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Check prices for these dates

This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

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Our top choices for Sanctuary hotels

Aerial view

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,001 reviews)
"very helpful staff and restaurant were excellent."
United States
rick
The price is ￥44,494
￥55,189 total
includes taxes & fees
Aug 31 - Sep 1
Tween Waters Island Resort & Spa
In-room safe, desk, laptop workspace, blackout drapes

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,638 reviews)
"Great location and breakfast was wonderdul"
United States
Tom
The price is ￥16,414
￥18,302 total
includes taxes & fees
Sep 12 - Sep 13
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Lobby

3. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (915 reviews)
"We had a pleasant stay, clean room, friendly staff, breakfast was good, all day coffee, free parking."
United States
Melissa
The price is ￥10,709
￥11,941 total
includes taxes & fees
Sep 3 - Sep 4
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
View from room

4. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,322 reviews)
"We liked the location and the pool. Breakfast was also served and although was not amazing, it was good enough to start off the day. We recommend to any family or people who are looking to go Sanibel Island or Fort Myers Beach and Downtown to stay at this hotel."
United States
Juliana
The price is ￥11,601
￥12,935 total
includes taxes & fees
Sep 14 - Sep 15
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Interior entrance

5. Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,002 reviews)
"Hotel was fine. Needs remodeling"
United States
Brian
The price is ￥10,072
￥11,230 total
includes taxes & fees
Aug 30 - Aug 31
Allure Suites
Free daily buffet breakfast

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Very close to the island, affordable, clean, family friendly, okay breakfast, everyone was very nice"
United States
Laura
The price is ￥14,342
￥15,991 total
includes taxes & fees
Aug 30 - Aug 31
Residence Inn by Marriott Fort Myers Sanibel
Premium bedding, down comforters, desk, laptop workspace

7. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,004 reviews)
"Great price, great place, great people. The only thing is that there's nothing really around there."
United States
Bret
The price is ￥9,402
￥10,483 total
includes taxes & fees
Sep 6 - Sep 7
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Balcony view

8. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
6.0 out of 10, (1,002 reviews)
"great view excellent value"
United States
David
The price is ￥8,384
￥9,348 total
includes taxes & fees
Sep 3 - Sep 4
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
5 restaurants; lunch and dinner served

9. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very Good, (1,002 reviews)
"Good time, very nice mini vacation, property had a few water issues but staff responded prompt, be aware everything closes early. We ate at Harborside and food was very good, staff was very nice."
United States
America
The price is ￥33,513
￥51,582 total
includes taxes & fees
Sep 7 - Sep 8
South Seas
Exterior

10. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"Very clean and friendly staff."
United States
Kirk
The price is ￥15,550
￥17,339 total
includes taxes & fees
Sep 3 - Sep 4
Homewood Suites by Hilton - Fort Myers
Exterior

11. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,689 reviews)
"Great place"
United States
moti
The price is ￥63,585
￥79,604 total
includes taxes & fees
Aug 30 - Aug 31
Sundial Beach Resort & Spa
Outdoor pool

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"This location is very clean and nice!"
United States
Johny
The price is ￥14,820
￥16,525 total
includes taxes & fees
Sep 1 - Sep 2
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Exterior

13. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,000 reviews)
"Property was clean and very friendly staff food and bar on property and restaurant amazing stay"
United States
William
The price is ￥43,485
￥58,615 total
includes taxes & fees
Aug 31 - Sep 1
Sanibel Inn
Lobby

14. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"The staff was fantastic and very friendly to work with. Breakfast was wonderful and the hotel room was well kept."
United States
Taylor
The price is ￥14,765
￥16,463 total
includes taxes & fees
Sep 6 - Sep 7
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
On the beach, sun loungers, beach towels

15. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,244 reviews)
"We loved the location to all of our stops during our stay we went to museums and preserves and beaches every day"
United States
David Jeffery
The price is ￥28,223
￥35,911 total
includes taxes & fees
Sep 3 - Sep 4
Sanibel Island Beach Resort
In-room safe, blackout drapes, iron/ironing board, cribs (surcharge)

16. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.8 out of 10, Excellent, (416 reviews)
The price is ￥47,405
￥52,857 total
includes taxes & fees
Sep 3 - Sep 4
Casa Ybel Resort
Terrace/patio

17. Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Great stay as always! Convenient location, friendly staff, perfectly clean room."
United States
Suzanna
The price is ￥12,908
￥14,392 total
includes taxes & fees
Sep 16 - Sep 17
Hilton Garden Inn Ft Myers
Floating Coconut Cottage Houseboat | Terrace/patio

18. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"Great place to stay"
United States
Rick
The price is ￥16,783
￥18,713 total
includes taxes & fees
Aug 30 - Aug 31
Latitude 26 Waterfront Resort & Marina
On the beach, white sand, snorkeling, surfing

19. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (83 reviews)
"Place is great, highly recommend"
United States
Aldo
The price is ￥32,112
￥35,805 total
includes taxes & fees
Aug 30 - Aug 31
Shalimar Beach Resort
Property amenity

20. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,150 reviews)
"Wonderful room and stay. Beachfront!"
United States
Cindi
The price is ￥31,713
￥35,360 total
includes taxes & fees
Sep 1 - Sep 2
Island Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

A variety of seashells on a beach.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Edison Beach House

Edison Beach House

10/10 Excellent
"The staff is excellent. The hotel is extremely clean."
Robert 7-night trip
Posted 4 hours ago
Edison Beach House

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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