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Our top choices for Sanctuary hotels

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
9.8 out of 10, Exceptional, (6 reviews)
"This hotel was perfect It was decorated beautifully and was so clean and the bed was so comfy and the rainfall shower was very nice, the room had everything you could need for a nice vacation there’s a market within walking distance which had everything you need to make your stay perfect highly recommend this hotel anytime we come back to Sanibel we will always stay here "
United States
Mary
The price is ¥49,213
¥57,240 total
includes taxes & fees
Mar 15 - Mar 16
The Anchor Inn

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (240 reviews)
"Beautiful resort, great communication, super clean "
United States
Ronald
The price is ¥15,620
¥27,971 total
includes taxes & fees
Mar 18 - Mar 19
Matlacha on Shoreview

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,007 reviews)
"Amazing room and view. Great place to stay/vacation. Would come back over and over again. "
United States
Frank
The price is ¥37,596
¥48,230 total
includes taxes & fees
Apr 5 - Apr 6
The Westin Cape Coral Resort At Marina Village

Canal-front Gem w/ Heated Pool in Cape Coral

Canal-front Gem w/ Heated Pool in Cape Coral
3.5 star property
20.7 km from Sanctuary
9.4 out of 10, Exceptional, (3 reviews)
"Excellent place ! the host was very kind ! for sure we will be back !"
United States
Edinaldo
The price is ¥20,196
¥69,901 total
includes taxes & fees
Mar 11 - Mar 12
Canal-front Gem w/ Heated Pool in Cape Coral

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,248 reviews)
"Nice room, great tiki bar and pool area, and friendly staff."
United States
Jason
The price is ¥15,778
¥17,592 total
includes taxes & fees
Apr 1 - Apr 2
Dolphin Key Resort

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,005 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is ¥17,984
¥20,053 total
includes taxes & fees
Apr 5 - Apr 6
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,285 reviews)
"Good place to stay"
United States
Rashad
The price is ¥15,936
¥17,769 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,015 reviews)
"Great stay staff was great . Lake veiw was beautifully i definitely rerent rm 207. Has beautiful restaurant next door work price and ambience. "
United States
Rachel
The price is ¥17,088
¥20,867 total
includes taxes & fees
Mar 9 - Mar 10
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (153 reviews)
"Nice new rooms and great outdoor seating on the waterway, we saw lots of manatees "
United States
Ellen
The price is ¥22,471
¥30,332 total
includes taxes & fees
Apr 1 - Apr 2
Off the Charts Inn & Out Island Resort

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.2 out of 10, Very Good, (54 reviews)
"Clean, easy access, quiet, best bed and sheets ever!!!"
United States
Brooke
The price is ¥14,989
¥21,815 total
includes taxes & fees
Apr 1 - Apr 2
White Orchid Apartments

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.2 out of 10, Very Good, (13 reviews)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is ¥14,989
¥21,815 total
includes taxes & fees
Apr 7 - Apr 8
Summerwind Studios

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,664 reviews)
"Staff is amazing, amenities are great and is so beautiful! "
United States
Erica
The price is ¥64,455
¥75,813 total
includes taxes & fees
Apr 8 - Apr 9
Sanibel Island Beach Resort

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.0 out of 10, Very Good, (20 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is ¥14,694
¥21,486 total
includes taxes & fees
Apr 7 - Apr 8
TriLuxe Inn & Studios

MALU LANI Inn & Marina

MALU LANI Inn & Marina
2.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (2 reviews)
"Clean Rooms, Beautiful Setting and lots of wildlife just outside the porch! We saw a Manatee, Dolphins, Alligator and plenty of Bird Life! The area is an excellent spot for biking and hiking! The Calusa Habitat Mounds are nearby and a friendly day hike! Also nearby is a Marina that takes you to an Island for lunch and hiking as well as visiting Islands in the area! Very relaxing and fun place to take the whole Family!"
United States
Mark Forrest
The price is ¥28,812
¥46,325 total
includes taxes & fees
Mar 10 - Mar 11
MALU LANI Inn & Marina

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very Good, (1,010 reviews)
"Nice room and perfect location"
United States
Matthias
The price is ¥55,065
¥66,919 total
includes taxes & fees
Apr 6 - Apr 7
Marriott Sanibel Harbour Resort & Spa

Sunshine Island Inn

Sunshine Island Inn
2.5 star property
East End, 14.3 km from Sanctuary
9.0 out of 10, Wonderful, (294 reviews)
"Great stay. "
United States
Aundrea
The price is ¥47,176
¥54,180 total
includes taxes & fees
Mar 10 - Mar 11
Sunshine Island Inn

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,007 reviews)
"Yes great place"
United States
Jason
The price is ¥15,936
¥17,769 total
includes taxes & fees
Apr 6 - Apr 7
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Clean room and friendly staff. "
United States
Cindy
The price is ¥26,980
¥30,083 total
includes taxes & fees
Apr 5 - Apr 6
Residence Inn by Marriott Fort Myers Sanibel

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,025 reviews)
"Wonderful stay "
United States
Brandi
The price is ¥23,159
¥25,822 total
includes taxes & fees
Apr 1 - Apr 2
Doubletree by Hilton Fort Myers at Bell Tower Shops

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,013 reviews)
"Great place"
United States
Brian
The price is ¥21,332
¥23,786 total
includes taxes & fees
Apr 5 - Apr 6
Hilton Garden Inn Ft Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Shell Harbor

Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Sanibel Moorings Botanical Gardens and Sanibel Sea School.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
With 10 Expedia hotels and other accommodations in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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