Photo by Ryan Watts
Find 4 Star Hotels in Upstate South Carolina, SC from ￥18,083
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Upstate South Carolina 4 Star Hotels
Our top choices for Upstate South Carolina 4-star hotels
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph CollectionGreenville Downtown
9.6 out of 10, Exceptional, (424)
"Absolutely one of the best hotels to stay at. "
stephen
The price is ￥49,163
￥55,554 total
includes taxes & fees
Jan 18 - Jan 19, 2026
9.2 out of 10, Wonderful, (1004)
"Great historic hotel. Great location and awesome staff."
John
The price is ￥28,026
￥30,829 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.8 out of 10, Exceptional, (745)
"Staff was amazing and our room was clean and comfortable. "
Amanda R
The price is ￥26,195
￥29,077 total
includes taxes & fees
Dec 30 - Dec 31
9.8 out of 10, Exceptional, (633)
"The hotel was clean staff was amazing room was outstanding."
Clifford
The price is ￥23,695
￥31,351 total
includes taxes & fees
Dec 30 - Dec 31
8.6 out of 10, Excellent, (612)
"Bed was SO comfortable, I slept all through the night!!! Staff incredible especially the girls at breakfast and Adam at the bar. "
LYNNE
The price is ￥16,440
￥18,083 total
includes taxes & fees
Jan 9 - Jan 10, 2026
9.2 out of 10, Wonderful, (782)
"Spotless wonderful stay"
Tanganica
9.6 out of 10, Exceptional, (558)
"location is amazing! "
colleen
7.6 out of 10, Good, (44)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike.
"
Kathie
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.
Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
Grand Bohemian Lodge Greenville, Autograph Collection
10/10 Excellent
Explore a world of travel with Expedia
- Inns in Clemson
- Villas in Iva
- Rv Parks in York
- Cabin Rentals in Welcome
- Apartments in Welcome
- Rv Parks in Liberty
- Berea Hotels
- B&B in Seneca
- Farmstay in Fountain Inn
- Villas in Sunset
- Union Hotels
- Resorts & Hotels with Spas in Upstate South Carolina
- Aparthotels in Lando
- Hotels near Clemson University
- Cheap Hotels in Simpsonville
- Luxury Hotels in Sandy Springs
- B&B in Lowndesville
- Mauldin Hotels
- Guest Houses in Fountain Inn
- Hotels with WiFi in Spartanburg
- Duncan Hotels
- B&B in Blacksburg
- B&B in Carlisle
- Hotels with Hot Tubs in Cleveland
- Resorts in Travelers Rest
- Luxury Hotels in Simpsonville
- Greenville Hotels
- Clemson Hotels
- Hotels near Falls Park on the Reedy
- Waterpark Hotels in Greenville
- All-Inclusive Hotel Hotels in Greenville Downtown
- Laurens Hotels
- Spartanburg Hotels
- Fountain Inn Hotels
- Cheap Hotels in Blackstock
- Apartments in Duncan
- Clover Hotels
- Rv Parks in Upstate South Carolina
- Resorts in Clemson
- Cheap Hotels in Greenville
- Hotels near Greenville-Spartanburg Intl.
- Aparthotels in Clemson
- Hotels with Early Check-in in Spartanburg
- Cheap Hotels in Greenville Downtown
- Aparthotels in Welcome
- Aparthotels in Clover
- Luxury Hotels in Greenville Downtown
- Rv Parks in Pendleton
- Historic Hotels in Anderson
- Sandy Springs Hotels
- Hotel with a Concierge Hotels in Greenville Downtown
- Sans Souci Hotels
- B&B in Greenville - Spartanburg
- Resorts in Newport
- Inns in Easley
- B&B in Belton
- B&B in Welcome
- Hostels in Greer
- Greer Hotels
- Hotel with a Concierge Hotels in Greenville - Spartanburg
- Anderson Hotels
- Cheap Hotels in Spartanburg County
- Hotels near Spartanburg Memorial Auditorium
- Beach Hotels in Sunset
- Hostels in York
- Pomaria Hotels
- Aparthotels in Sunset
- Travelers Rest Hotels
- Hotels near Fred W. Symmes Chapel
- Hotels near Bob Jones University
- Greenville Downtown Hotels
- Aparthotels in Sans Souci
- Golden Grove Hotels
- Hotels near Greenville Downtown
- Rv Parks in Spartanburg County
- B&B in Sunset
- Hotels near Rock Hill-York County
- All-Inclusive Hotel Hotels in Greenville
- Hotels near Greenville Station
- Inns in Woodruff
- Hotels near Lake Jocassee
- Rv Parks in Prosperity
- Resorts in Sunset
- Spartanburg County Hotels
- Guest Houses in Gantt
- Cheap Hotels in Carlisle
- Aparthotels in Central
- Adults Only Resorts & in Seneca
- Hotels near Donaldson Center
- Ski Hotels in Upstate South Carolina
- Hostels in Greenwood
- Rv Parks in Greenville County