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Check prices for these dates

This weekend
Jul 24 - Jul 26
Next weekend
Jul 31 - Aug 2

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Our top choices for Sanctuary hotels

In-room safe, desk, laptop workspace, blackout drapes

1. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,588 reviews)
"Staff is very friendly and helpful"
United States
Mark
The price is ￥16,414
￥18,302 total
includes taxes & fees
Aug 2 - Aug 3
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Aerial view

2. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,004 reviews)
"We had an amazing time!"
United States
Taylor
The price is ￥45,342
￥56,240 total
includes taxes & fees
Aug 5 - Aug 6
Tween Waters Island Resort & Spa
Exterior

3. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,002 reviews)
"Everything was great and easy to get everywhere"
United States
Sheri Lea
The price is ￥8,948
￥9,977 total
includes taxes & fees
Jul 27 - Jul 28
Candlewood Suites Fort Myers Sanibel Gateway by IHG
View from room

4. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,276 reviews)
"Clean room, helpful staff an good breakfast"
United States
ALICIA
The price is ￥11,831
￥13,192 total
includes taxes & fees
Aug 3 - Aug 4
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Terrace/patio

5. Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Good place to stay at a good price very clean great stuff"
United States
carl
The price is ￥16,251
￥18,120 total
includes taxes & fees
Aug 3 - Aug 4
Hilton Garden Inn Ft Myers
Balcony view

6. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
6.0 out of 10, (1,007 reviews)
"It was a good hotel for the price. It did its job for the night. Great for fun loving people"
United States
Chrystal
The price is ￥8,708
￥9,710 total
includes taxes & fees
Jul 30 - Jul 31
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Lobby

7. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (896 reviews)
"Friendly staff. Free parking in a safe area.. Excellent location"
United States
Maria
The price is ￥12,862
￥14,341 total
includes taxes & fees
Aug 5 - Aug 6
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Exterior

8. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,005 reviews)
"Great stay!"
United States
Tamora
The price is ￥16,646
￥18,561 total
includes taxes & fees
Jul 29 - Jul 30
Homewood Suites by Hilton - Fort Myers
Lobby

9. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.8 out of 10, Excellent, (1,012 reviews)
"Absolutely loved how nice and warm the pool was and that it was open until 10pm. The staff was exceptionally friendly and helpful 😊"
United States
Lisa
The price is ￥13,193
￥14,709 total
includes taxes & fees
Aug 20 - Aug 21
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Interior entrance

10. Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,005 reviews)
"Hotel was fine. Needs remodeling"
United States
Brian
The price is ￥11,444
￥12,760 total
includes taxes & fees
Jul 24 - Jul 25
Allure Suites
Exterior

11. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,005 reviews)
"Friendly folks all around!"
United States
John
The price is ￥13,793
￥15,379 total
includes taxes & fees
Jul 26 - Jul 27
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Free daily buffet breakfast

12. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Spacious accommodation, comfortable beds, great staff, great location close to both Fort Myers and Sanibel, and good breakfast. We truly enjoyed our stay and will probably stay there again."
United States
Catherine
The price is ￥14,616
￥16,296 total
includes taxes & fees
Aug 6 - Aug 7
Residence Inn by Marriott Fort Myers Sanibel
Floating Coconut Cottage Houseboat | Terrace/patio

13. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,003 reviews)
"Excellent service, we really enjoyed it, even though it was only one night I was very pleased"
United States
Jaroslava
The price is ￥17,115
￥19,084 total
includes taxes & fees
Jul 23 - Jul 24
Latitude 26 Waterfront Resort & Marina
Bar (on property)

14. Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,177 reviews)
"Always a great place to stay."
United States
heather
The price is ￥15,858
￥17,682 total
includes taxes & fees
Aug 9 - Aug 10
Doubletree by Hilton Fort Myers at Bell Tower Shops
3 restaurants; breakfast, lunch, dinner, and brunch served

15. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,777 reviews)
"Excellent place to stay "
United States
JUAN C
The price is ￥20,232
￥26,183 total
includes taxes & fees
Jul 26 - Jul 27
Lani Kai Beachfront Resort
Property amenity

16. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,139 reviews)
"The place was amazing and the host was very gracious."
United States
Wendy
The price is ￥42,090
￥46,930 total
includes taxes & fees
Aug 3 - Aug 4
Island Inn
Terrace/patio

17. Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,189 reviews)
"Great location!"
United States
Barbara
The price is ￥14,941
￥16,660 total
includes taxes & fees
Jul 26 - Jul 27
Dolphin Key Resort
Exterior

18. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"My husband and I stayed three nights and were thrilled with the clean modern room, incredible view of the ocean, and well manicured property. We would definitely stay again."
United States
Amy
The price is ￥44,579
￥60,028 total
includes taxes & fees
Aug 4 - Aug 5
Sanibel Inn
Lobby

19. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Great hotel"
United States
Cynthia
The price is ￥14,382
￥16,036 total
includes taxes & fees
Aug 11 - Aug 12
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
View from property

20. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,005 reviews)
"Love the hospitality especially the Valet staff. Onsite food and service was great!!I will definitely recommend and stay at this site again in the future."
United States
Kathryne
The price is ￥31,051
￥40,306 total
includes taxes & fees
Aug 19 - Aug 20
Marriott Sanibel Harbour Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Sanibel Island Southern Beach and Periwinkle Way.

A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Southern Beach and Sanibel Island Northern Beach.

A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

A variety of seashells on a beach.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

10/10 Excellent
"A perfect weekend getaway. Very easy to do with kids and has several dining options on site. The room was spacious but a bit outdated. The breakfast at Jack's was gteat and you can even do takeout."
Chelsea 2-night trip
Posted 3 hours ago
Pink Shell Beach Resort and Marina

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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