South America Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury vacation packages in South America
Price found within the past 48 hours. Click for updated prices.
5* Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
Top Luxury South America Hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Rodovia Br 469 Km 32 Foz do Iguaçu PR
￥135,546
￥156,854 total
Oct 16 - Oct 17
includes taxes & fees
Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...
Hotel Club Frances
Rodríguez Peña 1832 Buenos Aires Capital Federal
￥32,296
￥32,771 total
Oct 16 - Oct 17
Hotel Club Frances is one of the Buenos Aires sumptuous 5-star boutique properties where you can pamper yourself with deep soaking bathtubs and massage services. ...
9.4/10 Exceptional! (683 reviews)
"Clean friendly like home away from home"
Reviewed on Oct 4, 2026
Palacio del Inka, A Luxury Collection Hotel by Marriott
Plazoleta Santo Domingo No 259 Cusco Cusco
￥49,654
￥61,170 total
Oct 30 - Oct 31
Go for a luxurious stay at Palacio del Inka, A Luxury Collection Hotel by Marriott, where you can enjoy amenities like Champagne service, pillowtop beds, and ...
9.6/10 Exceptional! (1,004 reviews)
"Absolutely exceptional hotel. Couldn't have wished for better."
Reviewed on Oct 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
