A bench, a bicycle, and a lake surrounded by trees.

Find 4 Star Hotels in Upstate South Carolina, SC from ￥21,250

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Sep 9 - Sep 10
Tomorrow
Sep 10 - Sep 11
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Upstate South Carolina 4-star hotels

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A bar with multiple shelves of liquor bottles and glasses hanging above.

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
￥23,393
￥31,578 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Hartness
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
￥53,802
￥60,958 total
includes taxes & fees
Oct 4 - Oct 5
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
￥32,127
￥36,860 total
includes taxes & fees
Sep 20 - Sep 21
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Channell
￥19,916
￥22,565 total
includes taxes & fees
Sep 14 - Sep 15
Mint House Greenville Downtown by Kasa
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
richard
￥18,754
￥21,250 total
includes taxes & fees
Sep 17 - Sep 18
Greenville Marriott
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
￥36,739
￥40,780 total
includes taxes & fees
Sep 27 - Sep 28
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
￥24,337
￥27,014 total
includes taxes & fees
Sep 14 - Sep 15
The Abernathy of Clemson
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A row of modern, two-story buildings with a covered patio area.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
￥32,516
￥48,485 total
includes taxes & fees
Sep 15 - Sep 16
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A swimming pool with lounge chairs and a building with balconies.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
￥64,409
￥70,850 total
includes taxes & fees
Sep 13 - Sep 14
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.

11. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A cozy living room with a fireplace, leather armchair, and a large window.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
A spacious living room with a grey sofa, a wooden coffee table, and a blue rug. There is a dining area with a wooden table and chairs.
A wooden deck with a table and chairs, surrounded by trees.
A living room with a gray sofa, a wooden coffee table with decorative items, a television on a wooden stand, and a dining area with a wooden table and chairs.

13. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A multi-story building with a symmetrical facade, large windows, and two flags on top.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A modern kitchen with a central island, stainless steel appliances, and pendant lighting.
A two-story house with a front porch, a garage, and a small front yard with landscaping.
A covered patio area with outdoor seating, large windows, and a white exterior.
A modern kitchen with white cabinets, a stainless steel refrigerator, and pendant lighting.

15. Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
Greenwood
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A multi-story hotel with a parking lot and a view of a lake.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A marina with boats docked, surrounded by greenery and trees.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A sandy beach with a calm lake surrounded by trees.
A multi-story hotel with a parking lot and a view of a lake.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A marina with boats docked, surrounded by greenery and trees.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A swimming pool with a view of a lake and docked boats.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A sandy beach with a calm lake surrounded by trees.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
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Learn more about Upstate South Carolina

Venture to sights like Heritage Park and CCNB Amphitheatre as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

10/10 Excellent
"Felt like our own little apartment! It was clean and loved the safety features"
Hannah 2-night trip
Posted 16 hours ago
Mint House Greenville Downtown by Kasa
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Absolutely perfect in every way!"
Heather 1-night trip
Posted 2 days ago
The Shepherd Hotel Downtown Clemson

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