Photo by Alice Burghart

Find Gay friendly Hotels in Cape Girardeau, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Cape Girardeau Gay friendly Hotels

Tonight
Dec 27 - Dec 28
Tomorrow
Dec 28 - Dec 29
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Cape Girardeau LGBT-friendly hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ￥14,090
￥15,894 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,248
￥16,073 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is ￥10,958
￥12,362 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau West
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (469)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
The price is ￥19,571
￥22,178 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Courtyard by Marriott Cape Girardeau Downtown
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is ￥14,090
￥15,894 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Inn & Suites Cape Girardeau
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is ￥16,562
￥18,684 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Cape Girardeau I 55 East
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (886)
"Room was clean and spacious."
United States
George
The price is ￥10,960
￥13,225 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ￥10,958
￥12,362 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,994
￥13,738 total
includes taxes & fees
Dec 29 - Dec 30
Drury Inn & Suites Jackson MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Cape Girardeau Hotel Reviews

Frequently asked questions

Looking for a gay-friendly hotel in Cape Girardeau?
Consider this your open invitation to pack your bags and find Cape Girardeau hotels that are members of the International Gay & Lesbian Travel Association on Expedia. The restaurants is something travelers enjoy about this welcoming area.
What's the best LGBTQ-friendly place to stay in Cape Girardeau?
Pear Tree Inn Cape Girardeau Near the Medical Center is a top LGBTQ-friendly hotel, and features free WiFi and LCD TVs. Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are two other good options for your stay.
How many gay-friendly hotels will I find in Cape Girardeau?
There are currently 8 LGBTQ-friendly accommodations in Cape Girardeau.
What are the top places to visit in Cape Girardeau?
During your vacation, get out and enjoy all that Cape Girardeau has to offer. You and your traveling companions may want to visit Isle Casino Cape Girardeau, Show Me Center, and Hunter Valley Winery. While you're here, create some great memories of your trip with stops at Trail of Tears State Park, Shawnee National Forest, and Mississippi River.
What is a gay-friendly hotel in Cape Girardeau?
LGBTQ-friendly hotels are places where lesbian, gay, bisexual, and transgender travelers are proudly welcomed. You'll find a selection of LGBTQ-friendly accommodations on our site. In Cape Girardeau, these hotels prioritize a diverse environment in which guests are welcomed, respected, and not obliged to declare or hide their sexual orientation.
What can I expect from a gay-friendly hotel in Cape Girardeau?
Take a vacation from the ordinary; stay at a gay-friendly hotel in Cape Girardeau, and you won't have to hide or your sexuality or your gender identity when you check-in. Many of our LGBTQ-friendly accommodations offer concierge services that provide information about nearby LGBTQ restaurants and local events.