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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,004 reviews)
"Another great stay at Tween Waters!"
United States
Sheryl
The price is ¥45,714
¥56,702 total
includes taxes & fees
Aug 9 - Aug 10
Tween Waters Island Resort & Spa

2. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,599 reviews)
"Room was clean breakfast was excellent. "
United States
Kara
The price is ¥16,537
¥18,438 total
includes taxes & fees
Aug 9 - Aug 10
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

3. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very Good, (1,286 reviews)
"Clean room, helpful staff an good breakfast"
United States
ALICIA
The price is ¥11,789
¥13,144 total
includes taxes & fees
Aug 12 - Aug 13
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

4. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Spacious accommodation, comfortable beds, great staff, great location close to both Fort Myers and Sanibel, and good breakfast. We truly enjoyed our stay and will probably stay there again."
United States
Catherine
The price is ¥14,736
¥16,430 total
includes taxes & fees
Aug 10 - Aug 11
Residence Inn by Marriott Fort Myers Sanibel

5. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,002 reviews)
"My stay was great! Staff are awesome. Rooms are very clean."
United States
Amanda
The price is ¥7,946
¥8,860 total
includes taxes & fees
Aug 11 - Aug 12
Candlewood Suites Fort Myers Sanibel Gateway by IHG

6. Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,007 reviews)
"Hotel was fine. Needs remodeling"
United States
Brian
The price is ¥11,788
¥13,144 total
includes taxes & fees
Jul 31 - Aug 1
Allure Suites

7. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
6.0 out of 10, (1,004 reviews)
"It was a good hotel for the price. It did its job for the night. Great for fun loving people"
United States
Chrystal
The price is ¥8,779
¥9,789 total
includes taxes & fees
Jul 31 - Aug 1
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

8. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.8 out of 10, Excellent, (1,020 reviews)
"The friendliness of the staff and breakfast was great."
United States
Daveanand
The price is ¥13,292
¥14,821 total
includes taxes & fees
Aug 12 - Aug 13
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

9. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,007 reviews)
"My husband and I stayed three nights and were thrilled with the clean modern room, incredible view of the ocean, and well manicured property. We would definitely stay again."
United States
Amy
The price is ¥41,600
¥56,791 total
includes taxes & fees
Aug 19 - Aug 20
Sanibel Inn

10. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (897 reviews)
"We had a pleasant stay, clean room, friendly staff, breakfast was good, all day coffee, free parking."
United States
Melissa
The price is ¥12,967
¥14,459 total
includes taxes & fees
Aug 10 - Aug 11
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

11. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very Good, (1,005 reviews)
"Our family loved our stay! It was so close to all the wonderful aspects of Captiva and we could walk with our younger children to everything. We will definitely be making this a regular vacation spot!"
United States
Erin
The price is ¥41,113
¥65,946 total
includes taxes & fees
Aug 11 - Aug 12
South Seas

12. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,008 reviews)
"Staff was extremely helpful and kind!"
United States
Lori
The price is ¥13,906
¥15,505 total
includes taxes & fees
Aug 11 - Aug 12
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

13. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,141 reviews)
"Beautiful place would recommend to anyone to stay here. The room was so clean a very nice kitchen as well and the view of the beach was outstanding. We enjoyed the balcony to just relax from the heat and enjoy our lunch or dinner. We could just walk out and there was the beach this was just what we wanted. Great place will go back!!!"
United States
Valerie
The price is ¥42,406
¥47,282 total
includes taxes & fees
Aug 12 - Aug 13
Island Inn

14. Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,012 reviews)
"Good place to stay at a good price very clean great stuff"
United States
carl
The price is ¥15,977
¥17,815 total
includes taxes & fees
Aug 16 - Aug 17
Hilton Garden Inn Ft Myers

15. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (72 reviews)
"Beautiful place! Would definitely stay again."
United States
Vickie
The price is ¥36,655
¥40,870 total
includes taxes & fees
Aug 25 - Aug 26
Shalimar Beach Resort

16. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,676 reviews)
"Excellent stay and amenities for families. "
United States
Megan
The price is ¥65,328
¥81,787 total
includes taxes & fees
Jul 31 - Aug 1
Sundial Beach Resort & Spa

17. Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,181 reviews)
"Always a great place to stay."
United States
heather
The price is ¥15,977
¥17,815 total
includes taxes & fees
Aug 15 - Aug 16
Doubletree by Hilton Fort Myers at Bell Tower Shops

18. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,000 reviews)
"Great hotel"
United States
Cynthia
The price is ¥14,900
¥16,614 total
includes taxes & fees
Aug 19 - Aug 20
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

19. Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,014 reviews)
"Great hotel and great location"
United States
Fathi
The price is ¥16,782
¥18,712 total
includes taxes & fees
Aug 8 - Aug 9
Homewood Suites by Hilton - Fort Myers

20. Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (1,005 reviews)
"Great place to stay and the staff was very helpful"
United States
Gregory John
The price is ¥26,377
¥30,296 total
includes taxes & fees
Jul 29 - Jul 30
Kona Kai Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travelers are sure to enjoy a stay in Sanibel's Sanctuary neighborhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels are there in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodations in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review top deals in Sanctuary.
Where can I learn more about changing or cancelling my trip to Sanctuary?
For more information about updating your trip to Sanctuary or cancelling it, click here.
What is there to do around this Sanibel neighborhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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