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Find hotels in Upstate South Carolina, SC from ￥10,878

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Our top choices for Upstate South Carolina hotels

Property entrance
Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel
3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (709)
"It was a very clean and beautiful lace to stay. We were there for our honeymoon "
United States
Tracy
The price is ￥17,223
￥19,118 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Inn on the Square, an Ascend Collection Hotel
Free daily buffet breakfast
Holiday Inn Express & Suites Greenwood Mall by IHG

Holiday Inn Express & Suites Greenwood Mall by IHG

Holiday Inn Express & Suites Greenwood Mall by IHG
2.5 star property
Greenwood
9.0 out of 10, Wonderful, (479)
"Clean , new property. Located right behind the mall."
United States
judith b
The price is ￥23,527
￥26,115 total
includes taxes & fees
Dec 19 - Dec 20
Holiday Inn Express & Suites Greenwood Mall by IHG
Two queen beds nonsmoking | In-room safe, desk, blackout drapes, iron/ironing board
Hampton Inn Easley

Hampton Inn Easley

Hampton Inn Easley
2.5 star property
Easley
9.4 out of 10, Exceptional, (680)
"Friendly staff, very comfortable room, excellent hot breakfast."
United States
Thomas
The price is ￥21,464
￥23,824 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn Easley
Lobby
Quality Inn Clinton - Laurens I-26

Quality Inn Clinton - Laurens I-26

Quality Inn Clinton - Laurens I-26
2.5 star property
Clinton
7.4 out of 10, Good, (517)
"Very friendly staff and places to eat close by! "
United States
Burit
The price is ￥8,814
￥10,397 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Quality Inn Clinton - Laurens I-26
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (642)
"The stay was amazing "
United States
Tabatha
The price is ￥13,906
￥15,295 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Seneca-Clemson
Exterior
Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport
2.5 star property
Greenville
8.2 out of 10, Very Good, (301)
"Clean room, friendly staff, I would definitely stay here again!"
United States
Melissa
The price is ￥12,309
￥13,541 total
includes taxes & fees
Dec 15 - Dec 16
Woodspring Suites Greenville Airport
Lobby
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (792)
"Michail was the best. He was so welcoming, helpful and professional. Parking was easy and rooms were nice and clean. I will definitely stay again. "
United States
Jakeria
The price is ￥14,833
￥16,316 total
includes taxes & fees
Dec 21 - Dec 22
Tru by Hilton Seneca Clemson
Outdoor pool
Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC
2.5 star property
Greer
9.6 out of 10, Exceptional, (413)
"Nice hotel, convenient location with helpful staff."
United States
Mike
The price is ￥21,658
￥23,607 total
includes taxes & fees
Dec 18 - Dec 19
Hampton Inn Greer Greenville, SC
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1001)
"Great place to stay. "
United States
Gene
The price is ￥16,983
￥21,082 total
includes taxes & fees
Dec 15 - Dec 16
Lakeside Lodge Clemson
Reception hall
The Inn at Patrick Square

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (781)
"Clean room. Nice front desk concierge. Very cute hotel"
United States
Anisha
The price is ￥23,216
￥25,771 total
includes taxes & fees
Dec 15 - Dec 16
The Inn at Patrick Square
Exterior
Home2 Suites by Hilton Duncan

Home2 Suites by Hilton Duncan

Home2 Suites by Hilton Duncan
3.0 star property
Duncan
9.4 out of 10, Exceptional, (283)
"The lady that greeted us was excellent and exceptional "
United States
Manuel
The price is ￥16,703
￥18,540 total
includes taxes & fees
Dec 25 - Dec 26
Home2 Suites by Hilton Duncan
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Exterior
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (662)
"Great place to stay"
United States
Jose
The price is ￥15,830
￥17,411 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Seneca-Clemson Area
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (665)
"Friendly check in, clean room."
United States
connie
The price is ￥11,451
￥13,526 total
includes taxes & fees
Dec 21 - Dec 22
Quality Inn Seneca Clemson Area US-123
Coffee shop
Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg
3.0 star property
Spartanburg
9.4 out of 10, Exceptional, (434)
"The room was very nice and the staff was very professional "
United States
John T
The price is ￥18,541
￥20,582 total
includes taxes & fees
Dec 21 - Dec 22
Four Points by Sheraton Spartanburg
View from property
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.6 out of 10, Exceptional, (960)
"Great place to stay!"
United States
Mindi
The price is ￥23,216
￥25,770 total
includes taxes & fees
Dec 15 - Dec 16
Clemson University's James F. Martin Inn
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Greenville Airport

Comfort Suites Greenville Airport

Comfort Suites Greenville Airport
2.5 star property
Greenville
9.4 out of 10, Exceptional, (1000)
"Clean room and very friendly front desk staff"
United States
Lakisha
The price is ￥15,354
￥17,350 total
includes taxes & fees
Dec 27 - Dec 28
Comfort Suites Greenville Airport
Terrace/patio
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1007)
"The breakfast was great. It was a great stay"
United States
Terry
The price is ￥14,334
￥15,769 total
includes taxes & fees
Dec 21 - Dec 22
Embassy Suites Greenville Golf Resort & Conference Center
Lobby
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.2 out of 10, Very Good, (1001)
"Great stay "
United States
Linda
The price is ￥14,436
￥16,024 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites Clemson - University Area
Gazebo
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
3.0 star property
Greenville
8.4 out of 10, Very Good, (70)
"Love this new hotel. Safe good breakfast and friendly staff "
United States
Dorothea
The price is ￥12,789
￥14,490 total
includes taxes & fees
Dec 16 - Dec 17
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Dec 26 - Dec 28

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Lake Retreat House

Anderson
10/10Exceptional (20 reviews)
10% off
Price is ￥49,080
￥210,133 total
includes taxes & fees
Lake Retreat House
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Stay near popular Southeastern United States attractions

"Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"

Clemson University

4.7/5 (738 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
See properties
Exploring Falls Park on the Reedy in Downtown Greenville, South Carolina during a peaceful afternoon stroll with scenic views

Falls Park on the Reedy

4.7/5 (1,399 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
See properties

Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina
It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall
Photo by Ryan Watts
Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Drury Inn & Suites Greenville

Drury Inn & Suites Greenville

10/10 Excellent
"Each room gets free breakfast, but also between 5:30pm- 7:00pm you also get 3 free alcohol drinks and food. The food we had was Chicken Alfredo, Salad, veggies, etc. The fountain drinks also were free to guest. I would definitely recommend this place."
Steven 1-night trip
Posted 22 hours ago
Drury Inn & Suites Greenville

More cheap stays in Upstate South Carolina

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ￥9,800 per night from Dec 17 to Dec 18
￥9,800
￥10,878 total
Dec 17 - Dec 18
includes taxes & fees
7.6/10 Good! (1,004 reviews)

Hotels in Upstate South Carolina with star-rating

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