San Luis Obispo Wine Country Luxury Vacations

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Top Luxury San Luis Obispo Wine Country Hotels

Madonna Inn

Madonna Inn

3.5 out of 5
100 Madonna Road, San Luis Obispo, CA
  • 6 min drive from California Polytechnic State University
Madonna Inn delivers luxe lodging where you'll enjoy pillowtop beds and more. Notable amenities include a spa, 2 outdoor tennis courts, and an outdoor pool.
9.2/10 Wonderful! (1,247 reviews)
"Loved it"

Reviewed on Sep 25, 2025

Madonna Inn
Avenue Inn Downtown San Luis Obispo

Avenue Inn Downtown San Luis Obispo

2.5 out of 5
345 Marsh St, San Luis Obispo, CA
  • 4 min drive from California Polytechnic State University
Be treated to luxurious accommodations at Avenue Inn Downtown San Luis Obispo, where you can enjoy amenities like premium channels, flat-screen TVs, and ...
9/10 Wonderful! (1,089 reviews)
"We always try and stay at the Avenue Inn when we travel to SLO. It’s always consistently clean, friendly staff, convenient to downtown, and a safe area!"

Reviewed on Sep 25, 2025

Avenue Inn Downtown San Luis Obispo
Avila La Fonda Hotel

Avila La Fonda Hotel

4 out of 5
101 San Miguel St, Avila Beach, CA
  • 22 min drive from California Polytechnic State University
Enjoy a posh stay at Avila La Fonda Hotel, where you'll find private hot tubs and pillowtop beds.
9.4/10 Exceptional! (1,002 reviews)
"Great staff and service"

Reviewed on Sep 17, 2025

Avila La Fonda Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.