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Top Luxury Southwest Coast Florida Hotels

Wyvern Hotel, an Ascend Collection Hotel

101 E Retta Esplanade Punta Gorda FL

1 hour drive from Siesta Key Beach

Stay in the lap of luxury at Wyvern Hotel, an Ascend Collection Hotel, where you can enjoy amenities like plush bedding, designer toiletries, and more. Deluxe ...

8.8/10 Excellent! (1,002 reviews)

The staff was very accommodating and the room was very comfortable and clean. Convenient location!

Reviewed on Mar 19, 2026

Naples Grande Beach Resort

475 Seagate Drive Naples FL

3 hours drive from Siesta Key Beach

Naples Grande Beach Resort is one of the Naples lavish 4.5-star beach properties where you can treat yourself to deep soaking bathtubs and massage services. ...

9/10 Wonderful! (2,035 reviews)

Loved our stay at Naples Grande, my wife loved it as well so much so she is already wanting to go back. Loads of privacy in the Villa didn't make it feel like a hotel. An awesome experience.

Reviewed on Mar 20, 2026

The Ritz-Carlton, Sarasota

1111 Ritz Carlton Dr Sarasota FL

12 min drive from Siesta Key Beach

The Ritz-Carlton, Sarasota is a Sarasota luxury 5-star beach property where you can treat yourself to pillowtop beds, designer toiletries, and more. The 2 outdoor ...

9.2/10 Wonderful! (1,000 reviews)

Classic Rittz, but could use a few updates so it doesn't start looking like a Marriott.

Reviewed on Mar 4, 2026

See all 46,881 properties in Southwest Coast Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.