Southeast Missouri, MO Vacation Homes from ￥17,026

Southeast Missouri Vacation Homes
United States of America
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Our top choices for Southeast Missouri vacation homes

A porch with four green Adirondack chairs, a small table, and string lights.

A modern kitchen with white cabinets, stainless steel appliances, and a blue accent wall.

A green bicycle with a basket and a brown seat parked in front of a house with a porch.

A living room with a stone fireplace, a flat-screen TV mounted above it, and a ceiling fan.

1. State ParksBungalowCoffeeBarPet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

Ironton

10.0 out of 10, Exceptional, (41 reviews)

10/10

Exceptional

(41 reviews)

"Great place to stay!"

Derek R.

The price is ￥20,623

￥20,623

￥42,343 total

includes taxes & fees

Sep 28 - Sep 29

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

A bedroom with a bed, a bench, and a ceiling fan.

A single-story house with a stone facade and a satellite dish.

A kitchen with a stainless steel sink, a coffee maker, a bottle of dish soap, and a towel on the counter.

A modern room with a black leather sofa, a small table with a lamp, and a view through a window with curtains.

2. AV Bungalows #9B

AV Bungalows #9B

Arcadia

10.0 out of 10, Exceptional, (2 reviews)

10/10

Exceptional

(2 reviews)

"My husband and I really enjoyed our stay! The Bungalow was perfect for us and will definitely be staying again when we come back to Arcadia!!"

Theresa R.

The price is ￥21,327

￥21,327

￥26,284 total

includes taxes & fees

Sep 27 - Sep 28

AV Bungalows #9B

A wooden deck with outdoor seating and a fire pit, surrounded by trees.

A grey sofa with a white and black striped pillow and a white knitted throw.

A compact kitchen with a wooden countertop, a built-in microwave, and a window with a view of trees.

A bedroom with a sloped ceiling, a wooden bench with potted plants, a bed with pillows, and a door with a mirror.

3. The Stonehouse - Private Hot Tub - Sleeps 5

The Stonehouse - Private Hot Tub - Sleeps 5

Fredericktown

9.8 out of 10, Exceptional, (8 reviews)

9.8/10

Exceptional

(8 reviews)

"The Stonehouse was every bit as cute and comfortable as expected! We enjoyed staying here as a great base for hiking in the area. The tiny town is a neat complex of different types of place to stay plus the Station coffee house was great to have in walking distance. "

Beth A.

The price is ￥22,319

￥22,319

￥37,998 total

includes taxes & fees

Sep 27 - Sep 28

The Stonehouse - Private Hot Tub - Sleeps 5

A modern kitchen with white cabinets, a stainless steel microwave, and a coffee bar with stools.

A backyard with a patio table and chairs, a barbecue grill, and a red building in the background.

A red house with a gray roof, a front porch, and an American flag.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a sign above the sink that reads "FARMER'S DAUGHTERS BAKERY SHOPPE".

4. Charming 1860s Renovated Home

Charming 1860s Renovated Home

Ironton

8.0 out of 10, Very good, (20 reviews)

8.0/10

Very good

(20 reviews)

"Had a great stay"

Kevin S.

The price is ￥21,649

￥21,649

￥42,275 total

includes taxes & fees

Oct 20 - Oct 21

Charming 1860s Renovated Home

A window with a vase of flowers and a book on a wooden table.

A two-story house with a wrap-around porch and a turret.

A laundry room with two stacked washers and dryers, a window, and a wooden ceiling beam.

A modern kitchen with a central island, bar stools, a microwave, a refrigerator, and a window with a flower vase.

5. The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square

Ironton

10.0 out of 10, Exceptional, (63 reviews)

10/10

Exceptional

(63 reviews)

"This property is beautiful and everything is thought of for the guests. The hosts were amazing. It is close to wonderful state parks. My family had a great time. I would stay here again!"

Jennifer D.

The price is ￥26,609

￥26,609

￥32,844 total

includes taxes & fees

Sep 30 - Oct 1

The Sutton House 2 blocks from Main Street & Courthouse Square

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

6. Tiny Houses of French Village

Tiny Houses of French Village

2.5 star property

French Village

10.0 out of 10, Exceptional, (6 reviews)

10/10

Exceptional

(6 reviews)

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Chris

The price is ￥23,932

￥23,932

￥39,899 total

includes taxes & fees

Sep 28 - Sep 29

Tiny Houses of French Village

A wooden deck with steps leading to a house, surrounded by trees.

A living room with a wooden floor, a round table with a green tablecloth, a dark-colored sofa, a wooden chair, a ceiling fan, and a round mirror on the wall.

A grassy park area with trees and a fenced area.

A small, single-story house with a gabled roof, wooden shutters, and a front door.

7. Get Away Acres 1/2 mile off highway 60 extra sanitized

Get Away Acres 1/2 mile off highway 60 extra sanitized

Ellsinore

10.0 out of 10, Exceptional, (100 reviews)

10/10

Exceptional

(100 reviews)

"Gorgeous property, wonderful hosts. Would love to visit again "

Anonymous traveler

The price is ￥16,618

￥16,618

￥20,736 total

includes taxes & fees

Sep 28 - Sep 29

Get Away Acres 1/2 mile off highway 60 extra sanitized

A kitchen with white cabinets, a wooden dining table, a built-in stove, and a trash can.

A living room with a sofa, armchair, coffee table, and fireplace.

A neatly made bed with a white comforter and pillows, a small bedside table with a lamp, a wall-mounted mirror, and a ceiling fan.

A bathroom with a shower curtain, a toilet, a sink, and a towel rack with towels.

8. Cozy Three bedroom home in Central Farmington

Cozy Three bedroom home in Central Farmington

Farmington

9.8 out of 10, Exceptional, (35 reviews)

9.8/10

Exceptional

(35 reviews)

"Great little house and was perfect for our weekend trip to Farmington! Would recommend."

Daniel K.

The price is ￥17,005

￥17,005

￥39,900 total

includes taxes & fees

Sep 26 - Sep 27

Cozy Three bedroom home in Central Farmington

A modern kitchen with grey cabinets, a black refrigerator, and a microwave.

A bedroom with a bed, a ceiling fan, a window with curtains, a bedside table, and a lamp.

A dining area with a wooden table and chairs, a ceiling fan, a window with a valance, and a framed picture on the wall.

A single-story house with a grey siding exterior, two windows, a small porch, and a planter with plants.

9. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Farmington

10.0 out of 10, Exceptional, (29 reviews)

10/10

Exceptional

(29 reviews)

"Very nice stay we enjoyed would definitely stay again"

Ben C.

The price is ￥19,051

￥19,051

￥37,055 total

includes taxes & fees

Sep 28 - Sep 29

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

A compact living space with a sofa, dining table, kitchen area, and a ceiling fan.

A kitchen with a white stove, black cabinets, a window with blue curtains, and a wooden floor.

A bedroom with a bed, a window with curtains, a ceiling light, and a wall clock.

A modern living room with a grey sofa, wooden flooring, and a black-framed TV on the wall.

10. Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Farmington

9.2 out of 10, Wonderful, (10 reviews)

9.2/10

Wonderful

(10 reviews)

"Host was very helpful and accommodating! Very cute and small house, perfect for our weekend stay! "

Amber P.

The price is ￥10,628

￥10,628

￥23,287 total

includes taxes & fees

Sep 30 - Oct 1

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

A kitchen counter with a coffee maker, a toaster, and three jars labeled "Fresh Sugar," "Fresh Tea," and "Fresh Coffee." There is a framed picture above the counter and a sign with a coffee cup saying "Good Morning."

A kitchen with wooden cabinets, a microwave, a dishwasher, and a ceiling fan.

A dining area with a glass table, wicker chairs, and a ceiling fan.

A house with a white front door, a mailbox, and a welcome sign.

11. Adorable Farmington Home, 5 Star Rated Stay!

Adorable Farmington Home, 5 Star Rated Stay!

Farmington

The price is ￥14,171

￥14,171

￥24,744 total

includes taxes & fees

Sep 27 - Sep 28

Adorable Farmington Home, 5 Star Rated Stay!

A campfire surrounded by benches in a wooded park area.

A compact kitchen with a dining table and chairs, a microwave, stove, and a sink.

A compact laundry room with a white washing machine and dryer, a lint bin, and a shelf with a box.

A bedroom with two beds, a nightstand, a lamp, a ceiling fan, and a window.

12. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Wappapello

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

"Very cozy"

Shea E.

The price is ￥16,532

￥16,532

￥35,483 total

includes taxes & fees

Oct 6 - Oct 7

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

A person sitting on rocks by a flowing river surrounded by greenery.

A two-story house with a balcony, surrounded by trees and a well-maintained lawn.

A modern kitchen with white cabinets, a marble countertop, and a built-in oven.

A modern kitchen with a marble countertop, a coffee table, a television, and a sliding glass door leading to an outdoor area.

13. Your home away from home in downtown, historic Farmington!

Your home away from home in downtown, historic Farmington!

Farmington

10.0 out of 10, Exceptional, (51 reviews)

10/10

Exceptional

(51 reviews)

"Great location. We loved watching the chickens."

Emily N.

The price is ￥20,311

￥20,311

￥39,057 total

includes taxes & fees

Sep 27 - Sep 28

Your home away from home in downtown, historic Farmington!

A covered outdoor seating area with a table and chairs, string lights, and a gravel ground.

A dining area with a wooden table, chairs, a bench, a hanging light fixture, a 'WELCOME' sign, a framed quote, and a window with blinds.

A kitchen with a stainless steel refrigerator, a microwave, and a stone island with two stools.

A living room with a rustic wooden wall, a fireplace, a flat-screen TV, and a white sideboard.

14. Clifford's Country Cottage

Clifford's Country Cottage

Bonne Terre

10.0 out of 10, Exceptional, (44 reviews)

10/10

Exceptional

(44 reviews)

"This place is a gem! Country setting, but only a few minutes from shops and restaurants. New and extremely well stocked. Perfect for a couple looking to get away. Host is super responsive and accommodating! Will definitely be back."

Philip

The price is ￥19,681

￥19,681

￥23,994 total

includes taxes & fees

Sep 27 - Sep 28

Clifford's Country Cottage

A house with a porch, a staircase, and a door.

A modern kitchen with grey cabinets, a white tiled backsplash, a stainless steel sink, a microwave, and a coffee maker.

A gazebo with a table and chairs, surrounded by greenery and trees.

A living room with a gray sectional sofa, a floral armchair, a round coffee table, and a ceiling fan.

15. "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

Farmington

10.0 out of 10, Exceptional, (11 reviews)

10/10

Exceptional

(11 reviews)

"Thank you again for a great stay! This is a perfect little cabin !"

Angela S.

The price is ￥19,051

￥19,051

￥37,528 total

includes taxes & fees

Sep 27 - Sep 28

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

A living room with a TV, a fireplace, a sofa, and wall art.

A residential house with a red door, a front porch, and two trees in the yard.

A compact kitchen with a sink, countertop, and wooden cabinets.

A room with a TV on a white stand, curtains, and a wooden floor.

16. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau

8.4 out of 10, Very good, (58 reviews)

8.4/10

Very good

(58 reviews)

"Great cute place. "

Jeremy W.

The price is ￥12,753

￥12,753

￥17,026 total

includes taxes & fees

Sep 28 - Sep 29

Little Blue Cottage on Spanish

A kitchen with granite countertops, wooden cabinets, a stainless steel sink, and a wooden chair.

A porch with a door, two chairs, and potted plants.

A kitchen with wooden cabinets, a refrigerator, a stove, and a sink.

A spacious living area with a wooden floor, a dining table, a sofa, and a kitchen with a microwave and stove.

17. Home Near Eleven Point River & Nat'l Forest!

Home Near Eleven Point River & Nat'l Forest!

Alton

7.0 out of 10, Good, (2 reviews)

7.0/10

Good

(2 reviews)

"We had a great stay! The getaway was clean and inviting. Its super artsy and creative-just a really fun place. Amber and Marc were very informative. Any and all questions we had were answered. Everything was ready and available. Amber is super helpful and just a really great person. Will be back and highly recommend!!!"

Amy

The price is ￥12,439

￥12,439

￥32,408 total

includes taxes & fees

Oct 5 - Oct 6

Home Near Eleven Point River & Nat'l Forest!

A kitchen with wooden cabinets, a stainless steel refrigerator, a stove, and a window.

A bathroom with a large mirror, wooden cabinets, and a bed visible through a glass door.

A living room with a brown armchair, a sofa, a TV, and framed pictures on the walls.

A round metal table with two plates and a blue bowl, surrounded by metal chairs on a wooden deck.

18. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello

Williamsville

The price is ￥20,783

￥20,783

￥38,968 total

includes taxes & fees

Sep 25 - Sep 26

Hunting / Fishing Cabin at Lake Wappapello

A house with a front porch decorated with hay bales, a scarecrow, and pumpkins.

A stainless steel refrigerator and a built-in oven with pots on top.

A covered deck with a table and chairs, a grill, and a view of a house in the background.

A modern kitchen with wooden cabinets, a stainless steel refrigerator, an oven, and a dishwasher. There is a dining table with chairs and a small rug on the floor.

19. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Poplar Bluff

8.8 out of 10, Excellent, (16 reviews)

8.8/10

Excellent

(16 reviews)

The price is ￥18,107

￥18,107

￥43,321 total

includes taxes & fees

Sep 28 - Sep 29

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

A living room with a brick fireplace, a sofa, a coffee table, and a television mounted on the wall.

A kitchen with wooden cabinets, a microwave, stove, and a dishwasher.

A laundry area with two white Whirlpool washers and dryers, a shelf with cleaning supplies, and a door to the right.

20. Serenity in Town 2-bedroom, 4 beds house in charming Farmington

Serenity in Town 2-bedroom, 4 beds house in charming Farmington

Farmington

10.0 out of 10, Exceptional, (4 reviews)

10/10

Exceptional

(4 reviews)

"Really enjoyed our stay. It was clean, close to town and shopping. Not to far from St Genevieve where we went to an event. I would stay here again."

Beth M.

The price is ￥20,154

￥20,154

￥40,915 total

includes taxes & fees

Sep 30 - Oct 1

Serenity in Town 2-bedroom, 4 beds house in charming Farmington

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"Perfect Stay. Friendly Staff. Conveniently Located. Comfortable Bed. Nice Hot Shower. Ice Cold Shower."

Ronald 3-night trip

Posted 4 hours ago

Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."

Hiram 1-night trip

Posted 13 hours ago

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Poplar Bluff

10/10 Excellent

"Clean room, staff"

Lavonne 2-night trip

Posted 1 day ago

Drury Inn & Suites Poplar Bluff

Comfort Inn Festus - St Louis South

8/10 Good

"Our room was clean, the beds were comfortable. I liked the sink/mirror seperate from the toilet/shower. The breakfast was pretty typical for a complimentary breakfast. I was pleasantly surprised that they had real butter provided in the little refrigerator."

Jody 1-night trip

Posted 2 days ago

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Easy checkin, clean facilities, safe area. Quiet with a comfy bed."

Deandra 1-night trip

Posted 2 days ago

Motel 6 Poplar Bluff, MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Great experience will definitely be doing it again"

tyesha 2-night trip

Posted 2 days ago

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

David 1-night trip

Posted 2 days ago

Days Inn and Suites by Wyndham Sikeston

Hampton Inn Poplar Bluff

10/10 Excellent

"It was a great experience."

JESUS M 1-night trip

Posted 3 days ago

Hampton Inn Poplar Bluff

Pear Tree Inn Cape Girardeau West

8/10 Good

"I was looking for something that was good quality and wouldn’t break my wallet. This place was what I was expecting. Lady working the breakfast was extremely polite and helpful."

Jennifer 1-night trip

Posted 3 days ago

Pear Tree Inn Cape Girardeau West

Find out more about Southeast Missouri

Southeast Missouri Vacation Homes information

Number of reviews	446
Accommodation	208 Vacation Homes
Lowest Price	￥17,026
Highest Price	￥43,321

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Book Vacation Homes in Southeast Missouri on Expedia.com

Search Vacation Homes in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri vacation homes

1. *State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

2. AV Bungalows #9B

3. The Stonehouse - Private Hot Tub - Sleeps 5

4. Charming 1860s Renovated Home

5. The Sutton House 2 blocks from Main Street & Courthouse Square

6. Tiny Houses of French Village

7. Get Away Acres 1/2 mile off highway 60 extra sanitized

8. Cozy Three bedroom home in Central Farmington

9. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

10. Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

11. Adorable Farmington Home, 5 Star Rated Stay!

12. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

13. Your home away from home in downtown, historic Farmington!

14. Clifford's Country Cottage

15. "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

16. Little Blue Cottage on Spanish

17. Home Near Eleven Point River & Nat'l Forest!

18. Hunting / Fishing Cabin at Lake Wappapello

19. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

20. Serenity in Town 2-bedroom, 4 beds house in charming Farmington

Find vacation rentals that suit your style

Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Find out more about Southeast Missouri

Southeast Missouri Vacation Homes information

Explore a world of travel with Expedia

1. State ParksBungalowCoffeeBarPet Friendly*Porch