What is Sanctuary like?

Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels are there in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 7 hotels and other accommodations in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.

Where can I learn more about changing or cancelling my trip to Sanctuary?

For more information about updating your trip to Sanctuary or cancelling it, click here .

What is there to do around this Sanibel neighborhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Top Sanctuary Hotels

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

rick

￥55,338 total

includes taxes & fees

Sep 7 - Sep 8

2. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Sidney

￥14,253 total

includes taxes & fees

Sep 10 - Sep 11

3. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Suzanna

￥15,646 total

includes taxes & fees

Sep 3 - Sep 4

4. Candlewood Suites Fort Myers Sanibel Gateway by IHG

25.4 km from Sanctuary

John

￥9,463 total

includes taxes & fees

Sep 13 - Sep 14

5. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Kenton Sean

￥16,570 total

includes taxes & fees

Sep 14 - Sep 15

6. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Laura

￥15,323 total

includes taxes & fees

Sep 7 - Sep 8

7. Allure Suites

27.2 km from Sanctuary

Vernon

￥11,359 total

includes taxes & fees

Sep 4 - Sep 5

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

30.1 km from Sanctuary

Adelaide

￥14,110 total

includes taxes & fees

Sep 9 - Sep 10

9. South Seas

5.5 km from Sanctuary

America

￥55,015 total

includes taxes & fees

Sep 8 - Sep 9

10. Homewood Suites by Hilton - Fort Myers

30.9 km from Sanctuary

Shelley

￥17,384 total

includes taxes & fees

Sep 9 - Sep 10

11. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

22.6 km from Sanctuary

Taylor

￥16,508 total

includes taxes & fees

Sep 13 - Sep 14

12. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

25.2 km from Sanctuary

Sarah

￥9,372 total

includes taxes & fees

Sep 17 - Sep 18

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

21.5 km from Sanctuary

Jennifer

￥15,674 total

includes taxes & fees

Sep 3 - Sep 4

14. Casa Ybel Resort

Ybel, 11.6 km from Sanctuary

Cecilio

￥45,298 total

includes taxes & fees

Sep 4 - Sep 5

15. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Natalia

￥36,008 total

includes taxes & fees

Sep 9 - Sep 10

16. Sundial Beach Resort & Spa

Mid Island, 12.8 km from Sanctuary

moti

￥69,668 total

includes taxes & fees

Sep 9 - Sep 10

17. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Scott

￥39,659 total

includes taxes & fees

Sep 17 - Sep 18

18. Island Inn

West End, 9.6 km from Sanctuary

Cindi

￥35,450 total

includes taxes & fees

Sep 8 - Sep 9

19. Kona Kai Motel

Mid Island, 12.2 km from Sanctuary

Presley

￥29,566 total

includes taxes & fees

Sep 7 - Sep 8

20. Sanibel Inn

East End, 13.8 km from Sanctuary

William

￥59,314 total

includes taxes & fees

Sep 3 - Sep 4

View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

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Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Sanctuary Hotel Reviews

Marriott Sanibel Harbour Resort & Spa

10/10 Excellent

"Great amenities, attentive staff, beautiful location, one of the best facilities in the SWFL area"

Pink Shell Beach Resort and Marina

10/10 Excellent

"Me encantó sin duda lo repetiré, el personal súper atento, las habitaciones muy limpias y muy cómodas con todo lo necesario para no pasar trabajo, la cocinita con todo tipo de utensilios si estás pensando cocinar algo o vas con niños como yo.el desayuno muy bueno y variado. Y la playa excelente"

Sanibel Island Beach Resort

10/10 Excellent

"Excellent all around, everything was immaculate...the beach just steps away. Beach t towels and chairs (umbrellas sold in lobby, we brought our own. Breakfast could be improved...on last day we had pre-made egg sandwiches like the ones you get at the coffee place with the mermaid logo which were mediocre. It be nice if they could fry up some eggs and bacon. The coffee was excellent. We're already planning our next trip there from Miami. Sanibel is just a couple of hours and you step into relax mode the minute you get on the island. Don' miss the National Wildlife Refuge. Drive, bike or hike through it... i'ts wonderful."

Find hotels in Sanctuary, Sanibel

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Guest rating

Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

2. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3. Hilton Garden Inn Ft Myers

4. Candlewood Suites Fort Myers Sanibel Gateway by IHG

5. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

6. Residence Inn by Marriott Fort Myers Sanibel

7. Allure Suites

8. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

9. South Seas

10. Homewood Suites by Hilton - Fort Myers

11. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

12. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

14. Casa Ybel Resort

15. Sanibel Island Beach Resort

16. Sundial Beach Resort & Spa

17. Marriott Sanibel Harbour Resort & Spa

18. Island Inn

19. Kona Kai Motel

20. Sanibel Inn

Where to stay in Sanctuary

West End

Mid Island

East End

Beachview Country Club Estates

Gulf Shores

Top Sanctuary Hotel Reviews

Marriott Sanibel Harbour Resort & Spa

Frequently asked questions

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