Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

￥20,058 total

includes taxes & fees

Jul 12 - Jul 13

Suite Dreams Hotel

Mattoon

Judd

￥15,512 total

includes taxes & fees

Jun 16 - Jun 17

Drury Inn & Suites Marion

Marion

Brandy

￥24,991 total

includes taxes & fees

Jul 2 - Jul 3

Holiday Inn Effingham by IHG

Effingham

Glenn

￥17,405 total

includes taxes & fees

Jul 5 - Jul 6

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jennifer

￥16,219 total

includes taxes & fees

Jul 6 - Jul 7

Cobblestone Inn & Suites - Altamont

Altamont

Dominic

￥16,444 total

includes taxes & fees

Jun 16 - Jun 17

Hampton Inn & Suites Effingham

Effingham

Andrew

￥21,733 total

includes taxes & fees

Jul 3 - Jul 4

The Principal Hotel

Columbia

Michelle

￥19,660 total

includes taxes & fees

Jun 15 - Jun 16

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

Mark

￥20,985 total

includes taxes & fees

Jun 21 - Jun 22

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Brandon

￥15,203 total

includes taxes & fees

Jun 30 - Jul 1

Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Suzanne

￥15,103 total

includes taxes & fees

Jun 21 - Jun 22

Ramada by Wyndham Effingham

Effingham

Martin

￥12,202 total

includes taxes & fees

Jun 28 - Jun 29

Fairfield by Marriott Inn & Suites Mattoon

Mattoon

Stephen

￥25,429 total

includes taxes & fees

Jul 2 - Jul 3

Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board

Days Inn & Suites by Wyndham Casey

Casey

Juan

￥12,643 total

includes taxes & fees

Jun 15 - Jun 16

Fairfield Inn & Suites Marriott Effingham

Effingham

thomas

￥17,058 total

includes taxes & fees

Jun 21 - Jun 22

Home2 Suites by Hilton Carbondale

Carbondale

Akoswa

￥21,866 total

includes taxes & fees

Jun 21 - Jun 22

Best Western Marion Hotel

Marion

Dennis

￥14,458 total

includes taxes & fees

Jul 5 - Jul 6

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

￥19,218 total

includes taxes & fees

Jun 28 - Jun 29

Holiday Inn Express & Suites Vandalia by IHG

Vandalia

Joyce

￥18,510 total

includes taxes & fees

Jun 21 - Jun 22

Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Carterville

Monique

￥23,039 total

includes taxes & fees

Jun 15 - Jun 16

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Vacation Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Vacation Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Radisson Hotel Fairview Heights - St. Louis

8/10 Good

"Newly renovated! Clean comfy beds Large rooms Refrigerator and microwave Only small complaint was the AC didn’t work as well as I would have liked. I had it set on 60 and I was still hot. I luckily brought a fan so it was fine but it was NO way 60 degrees. It worked , but just not as well as it should ! Definately would stay again at this property !"

Comfort Suites Fairview Heights - St. Louis

2/10 Terrible

"I ASKED FOR A REFUND checked in left went to casino came back & the room was absolutely horrible. Bed bugs dirty sheets I took pictures asked they lady at the front desk if ahe would sleep on that. She said thats house keeping not me that does not answer the question. STAY AWAY FROM HERE!"

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"A clean room but most impressive was the kind and courteous staff. Breakfast was plentiful and area kept clean. Dinner was impressive considering one usually doesn’t get an evening snack/ dinner with drinks served and included with room. Great for families and events. The hotel was busy and full throughout our stay. So obviously a great place to stay."