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Find Historic Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri Historic Hotels

Tonight
Dec 27 - Dec 28
Tomorrow
Dec 28 - Dec 29
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Southeast Missouri historic hotels

Fridge, microwave, oven, stovetop
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
2.0 star property
Ste. Genevieve
10.0 out of 10, Exceptional, (18)
"Great historic property!"
United States
Rhonda R.
The price is ￥17,566
￥32,399 total
includes taxes & fees
Dec 30 - Dec 31
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
The price is ￥23,109
￥28,057 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Beautiful Modern Loft In Wine Country!
Property grounds
The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!
Frohna
10.0 out of 10, Exceptional, (32)
"Hosts were great. I just wish they had a second bath or atleast a larger bathroom. "
United States
Dennis H.
The price is ￥14,937
￥26,025 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Weber Farm - Enjoy a beautiful 100 acre farm!
Exterior detail
"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”
Ste. Genevieve
10.0 out of 10, Exceptional, (63)
"Great place to stay!"
United States
Lettitia B.
The price is ￥18,549
￥24,795 total
includes taxes & fees
Jan 5 - Jan 6, 2026
"Little Brick House on Main (1865)”
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (149)
"Such a great place and location"
United States
Tracy H.
The price is ￥23,421
￥38,246 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Serenity South -- Gardens, River-Views, and Refreshing Space
Property grounds
Country Inn Motel

Country Inn Motel

Country Inn Motel
2.0 star property
Licking
7.2 out of 10, Good, (332)
"Very clean room. Staff was helpful and courteous. Good value for the price. "
United States
Peggy
The price is ￥8,588
￥9,359 total
includes taxes & fees
Dec 28 - Dec 29
Country Inn Motel
Exterior
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
The price is ￥21,079
￥43,850 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Charming cottage overlooking Lake Acre
Exterior
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (405)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is ￥18,319
￥31,695 total
includes taxes & fees
Dec 28 - Dec 29
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Fridge, microwave, oven, stovetop
Chic Minimalist Gem w/ Fenced Backyard + W/D

Chic Minimalist Gem w/ Fenced Backyard + W/D

Chic Minimalist Gem w/ Fenced Backyard + W/D
Princeton Heights
9.6 out of 10, Exceptional, (9)
"Nice location."
United States
Holly R.
The price is ￥10,334
￥29,680 total
includes taxes & fees
Dec 30 - Dec 31
Chic Minimalist Gem w/ Fenced Backyard + W/D
Fridge, microwave, oven, stovetop
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
The Hill
9.8 out of 10, Exceptional, (160)
"Very clean, check in was easy, great neighborhood with lots of food close. "
United States
Laura H.
The price is ￥13,387
￥22,466 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Reasonably priced spacious room. The bed was very comfortable and great water pressure for the shower. Incredibly friendly staff. Plenty of parking for truck with trailer and parking lots were well lit. Couple items in our room could use attention or update, but overall a great value and pleasant place to stay."
Holly 1-night trip
Posted 3 days ago
Baymont Inn and Suites by Wyndham Farmington, MO