Upstate South Carolina Vacations

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

2 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Find the Best Upstate South Carolina Vacation Packages

Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
The price is ￥19,848 per night from Aug 7 to Aug 8
￥19,848
￥22,427 total
Aug 7 - Aug 8
includes taxes & fees
8.4/10 Very Good! (1,020 reviews)
"good!"

Reviewed on Jul 13, 2026

Hilton Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
The price is ￥28,916 per night from Jul 28 to Jul 29
￥28,916
￥32,762 total
Jul 28 - Jul 29
includes taxes & fees
8.8/10 Excellent! (1,013 reviews)
"Bar is great, $21 for breakfast buffet too much"

Reviewed on Jul 14, 2026

Hyatt Regency Greenville
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
The price is ￥63,193 per night from Jul 19 to Jul 20
￥63,193
￥71,407 total
Jul 19 - Jul 20
includes taxes & fees
9.6/10 Exceptional! (528 reviews)
"This was our 2nd time staying here for our anniversary. It was wonderful."

Reviewed on Jul 14, 2026

Grand Bohemian Lodge Greenville, Autograph Collection
See all 3,052 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
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What to do in Upstate South Carolina

Spooky & Haunted Paranormal Bar Crawl Downtown Greenville

Greenville Haunted Bar Tour

￥5,689
per adult
100% of travellers recommend
Greenville Haunted Bar Tour
Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

￥15,441
per adult
Just Desserts Tour In Greenville
Gorgeous loop around Swan Lake at Furman University.

Guided E-Bike Tour in Greenville South Carolina with Brunch

￥17,057
per adult
Guided E-Bike Tour in Greenville South Carolina with Brunch
See all activities in Upstate South Carolina

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
From as low as . Yes, you read that right. Our Upstate South Carolina vacation packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina vacation packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there's a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you're heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina vacation?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you've made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we're a one-stop shop for all of them. You'll save big bucks just by bundling your bookings. Whether you're embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes — that's one of the best things about an Expedia vacation package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.