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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

1. Depot Inn and Suites

La Plata

Kimberly

￥15,069 total

includes taxes & fees

Dec 6 - Dec 7

A bathroom with a large bathtub, a chair, and a small shelf with plants.

2. Pinemark Inn & Suites

St. Clair

Michael

￥22,391 total

includes taxes & fees

Nov 10 - Nov 11

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

3. Best Western On The River

Hannibal

Rob

￥18,461 total

includes taxes & fees

Nov 9 - Nov 10

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

4. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

￥19,936 total

includes taxes & fees

Dec 6 - Dec 7

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

5. Sleep Inn & Suites Hannibal West

Hannibal

Sarah

￥20,219 total

includes taxes & fees

Dec 6 - Dec 7

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

6. Super 8 by Wyndham Kirksville-University Area

Kirksville

Maria Modesta

￥11,571 total

includes taxes & fees

Nov 22 - Nov 23

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

7. Comfort Inn Sullivan

Sullivan

Wayne

￥19,671 total

includes taxes & fees

Nov 29 - Nov 30

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

8. Best Western Plus Washington Hotel

Washington

Carl

￥24,178 total

includes taxes & fees

Nov 9 - Nov 10

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

9. Super 8 by Wyndham Washington

Washington

Gary

￥14,451 total

includes taxes & fees

Nov 17 - Nov 18

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

10. Quality Inn & Suites Hannibal West

Hannibal

Gayle

￥13,378 total

includes taxes & fees

Dec 6 - Dec 7

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

11. Travelier Motel

Macon

Dovey

￥10,306 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

12. Oak Hill Inn & Suites

Canton

Peter

￥16,290 total

includes taxes & fees

Dec 9 - Dec 10

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

13. Hampton Inn By Hilton Warrenton I-70

Warrenton

Richard

￥25,215 total

includes taxes & fees

Dec 9 - Dec 10

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

14. La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

Edward

￥16,909 total

includes taxes & fees

Nov 9 - Nov 10

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

15. Drury Inn & Suites St. Louis Arnold

Arnold

Kristine

￥23,083 total

includes taxes & fees

Nov 12 - Nov 13

A hotel room with two beds, a desk, and a window with a view of trees.

16. Best Western Plus Fenton

Fenton

Brian

￥16,957 total

includes taxes & fees

Nov 9 - Nov 10

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

17. The Wildwood Hotel

Wildwood

Lori

￥14,770 total

includes taxes & fees

Dec 8 - Dec 9

A hotel room with a bed, a lamp, a mirror, and a door.

18. Town & Country Inn and Suites

Quincy

Kelly

￥22,596 total

includes taxes & fees

Nov 9 - Nov 10

A spacious lobby with a checkered floor, a large framed welcome sign, a ceiling fan, and a bar area.

19. Super 8 by Wyndham Union

Union

William

￥13,866 total

includes taxes & fees

Nov 17 - Nov 18

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

20. Hyatt Place St. Louis/Chesterfield

Chesterfield

Karin

￥23,823 total

includes taxes & fees

Nov 11 - Nov 12

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Vacation Rentals in Northeast Missouri

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Vacation Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Cottage

A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

Apartment

A sauna room with wooden benches and frosted glass windows.

Augusta Studio at Halcyon Spa Bed & Breakfast

Augusta

"Everything was great with this place"

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Sonesta ES Suites St. Louis - Chesterfield

10/10 Excellent

"A few families all stayed here this weekend. We will absolutely stay again. My only suggestion is to check the dishwasher when you het in the room. All the dishes were in there and we thought we didn't have anything to cook with. Luckily for us I brought our own things since we stay at places like this all the time. The other families and I all laughed about it. They also thought the same thing."