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Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,461 reviews)
"Loved the resort and amenities"
United States
Steven
The price is ¥22,665
¥28,757 total
includes taxes & fees
May 12 - May 13
Lani Kai Beachfront Resort

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (402 reviews)
"front desk workers were extremely pleasant"
United States
Dave
The price is ¥18,148
¥23,722 total
includes taxes & fees
May 10 - May 11
The Bay Inn at Lani Kai

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"Love this place!!"
United States
Teneille
The price is ¥20,494
¥73,617 total
includes taxes & fees
May 26 - May 27
Pointe Estero Beach Resort

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,345 reviews)
"Staff very friendly, room clean and property very clean "
United States
Kenneth
The price is ¥36,438
¥50,913 total
includes taxes & fees
May 20 - May 21
Pink Shell Beach Resort and Marina

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very Good, (117 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is ¥28,919
¥32,245 total
includes taxes & fees
May 11 - May 12
The Palmetto Inn

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,868 reviews)
"Loved the room and the location, the grounds were beautiful and had a convenient beach access, very charming!"
United States
Hillary
The price is ¥35,224
¥43,182 total
includes taxes & fees
May 31 - Jun 1
Sanibel Island Beach Resort

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (32 reviews)
"Anchor Inn is not only in a great location but beautiful. We used the bikes every day!"
United States
Renee
The price is ¥30,369
¥36,207 total
includes taxes & fees
May 31 - Jun 1
The Anchor Inn

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,009 reviews)
"Amazing place to stay! "
United States
Kristen
The price is ¥19,549
¥21,797 total
includes taxes & fees
May 13 - May 14
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

1 Island Hideaway

1 Island Hideaway
3.0 star property
24.3 km from Sanctuary
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is ¥31,108
¥69,372 total
includes taxes & fees
May 10 - May 11
1 Island Hideaway

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,005 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is ¥17,195
¥19,172 total
includes taxes & fees
May 12 - May 13
Latitude 26 Waterfront Resort & Marina

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Loved having two bedrooms, two bathrooms, and a full sized refrigerator. Breakfast was fantastic! Lots of choices!"
United States
Sheila Margaret
The price is ¥16,101
¥17,952 total
includes taxes & fees
May 13 - May 14
Residence Inn by Marriott Fort Myers Sanibel

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,445 reviews)
"Love it here! Clean rooms, great staff, great breakfast!"
United States
Amy
The price is ¥17,820
¥19,869 total
includes taxes & fees
May 21 - May 22
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,644 reviews)
"Great place! Very clean, great amenities."
United States
Karen
The price is ¥57,468
¥72,617 total
includes taxes & fees
May 27 - May 28
Sundial Beach Resort & Spa

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"This is an amazing hotel! Every staff member was kind, friendly, and welcoming. The room was clean and had everything we needed for our stay. "
United States
Stephanie
The price is ¥37,944
¥42,308 total
includes taxes & fees
May 21 - May 22
Best Western Plus Beach Resort

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,144 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is ¥11,005
¥12,270 total
includes taxes & fees
May 21 - May 22
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (864 reviews)
"Best Fairfield we have stayed in."
United States
Martin
The price is ¥13,928
¥15,529 total
includes taxes & fees
May 27 - May 28
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

MALU LANI Inn & Marina

MALU LANI Inn & Marina
3.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful property, peaceful, clean rental. Super responsive owner and all the things you need. Perfect location for boaters. Loved this stay and would definitely rent again! "
United States
April
The price is ¥30,641
¥62,178 total
includes taxes & fees
May 19 - May 20
MALU LANI Inn & Marina

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,165 reviews)
"Great room, great staff and great beach! Really enjoyed the location as well. Would stay here again"
United States
Kristen
The price is ¥33,864
¥43,859 total
includes taxes & fees
Jun 1 - Jun 2
DiamondHead Beach Resort

Angler's Inn

Angler's Inn
2.5 star property
18.8 km from Sanctuary
9.4 out of 10, Exceptional, (329 reviews)
"Great location and close to lots of restaurants. Jeannette is a great host. Love this place an will stay again "
United States
Cindy
The price is ¥24,230
¥40,961 total
includes taxes & fees
May 8 - May 9
Angler's Inn

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (287 reviews)
"Super cute place!! Super clean and comfortable."
United States
Francesca
The price is ¥17,913
¥43,421 total
includes taxes & fees
May 9 - May 10
Matlacha Tiny Village
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 10 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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