A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
Mount Vernon
United States
Rachid
¥17,510
¥19,749 total
includes taxes & fees
Sep 6 - Sep 7
Drury Plaza Hotel Mt. Vernon

2. Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
Mount Vernon
United States
Erica
¥18,729
¥21,105 total
includes taxes & fees
Aug 16 - Aug 17
Comfort Suites Mount Vernon

3. Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
Mount Vernon
United States
Angela D
¥18,616
¥20,976 total
includes taxes & fees
Aug 16 - Aug 17
Holiday Inn Express & Suites Mount Vernon by IHG

4. Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
Mount Vernon
United States
Matthew W,
¥10,649
¥12,135 total
includes taxes & fees
Aug 30 - Aug 31
Super 8 by Wyndham Mt. Vernon IL

5. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Mount Vernon
United States
Blake
¥18,167
¥20,480 total
includes taxes & fees
Aug 21 - Aug 22
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

6. DoubleTree by Hilton Mt. Vernon

DoubleTree by Hilton Mt. Vernon
Mount Vernon
United States
Samuel
¥20,174
¥22,706 total
includes taxes & fees
Sep 3 - Sep 4
DoubleTree by Hilton Mt. Vernon

7. SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
Whittington
United States
Debbie
¥12,738
¥14,136 total
includes taxes & fees
Aug 12 - Aug 13
SureStay Hotel by Best Western Whittington Rend Lake

8. Best Western Plus MidAmerica Hotel

Best Western Plus MidAmerica Hotel
Mascoutah
United States
Jaysen
¥17,283
¥19,698 total
includes taxes & fees
Aug 19 - Aug 20
Best Western Plus MidAmerica Hotel

9. Days Inn by Wyndham Mount Vernon

Days Inn by Wyndham Mount Vernon
Mount Vernon
United States
Norberto
¥11,398
¥12,966 total
includes taxes & fees
Aug 24 - Aug 25
Days Inn by Wyndham Mount Vernon

10. Cobblestone Inn & Suites - Altamont

Cobblestone Inn & Suites - Altamont
Altamont
United States
Daria
¥14,836
¥16,020 total
includes taxes & fees
Aug 12 - Aug 13
Cobblestone Inn & Suites - Altamont

11. Drury Inn & Suites Marion

Drury Inn & Suites Marion
Marion
United States
Alicia
¥16,721
¥20,062 total
includes taxes & fees
Aug 23 - Aug 24
Drury Inn & Suites Marion

12. The Principal Hotel

The Principal Hotel
Columbia
United States
Daniel
¥16,831
¥18,680 total
includes taxes & fees
Aug 24 - Aug 25
The Principal Hotel

13. Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG
Metropolis
United States
James
¥16,721
¥18,557 total
includes taxes & fees
Aug 16 - Aug 17
Holiday Inn Express Metropolis by IHG

14. Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Metropolis
United States
Melinda
¥12,190
¥16,052 total
includes taxes & fees
Sep 7 - Sep 8
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

15. Baymont by Wyndham Marion

Baymont by Wyndham Marion
Marion
United States
james
¥14,046
¥16,853 total
includes taxes & fees
Aug 16 - Aug 17
Baymont by Wyndham Marion

16. Quality Inn Mount Vernon, IL

Quality Inn Mount Vernon, IL
Mount Vernon
United States
David
¥12,039
¥13,680 total
includes taxes & fees
Aug 23 - Aug 24
Quality Inn Mount Vernon, IL

17. Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis
Edwardsville
United States
Debra
¥14,651
¥16,845 total
includes taxes & fees
Sep 1 - Sep 2
Comfort Inn Edwardsville - St. Louis

18. Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
Centralia
United States
Corey
¥23,506
¥26,322 total
includes taxes & fees
Aug 26 - Aug 27
Best Western Plus Centralia Hotel & Suites

19. Country Hearth Inn & Suites Edwardsville St. Louis

Country Hearth Inn & Suites Edwardsville St. Louis
Edwardsville
United States
les
¥17,196
¥19,772 total
includes taxes & fees
Aug 12 - Aug 13
Country Hearth Inn & Suites Edwardsville St. Louis

20. La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
Effingham
United States
Alexis
¥16,379
¥18,341 total
includes taxes & fees
Aug 23 - Aug 24
La Quinta Inn & Suites by Wyndham Effingham
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Vacation Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg Home w/ Private Yard + Screened Porch!
Harrisburg
"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."
Harrisburg Home w/ Private Yard + Screened Porch!
Cottage

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Peaceful Robinson Home w/ Yard, Near Golf Courses!
Robinson
Peaceful Robinson Home w/ Yard, Near Golf Courses!
Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro Retreat w/ Deck Near Kinkaid Lake!
Murphysboro
"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "
Murphysboro Retreat w/ Deck Near Kinkaid Lake!
Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Cozy Anna Home Near Southern Illinois Attractions!
Anna
"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."
Cozy Anna Home Near Southern Illinois Attractions!
Cottage

Illinois Vacation Rental Home: Pets Welcome

Illinois Vacation Rental Home: Pets Welcome
Palestine
Illinois Vacation Rental Home: Pets Welcome
Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Beautiful Makanda Cabin in Shawnee National Forest
Makanda
"It was very peaceful and relaxing. "
Beautiful Makanda Cabin in Shawnee National Forest
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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
See properties

O'Fallon Family Sports Park

8.6/10 (137 reviews)
This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.
See properties

World Wide Technology Raceway

9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

Harrah's Metropolis

8.0/10 (310 reviews)
This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards program to maximize your experience while enjoying Southern classics at the on-site restaurants.
See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois
A forested valley with autumn foliage, a rocky cliff, and a sunset.
Photo by Southernmost Illinois Tourism Bureau

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

10/10 Excellent
"Clean room, good breakfast "
Karen 1-night trip
Posted 14 hours ago
Holiday Inn Express Metropolis by IHG
The Principal Hotel

The Principal Hotel

10/10 Excellent
"great stay. Have to have front desk adjust room temperature."
Andrew 1-night trip
Posted 14 hours ago
The Principal Hotel
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent
"The hotel was clean and the rooms were comfortable. We had small children with us and were hoping to check-in early to get some nap time. They were able to get both joining rooms available for us! It was much appreciated. We also enjoyed the indoor pool and the fitness gym during our stay."
Amy 1-night trip
Posted 21 hours ago
Country Inn & Suites by Radisson, Effingham, IL
Baymont by Wyndham Marion

Baymont by Wyndham Marion

10/10 Excellent
"It was clean, quiet, and good parking."
William 1-night trip
Posted 1 day ago
Baymont by Wyndham Marion
Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

10/10 Excellent
"The front desk was very nice and helpful the hotel is being remolded but clean. Itwas clean and the Ac blow cold, the breakfast was good for a hotel with different items.Also was in a nice safe area , easy access to the interstate and stores and restaurants me and wife both said we would stay here again"
Joseph 3-night trip
Posted 2 days ago
Best Western St. Louis Fairview Heights
Comfort Suites Fairview Heights - St. Louis

Comfort Suites Fairview Heights - St. Louis

8/10 Good
"Service was good. Rooms were as expected for the price. However, one room had a bad smell that I think was coming from the tub. Swimming pool was not good. Very cloudy water and smelled of algae. Overall not bad for the price."
David 1-night trip
Posted 2 days ago
Comfort Suites Fairview Heights - St. Louis

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL
¥8,528
¥9,804 total
Aug 17 - Aug 18
includes taxes & fees
Super 8 by Wyndham O'Fallon
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

1811 W Fayette Avenue Effingham IL
¥11,398
¥12,650 total
Aug 30 - Aug 31
includes taxes & fees
8.2/10 Very Good! (1,011 reviews)
Baymont by Wyndham Effingham
Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

150 Ludwig Dr Fairview Heights IL
¥12,607
¥14,244 total
Aug 26 - Aug 27
includes taxes & fees
Best Western St. Louis Fairview Heights
Baymont by Wyndham Marion

Baymont by Wyndham Marion

2608 W Main St Marion IL
¥14,046
¥16,853 total
Aug 16 - Aug 17
includes taxes & fees
8.4/10 Very Good! (1,090 reviews)
Baymont by Wyndham Marion
Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

2179 East 5th Street Metropolis IL
¥16,721
¥18,557 total
Aug 16 - Aug 17
includes taxes & fees
8.8/10 Excellent! (1,020 reviews)
Holiday Inn Express Metropolis by IHG
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

404 South 44th Street Mount Vernon IL
¥18,729
¥21,105 total
Aug 16 - Aug 17
includes taxes & fees
Comfort Suites Mount Vernon

Hotels in Southern Illinois with star-rating

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