Find Luxury Hotels in Cairo, IL

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Recommended hotels in Cairo

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
The price is ¥11,059
¥12,273 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Quality Inn Cairo I-57

Beautiful Cabin Retreat

Beautiful Cabin Retreat
tamms
8.2 out of 10, Very Good, (41)
"This is a very nice, peaceful cabin. The host was very friendly and accommodating. I would definitely stay here again."
United States
Randy V.
The price is ¥22,611
¥36,853 total
includes taxes & fees
Dec 27 - Dec 28
Beautiful Cabin Retreat

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
"Quiet and convenient."
United States
Alma
La Center Motel

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
The price is ¥9,433
¥10,468 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Eagle Inn Charleston

Charming 3-bedroom house near ball park in quiet neighborhood

Charming 3-bedroom house near ball park in quiet neighborhood
Bardwell
10.0 out of 10, Exceptional, (12)
"Quaint stay to see Grand and kids. "
United States
Sheila C.
The price is ¥14,035
¥25,043 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Charming 3-bedroom house near ball park in quiet neighborhood

Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (20)
"We enjoyed staying here very much. Clean and close to where we wanted to be!"
United States
Becky C.
The price is ¥17,153
¥29,182 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Charming Home just minutes from Interstate and Mall

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
The price is ¥17,543
¥21,898 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Cozy cabins on beautiful Horseshoe Lake

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
The price is ¥21,052
¥44,290 total
includes taxes & fees
Dec 28 - Dec 29
Charming cottage overlooking Lake Acre

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ¥18,869
¥45,218 total
includes taxes & fees
Dec 27 - Dec 28
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
2.0 star property
Cunningham
The price is ¥16,842
¥44,468 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Cairo Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Cairo?
Let Expedia help you arrange your flight to Cairo, IL (CIR-Cairo Regional) airport or Paducah, KY (PAH-Barkley Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Cairo has to offer. Cairo has some interesting things to see and do including Mississippi River and Ohio River Valley, so you might want to take in the local sights during your visit.
When can I expect good weather in Cairo?
Planning for the weather is an important factor for making your trip to Cairo a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do in Cairo?
Enjoy all that Cairo has to offer when you visit Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have spare time during your trip, you might want to make a stop at Ballard Wildlife Management Area and Columbus-Belmont State Park.