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Check prices for these dates

This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

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Our top choices for Sanctuary hotels

Room

1. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,636 reviews)
"Great location and breakfast was wonderdul"
United States
Tom
The price is ￥14,758
￥16,456 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Aerial view

2. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"very helpful staff and restaurant were excellent."
United States
rick
The price is ￥44,418
￥55,094 total
includes taxes & fees
Aug 30 - Aug 31
Tween Waters Island Resort & Spa
Room

3. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,000 reviews)
"Great price, great place, great people. The only thing is that there's nothing really around there."
United States
Bret
The price is ￥10,659
￥11,884 total
includes taxes & fees
Aug 28 - Aug 29
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Interior entrance

4. Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,004 reviews)
"Hotel was fine. Needs remodeling"
United States
Brian
The price is ￥10,054
￥11,211 total
includes taxes & fees
Aug 27 - Aug 28
Allure Suites
View from room

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,318 reviews)
"We liked the location and the pool. Breakfast was also served and although was not amazing, it was good enough to start off the day. We recommend to any family or people who are looking to go Sanibel Island or Fort Myers Beach and Downtown to stay at this hotel."
United States
Juliana
The price is ￥11,717
￥13,064 total
includes taxes & fees
Sep 23 - Sep 24
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Breakfast meal

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Very close to the island, affordable, clean, family friendly, okay breakfast, everyone was very nice"
United States
Laura
The price is ￥14,318
￥15,965 total
includes taxes & fees
Aug 27 - Aug 28
Residence Inn by Marriott Fort Myers Sanibel
Exterior

7. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,008 reviews)
"Very clean and friendly staff."
United States
Kirk
The price is ￥15,524
￥17,310 total
includes taxes & fees
Sep 3 - Sep 4
Homewood Suites by Hilton - Fort Myers
Lobby

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (914 reviews)
"We had a pleasant stay, clean room, friendly staff, breakfast was good, all day coffee, free parking."
United States
Melissa
The price is ￥12,600
￥14,049 total
includes taxes & fees
Sep 6 - Sep 7
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Terrace/patio

9. Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,023 reviews)
"Great stay as always! Convenient location, friendly staff, perfectly clean room."
United States
Suzanna
The price is ￥12,895
￥14,377 total
includes taxes & fees
Sep 16 - Sep 17
Hilton Garden Inn Ft Myers
Balcony view

10. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
6.0 out of 10, (1,000 reviews)
"great view excellent value"
United States
David
The price is ￥8,530
￥9,512 total
includes taxes & fees
Aug 29 - Aug 30
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Exterior

11. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,009 reviews)
"This location is very clean and nice!"
United States
Johny
The price is ￥14,795
￥16,497 total
includes taxes & fees
Aug 29 - Aug 30
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Lobby

12. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"The staff was fantastic and very friendly to work with. Breakfast was wonderful and the hotel room was well kept."
United States
Taylor
The price is ￥14,740
￥16,435 total
includes taxes & fees
Sep 6 - Sep 7
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Exterior

13. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,689 reviews)
"Great place"
United States
moti
The price is ￥61,679
￥77,469 total
includes taxes & fees
Sep 23 - Sep 24
Sundial Beach Resort & Spa
Exterior

14. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"Property was clean and very friendly staff food and bar on property and restaurant amazing stay"
United States
William
The price is ￥43,894
￥59,053 total
includes taxes & fees
Aug 30 - Aug 31
Sanibel Inn
Bar (on property)

15. Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,182 reviews)
"Always a great place to stay."
United States
heather
The price is ￥14,872
￥16,582 total
includes taxes & fees
Sep 6 - Sep 7
Doubletree by Hilton Fort Myers at Bell Tower Shops
Beach

16. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,239 reviews)
"We loved the location to all of our stops during our stay we went to museums and preserves and beaches every day"
United States
David Jeffery
The price is ￥28,779
￥36,523 total
includes taxes & fees
Aug 30 - Aug 31
Sanibel Island Beach Resort
Floating Coconut Cottage Houseboat | Terrace/patio

17. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,009 reviews)
"Great place to stay"
United States
Rick
The price is ￥22,644
￥25,248 total
includes taxes & fees
Sep 23 - Sep 24
Latitude 26 Waterfront Resort & Marina
Couples dining

18. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
8.8 out of 10, Excellent, (1,956 reviews)
"Great beach!"
United States
Michael
The price is ￥21,349
￥27,355 total
includes taxes & fees
Aug 31 - Sep 1
Lani Kai Beachfront Resort
Property amenity

19. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,150 reviews)
"Wonderful room and stay. Beachfront!"
United States
Cindi
The price is ￥31,681
￥35,325 total
includes taxes & fees
Aug 31 - Sep 1
Island Inn
Deluxe Suite (Second Floor Only) | Terrace/patio

20. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (164 reviews)
"Very comfortable and convenient location!"
United States
Lisa
The price is ￥26,269
￥34,611 total
includes taxes & fees
Sep 15 - Sep 16
Off the Charts Inn & Out Island Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

A variety of seashells on a beach.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

10/10 Excellent
"Everything excellent"
Lendy 3-night trip
Posted 8 hours ago
Marriott Sanibel Harbour Resort & Spa

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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