What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

1. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Tom

￥16,462 total

includes taxes & fees

Sep 7 - Sep 8

A resort with a central pool, multiple lounge areas, and a beach view.

2. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

rick

￥55,133 total

includes taxes & fees

Aug 28 - Aug 29

A hotel room with a large bed, two bedside tables with lamps, a nightstand, and a window with curtains.

3. Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

Bret

￥11,892 total

includes taxes & fees

Aug 30 - Aug 31

A spacious lobby with large windows, several chairs, and potted plants.

4. Allure Suites

27.2 km from Sanctuary

Brian

￥11,218 total

includes taxes & fees

Aug 28 - Aug 29

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Juliana

￥12,929 total

includes taxes & fees

Sep 14 - Sep 15

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

6. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Laura

￥15,976 total

includes taxes & fees

Aug 30 - Aug 31

A hotel with a covered entrance, palm trees, and a well-maintained garden.

7. Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Kirk

￥17,321 total

includes taxes & fees

Sep 5 - Sep 6

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Melissa

￥14,059 total

includes taxes & fees

Sep 6 - Sep 7

An outdoor patio with wicker furniture, a fire feature, and string lights.

9. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Suzanna

￥14,383 total

includes taxes & fees

Sep 16 - Sep 17

A balcony with a pool view, a table, and chairs.

10. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

David

￥9,313 total

includes taxes & fees

Sep 3 - Sep 4

An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

11. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Johny

￥16,508 total

includes taxes & fees

Aug 30 - Aug 31

A modern hotel lobby with a seating area, a reception desk, and a dining area.

12. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

22.6 km from Sanctuary

Taylor

￥16,447 total

includes taxes & fees

Sep 6 - Sep 7

A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

13. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

moti

￥79,523 total

includes taxes & fees

Sep 2 - Sep 3

A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

14. Sanibel Inn

East End, 13.8 km from Sanctuary

William

￥59,633 total

includes taxes & fees

Aug 30 - Aug 31

An outdoor patio area with round tables and chairs, ceiling fans, and a bar area with shelves of bottles.

15. Doubletree by Hilton Fort Myers at Bell Tower Shops

30.8 km from Sanctuary

heather

￥16,593 total

includes taxes & fees

Sep 6 - Sep 7

A beach with a variety of seashells and pebbles.

16. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

David Jeffery

￥35,762 total

includes taxes & fees

Sep 3 - Sep 4

A balcony with a wicker sofa, a yellow table, and a potted plant.

17. Latitude 26 Waterfront Resort & Marina

22 km from Sanctuary

Rick

￥25,815 total

includes taxes & fees

Sep 1 - Sep 2

A beach view with rows of empty wine glasses lined up on a balcony.

18. Lani Kai Beachfront Resort

21.8 km from Sanctuary

Abigail

￥27,366 total

includes taxes & fees

Aug 31 - Sep 1

A beach with a view of the ocean and a sunset.

19. Island Inn

West End, 9.6 km from Sanctuary

Cindi

￥35,325 total

includes taxes & fees

Sep 8 - Sep 9

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

20. Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

Lisa

￥34,635 total

includes taxes & fees

Sep 22 - Sep 23

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Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

The Lighthouse Resort Inn & Suites

8/10 Good

"Great location for Fort Meyers beach. Our room was dated/worn and not particularly clean (bedsheets stained etc). That being said, our room was old in the older part of the resort, so the newer side may be better? On site bar is worth a visit for food/drink"

South Seas

10/10 Excellent

"recently stayed at this hotel and had an excellent experience. From the moment I arrived, the staff was friendly, welcoming, and very helpful. The room was clean, comfortable, and well maintained, and the entire property had a pleasant atmosphere. Everything was handled professionally, and I truly appreciated the great service throughout my stay. I would definitely recommend this hotel to anyone looking for a comfortable and enjoyable place to stay. I look forward to coming back in the future!"

Edison Beach House

10/10 Excellent

"This is an amazing location steps from white sands! Everything you need is provided for a perfect stay.very friendly and very safe.we have returned here many times and nothing seems to change, it just feels like coming home. Perfect views from our balcony of the gulf and lovely air conditioned rooms with the comfiest beds ever. S lovely addition is that breakfast is now available which is included and although basic is a perfect way to start the day. See you soon Edison."

Find hotels in Sanctuary, Sanibel

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Our top choices for Sanctuary hotels

1. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2. Tween Waters Island Resort & Spa

3. Candlewood Suites Fort Myers Sanibel Gateway by IHG

4. Allure Suites

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

6. Residence Inn by Marriott Fort Myers Sanibel

7. Homewood Suites by Hilton - Fort Myers

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

9. Hilton Garden Inn Ft Myers

10. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

11. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

12. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

13. Sundial Beach Resort & Spa

14. Sanibel Inn

15. Doubletree by Hilton Fort Myers at Bell Tower Shops

16. Sanibel Island Beach Resort

17. Latitude 26 Waterfront Resort & Marina

18. Lani Kai Beachfront Resort

19. Island Inn

20. Off the Charts Inn & Out Island Resort

Where to stay in Sanctuary

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

The Lighthouse Resort Inn & Suites

Frequently asked questions

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