South America Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury vacation packages in South America
Price found within the past 48 hours. Click for updated prices.
CasaSur Recoleta
Recoleta
￥306,906
per person
Oct 22 - Oct 24
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9/10 Wonderful! (664 reviews)
We had an excellent one night stay during a layover. The staff were all amazing and so helpful. We arranged for a couples massage in the spa, and enjoyed every minute and wished it would never end. We would stay here again for sure.
Reviewed on Sep 11, 2026
5* Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
3 Night Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
CasaSur Recoleta
Recoleta
￥306,906
per person
Oct 22 - Oct 24
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9/10 Wonderful! (664 reviews)
We had an excellent one night stay during a layover. The staff were all amazing and so helpful. We arranged for a couples massage in the spa, and enjoyed every minute and wished it would never end. We would stay here again for sure.
Reviewed on Sep 11, 2026
4 Night Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
Don't see what you're looking for?
See all available trips from Mexico City to South America
View all tripsTop Luxury South America Hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Rodovia Br 469 Km 32 Foz do Iguaçu PR
￥112,503
￥130,227 total
Sep 23 - Sep 24
includes taxes & fees
Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...
10/10 Exceptional! (1,000 reviews)
"Since this property is located right on the Falls, it is so incredible to have the opportunity to go out before the regular park visitors and see everything almost by yourself."
Reviewed on Sep 16, 2026
Hotel Club Frances
Rodríguez Peña 1832 Buenos Aires Capital Federal
￥34,717
￥35,185 total
Sep 19 - Sep 20
Hotel Club Frances is one of the Buenos Aires sumptuous 5-star boutique properties where you can pamper yourself with deep soaking bathtubs and massage services. ...
9.4/10 Exceptional! (678 reviews)
"N/A"
Reviewed on Sep 16, 2026
Palacio del Inka, A Luxury Collection Hotel by Marriott
Plazoleta Santo Domingo No 259 Cusco Cusco
￥49,017
￥60,386 total
Oct 12 - Oct 13
Go for a luxurious stay at Palacio del Inka, A Luxury Collection Hotel by Marriott, where you can enjoy amenities like Champagne service, pillowtop beds, and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
