Lodging Image

Find hotels in Siesta Isle, Fort Myers Beach

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Siesta Isle hotels

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

1. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
Siesta Isle
9.0 out of 10, Wonderful, (1,000 reviews)
"Perfect hotel"
United States
Ana
The price is ￥13,638
￥15,205 total
includes taxes & fees
Oct 4 - Oct 5
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
A large, clear swimming pool with multiple lounge areas and palm trees.

2. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
2.6 km from Siesta Isle
9.0 out of 10, Wonderful, (2,621 reviews)
"Very nice place to stay in for the weekend"
United States
Jose
The price is ￥25,089
￥35,904 total
includes taxes & fees
Oct 6 - Oct 7
Margaritaville Beach Resort Fort Myers
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

3. Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
1.8 km from Siesta Isle
9.4 out of 10, Exceptional, (1,457 reviews)
"It's nice place to stay"
United States
Mario
The price is ￥34,790
￥49,188 total
includes taxes & fees
Oct 19 - Oct 20
Pink Shell Beach Resort and Marina
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

4. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
2.2 km from Siesta Isle
9.4 out of 10, Exceptional, (1,000 reviews)
"Great location next to the beach. Room and view were great. Enjoyed the place very well."
United States
Hassan
The price is ￥34,197
￥38,129 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Plus Beach Resort
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

5. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
2.6 km from Siesta Isle
8.8 out of 10, Excellent, (1,000 reviews)
"Had a good experience here room was clean breakfast was good"
United States
Robert
The price is ￥13,651
￥15,221 total
includes taxes & fees
Oct 8 - Oct 9
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

6. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
2.7 km from Siesta Isle
9.2 out of 10, Wonderful, (1,000 reviews)
"Very clean and comfortable hotel! Great breakfast too!"
United States
Gigette
The price is ￥13,259
￥14,784 total
includes taxes & fees
Oct 7 - Oct 8
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a stone archway.

7. The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
2.4 km from Siesta Isle
8.6 out of 10, Excellent, (1,801 reviews)
"Amazing rebuild after the hurricane. The staff was so friendly & the food & entertainment was great"
United States
Donna
The price is ￥13,449
￥18,153 total
includes taxes & fees
Nov 2 - Nov 3
The Lighthouse Resort Inn & Suites
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

8. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
2.3 km from Siesta Isle
8.2 out of 10, Very good, (1,366 reviews)
"Perfect stay"
United States
Jorge
The price is ￥12,628
￥14,081 total
includes taxes & fees
Oct 11 - Oct 12
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

9. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (1,003 reviews)
"The hotel was in a great location, very clean and had great breakfast options."
United States
jennifer
The price is ￥13,575
￥15,136 total
includes taxes & fees
Oct 6 - Oct 7
Residence Inn by Marriott Fort Myers Sanibel
A beach view with rows of empty wine glasses lined up on a balcony.

10. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (2,080 reviews)
"Great place to stay!!"
United States
ROBERT
The price is ￥18,123
￥23,727 total
includes taxes & fees
Oct 12 - Oct 13
Lani Kai Beachfront Resort
A beach view from a balcony with a pool, palm trees, and a building with a balcony.

11. Edison Beach House

Edison Beach House
3.5 star property
2.3 km from Siesta Isle
9.4 out of 10, Exceptional, (1,923 reviews)
"Great stay."
United States
Angie
The price is ￥28,875
￥38,356 total
includes taxes & fees
Oct 8 - Oct 9
Edison Beach House
A beachfront hotel with a pool, beach, and ocean view.

12. DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
2.9 km from Siesta Isle
9.2 out of 10, Wonderful, (1,309 reviews)
"We had a great stay. Beautiful property and great staff."
United States
Tiffani
The price is ￥30,415
￥40,080 total
includes taxes & fees
Oct 25 - Oct 26
DiamondHead Beach Resort
A modern kitchen with white cabinets, a built-in microwave, a stove, and a sink.

13. Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina
3.0 star property
2.1 km from Siesta Isle
9.4 out of 10, Exceptional, (1,000 reviews)
"The room was clean and nicely appointed. The location is great, we could walk to everywhere."
United States
Janine
The price is ￥25,403
￥32,270 total
includes taxes & fees
Oct 4 - Oct 5
Matanzas Inn Bayside Resort and Marina
A wooden deck with outdoor seating, a thatched-roof structure, and string lights.

14. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
1.1 km from Siesta Isle
8.6 out of 10, Excellent, (1,000 reviews)
"Definitely would stay again"
United States
Sebastian
The price is ￥19,521
￥21,766 total
includes taxes & fees
Oct 26 - Oct 27
Latitude 26 Waterfront Resort & Marina
A balcony with tables set for dining, overlooking a beach with palm trees and the ocean.

15. The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
2.7 km from Siesta Isle
8.0 out of 10, Very good, (522 reviews)
"Clean room, helpful staff, very close to the beach."
United States
Andrea
The price is ￥16,906
￥22,370 total
includes taxes & fees
Oct 6 - Oct 7
The Bay Inn at Lani Kai
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

16. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
9.7 km from Siesta Isle
9.4 out of 10, Exceptional, (1,679 reviews)
"Clean linens everyday, great breakfast and helpful staff"
United States
Brett R
The price is ￥16,259
￥18,130 total
includes taxes & fees
Oct 13 - Oct 14
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
An indoor swimming pool with clear water, a lifeguard station, and a seating area with chairs.

17. Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport
2.5 star property
18.1 km from Siesta Isle
8.8 out of 10, Excellent, (1,155 reviews)
"For the price I love the room everytime I visit family I try to book this hotel and very close to lots of things"
United States
Carmen
The price is ￥11,348
￥12,653 total
includes taxes & fees
Oct 11 - Oct 12
Comfort Inn & Suites Fort Myers Airport
An outdoor patio with a barbecue area, seating, and string lights.

18. Homewood Suites by Hilton Fort Myers Airport/FGCU

Homewood Suites by Hilton Fort Myers Airport/FGCU
3.0 star property
17 km from Siesta Isle
9.4 out of 10, Exceptional, (1,001 reviews)
"Great location!!!"
United States
Kieran
The price is ￥18,650
￥20,794 total
includes taxes & fees
Oct 18 - Oct 19
Homewood Suites by Hilton Fort Myers Airport/FGCU
A beach with a variety of seashells and pebbles.

19. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
10.1 km from Siesta Isle
9.2 out of 10, Wonderful, (2,337 reviews)
"Absolutely beautiful place with wonderful beach access to the incredibly warm Gulf!"
United States
Shana
The price is ￥28,255
￥35,905 total
includes taxes & fees
Oct 6 - Oct 7
Sanibel Island Beach Resort
A balcony with a table and chairs, large windows, and a view of the sea.

20. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
8.3 km from Siesta Isle
9.0 out of 10, Wonderful, (1,002 reviews)
"The hotel was very nice and great views of the water."
United States
Eric
The price is ￥23,117
￥32,824 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Cape Coral Resort At Marina Village
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Siesta Isle

Find the best Siesta Isle areas and neighborhoods for the activities you enjoy most.
A sunset over a calm sea with trees framing the view.

Mid Island

While visiting Mid Island, you might make a stop by sights like Estero Boulevard Beach and Sterling Ave Beach.

A pier extending into the water with two gazebos at the end, under a sunset sky.

South Island

While visiting South Island, you might make a stop by sights like Santini Marina Shopping Plaza and Castle Beach.

A coastal town with a marina, residential buildings, and a clear view of the ocean.

TP Hill's

When in TP Hill's, you can plan a visit to Key West Express and Estero Boulevard Beach, some noteworthy sights in the nearby area.

A beach at sunset with a pink and purple sky, people walking, and a lifeguard tower in the distance.
Photo by Abby Chase
Open Photo by Abby Chase

Downtown Fort Myers Beach

If you're spending some time in Downtown Fort Myers Beach, Lynn Hall Memorial Park and Estero Boulevard Beach are top sights worth seeing.

A coastal town with a beach, buildings, and a road.

Winklers

While Winklers might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Key West Express and Estero Boulevard Beach.

Top Siesta Isle Hotel Reviews

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

10/10 Excellent
"Our experience at this resort was a five star. We ate at all of the properties restaurants with complete satisfaction. The property was emaculate and the staff was very friendly."
Melisaa 4-night trip
Posted 3 hours ago
Margaritaville Beach Resort Fort Myers

Frequently asked questions

What is Siesta Isle like?
Travelers will be sure to find plenty to entertain them in Fort Myers Beach's Siesta Isle neighborhood. Consider a visit to San Carlos Bay - Bunche Beach Preserve as part of your Siesta Isle travel plans.
Where is the best place to stay in Siesta Isle?
Based on our traveler data, Latitude 26 Waterfront Boutique Resort - Fort Myers Beach is one of the top choices for your stay in Siesta Isle. This hotel offers a marina and free breakfast.
How many hotels will I find in Siesta Isle?
If you're searching for places to stay in Fort Myers Beach, Expedia has something to meet your needs with 27 Siesta Isle hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Siesta Isle, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, you might still have the option to cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to view the top deals on offer in Siesta Isle.
Where can I learn more about changing or cancelling my trip to Siesta Isle?
To access more information about picking new dates or cancelling your trip to Siesta Isle, head over to our customer service page.
What are the top things to see and do in Siesta Isle?
San Carlos Bay - Bunche Beach Preserve is an attraction you might want to check out while you're in Siesta Isle. Key West Express and Bunche Beach are also worth a visit when you're out sightseeing in Fort Myers Beach.