property
9.2 out of 10, Wonderful, (762)
"It's clean it's safe the staff is wonderful fitness room everything was great they even have washer and dryer"
The price is ¥17,221
¥19,924 total
includes taxes & fees
Sep 14 - Sep 15
Holiday Inn Express Hotel & Suites St. Joseph by IHG

Whiskey Mansion

2.5 star property
9.2 out of 10, Wonderful, (577)
"Staff was considerate and everything was clean and nice! "
The price is ¥16,823
¥19,464 total
includes taxes & fees
Sep 8 - Sep 9
Whiskey Mansion

Capri Motel By OYO Elwood, Wathena

2.0 star property
Capri Motel By OYO Elwood, Wathena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Where is the best place to stay in Clarksdale?

Located 13.2 mi (21.3 km) from the heart of Clarksdale, Stoney Creek Hotel St. Joseph is a top choice for your stay based on our traveler data. Two other options for your visit to the area are Drury Inn & Suites St Joseph and My Place Hotel St Joseph MO. See all available top hotels, or vacation rentals in Clarksdale.

What are some of the best vacation home rentals that Clarksdale has to offer?

3-bedroom Waterfront house w/ WiFi, AC and the BEST VIEW: This vacation home rental near Clarksdale offers a balcony, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. See all vacation rentals in Clarksdale.

If I need to cancel my hotel reservation in Clarksdale, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Clarksdale.

Where can I learn more about changing or cancelling my trip to Clarksdale?

To access more information about changing or cancelling your trip to Clarksdale, head over to our customer service page.

What is staying in Clarksdale like?

Visitors are sure to enjoy all that Clarksdale has to offer. There are 116 hotels and other accommodations in the surrounding area. Find out more about Clarksdale.

What should I do while I'm visiting Clarksdale?

Places to visit in the wider area include Glore Psychiatric Museum, Jesse James Home Museum, and Pony Express Museum. You'll also find Buchanan County Courthouse and St. Jo Frontier Casino in the area. Check out what more to see and do in Expedia's Clarksdale guide.

What's the seasonal weather like in Clarksdale?

The hottest months are usually July and August with an average temp of 74°F, while the coldest months are January and February with an average of 33°F. Average annual precipitation for Clarksdale is 45 inches.