Photo by Ryan Watts

Find 4 Star Hotels in Upstate South Carolina, SC from ¥18,083

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

This weekend
Next weekend

Our top choices for Upstate South Carolina 4-star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (424)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is ¥49,163
¥55,554 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Grand Bohemian Lodge Greenville, Autograph Collection

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1004)
"Great historic hotel. Great location and awesome staff."
United States
John
The price is ¥28,026
¥30,829 total
includes taxes & fees
Jan 11 - Jan 12, 2026
The Westin Poinsett Greenville

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (745)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is ¥26,195
¥29,077 total
includes taxes & fees
Dec 30 - Dec 31
The Shepherd Hotel Downtown Clemson

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (633)
"The hotel was clean staff was amazing room was outstanding."
United States
Clifford
The price is ¥23,695
¥31,351 total
includes taxes & fees
Dec 30 - Dec 31
Hotel Hartness

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (612)
"Bed was SO comfortable, I slept all through the night!!! Staff incredible especially the girls at breakfast and Adam at the bar. "
United States
LYNNE
The price is ¥16,440
¥18,083 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Greenville Marriott

Mint House Greenville - Downtown

Mint House Greenville - Downtown
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (782)
"Spotless wonderful stay"
United States
Tanganica
Mint House Greenville - Downtown

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (558)
"location is amazing! "
United States
colleen
The Abernathy of Clemson

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (44)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (15)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is ¥24,676
¥40,061 total
includes taxes & fees
Jan 29 - Jan 30, 2026
The Station by Compo Hotels

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is ¥43,057
¥47,363 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Domestique

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is ¥17,528
¥27,285 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Liberty Hall Bed and Breakfast
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

It is only a 1 mile hike to this beauty.  View a video about it here:  https://www.hdcarolina.com/episode/riley-moore-falls

#Waterfall
Photo by Ryan Watts
Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Explore a world of travel with Expedia