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Check prices for these dates

This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

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Our top choices for Sanctuary hotels

A resort with a central pool, multiple lounge areas, and a beach view.

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,005 reviews)
"very helpful staff and restaurant were excellent."
United States
rick
The price is ￥44,614
￥55,338 total
includes taxes & fees
Sep 2 - Sep 3
Tween Waters Island Resort & Spa
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

2. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,325 reviews)
"Clean room, great staff, delicious breakfast."
United States
Sidney
The price is ￥12,911
￥14,396 total
includes taxes & fees
Sep 15 - Sep 16
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
An outdoor patio with wicker furniture, a fire feature, and string lights.

3. Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
9.0 out of 10, Wonderful, (1,002 reviews)
"Great stay as always! Convenient location, friendly staff, perfectly clean room."
United States
Suzanna
The price is ￥13,995
￥15,604 total
includes taxes & fees
Sep 3 - Sep 4
Hilton Garden Inn Ft Myers
A hotel room with a large bed, two bedside tables with lamps, a nightstand, and a window with curtains.

4. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,005 reviews)
"Great price, great place, great people. The only thing is that there's nothing really around there."
United States
Bret
The price is ￥9,428
￥10,513 total
includes taxes & fees
Sep 6 - Sep 7
Candlewood Suites Fort Myers Sanibel Gateway by IHG
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

5. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,007 reviews)
"This location is very clean and nice!"
United States
Johny
The price is ￥14,860
￥16,570 total
includes taxes & fees
Sep 15 - Sep 16
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,008 reviews)
"Very close to the island, affordable, clean, family friendly, okay breakfast, everyone was very nice"
United States
Laura
The price is ￥14,381
￥16,034 total
includes taxes & fees
Sep 2 - Sep 3
Residence Inn by Marriott Fort Myers Sanibel
A spacious lobby with large windows, several chairs, and potted plants.

7. Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,000 reviews)
"It’s okay to be there and price is very reasonable"
United States
Vernon
The price is ￥10,187
￥11,359 total
includes taxes & fees
Sep 4 - Sep 5
Allure Suites

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (918 reviews)
"Clean room, staff ,breakfast,Parking. Everything was great about this place"
United States
Adelaide
The price is ￥12,655
￥14,110 total
includes taxes & fees
Sep 9 - Sep 10
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
A beachfront hotel with a central entrance, outdoor seating, and palm trees.

9. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very Good, (1,004 reviews)
"Good time, very nice mini vacation, property had a few water issues but staff responded prompt, be aware everything closes early. We ate at Harborside and food was very good, staff was very nice."
United States
America
The price is ￥33,667
￥51,819 total
includes taxes & fees
Sep 7 - Sep 8
South Seas
A hotel with a covered entrance, palm trees, and a well-maintained garden.

10. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff was very friendly- great morning breakfast"
United States
Shelley
The price is ￥15,592
￥17,384 total
includes taxes & fees
Sep 9 - Sep 10
Homewood Suites by Hilton - Fort Myers
A modern hotel lobby with a seating area, a reception desk, and a dining area.

11. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,002 reviews)
"The staff was fantastic and very friendly to work with. Breakfast was wonderful and the hotel room was well kept."
United States
Taylor
The price is ￥14,805
￥16,508 total
includes taxes & fees
Sep 13 - Sep 14
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
A balcony with a pool view, a table, and chairs.

12. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
6.0 out of 10, (1,005 reviews)
"Plenty of parking and staff wad very professional and helpful"
United States
Sarah
The price is ￥8,536
￥9,517 total
includes taxes & fees
Sep 9 - Sep 10
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Great place!"
United States
Jennifer
The price is ￥14,159
￥15,787 total
includes taxes & fees
Sep 29 - Sep 30
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

14. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.8 out of 10, Excellent, (417 reviews)
"Excellent property and service!!!"
United States
Cecilio
The price is ￥40,627
￥45,299 total
includes taxes & fees
Sep 2 - Sep 3
Casa Ybel Resort
A beach with a variety of seashells and pebbles.

15. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,255 reviews)
"How close the beach is and staff was amazing."
United States
Natalia
The price is ￥28,299
￥36,008 total
includes taxes & fees
Sep 9 - Sep 10
Sanibel Island Beach Resort
A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

16. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,690 reviews)
"Great place"
United States
moti
The price is ￥53,055
￥69,668 total
includes taxes & fees
Sep 9 - Sep 10
Sundial Beach Resort & Spa
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

17. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,002 reviews)
"The stay was great."
United States
Scott
The price is ￥30,552
￥39,659 total
includes taxes & fees
Sep 15 - Sep 16
Marriott Sanibel Harbour Resort & Spa
A beach with a view of the ocean and a sunset.

18. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,150 reviews)
"Wonderful room and stay. Beachfront!"
United States
Cindi
The price is ￥31,770
￥35,424 total
includes taxes & fees
Sep 8 - Sep 9
Island Inn
A pathway flanked by palm trees and wooden buildings with thatched roofs.

19. Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (1,001 reviews)
"Good location"
United States
Presley
The price is ￥25,742
￥29,566 total
includes taxes & fees
Sep 2 - Sep 3
Kona Kai Motel
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

20. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Property was clean and very friendly staff food and bar on property and restaurant amazing stay"
United States
William
The price is ￥44,088
￥59,314 total
includes taxes & fees
Sep 25 - Sep 26
Sanibel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

A variety of seashells on a beach.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

8/10 Good
"*"
Dean 2-night trip
Posted 9 hours ago
The Lighthouse Resort Inn & Suites

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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