Find Luxury Hotels in Cairo, IL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Cairo Luxury Hotels

Next weekend
In two weeks
No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (285 reviews)
"The room is big and comfortable."
United States
Karen
The price is ¥11,627
¥12,904 total
includes taxes & fees
Jun 12 - Jun 13
Quality Inn Cairo I-57

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"Very clean and nice room"
United States
Alan
The price is ¥11,143
¥12,367 total
includes taxes & fees
May 25 - May 26
The Riverstone Hotel Charleston-Sikeston

La Center Motel

La Center Motel
2.0 star property
La Center
7.6 out of 10, Good, (19 reviews)
"Nice economy stay on the way to Paducah. Had a microwave, refrigerator and satellite TV. Could use a little paint. Bed was comfortable. "
United States
Wendi
The price is ¥8,596
¥10,056 total
includes taxes & fees
May 25 - May 26
La Center Motel

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (634 reviews)
"I was passing by and decided to take a break here. The bed was clean, had hot water and the heat was working. Took a quick 5 hour sleep and was back on the road. "
United States
Krastyu
The price is ¥9,742
¥10,812 total
includes taxes & fees
Jun 3 - Jun 4
Super 8 by Wyndham Charleston/Sikeston East MO

Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (27 reviews)
"This stay was comfortable and quiet an amazing weekend stay!!"
United States
Chyaria B.
The price is ¥17,510
¥29,017 total
includes taxes & fees
May 29 - May 30
Peaceful secluded cabin located near Horseshoe Lake

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ¥19,261
¥46,158 total
includes taxes & fees
May 26 - May 27
Quiet Country Stay: Modern Home Near Paducah

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (103 reviews)
"The cabin is so comfy and homey. We loved the setting and could watch birds as we ate on the deck. Centrally located for birding. Only 30 minutes from several hot birding/hiking spots. We thoroughly enjoyed the stay and hope to be back soon."
United States
Barbara S.
The price is ¥21,489
¥44,704 total
includes taxes & fees
May 30 - May 31
Charming cottage overlooking Lake Acre

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (39 reviews)
"Pretty, secluded location. The pictures may be deceiving to some, but we stayed with 4 people and there was plenty of room. Communication was super easy with host, very responsive. Cabin was supplied with many amenities for cooking and just basic stay needs. Host pretty thought of everything. "
United States
Gerald
The price is ¥17,908
¥22,354 total
includes taxes & fees
May 26 - May 27
Cozy cabins on beautiful Horseshoe Lake

Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (23 reviews)
"Everything was perfect. Cozy, comfortable beds and the home was comfy!! Would stay again!!!"
United States
mike a.
The price is ¥17,510
¥29,789 total
includes taxes & fees
May 28 - May 29
Charming Home just minutes from Interstate and Mall

Beautiful Cabin Retreat

Beautiful Cabin Retreat
tamms
8.2 out of 10, Very Good, (41 reviews)
"Host had the cabin very clean. New leather couch & recliner. Mattress was extremely comfortable. Washer & Dryer were excellent. Another Rental house near, long-term renters were very quiet. Internet not very good in the Illinois woods. Closed cabin has a musty smell from humidity in the woods. Host had an automatic air freshener going to help with air quality."
Canada
Bob & Patricia B.
The price is ¥21,489
¥35,427 total
includes taxes & fees
May 31 - Jun 1
Beautiful Cabin Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Cairo Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Cairo?
Let Expedia help you arrange your flight to Cairo, IL (CIR-Cairo Regional) airport or Paducah, KY (PAH-Barkley Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Cairo has to offer. Cairo has some interesting things to see and do including Mississippi River and Ohio River Valley, so you might want to take in the local sights during your visit.
When can I expect good weather in Cairo?
Planning for the weather is an important factor for making your trip to Cairo a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do in Cairo?
Enjoy all that Cairo has to offer when you visit Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have spare time during your trip, you might want to make a stop at Ballard Wildlife Management Area and Columbus-Belmont State Park.