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Check prices for these dates

In two weeks
Mar 27 - Mar 29
In two months
May 8 - May 10
In three months
Jun 5 - Jun 7
In four months
Jul 3 - Jul 5

Our top choices for Southeast Missouri vacation homes

Terrace/patio

Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (3 reviews)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
United States
Norma
Tiny Houses of French Village
Interior

Charming 2-bedroom house with AC, WiFi in serene Van Buren

Charming 2-bedroom house with AC, WiFi in serene Van Buren
Van Buren
9.0 out of 10, Wonderful, (15 reviews)
"It was beautiful and homey. We really enjoyed our stay. "
United States
Jessica
The price is ￥11,128
￥26,822 total
includes taxes & fees
Mar 16 - Mar 17
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Property grounds

Get Away Acres 1/2 mile off highway 60 extra sanitized

Get Away Acres 1/2 mile off highway 60 extra sanitized
Ellsinore
10.0 out of 10, Exceptional, (95 reviews)
"We really enjoyed our stay! Host was very friendly and quick to respond to questions! We will definitely stay again!!"
United States
Anonymous traveler
The price is ￥16,692
￥20,828 total
includes taxes & fees
Mar 19 - Mar 20
Get Away Acres 1/2 mile off highway 60 extra sanitized
Exterior detail

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Farmington
10.0 out of 10, Exceptional, (8 reviews)
"It is a very nice place and very comfortable has everything you could possibly need for homeaway from home."
United States
Scott
The price is ￥19,235
￥37,731 total
includes taxes & fees
Mar 14 - Mar 15
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Dining

Cozy 1-bedroom house with AC and WiFi in charming Farmington

Cozy 1-bedroom house with AC and WiFi in charming Farmington
Farmington
10.0 out of 10, Exceptional, (9 reviews)
"Beautiful and perfect for travelers!!!!!"
United States
Elizabeth
The price is ￥12,161
￥30,258 total
includes taxes & fees
Mar 18 - Mar 19
Cozy 1-bedroom house with AC and WiFi in charming Farmington
Exterior

Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.

Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.
Bloomsdale
10.0 out of 10, Exceptional, (11 reviews)
"What a beautiful fun stay that was a nice quick getaway for us! Everything was perfect from booking, to arrival, to overall stay, we had the best time! "
United States
Blake H.
The price is ￥28,615
￥44,111 total
includes taxes & fees
Mar 15 - Mar 16
Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.
Terrace/patio

Clifford's Country Cottage

Clifford's Country Cottage
Bonne Terre
10.0 out of 10, Exceptional, (28 reviews)
"We have been there three times and it was just as peaceful, clean and exactly what we needed. "
United States
Kimber L.
The price is ￥19,871
￥24,225 total
includes taxes & fees
Mar 16 - Mar 17
Clifford's Country Cottage
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (39 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is ￥21,461
￥34,274 total
includes taxes & fees
Mar 26 - Mar 27
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Fridge, microwave, oven, stovetop

Cozy Three bedroom home in Central Farmington

Cozy Three bedroom home in Central Farmington
Farmington
9.6 out of 10, Exceptional, (29 reviews)
"House was adorable and comfortable. Location close to everything. Drive to The Landing was not bad at all. Host was friendly and available. I would stay again!"
United States
Jody C.
The price is ￥17,169
￥39,808 total
includes taxes & fees
Mar 25 - Mar 26
Cozy Three bedroom home in Central Farmington
Smart TV, fireplace, books

Doc's Cottage - A-Frame in Piggott, AR

Doc's Cottage - A-Frame in Piggott, AR
Piggott
10.0 out of 10, Exceptional, (11 reviews)
"Very clean and well stocked. Host was excellent to communicate with. We would definitely stay again!"
United States
Ken R.
The price is ￥18,320
￥35,908 total
includes taxes & fees
Mar 16 - Mar 17
Doc's Cottage - A-Frame in Piggott, AR
Fridge, microwave, oven, stovetop

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Farmington
10.0 out of 10, Exceptional, (13 reviews)
"Beyond our expectations, nextwe are in Farmington we will stay again. Very Charming in a convenient location. Host made are stay very enjoyable."
United States
Unspecified U.
The price is ￥19,235
￥37,731 total
includes taxes & fees
Mar 14 - Mar 15
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Smart TV, fireplace, books

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Farmington
8.8 out of 10, Excellent, (5 reviews)
"Great place. "
United States
Diana
The price is ￥11,923
￥24,811 total
includes taxes & fees
Apr 6 - Apr 7
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Living area

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.2 out of 10, Very Good, (53 reviews)
"Cozy and perfect for a couple. Great communication with the host"
United States
Beth G.
The price is ￥12,903
￥17,226 total
includes taxes & fees
Mar 15 - Mar 16
Little Blue Cottage on Spanish
Interior

Cozy Haven Little Hidden Gem Sleeps 4

Cozy Haven Little Hidden Gem Sleeps 4
Ste.Genevieve
9.8 out of 10, Exceptional, (59 reviews)
"Everything was perfect. The host was very responsive and friendly and the house was perfect for our stay. It has lots of character and the perfect amount of upgrades. We will definitely stay here again."
United States
Brenda R.
The price is ￥16,453
￥34,755 total
includes taxes & fees
Mar 16 - Mar 17
Cozy Haven Little Hidden Gem Sleeps 4
Beach

Your home away from home in downtown, historic Farmington!

Your home away from home in downtown, historic Farmington!
Farmington
10.0 out of 10, Exceptional, (39 reviews)
"The kitchen was fully equipped and clean. Great place to stay when visiting Farmington!"
United States
Linda B.
The price is ￥20,507
￥39,434 total
includes taxes & fees
Mar 18 - Mar 19
Your home away from home in downtown, historic Farmington!
Interior

The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square
Ironton
10.0 out of 10, Exceptional, (47 reviews)
"Adorable house with everyone you need provided! Super clean and the beds were very comfy. Will stay here again on our next trip to the area. "
United States
Brandi
The price is ￥26,866
￥33,161 total
includes taxes & fees
Mar 18 - Mar 19
The Sutton House 2 blocks from Main Street & Courthouse Square
Property grounds

"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”
Ste. Genevieve
10.0 out of 10, Exceptional, (68 reviews)
"Great place to stay!"
United States
Lettitia B.
The price is ￥18,886
￥27,362 total
includes taxes & fees
Mar 25 - Mar 26
"Little Brick House on Main (1865)”
Terrace/patio

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Ironton
10.0 out of 10, Exceptional, (34 reviews)
"enjoyed our stay, nice location to downtown and coffee. "
United States
Aaron L.
The price is ￥27,454
￥49,382 total
includes taxes & fees
Mar 25 - Mar 26
*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Fridge, microwave, oven, coffee/tea maker

FS Rental #2 Annapolis, MO Black River

FS Rental #2 Annapolis, MO Black River
Annapolis
7.2 out of 10, Good, (7 reviews)
"Great experience "
United States
West n.
The price is ￥15,738
￥30,999 total
includes taxes & fees
Mar 14 - Mar 15
FS Rental #2 Annapolis, MO Black River
Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (151 reviews)
"Such a great place and location"
United States
Tracy H.
The price is ￥23,846
￥39,047 total
includes taxes & fees
Mar 23 - Mar 24
Serenity South -- Gardens, River-Views, and Refreshing Space
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"I was amazed to find out this place is 20+ years old. It is in great shape. Room was wonderful. Breakfast was great; very lovely stay."
Andrew 1-night trip
Posted 6 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Find out more about Southeast Missouri

Southeast Missouri Vacation Homes information

Number of reviews
641
Accommodation
190 Vacation Homes
Lowest Price
￥17,226
Highest Price
￥49,382