Top Cherokee Seneca Hotels from ￥11,047

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Our top choices for Cherokee Seneca hotels

A Holiday Inn Express hotel with a covered parking area and a well-lit facade.

1. Holiday Inn Express Louisville Airport Expo Center by IHG

4 km from Cherokee Seneca

sostene

￥15,651 total

includes taxes & fees

Dec 2 - Dec 3

A bar area with multiple seating options and a large display of liquor bottles.

2. Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

6 km from Cherokee Seneca

matthew

￥19,591 total

includes taxes & fees

Nov 16 - Nov 17

A modern dining area with multiple tables and chairs, a kitchen area with stainless steel appliances, and a large window with blue curtains.

3. Wingate by Wyndham Louisville Fair and Expo

3.7 km from Cherokee Seneca

Bobi

￥12,997 total

includes taxes & fees

Nov 25 - Nov 26

A Hilton Garden Inn hotel with a modern design, multiple floors, and a well-lit entrance.

4. Hilton Garden Inn Louisville Mall of St. Matthews

St. Matthews, 5.2 km from Cherokee Seneca

Michael

￥18,638 total

includes taxes & fees

Nov 22 - Nov 23

An indoor swimming pool with lounge chairs and umbrellas, surrounded by arched windows and a tiled floor.

5. Hawthorn Suites by Wyndham Louisville East

St. Matthews, 5.2 km from Cherokee Seneca

Vickie

￥16,223 total

includes taxes & fees

Nov 8 - Nov 9

A grand lobby with ornate columns, plush seating, and a chandelier.

6. The Brown Hotel

Downtown Louisville, 6.4 km from Cherokee Seneca

Brianne

￥19,451 total

includes taxes & fees

Nov 25 - Nov 26

A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

7. Courtyard by Marriott Louisville Airport

7.1 km from Cherokee Seneca

RonNeisha

￥18,277 total

includes taxes & fees

Nov 21 - Nov 22

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

8. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 6.5 km from Cherokee Seneca

Shun

￥25,361 total

includes taxes & fees

Nov 24 - Nov 25

A reception desk with a wooden panel wall, a circular decorative piece, and a sign indicating 'Marriott Bonvoy'.

9. Fairfield Inn & Suites by Marriott Louisville Airport

7.3 km from Cherokee Seneca

Irina

￥17,262 total

includes taxes & fees

Nov 20 - Nov 21

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

10. Omni Louisville Hotel

Downtown Louisville, 6.2 km from Cherokee Seneca

Brian

￥24,484 total

includes taxes & fees

Nov 6 - Nov 7

A rooftop patio with a fire feature, seating, and a view of the sunset.

11. Crowne Plaza Louisville Airport Expo Ctr by IHG

Fairgrounds, 7 km from Cherokee Seneca

Scott

￥20,496 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

12. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 4.9 km from Cherokee Seneca

Addison

￥18,962 total

includes taxes & fees

Nov 26 - Nov 27

A hotel corridor with a snack bar, refrigerated display, and a long hallway with a patterned carpet.

13. Hampton Inn Louisville-Airport

Fairgrounds, 7.2 km from Cherokee Seneca

Ronald

￥17,876 total

includes taxes & fees

Nov 19 - Nov 20

A modern lobby with a curved reception desk, seating area with sofas and armchairs, and a central coffee table.

14. Springhill Suites by Marriott Louisville Airport

Fairgrounds, 7.1 km from Cherokee Seneca

Katina

￥16,411 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

15. Embassy Suites Louisville Downtown

Downtown Louisville, 6.4 km from Cherokee Seneca

Chase

￥24,291 total

includes taxes & fees

Nov 24 - Nov 25

An indoor swimming pool with clear water, surrounded by blue walls and large windows.

16. Hampton Inn & Suites By Hilton Louisville East Oxmoor

5.8 km from Cherokee Seneca

Richard

￥22,112 total

includes taxes & fees

Nov 8 - Nov 9

A modern indoor seating area with wooden tables and chairs, large windows offering a view of the outdoors, and a mix of red and beige seating.

17. Tru by Hilton Louisville Airport

Fairgrounds, 7.2 km from Cherokee Seneca

Massimo

￥18,014 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a blue sofa, yellow chairs, and a dining area with tables and chairs.

18. Hilton Garden Inn Louisville Airport

Fairgrounds, 6.9 km from Cherokee Seneca

Stacy

￥20,397 total

includes taxes & fees

Nov 27 - Nov 28

A spacious lobby with a central escalator, seating areas, and modern lighting.

19. Hyatt Regency Louisville

Downtown Louisville, 6.4 km from Cherokee Seneca

Michael Jered

￥23,280 total

includes taxes & fees

Nov 25 - Nov 26

A modern bar area with a circular bar, multiple seating options, and a large screen.

20. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 5.8 km from Cherokee Seneca

Trista

￥17,737 total

includes taxes & fees

Dec 1 - Dec 2

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Compare popular hotels in Cherokee Seneca

Property	Star rating	Guest rating
Hilton Garden Inn Louisville Mall of St. Matthews	3.0 star property	9.0 Wonderful 1,000 reviews	View
Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)	4.0 star property	9.4 Exceptional 2,612 reviews	View
Hampton Inn & Suites By Hilton Louisville East Oxmoor	2.5 star property	9.8 Exceptional 266 reviews	View
The Brown Hotel	4.5 star property	9.4 Exceptional 1,455 reviews	View
Holiday Inn Express Louisville Airport Expo Center by IHG	2.5 star property	8.6 Excellent 1,001 reviews	View

Where to stay in Cherokee Seneca

Find the best Cherokee Seneca areas and neighborhoods for the activities you enjoy most.

A steamboat docked at a pier with a bridge in the background.

Downtown Louisville

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

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A nighttime cityscape with a brightly lit bridge and a skyline featuring a prominent dome-shaped building.

St. Matthews

Major shopping destination with the fifth-largest mall in Kentucky, Mall St. Matthews, and smaller centers along Shelbyville Road. Don't miss the historic St. Matthew's Episcopal Church and Holy Trinity.

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A historical marker for the Conrad-Caldwell House, detailing its architectural style and history.

Old Louisville

Boasting Victorian architecture and the highest concentration of stained glass windows in residential homes, Old Louisville offers a walkable neighborhood with pedestrian-only streets, diverse dining options, and attractions like Central Park and the Conrad-Caldwell House.

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A nighttime hot air balloon festival with colorful balloons, including one labeled "OLIVER WINERY."

Fairgrounds

While visiting Fairgrounds, you might make a stop by sights like Freedom Hall and Kentucky Kingdom.

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A city skyline at dusk with illuminated buildings reflecting on the water.

Jeffersontown

Jeffersontown is known for its abundant dining options, and you can plan a trip to Jeffersontown Commons Shopping Center and Bluegrass Indoor Karting while you're in town.

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Top Cherokee Seneca Hotel Reviews

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

Louisville

10/10 Excellent

Patricia

Hampton Inn & Suites By Hilton Louisville East Oxmoor

Louisville

10/10 Excellent

Benjamin

Holiday Inn Express Louisville Airport Expo Center by IHG

Hayfield Dundee

10/10 Excellent

Barbara

Hilton Garden Inn Louisville Mall of St. Matthews

St. Matthews

10/10 Excellent

John

Courtyard by Marriott Louisville Airport

Louisville

10/10 Excellent

Heath

Tempo By Hilton Louisville Downtown Nulu

Downtown Louisville

10/10 Excellent

Marsha

An outdoor patio with a stone fire pit, wicker furniture, and a stone wall.

Residence Inn by Marriott Louisville East/Oxmoor

Louisville

10/10 Excellent

Cornell

Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

10/10 Excellent

Andre

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

The Grady

Downtown Louisville

10/10 Excellent

Anonymous traveler

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville

10/10 Excellent

Scott

An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

Hotel Genevieve part of JdV by Hyatt

Downtown Louisville

10/10 Excellent

davide

Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville

10/10 Excellent

Terry

Wingate by Wyndham Louisville Fair and Expo

Hayfield Dundee

10/10 Excellent

Zhancai

A classical gold statue in front of a multi-story building with large windows and a brick facade.

21c Museum Hotel Louisville

Downtown Louisville

10/10 Excellent

Heather

Hawthorn Suites by Wyndham Louisville East

St. Matthews

10/10 Excellent

Jayson

An outdoor patio with a brick wall, a flat-screen TV mounted above a fireplace, and a seating area with sofas and round tables.

Homewood Suites By Hilton Louisville Airport

Fairgrounds

10/10 Excellent

Sarah

Frequently Asked Questions

What is Cherokee Seneca like?

You'll be sure to have fun visiting Louisville's Cherokee Seneca neighborhood.

If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to review top deals in Cherokee Seneca.

Where can I learn more about changing or cancelling my trip to Cherokee Seneca?

To find more details about changing or cancelling your trip to Cherokee Seneca, head over to our customer service page.

What is there to do around this Louisville neighborhood?

Peterson-Dumesnil House, Historic Frankfort Avenue, and Colonel Sanders' Grave are just a few of the places to visit in and around Cherokee Seneca. Norton Fine Arts Center and Muhammad Ali Gravesite are also worth a visit when you're out sightseeing in Louisville.

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Find hotels in Cherokee Seneca, Louisville from ￥11,047

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Cherokee Seneca hotels

1. Holiday Inn Express Louisville Airport Expo Center by IHG

2. Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

3. Wingate by Wyndham Louisville Fair and Expo

4. Hilton Garden Inn Louisville Mall of St. Matthews

5. Hawthorn Suites by Wyndham Louisville East

6. The Brown Hotel

7. Courtyard by Marriott Louisville Airport

8. Galt House Hotel Trademark Collection by Wyndham

9. Fairfield Inn & Suites by Marriott Louisville Airport

10. Omni Louisville Hotel

11. Crowne Plaza Louisville Airport Expo Ctr by IHG

12. Tempo By Hilton Louisville Downtown Nulu

13. Hampton Inn Louisville-Airport

14. Springhill Suites by Marriott Louisville Airport

15. Embassy Suites Louisville Downtown

16. Hampton Inn & Suites By Hilton Louisville East Oxmoor

17. Tru by Hilton Louisville Airport

18. Hilton Garden Inn Louisville Airport

19. Hyatt Regency Louisville

20. Cambria Hotel Louisville Downtown-Whiskey Row

Compare popular hotels in Cherokee Seneca

Where to stay in Cherokee Seneca

Downtown Louisville

St. Matthews

Old Louisville

Fairgrounds

Jeffersontown

Top Cherokee Seneca Hotel Reviews

Derby City Gaming & Hotel - A Churchill Downs Property (Adults Only)

10/10 Excellent

Frequently Asked Questions

What is Cherokee Seneca like?

If I need to cancel my hotel reservation in Cherokee Seneca, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Cherokee Seneca?

What is there to do around this Louisville neighborhood?

Explore a world of travel with Expedia