Lodging Image

Search Vacation Homes in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Southeast Missouri vacation homes

A modern kitchen with grey cabinets, a black refrigerator, and a microwave.

1. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Farmington
10.0 out of 10, Exceptional, (30 reviews)
"Very nice stay we enjoyed would definitely stay again"
United States
Ben C.
The price is ￥19,107
￥38,108 total
includes taxes & fees
Oct 11 - Oct 12
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
A bedroom with a bed, a bench, and a ceiling fan.

2. AV Bungalows #9B

AV Bungalows #9B
Arcadia
10.0 out of 10, Exceptional, (2 reviews)
"My husband and I really enjoyed our stay! The Bungalow was perfect for us and will definitely be staying again when we come back to Arcadia!!"
United States
Theresa R.
The price is ￥21,389
￥26,360 total
includes taxes & fees
Oct 13 - Oct 14
AV Bungalows #9B
A compact living space with a sofa, dining table, kitchen area, and a ceiling fan.

3. Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Farmington
9.2 out of 10, Wonderful, (10 reviews)
"Host was very helpful and accommodating! Very cute and small house, perfect for our weekend stay! "
United States
Amber P.
The price is ￥10,659
￥23,448 total
includes taxes & fees
Oct 13 - Oct 14
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
A covered outdoor seating area with a table and chairs, string lights, and a gravel ground.

4. Clifford's Country Cottage

Clifford's Country Cottage
Bonne Terre
10.0 out of 10, Exceptional, (44 reviews)
"This place is a gem! Country setting, but only a few minutes from shops and restaurants. New and extremely well stocked. Perfect for a couple looking to get away. Host is super responsive and accommodating! Will definitely be back."
United States
Philip
The price is ￥19,739
￥24,262 total
includes taxes & fees
Oct 15 - Oct 16
Clifford's Country Cottage
A wooden deck with outdoor seating and a fire pit, surrounded by trees.

5. The Stonehouse - Private Hot Tub - Sleeps 5

The Stonehouse - Private Hot Tub - Sleeps 5
Fredericktown
9.8 out of 10, Exceptional, (8 reviews)
"The Stonehouse was every bit as cute and comfortable as expected! We enjoyed staying here as a great base for hiking in the area. The tiny town is a neat complex of different types of place to stay plus the Station coffee house was great to have in walking distance. "
United States
Beth A.
The price is ￥22,384
￥38,109 total
includes taxes & fees
Oct 13 - Oct 14
The Stonehouse - Private Hot Tub - Sleeps 5
A wooden deck with steps leading to a house, surrounded by trees.

6. Get Away Acres 1/2 mile off highway 60 extra sanitized

Get Away Acres 1/2 mile off highway 60 extra sanitized
Ellsinore
10.0 out of 10, Exceptional, (100 reviews)
"Gorgeous property, wonderful hosts. Would love to visit again "
United States
Anonymous traveler
The price is ￥16,581
￥20,690 total
includes taxes & fees
Oct 8 - Oct 9
Get Away Acres 1/2 mile off highway 60 extra sanitized
A porch with four green Adirondack chairs, a small table, and string lights.

7. *State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Ironton
10.0 out of 10, Exceptional, (41 reviews)
"Great place to stay!"
United States
Derek R.
The price is ￥22,611
￥46,249 total
includes taxes & fees
Oct 8 - Oct 9
*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
A house with a porch, a staircase, and a door.

8. "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Farmington
10.0 out of 10, Exceptional, (11 reviews)
"Thank you again for a great stay! This is a perfect little cabin !"
United States
Angela S.
The price is ￥19,107
￥38,108 total
includes taxes & fees
Oct 13 - Oct 14
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
A kitchen with wooden cabinets, a stainless steel refrigerator, a stove, and a window.

9. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello
Williamsville
The price is ￥20,880
￥39,150 total
includes taxes & fees
Oct 8 - Oct 9
Hunting / Fishing Cabin at Lake Wappapello
A kitchen with white cabinets, a wooden dining table, a built-in stove, and a trash can.

10. Cozy Three bedroom home in Central Farmington

Cozy Three bedroom home in Central Farmington
Farmington
9.8 out of 10, Exceptional, (37 reviews)
"Super cute house in a great location."
United States
Theresa
The price is ￥17,054
￥40,496 total
includes taxes & fees
Oct 14 - Oct 15
Cozy Three bedroom home in Central Farmington
A window with a vase of flowers and a book on a wooden table.

11. The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square
Ironton
10.0 out of 10, Exceptional, (63 reviews)
"This property is beautiful and everything is thought of for the guests. The hosts were amazing. It is close to wonderful state parks. My family had a great time. I would stay here again!"
United States
Jennifer D.
The price is ￥26,687
￥32,624 total
includes taxes & fees
Oct 26 - Oct 27
The Sutton House 2 blocks from Main Street & Courthouse Square
A campfire surrounded by benches in a wooded park area.

12. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello
Wappapello
10.0 out of 10, Exceptional, (1 review)
"Very cozy"
United States
Shea E.
The price is ￥19,614
￥38,515 total
includes taxes & fees
Nov 2 - Nov 3
Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello
A person sitting on rocks by a flowing river surrounded by greenery.

13. Your home away from home in downtown, historic Farmington!

Your home away from home in downtown, historic Farmington!
Farmington
10.0 out of 10, Exceptional, (51 reviews)
"Great location. We loved watching the chickens."
United States
Emily N.
The price is ￥20,370
￥39,648 total
includes taxes & fees
Oct 13 - Oct 14
Your home away from home in downtown, historic Farmington!
A modern kitchen with white cabinets, a stainless steel microwave, and a coffee bar with stools.

14. Charming 1860s Renovated Home

Charming 1860s Renovated Home
Ironton
8.0 out of 10, Very good, (20 reviews)
"Had a great stay"
United States
Kevin S.
The price is ￥21,713
￥42,399 total
includes taxes & fees
Oct 8 - Oct 9
Charming 1860s Renovated Home
A living room with a TV, a fireplace, a sofa, and wall art.

15. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is ￥12,791
￥17,077 total
includes taxes & fees
Oct 14 - Oct 15
Little Blue Cottage on Spanish
A bedroom with a bed, wooden ceiling, a ceiling fan, a nightstand, a lamp, and a wall with various items.

16. Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (6 reviews)
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
United States
Chris
The price is ￥31,204
￥48,976 total
includes taxes & fees
Oct 8 - Oct 9
Tiny Houses of French Village
A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

17. 40-Acre Poplar Bluff Nature Lovers Paradise!

40-Acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
9.4 out of 10, Exceptional, (36 reviews)
"Beautiful location!! Had issues with the key pad - other than that all was great!"
United States
Jennie M.
The price is ￥13,129
￥47,905 total
includes taxes & fees
Oct 13 - Oct 14
40-Acre Poplar Bluff Nature Lovers Paradise!
A fire pit table with four Adirondack chairs around it, set on a concrete patio with a grassy field in the background.

18. Golf Getaway Sleeps 8 • King Bed • Arcade • Bumper Pool • Full Kitchen

Golf Getaway Sleeps 8 • King Bed • Arcade • Bumper Pool • Full Kitchen
Farmington
10.0 out of 10, Exceptional, (34 reviews)
"Awesome place to stay and great host!"
United States
Mike M.
The price is ￥20,844
￥54,694 total
includes taxes & fees
Oct 13 - Oct 14
Golf Getaway Sleeps 8 • King Bed • Arcade • Bumper Pool • Full Kitchen
A living room with a brick fireplace, a sofa, a coffee table, and a television mounted on the wall.

19. Serenity in Town 2-bedroom, 4 beds house in charming Farmington

Serenity in Town 2-bedroom, 4 beds house in charming Farmington
Farmington
10.0 out of 10, Exceptional, (4 reviews)
"Really enjoyed our stay. It was clean, close to town and shopping. Not to far from St Genevieve where we went to an event. I would stay here again."
United States
Beth M.
The price is ￥24,792
￥46,997 total
includes taxes & fees
Oct 19 - Oct 20
Serenity in Town 2-bedroom, 4 beds house in charming Farmington
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, an oven, and a granite countertop.

20. RUSTIC RETREAT Cozy 2 Bed 1.5 Bath Home, in Rural Farmington, Wooded Outdoor.

RUSTIC RETREAT Cozy 2 Bed 1.5 Bath Home, in Rural Farmington, Wooded Outdoor.
Farmington
9.2 out of 10, Wonderful, (10 reviews)
"Thank you for your hospitality."
United States
Kim W.
The price is ￥25,108
￥30,302 total
includes taxes & fees
Oct 13 - Oct 14
RUSTIC RETREAT Cozy 2 Bed 1.5 Bath Home, in Rural Farmington, Wooded Outdoor.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"We love staying in this hotel when we are traveling through the area. The staff are great, the rooms are consistently clean and the beds are very comfortable. We enjoy the complementary wine that is served each evening as well. Breakfast is good too."
Tamara 1-night trip
Posted 9 hours ago
Drury Inn & Suites Sikeston, MO

Find out more about Southeast Missouri

Southeast Missouri Vacation Homes information

Number of reviews
547
Accommodation
208 Vacation Homes
Lowest Price
￥17,077
Highest Price
￥54,694