What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Our top choices for Sanctuary hotels

1. Cape Coral Retreat w Pool & Court

24.2 km from Sanctuary

￥57,819 total

includes taxes & fees

Aug 1 - Aug 2

In-room safe, desk, laptop workspace, blackout drapes

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Kara

￥18,449 total

includes taxes & fees

Aug 9 - Aug 10

3. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Sheryl

￥56,737 total

includes taxes & fees

Aug 15 - Aug 16

4. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

ALICIA

￥13,737 total

includes taxes & fees

Aug 10 - Aug 11

5. Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

Amanda

￥10,778 total

includes taxes & fees

Aug 2 - Aug 3

6. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

carl

￥17,825 total

includes taxes & fees

Aug 10 - Aug 11

7. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Chrystal

￥9,795 total

includes taxes & fees

Jul 30 - Jul 31

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Clifford

￥14,467 total

includes taxes & fees

Aug 2 - Aug 3

9. Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Fathi

￥18,725 total

includes taxes & fees

Aug 1 - Aug 2

10. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Catherine

￥16,441 total

includes taxes & fees

Aug 3 - Aug 4

11. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Daveanand

￥14,830 total

includes taxes & fees

Aug 20 - Aug 21

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Lori

￥15,514 total

includes taxes & fees

Aug 2 - Aug 3

13. Allure Suites

27.2 km from Sanctuary

Brian

￥13,151 total

includes taxes & fees

Jul 31 - Aug 1

14. Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

heather

￥18,724 total

includes taxes & fees

Aug 1 - Aug 2

15. Sanibel Inn

East End, 13.8 km from Sanctuary

Amy

￥60,556 total

includes taxes & fees

Aug 10 - Aug 11

Floating Coconut Cottage Houseboat | Terrace/patio

16. Latitude 26 Waterfront Resort & Marina

22 km from Sanctuary

Caroline

￥19,238 total

includes taxes & fees

Jul 28 - Jul 29

3 restaurants; breakfast, lunch, dinner, and brunch served

17. Lani Kai Beachfront Resort

21.8 km from Sanctuary

JUAN C

￥30,140 total

includes taxes & fees

Jul 30 - Jul 31

18. Island Inn

West End, 9.6 km from Sanctuary

Valerie

￥47,312 total

includes taxes & fees

Aug 23 - Aug 24

19. South Seas

5.5 km from Sanctuary

Erin

￥65,987 total

includes taxes & fees

Aug 10 - Aug 11

20. Dolphin Key Resort

23.8 km from Sanctuary

Jacquelyn

￥16,805 total

includes taxes & fees

Jul 28 - Jul 29

View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

See properties

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

See properties

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

See properties

A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

See properties

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

See properties

Top Sanctuary Hotel Reviews

Hilton Garden Inn Ft Myers

10/10 Excellent

"Staff were fantastic the WHOLE time, not just on check in & check out. Rooms were clean and cozy. My only complaint was the bed was uncomfortable after 1 night but I’m used to a foam mattress & springs are brutal now, so to each their own. Otherwise, loved the property & would stay again."

The Westin Cape Coral Resort At Marina Village

10/10 Excellent

"Everything was amazing... the room was luxurious and well-maintained. The marina views were breathtaking. Service at the front desk and bars was phenomenal. My entire family enjoyed our stay! The complimentary dolphin sunset cruise was awesome too!! I highly recommend The Westin in Cape Coral!"

Candlewood Suites Fort Myers Sanibel Gateway by IHG

10/10 Excellent

"This is an extended stay property and I was only staying 2 nights. I picked it for the location, so didn’t cook or need the fridge. The room was very clean, plenty of towels, etc, and the staff was very nice. I will definitely stay again if going to that area."

Find hotels in Sanctuary, Sanibel

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Sanctuary hotels

1. Cape Coral Retreat w Pool & Court

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

3. Tween Waters Island Resort & Spa

4. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

5. Candlewood Suites Fort Myers Sanibel Gateway by IHG

6. Hilton Garden Inn Ft Myers

7. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

9. Homewood Suites by Hilton - Fort Myers

10. Residence Inn by Marriott Fort Myers Sanibel

11. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

13. Allure Suites

14. Doubletree by Hilton Fort Myers at Bell Tower Shops

15. Sanibel Inn

16. Latitude 26 Waterfront Resort & Marina

17. Lani Kai Beachfront Resort

18. Island Inn

19. South Seas

20. Dolphin Key Resort

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Hilton Garden Inn Ft Myers

Frequently asked questions

Explore a world of travel with Expedia