Photo by Southernmost Illinois Tourism Bureau

Find Family Hotels in Southern Illinois, IL

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Family Hotels

Next weekend
In two weeks

Our top choices for Southern Illinois family-friendly hotels

Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (684)
"Very clean, nice hot breakfast, and kind staff. "
United States
Erin
The price is ¥16,516
¥18,330 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Effingham

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1001)
"Hotel is very clean and staff is also friendly."
United States
Tonya
The price is ¥10,148
¥12,176 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Inn & Suites Marion

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1005)
"Check in was quick, staff was friendly and helpful, room was very nice and clean."
United States
Don
The price is ¥17,019
¥19,200 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Mount Vernon

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (512)
"great property, great breakfast, friendly and knowledgable staff."
United States
Ronald
The price is ¥15,146
¥16,810 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1593)
"Amazing room, clean, staff were kind! "
United States
Stephanie
The price is ¥14,676
¥16,599 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Drury Plaza Hotel Mt. Vernon

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1001)
"Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!"
United States
Barbara
The price is ¥14,506
¥16,244 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Effingham

Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24
2.5 star property
Metropolis
8.0 out of 10, Very Good, (1001)
"Courteous staff, clean rooms. "
United States
Jennifer
The price is ¥8,596
¥10,008 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Quality Inn & Suites Metropolis I-24

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1000)
"reception was great, room clean, and the price was right."
United States
tom
The price is ¥9,864
¥11,260 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Super 8 by Wyndham Mt. Vernon IL

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1080)
"This place was nice for the money and our 1 night stay. "
United States
Charles
The price is ¥11,570
¥13,883 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Baymont by Wyndham Marion

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
2.5 star property
Mount Vernon
8.8 out of 10, Excellent, (684)
"Good place to stay."
United States
Timothy
The price is ¥15,701
¥17,738 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southern Illinois Hotel Reviews

Explore a world of travel with Expedia