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Our top choices for Southern Illinois hotels

A hotel with a covered entrance, stone pillars, and a modern design.

1. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

￥19,136 total

includes taxes & fees

Dec 6 - Dec 7

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.

2. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Mei

￥19,793 total

includes taxes & fees

Dec 6 - Dec 7

A hotel lobby with a reception desk, seating area, and a large screen TV.

3. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

￥21,002 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

4. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

￥13,156 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

5. Hampton Inn & Suites Effingham

Effingham

Scott

￥22,126 total

includes taxes & fees

Nov 23 - Nov 24

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

￥17,953 total

includes taxes & fees

Dec 6 - Dec 7

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

7. Best Western Delta Inn

Effingham

Melissa Rae

￥17,604 total

includes taxes & fees

Nov 8 - Nov 9

A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.

8. Country Inn & Suites by Radisson, Marion, IL

Marion

Rhonda

￥20,091 total

includes taxes & fees

Nov 15 - Nov 16

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

9. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Steve

￥19,611 total

includes taxes & fees

Nov 15 - Nov 16

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

10. Hampton Inn O'Fallon

O'Fallon

"The gentleman checking us in and the one checking us out were both very friendly and welcoming, plus the one checking us in was very helpful telling us about the facility we didn’t need to ask any questions… property was very bright and clean and safe. Also appeared to have been updated in the last few years, no dingy poorly lit hallways, everything well maintained, room was very spacious and clean"

Beverly

￥20,936 total

includes taxes & fees

Nov 15 - Nov 16

A Holiday Inn Express hotel with a brick facade, large windows, and a central entrance with columns.

11. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

Jennifer

￥23,008 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

12. Drury Inn & Suites Marion

Marion

Heather

￥17,872 total

includes taxes & fees

Nov 15 - Nov 16

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

13. Comfort Inn & Suites Marion I-57

Marion

Suzan

￥20,525 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

14. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Tammi

￥22,809 total

includes taxes & fees

Nov 12 - Nov 13

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

15. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

￥12,981 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

16. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

￥13,368 total

includes taxes & fees

Dec 7 - Dec 8

A Best Western hotel with a parking lot and a covered entrance.

17. Best Western Marion Hotel

Marion

Cornell

￥16,078 total

includes taxes & fees

Nov 10 - Nov 11

A Country Inn & Suites building with a covered entrance and a sign.

18. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Sonya

￥15,973 total

includes taxes & fees

Nov 15 - Nov 16

A Holiday Inn lobby with a reception desk, two armchairs, and a decorative ceiling light.

19. Holiday Inn Effingham by IHG

Effingham

Penny

￥18,694 total

includes taxes & fees

Dec 6 - Dec 7

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

20. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

￥25,092 total

includes taxes & fees

Nov 30 - Dec 1

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Vacation Rentals in Southern Illinois

Apartment

A kitchen with wooden cabinets, a microwave, and a stove. There is a dining area with a table and chairs.

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

A covered porch with blue plastic chairs, a ceiling fan, and large windows offering a view of the outdoors.

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

A modern kitchen with white cabinetry, a coffee maker, a sink, a dishwasher, and a built-in oven.

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

Cottage

A modern kitchen with dark cabinets, a round dining table, and a tufted bench.

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

"The hosts were fantastic about working with us on our check-in time, since we were on time commitment. The house was in a great location. The interior was perfect for our needs. Nick responded immediately when I had a question. Very friendly. I will definitely stay here again if my family ever returns Robinson!"

Cottage

A long, narrow hallway with wooden floors and large windows.

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

A living room with a fireplace, leather sofas, and a clock on the wall.

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

A wooden deck with a ceiling fan, outdoor furniture, and a view of a garden.

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

Best Western Marion Hotel

10/10 Excellent

"The staff were really friendly. There were renovations going on but everyone was so helpful and considerate. Breakfast was good with plenty of variety. Room was clean and comfortable. I would stay again if I was in the area."

Drury Inn & Suites Marion

10/10 Excellent

"It’s been a year since we visited this Drury Inn. I was pleasantly surprised that it’s just as clean, the staff is just as friendly & helpful and the food keeps getting better and better! Mexican dinner nite has been upgraded from mystery ground beef to pulled pork. Yummy! Breakfast now offers large or mini make your own waffles and blueberry pancakes. The scrambled eggs with bacon and cheese was excellent. The orange splash drink is really orange juice with a splash of tangerine juice so it’s 100% juice. Yay! The cocktails at 5:30 kickback were tasty. Pool & hot tub were very clean with towels placed on the tables & around the room. But the pool water was really chilly. The hot tub was more like a warm pool temp, which was great, we cud spend more time enjoying the massage jets. There were plenty of carts by all outside doors. The manager walked around during 5:30 kickback asking people how they liked the food and he was there again at breakfast. A very nice person to chat with & very dedicated! Can’t beat the location. One of our favorite Drury Inns."