South America Luxury Vacations
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Top Luxury vacation packages in South America
Price found within the past 48 hours. Click for updated prices.
Regal Pacific Buenos Aires
El Centro
￥105,316
per person
Oct 19 - Oct 26
found 1 day ago
Roundtrip flight included
Santiago (SCL) to Buenos Aires (EZE)
8.8/10 Excellent! (1,000 reviews)
Deben de revisar todos los dispositivos electrónicos.
Y un mejor acompañamiento de las amenidades del hotel
Reviewed on Sep 6, 2026
Palacio Manco Capac by Ananay Hotels
Cusco Historic Center
￥178,856
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip non-stop flight included
Mexico City (MEX) to Cusco (CUZ)
9.6/10 Exceptional! (356 reviews)
Palacio Manco Capac was truly exceptional. When my husband unexpectedly needed medical attention, Pilar at the front desk went above and beyond to assist us, even arranging for a doctor to come to the hotel.
We are extremely grateful to Pilar and the entire staff for their kindness, attentiveness, and genuine care. The accommodations were beautiful, the service was excellent, and the restaurant has an amazing view. Every member of the staff made us feel welcomed and cared for. We would absolutely recommend Palacio Manco Capac to anyone visiting Cusco.
Reviewed on Sep 3, 2026
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View all trips5* Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
3 Night Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
CasaSur Recoleta
Recoleta
￥306,906
per person
Oct 22 - Oct 24
found 8 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9/10 Wonderful! (664 reviews)
We had an excellent one night stay during a layover. The staff were all amazing and so helpful. We arranged for a couples massage in the spa, and enjoyed every minute and wished it would never end. We would stay here again for sure.
Reviewed on Sep 11, 2026
4 Night Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
Palacio Manco Capac by Ananay Hotels
Cusco Historic Center
￥178,856
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip non-stop flight included
Mexico City (MEX) to Cusco (CUZ)
9.6/10 Exceptional! (356 reviews)
Palacio Manco Capac was truly exceptional. When my husband unexpectedly needed medical attention, Pilar at the front desk went above and beyond to assist us, even arranging for a doctor to come to the hotel.
We are extremely grateful to Pilar and the entire staff for their kindness, attentiveness, and genuine care. The accommodations were beautiful, the service was excellent, and the restaurant has an amazing view. Every member of the staff made us feel welcomed and cared for. We would absolutely recommend Palacio Manco Capac to anyone visiting Cusco.
Reviewed on Sep 3, 2026
Palacio del Inka, A Luxury Collection Hotel by Marriott
Cusco Historic Center
￥192,134
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip non-stop flight included
Mexico City (MEX) to Cusco (CUZ)
9.6/10 Exceptional! (1,002 reviews)
Beautiful hotel but there is no AC and the room is dry. We had to open the windows to lair out the room
Reviewed on Sep 12, 2026
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View all tripsTop Luxury South America Hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Rodovia Br 469 Km 32 Foz do Iguaçu PR
￥111,403
￥128,954 total
Sep 18 - Sep 19
includes taxes & fees
Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...
10/10 Exceptional! (1,006 reviews)
"Since this property is located right on the Falls, it is so incredible to have the opportunity to go out before the regular park visitors and see everything almost by yourself."
Reviewed on Sep 16, 2026
Hotel Club Frances
Rodríguez Peña 1832 Buenos Aires Capital Federal
￥34,178
￥34,643 total
Sep 20 - Sep 21
Hotel Club Frances is one of the Buenos Aires sumptuous 5-star boutique properties where you can pamper yourself with deep soaking bathtubs and massage services. ...
9.4/10 Exceptional! (678 reviews)
"N/A"
Reviewed on Sep 16, 2026
Palacio del Inka, A Luxury Collection Hotel by Marriott
Plazoleta Santo Domingo No 259 Cusco Cusco
￥48,657
￥59,942 total
Oct 12 - Oct 13
Go for a luxurious stay at Palacio del Inka, A Luxury Collection Hotel by Marriott, where you can enjoy amenities like Champagne service, pillowtop beds, and ...
9.6/10 Exceptional! (1,003 reviews)
"Beautiful hotel but there is no AC and the room is dry. We had to open the windows to lair out the room"
Reviewed on Sep 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
