Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

2 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

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Nicholtown

If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.

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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Overbrook Historic District

While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House.

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Hampton-Pinckney Historic District

Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center.

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A cityscape with a mix of modern and historic buildings, a large parking lot, and a highway.

West End

Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.

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Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
￥15,901
￥18,015 total
Sep 27 - Sep 28
includes taxes & fees
9/10 Wonderful! (1,386 reviews)
"Room was clean, staff was very nice"

Reviewed on Sep 14, 2026

Embassy Suites Greenville Golf Resort & Conference Center
Hilton Greenville

Hilton Greenville

45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
￥17,682
￥20,033 total
Sep 27 - Sep 28
includes taxes & fees
Hilton Greenville
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
￥12,494
￥14,155 total
Sep 21 - Sep 22
includes taxes & fees
8/10 Very Good! (1,008 reviews)
"Nice hotel for the price. Big rooms"

Reviewed on Sep 15, 2026

Hyatt Place Greenville/Haywood
See all 3,142 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
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A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Falls Park on the Reedy

9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.
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Greenville Convention Center

8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
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Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
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BMW Performance Center

9.0/10 (90 reviews)
You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.
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Haywood Mall

8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
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What to do in Upstate South Carolina

Spooky & Haunted Paranormal Bar Crawl Downtown Greenville

Greenville Haunted Bar Tour

￥4,483
per adult
100% of travellers recommend
Greenville Haunted Bar Tour
Gorgeous loop around Swan Lake at Furman University.

Guided E-Bike Tour in Greenville South Carolina with Brunch

￥16,800
per adult
Guided E-Bike Tour in Greenville South Carolina with Brunch
Saturday Evening Craft Cocktail Tour

Saturday Evening Craft Cocktail Tour

￥16,809
per adult
100% of travellers recommend
Saturday Evening Craft Cocktail Tour
See all activities in Upstate South Carolina

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
Our Upstate South Carolina vacation packages, which begin from just , are an awesome way to save loads of cash. Choose your preferred flights, hotels and rental cars to create your dream getaway.
How do I get a cheap travel package to Upstate South Carolina?
You'll save piles of cash if you bundle your hotels, flights and car rentals into a Upstate South Carolina vacation package. Sometimes cheap packages mean fewer options. But that's not the case with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of options to choose from. Eager to save even more? Add some fun activities to your package deal to unlock even bigger bargains! After all, travel is about more than simply getting to your destination.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the main things that attracts visitors to Upstate South Carolina, so it makes perfect sense that many choose to book their hotel in Greenville.
What are the top hotels in Upstate South Carolina?
Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall know how to make their guests feel at home in Greenville. If you also plan to explore Seneca, take a look at Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson. Both are very popular with travelers.
How far in advance should I book my Upstate South Carolina vacation?
It can be hard to know exactly when the best time is to book your Upstate South Carolina vacation. But typically the earlier you book, the more affordable the prices. Sometimes, you can lock in your flights and hotels up to 12 months prior to departure. If you're considering a last-minute getaway, no need to fret! There are plenty of fantastic bargains announced on Expedia every single day.
What does an Expedia Upstate South Carolina travel package include?
That depends on what sort of trip you have in mind. Upstate South Carolina vacation deals can include car rentals, flights and hotels. You can mix and match to find the travel package that suits your budget and style. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Upstate South Carolina travel package?
An Expedia travel package can be customized for your budget and is a fantastic way to make your budget go further. What you include is totally up to you. Rental cars, hotels and flights — decide on a combination that suits your style.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes, of course. Expedia has access to more than 550 airline partners globally, so go with the carrier that best fits your budget and travel needs.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
If your travel plans in Upstate South Carolina have been upended, it's comforting to know that you can cancel your booking. If you made your booking in the last 24 hours, you may be eligible for a refund. If your booking was made more than 24 hours ago, your airline, hotel or car rental company may impose fees. To learn more, check our Customer Service Portal.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.