Photo by Rachel Evan
Find hotels in Upstate South Carolina, SC from ¥10,878
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Check prices for these dates
Our top choices for Upstate South Carolina hotels

Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (709)
The price is ¥17,223
¥19,118 total
includes taxes & fees
Jan 4 - Jan 5, 2026

Holiday Inn Express & Suites Greenwood Mall by IHG
Holiday Inn Express & Suites Greenwood Mall by IHGGreenwood
9.0 out of 10, Wonderful, (479)
The price is ¥23,527
¥26,115 total
includes taxes & fees
Dec 19 - Dec 20
The price is ¥21,464
¥23,824 total
includes taxes & fees
Jan 1 - Jan 2, 2026

7.4 out of 10, Good, (517)
The price is ¥8,814
¥10,397 total
includes taxes & fees
Jan 2 - Jan 3, 2026

8.4 out of 10, Very Good, (642)
The price is ¥13,906
¥15,295 total
includes taxes & fees
Dec 21 - Dec 22

8.2 out of 10, Very Good, (301)
The price is ¥12,309
¥13,541 total
includes taxes & fees
Dec 15 - Dec 16
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Upstate South Carolina, SC
Showing deals for:Dec 26 - Dec 28
Image gallery for Lake Retreat House

Lake Retreat House
Anderson
10/10Exceptional (20 reviews)
10% off
Price is ¥49,080
¥210,133 total
includes taxes & fees
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southeastern United States attractions
Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews

Drury Inn & Suites Greenville
10/10 Excellent
More cheap stays in Upstate South Carolina

Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
The price is ¥9,800 per night from Dec 17 to Dec 18
¥9,800
¥10,878 total
Dec 17 - Dec 18
includes taxes & fees
7.6/10 Good! (1,004 reviews)
Hotels in Upstate South Carolina with star-rating

4 Star Hotels
11 properties
Explore a world of travel with Expedia
Hotels in Upstate South Carolina Neighborhoods
- Hotels in Greenville Downtown
- Hotels in West End
- Hotels in Green Avenue
- Hotels in Pettigru Street Historic District
- Hotels in Hampton-Pinckney Historic District
- Hotels in Colonel Elias Earle Historic District
- Hotels in Woodside Cotton Mill Village Historic District
- Hotels in Serenity Bay
- Hotels in Pine Ridge Point
- Hotels in Spartanburg Historic District
- Hotels in Indian Oaks
Stay near popular Upstate South Carolina attractions
More Accommodation Types in Upstate South Carolina
- Vacation Homes in Upstate South Carolina
- Cottages in Upstate South Carolina
- Apartments in Upstate South Carolina
- Cabin Rentals in Upstate South Carolina
- Condo Rentals in Upstate South Carolina
- Motels in Upstate South Carolina
- Farmstay in Upstate South Carolina
- RV Parks in Upstate South Carolina
- B&B in Upstate South Carolina
- Villas in Upstate South Carolina
- Aparthotels in Upstate South Carolina
- Guest Houses in Upstate South Carolina
- Lodges in Upstate South Carolina
- Chalets in Upstate South Carolina
- Houseboats in Upstate South Carolina
- Resorts in Upstate South Carolina
Hotels near Upstate South Carolina Airports
Upstate South Carolina Hotels by Brand
Other Hotels near Upstate South Carolina, South Carolina
- Greenville Hotels
- Highlands Hotels
- North Georgia Mountains Hotels
- Clemson Hotels
- North Carolina Mountains Hotels
- Hendersonville Hotels
- Blue Ridge Mountains Hotels
- Black Mountain Hotels
- Spartanburg Hotels
- Rock Hill Hotels
- Brevard Hotels
- Anderson Hotels
- Hiawassee Hotels
- Cashiers Hotels
- Franklin Hotels
- Lake Lure Hotels
- Tiger Hotels
- Sautee Nacoochee Hotels
- Cleveland Hotels
- Gastonia Hotels
Explore more hotels
More ways to book
Expedia's Latest Trends
General
- Visit Oahu
- Visit Catalina Island
- Visit Long Island
- Visit Florida Panhandle
- Visit Nantucket Island
- Visit Aleutian Islands
- Visit Northern Arkansas
- Visit Upstate New York
- Visit Greenville - Spartanburg
- Visit Whidbey Island
- Visit Bay Area
- Visit Cape Cod
- Visit Glen Canyon National Recreation Area
- Visit Napa Valley
- Visit Cape May - Wildwood





















































































































