Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

3 out of top 10 points of interest in this area
5/5(654 area reviews)

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is ￥16,578 per night from Oct 26 to Oct 27
￥16,578
￥18,732 total
Oct 26 - Oct 27
includes taxes & fees
8/10 Very Good! (1,014 reviews)
"Awesome"

Reviewed on Oct 8, 2025

Hilton Greenville
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
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Wooded Cottage - 3 Mi to Clemson University
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is ￥25,551 per night from Oct 19 to Oct 20
￥25,551
￥28,949 total
Oct 19 - Oct 20
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
"Good location, clean, and good staff. The facility itself is a little dated and the shower ceiling height was a little short."

Reviewed on Oct 5, 2025

Hyatt Regency Greenville
See all 2,845 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Upstate South Carolina

Clemson University

Clemson University

5/5(410 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

Clemson University
In my opinion this is a must see! Truly a spiritual experience. The drive up the mountain will feel long but it's worth every minute.

Fred W. Symmes Chapel

5/5(12 reviews)

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

Fred W. Symmes Chapel
Table Rock State Park

Table Rock State Park

4.5/5(110 reviews)

You can take time to visit Table Rock State Park during your travels to Pickens. Wander the riverfront or discover the waterfalls in this family-friendly area.

Table Rock State Park

What to do in Upstate South Carolina

Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

￥13,916
per adult
Just Desserts Tour In Greenville
A quick photo stop along the trail.

Guided E-Bike Tour in Greenville South Carolina with Brunch

￥15,372
per adult
Guided E-Bike Tour in Greenville South Carolina with Brunch
See all activities in Upstate South Carolina

Frequently asked questions

Can I cancel my flight booking to Upstate South Carolina due to COVID-19?
Head to our Customer Service Portal for important information about changing or canceling flights due to COVID-19. Make sure you also read through the terms and conditions of your chosen airline before booking your fare to Upstate South Carolina.
What's the best way to find cheap flights to Upstate South Carolina that have flexible change policies?
We understand that travel plans can change in the blink of an eye, so reserving a flexible ticket with Expedia is a sensible idea. Simply tick the "No change fee" box under the "Flexible change policies" filter. Your low-cost, flexible flight to Upstate South Carolina is just a few clicks away.
What are some of the general tips for travelers to Upstate South Carolina during the COVID-19 outbreak?
COVID-19 has affected how the world works in endless ways, and travel has changed with it. These tips will help you navigate these new challenges and prepare you for your trip to Upstate South Carolina:
  • Before booking anything, see if any travel bans or restrictions apply — in both your origin and destination. Get up-to-date information by reviewing government and travel websites.
  • Wear a face mask even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, place your pass on the scanner and then hold it up for inspection.
  • One container of liquid hand sanitizer is now allowed in your carry-on luggage. It must not be larger than 12 oz (350 ml), and you'll need to remove it from your bag for screening.
  • To reduce handling during screening, place items such as your phone and loose change into your carry-on rather than the bins.
  • Separate any food you're carrying for X-ray screening. Placing it in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Upstate South Carolina?
Secure your ticket with American Airlines and then start piecing together your Upstate South Carolina itinerary. This leading carrier offers 19932 flights each month to Charlotte-Douglas Intl. Airport (CLT), a key gateway.
How can I find cheap tickets to Upstate South Carolina?
You'll always nab a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred flight date, then check the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Upstate South Carolina in the last seven days.
How much is a flight to Upstate South Carolina?
One-way trips departing from () sold for as little as in the last seven days. During this period, the price of a round-trip fare to Upstate South Carolina ranged between and . If you find a bargain ticket, book as fast as you can — these prices don't stick around.
What are the most popular airports to fly into in Upstate South Carolina?
Book your flight to Charlotte-Douglas Intl. Airport (CLT) and experience everything that Upstate South Carolina has to offer. As the region's primary entry point, about 21666 flights touch down here every month.
When is the cheapest time to fly to Upstate South Carolina?
If you'd prefer to spend your hard-earned vacation money experiencing the delights of Upstate South Carolina rather than on your trip there, leave early in the week. The most affordable day to travel is normally Tuesday, with Monday coming in second. With many people traveling over the weekend, Saturday often has the costliest fares.
How much is a plane ticket to Upstate South Carolina?
Plane fares ranged anywhere from to in the last seven days. When you're ready to book, we'll help you find a low-cost flight to Upstate South Carolina.
Which airlines with flights to Upstate South Carolina employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, many airlines have introduced new rules and standards to help everybody get back in the skies. These carriers include:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.