A bench, a bicycle, and a lake surrounded by trees.

Find 4 Star Hotels in Upstate South Carolina, SC from ¥21,250

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
Sep 9 - Sep 10
Tomorrow
Sep 10 - Sep 11
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Upstate South Carolina 4-star hotels

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
¥23,393
¥31,578 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Hartness

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
¥53,802
¥60,958 total
includes taxes & fees
Oct 4 - Oct 5
Grand Bohemian Lodge Greenville, Autograph Collection

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
¥32,127
¥36,860 total
includes taxes & fees
Sep 20 - Sep 21
The Westin Poinsett Greenville

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Channell
¥19,916
¥22,565 total
includes taxes & fees
Sep 14 - Sep 15
Mint House Greenville Downtown by Kasa

5. Greenville Marriott

Greenville Marriott
Greenville
United States
richard
¥18,754
¥21,250 total
includes taxes & fees
Sep 17 - Sep 18
Greenville Marriott

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
¥36,739
¥40,780 total
includes taxes & fees
Sep 27 - Sep 28
The Shepherd Hotel Downtown Clemson

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
¥24,337
¥27,014 total
includes taxes & fees
Sep 14 - Sep 15
The Abernathy of Clemson

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
¥32,516
¥48,485 total
includes taxes & fees
Sep 15 - Sep 16
The Station by Compo Hotels

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
¥64,409
¥70,850 total
includes taxes & fees
Sep 13 - Sep 14
Hotel Domestique

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC

15. Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
Greenwood
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
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Learn more about Upstate South Carolina

Venture to sights like Heritage Park and CCNB Amphitheatre as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

10/10 Excellent
"Felt like our own little apartment! It was clean and loved the safety features"
Hannah 2-night trip
Posted 16 hours ago
Mint House Greenville Downtown by Kasa
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Absolutely perfect in every way!"
Heather 1-night trip
Posted 2 days ago
The Shepherd Hotel Downtown Clemson

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