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Our top choices for Central Iowa hotels

A modern hotel with a stone facade, labeled "Springhill Suites by Marriott," featuring a covered entrance and multiple windows.

1. SpringHill Suites by Marriott Ames

Ames

Tasha

￥16,444 total

includes taxes & fees

Nov 15 - Nov 16

A lobby with a fireplace, seating area, and a reception desk.

2. Comfort Inn and Suites Ames near ISU Campus

Ames

David

￥14,936 total

includes taxes & fees

Nov 22 - Nov 23

An indoor swimming pool with a hot tub, tiled flooring, and seating area with chairs and potted plants.

3. Gateway Hotel and Conference Center at Iowa State University

Ames

Kristin

￥15,265 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with a large bathtub, a sofa, a desk with a television, and a window with curtains.

4. Comfort Inn Story City

Story City

Tim

￥14,893 total

includes taxes & fees

Nov 24 - Nov 25

A spacious living area with a wooden dining table, comfortable seating, a brick fireplace, and a staircase leading to an upper level.

5. Best Western Plus University Park Inn & Suites

Ames

William

￥13,112 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a brown sofa, armchairs, and a coffee table.

6. Sleep Inn & Suites Ames near ISU Campus

Ames

Kristina

￥14,290 total

includes taxes & fees

Nov 16 - Nov 17

7. Microtel Inn & Suites by Wyndham Ames

Ames

Kathleen

￥11,733 total

includes taxes & fees

Nov 26 - Nov 27

A modern bar area with a long counter, multiple bar stools, and hanging pendant lights.

8. Hampton Inn & Suites Altoona-Des Moines

Altoona

Kim

￥16,693 total

includes taxes & fees

Dec 9 - Dec 10

A modern dining area with a kitchen in the background, a flat-screen TV displaying "Free Wi-Fi All Rooms", and a ceiling fan.

9. Sonesta Essential Ames

Ames

Bertis

￥11,132 total

includes taxes & fees

Nov 16 - Nov 17

A Holiday Inn Express & Suites hotel with a covered entrance and a brick facade.

10. Holiday Inn Express Hotel & Suites Altoona-Des Moines by IHG

Altoona

rick

￥16,508 total

includes taxes & fees

Dec 8 - Dec 9

A La Quinta hotel with a modern design, featuring a prominent sign, a covered entrance, and a brick facade.

11. La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

Ankeny

Paula

￥14,657 total

includes taxes & fees

Dec 6 - Dec 7

An indoor swimming pool with tiled walls, wooden ceiling beams, and lounge chairs.

12. Best Western Holiday Manor

Newton

Jennifer

￥16,544 total

includes taxes & fees

Nov 11 - Nov 12

An outdoor seating area with a circular fire pit surrounded by square stools.

13. Cobblestone Inn & Suites - Boone

Boone

William

￥17,520 total

includes taxes & fees

Nov 11 - Nov 12

An outdoor patio area with wooden beams and string lights, furnished with chairs and tables, and a stone wall backdrop.

14. Best Western Premier Des Moines-Ankeny Hotel

Ankeny

Jessica

￥14,177 total

includes taxes & fees

Dec 6 - Dec 7

A spacious indoor area with a long wooden table, several chairs, a fireplace, and a view through large windows.

15. La Quinta Inn & Suites by Wyndham Johnston

Johnston

Rosalee

￥15,770 total

includes taxes & fees

Nov 11 - Nov 12

A modern building with a prominent entrance, large windows, and a well-lit facade.

16. AmericInn by Wyndham Osceola

Osceola

William

￥17,751 total

includes taxes & fees

Dec 6 - Dec 7

A Sleep Inn & Suites building with a stone facade, multiple windows, and a clear sky.

17. Sleep Inn & Suites Ankeny - Des Moines

Ankeny

Karen

￥15,729 total

includes taxes & fees

Nov 24 - Nov 25

An outdoor patio with a round table and chairs, a view of a lake, and a grassy area with trees.

18. Country Inn & Suites by Radisson, Ankeny - Des Moines

Ankeny

Gayle

￥16,396 total

includes taxes & fees

Nov 15 - Nov 16

A hotel reception area with a counter, coffee machine, and various amenities.

19. Comfort Inn Altoona-Des Moines

Altoona

Luis

￥13,759 total

includes taxes & fees

Dec 6 - Dec 7

A swimming pool with four lounge chairs and a view of trees through large windows.

20. Holiday Inn Express Des Moines Ankeny by IHG

Ankeny

Kristi

￥14,335 total

includes taxes & fees

Dec 11 - Dec 12

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Vacation Rentals in Central Iowa

Aparthotel

A modern kitchen with a central island, bar stools, stainless steel appliances, and pendant lighting.

Kasa Downtown Des Moines

Downtown Des Moines

"Cute little area, close to downtown. Parking is close - do not risk parking on the road!"

Vacation Home

A backyard with a swimming pool, lounge chairs, a fire pit, and a covered patio area.

The Palms Mirage House 3 Bedroom Home

Southwestern Hills

"The house is lovely for a weekend of meditation or connecting with nature, but I wouldn't recommend it for very outgoing families, as the local community is very sensitive about music. I actually felt stressed by the surrounding environment; in my view, renting a house implies having more freedom to have fun, but that wasn't the case here. Next time, I’d choose a hotel instead—I’d have a better time and save money, too."

Cottage

A compact, multi-level living space with a loft bedroom, kitchen, and seating area.

Quaint Montezuma Cabin Near Lake Ponderosa!

Montezuma

"Great stay. Nice roomy place to stay. Stayed nice and cool during hot summer. Had a small issue and Kelly fixed it right away. Definitely will stay here again. "

Cottage

Family-friendly Des Moines Retreat w/ Patio!

Drake

See all vacation rentals

Hotels recommended for families in Central Iowa

Comfort Inn and Suites Ames near ISU Campus

Ames

￥14,936 total

includes taxes & fees

Nov 22 - Nov 23

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Stay near popular Central Iowa attractions

A colorful salad with various vegetables and cheese.

Jordan Creek Town Center

9.2/10 (1,624 reviews)

You can enjoy retail therapy at Jordan Creek Town Center during your visit to West Des Moines. Experience the area's acclaimed theater scene or attend a sporting event.

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Learn more about Central Iowa

Delve into rural America in the heart of Iowa, where rolling farmland, the state capital and a wealth of cultural attractions await.

See all hotels in Central Iowa

A grand building with a large dome and two smaller domes, surrounded by lush greenery and tall grass.

Top Central Iowa Hotel Reviews

La Quinta Inn & Suites by Wyndham Johnston

10/10 Excellent

"Very clean room and friendly staff."

Best Western Plus University Park Inn & Suites

10/10 Excellent

"The king bed suite with a sittings room and bedroom is very comfortable and we were glad to have a combination tub and shower as well as a mini-refrigerator, coffee maker, and microwave. Other niceties include hooks on the bathroom door inside and long mirrors in the room. There also is very adequate lighting and electrical outlets. The espresso machine was very welcome. (Breakfast could have been better if oatmeal was served and not some kind of gravy.) We especially appreciated the helpful front desk when we needed to revise our stay."