What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Sheryl

￥56,702 total

includes taxes & fees

Aug 9 - Aug 10

In-room safe, desk, laptop workspace, blackout drapes

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Kara

￥18,438 total

includes taxes & fees

Aug 9 - Aug 10

3. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

ALICIA

￥13,144 total

includes taxes & fees

Aug 12 - Aug 13

4. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Catherine

￥16,430 total

includes taxes & fees

Aug 10 - Aug 11

5. Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

Amanda

￥8,860 total

includes taxes & fees

Aug 11 - Aug 12

6. Allure Suites

27.2 km from Sanctuary

Brian

￥13,144 total

includes taxes & fees

Jul 31 - Aug 1

7. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Chrystal

￥9,789 total

includes taxes & fees

Jul 31 - Aug 1

8. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Daveanand

￥14,821 total

includes taxes & fees

Aug 12 - Aug 13

9. Sanibel Inn

East End, 13.8 km from Sanctuary

Amy

￥56,791 total

includes taxes & fees

Aug 19 - Aug 20

10. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Melissa

￥14,459 total

includes taxes & fees

Aug 10 - Aug 11

11. South Seas

5.5 km from Sanctuary

Erin

￥65,946 total

includes taxes & fees

Aug 11 - Aug 12

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Lori

￥15,505 total

includes taxes & fees

Aug 11 - Aug 12

13. Island Inn

West End, 9.6 km from Sanctuary

Valerie

￥47,282 total

includes taxes & fees

Aug 12 - Aug 13

14. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

carl

￥17,815 total

includes taxes & fees

Aug 16 - Aug 17

On the beach, white sand, snorkeling, surfing

15. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Vickie

￥40,870 total

includes taxes & fees

Aug 25 - Aug 26

16. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

Megan

￥81,787 total

includes taxes & fees

Jul 31 - Aug 1

17. Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

heather

￥17,815 total

includes taxes & fees

Aug 15 - Aug 16

18. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

22.6 km from Sanctuary

Cynthia

￥16,614 total

includes taxes & fees

Aug 19 - Aug 20

19. Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Fathi

￥18,712 total

includes taxes & fees

Aug 8 - Aug 9

20. Kona Kai Motel

Mid Island, 12.2 km from Sanctuary

Gregory John

￥30,296 total

includes taxes & fees

Jul 29 - Jul 30

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

The Bay Inn at Lani Kai

8/10 Good

"Excellent location"

Lani Kai Beachfront Resort

8/10 Good

"The rooms are clean and spacious, which is the main plus. The AC system is loud and distracting when you are trying to sleep. The rooftop restaurant's food is mediocre, but the Italian restaurant's food is good. There is a small pool on the side of the property that is dull and won’t allow alcoholic beverages. The price for the rooms is better than other rentals in the area. The Beach area is cleaned every morning and the ocean water is excellent"

Pink Shell Beach Resort and Marina

10/10 Excellent

"Everything about the Pink shell was amazing , we had a the best time and also was able to relax at the all adult area. The breakfast every morning was fresh and made to order thanks to the cook Fredy . The staff at the resort was pleasant and the room surpast what I expected."

Candlewood Suites Fort Myers Sanibel Gateway by IHG

10/10 Excellent

"This is an extended stay property and I was only staying 2 nights. I picked it for the location, so didn’t cook or need the fridge. The room was very clean, plenty of towels, etc, and the staff was very nice. I will definitely stay again if going to that area."

Find hotels in Sanctuary, Sanibel

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Treat yourself

Be picky

Check prices for these dates

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Guest rating

Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

3. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

4. Residence Inn by Marriott Fort Myers Sanibel

5. Candlewood Suites Fort Myers Sanibel Gateway by IHG

6. Allure Suites

7. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

8. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

9. Sanibel Inn

10. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

11. South Seas

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

13. Island Inn

14. Hilton Garden Inn Ft Myers

15. Shalimar Beach Resort

16. Sundial Beach Resort & Spa

17. Doubletree by Hilton Fort Myers at Bell Tower Shops

18. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

19. Homewood Suites by Hilton - Fort Myers

20. Kona Kai Motel

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

The Bay Inn at Lani Kai

Frequently asked questions

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