Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

2 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

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Nicholtown

If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.

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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Overbrook Historic District

While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bon Secours Wellness Arena and Beattie House.

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A cityscape with a mix of modern and historic buildings, a large parking lot, and a highway.

West End

Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.

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A cityscape with a mix of modern and historic buildings, a prominent bridge, and a river.

Green Avenue

If you're looking for some top things to see and do in Green Avenue and surrounding area, you can visit Fluor Field at the West End and The Peace Center.

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Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

45 W Orchard Park Dr Greenville SC
￥17,009
￥19,269 total
Nov 1 - Nov 2
includes taxes & fees
Hilton Greenville
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
￥14,595
￥16,535 total
Oct 19 - Oct 20
includes taxes & fees
8/10 Very Good! (1,008 reviews)
"Room was good size and clean. Staff were helpful and welcoming. Construction was ongoing and they did their best to accommodate in spite of all the activity. It was a busy weekend and their elevators couldn't keep up. Overall not bad."

Reviewed on Oct 11, 2026

Hyatt Place Greenville/Haywood
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
￥16,746
￥18,974 total
Oct 26 - Oct 27
includes taxes & fees
9/10 Wonderful! (1,426 reviews)
"A wonderful stay! Clean and very comfortable! We have stayed here several times and it won’t be the last!"

Reviewed on Oct 12, 2026

Embassy Suites Greenville Golf Resort & Conference Center
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
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A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Falls Park on the Reedy

9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
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A wooden cross with inscriptions, set against a mountainous landscape with a cloudy sky.
Photo by Karyn Thompson

Fred W. Symmes Chapel

9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.
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Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
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Greenville Convention Center

8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
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BMW Performance Center

9.0/10 (90 reviews)
You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.
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Haywood Mall

8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
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What to do in Upstate South Carolina

Greenville Haunted Bar Tour

Greenville Haunted Bar Tour

￥4,393
per adult
100% of travellers recommend
Greenville Haunted Bar Tour
Gorgeous loop around Swan Lake at Furman University.

Guided E-Bike Tour in Greenville South Carolina with Brunch

￥16,463
per adult
Guided E-Bike Tour in Greenville South Carolina with Brunch
Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

￥14,904
per adult
Just Desserts Tour In Greenville
See all activities in Upstate South Carolina

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
From as low as . Yes, you read that right. Our Upstate South Carolina vacation packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina vacation packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there's a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you're heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina vacation?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you've made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we're a one-stop shop for all of them. You'll save big bucks just by bundling your bookings. Whether you're embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes — that's one of the best things about an Expedia vacation package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.